| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anthony C Faber, Danan Li, Youngchul Song, Mei-Chih Liang, Beow Y Yeap, Roderick T Bronson, Eugene Lifshits, Zhao Chen, Sauveur-Michel Maira, Carlos García-Echeverría, Kwok-Kin Wong, Jeffrey A Engelma. Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 46. 2009-12-15. PMID:19850869. |
in egfr mutant lung cancers, down-regulation of both intracellular pathways converged on the bh3 family of proteins regulating apoptosis. |
2009-12-15 |
2023-08-12 |
Not clear |
| Cong Liu, Sheng Zhou, Chang-Shu Ke, Na-Ping Li, Ren-Liang W. [Activation and prognostic significance of AKT, NF-kappaB and STAT3 in breast cancer with lymph node metastasis and estrogen receptor expression]. Ai zheng = Aizheng = Chinese journal of cancer. vol 26. issue 9. 2009-12-03. PMID:17927847. |
being downstream targets of the phosphatase and tensin homolog deleted on chromosome ten (pten) and epidermal growth factor receptor (egfr) pathways, serine/threonine kinase akt, nuclear factor-kappab (nf-kappab) and signal transducer and activator of transcription-3 (stat3), play important roles in cell proliferation, apoptosis and oncogenesis. |
2009-12-03 |
2023-08-12 |
Not clear |
| J van der Veeken, S Oliveira, R M Schiffelers, G Storm, P M P van Bergen En Henegouwen, R C Roover. Crosstalk between epidermal growth factor receptor- and insulin-like growth factor-1 receptor signaling: implications for cancer therapy. Current cancer drug targets. vol 9. issue 6. 2009-11-24. PMID:19754359. |
both the epidermal growth factor receptor (egfr) and the insulin-like growth factor-1 receptor (igf-1r) can contribute to tumor development and -progression through their effects on cell proliferation, inhibition of apoptosis, angiogenesis, anchorage-independent growth and tumor-associated inflammation. |
2009-11-24 |
2023-08-12 |
Not clear |
| Adrienne J Smith, Yelena Karpova, Ralph D'Agostino, Mark Willingham, George Kuli. Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PloS one. vol 4. issue 7. 2009-11-10. PMID:19593445. |
thus, activation of egfr, gpcrs or pi3k pathway leads to bad phosphorylation and inhibition of apoptosis. |
2009-11-10 |
2023-08-12 |
Not clear |
| Fei Ye, Qinglei Gao, Tongjiang Xu, Liang Zeng, Yibo Ou, Feng Mao, Heping Wang, Yue He, Baofeng Wang, Zhengming Yang, Dongsheng Guo, Ting Le. Upregulation of LRIG1 suppresses malignant glioma cell growth by attenuating EGFR activity. Journal of neuro-oncology. vol 94. issue 2. 2009-11-05. PMID:19300910. |
upregulation of lrig1, followed by a decrease of egfr on the cytomembrane of the cells, induced cell apoptosis and cell growth inhibition, and further reversed invasion in glioma cell lines and primary glioma cells. |
2009-11-05 |
2023-08-12 |
Not clear |
| Nicola Normanno, Sabine Tejpar, Floriana Morgillo, Antonella De Luca, Eric Van Cutsem, Fortunato Ciardiell. Implications for KRAS status and EGFR-targeted therapies in metastatic CRC. Nature reviews. Clinical oncology. vol 6. issue 9. 2009-11-04. PMID:19636327. |
egfr regulates cancer-cell proliferation, apoptosis and tumor-induced neoangiogenesis, and has been validated as a relevant therapeutic target in several human cancers, including metastatic colorectal cancer (mcrc). |
2009-11-04 |
2023-08-12 |
human |
| Baofeng Wang, Lin Han, Rudong Chen, Mingjun Cai, Fuxin Han, Ting Lei, Dongsheng Gu. Downregulation of LRIG2 expression by RNA interference inhibits glioblastoma cell (GL15) growth, causes cell cycle redistribution, increases cell apoptosis and enhances cell adhesion and invasion in vitro. Cancer biology & therapy. vol 8. issue 11. 2009-11-03. PMID:19421009. |
downregulation of lrig2 expression resulted in: rapid egf-mediated loss of egfr; decreased proliferation; g(0)/g(1) arrest; increased spontaneous apoptosis; enhanced cell adhesion and increased invasion capability of gl15 cells in vitro. |
2009-11-03 |
2023-08-12 |
human |
| Mar Lorente, Arkaitz Carracedo, Sofía Torres, Francesco Natali, Ainara Egia, Sonia Hernández-Tiedra, María Salazar, Cristina Blázquez, Manuel Guzmán, Guillermo Velasc. Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis. Glia. vol 57. issue 13. 2009-10-30. PMID:19229996. |
our findings therefore identify amphirregulin as a factor for resistance of glioma cells to thc-induced apoptosis and contribute to unraveling the molecular bases underlying the emerging notion that targeted inhibition of the egfr pathway can improve the efficacy of antitumoral therapies. |
2009-10-30 |
2023-08-12 |
Not clear |
| P Klanrit, P Taebunpakul, M B Flinterman, E W Odell, M A Riaz, G Melino, P Salomoni, J S Mymryk, J Gäken, F Farzaneh, M Tavassol. PML involvement in the p73-mediated E1A-induced suppression of EGFR and induction of apoptosis in head and neck cancers. Oncogene. vol 28. issue 39. 2009-10-14. PMID:19597475. |
pml involvement in the p73-mediated e1a-induced suppression of egfr and induction of apoptosis in head and neck cancers. |
2009-10-14 |
2023-08-12 |
human |
| P Klanrit, P Taebunpakul, M B Flinterman, E W Odell, M A Riaz, G Melino, P Salomoni, J S Mymryk, J Gäken, F Farzaneh, M Tavassol. PML involvement in the p73-mediated E1A-induced suppression of EGFR and induction of apoptosis in head and neck cancers. Oncogene. vol 28. issue 39. 2009-10-14. PMID:19597475. |
egfr overexpression from a heterologous ltr promoter protected lung cancer cells from tap73beta-induced egfr suppression and apoptosis. |
2009-10-14 |
2023-08-12 |
human |
| P Klanrit, P Taebunpakul, M B Flinterman, E W Odell, M A Riaz, G Melino, P Salomoni, J S Mymryk, J Gäken, F Farzaneh, M Tavassol. PML involvement in the p73-mediated E1A-induced suppression of EGFR and induction of apoptosis in head and neck cancers. Oncogene. vol 28. issue 39. 2009-10-14. PMID:19597475. |
expression of tap73beta efficiently induced promyelocytic leukaemia (pml) protein expression and pml knockdown by shrna attenuated the downregulation of egfr and induction of apoptosis by p73 in hnscc cells. |
2009-10-14 |
2023-08-12 |
human |
| Elaine Lai-Han Leung, Issan Yee-San Tam, Vicky Pui-Chi Tin, Daniel Tsin-Tien Chua, Alan Dart-Loon Sihoe, Lik-Cheung Cheng, James Chung-Man Ho, Lap-Ping Chung, Maria Pik Won. SRC promotes survival and invasion of lung cancers with epidermal growth factor receptor abnormalities and is a potential candidate for molecular-targeted therapy. Molecular cancer research : MCR. vol 7. issue 6. 2009-09-18. PMID:19491201. |
this inhibition profile of egfr implicates that induction of apoptosis and sensitivity of mutant cells to ski treatment is mediated by egfr and egfr downstream pathways. |
2009-09-18 |
2023-08-12 |
Not clear |
| Elaine Lai-Han Leung, Issan Yee-San Tam, Vicky Pui-Chi Tin, Daniel Tsin-Tien Chua, Alan Dart-Loon Sihoe, Lik-Cheung Cheng, James Chung-Man Ho, Lap-Ping Chung, Maria Pik Won. SRC promotes survival and invasion of lung cancers with epidermal growth factor receptor abnormalities and is a potential candidate for molecular-targeted therapy. Molecular cancer research : MCR. vol 7. issue 6. 2009-09-18. PMID:19491201. |
cotreatment with ski-1 and gefitinib enhanced apoptosis in cancer cells that contained egfr mutation and/or amplification. |
2009-09-18 |
2023-08-12 |
Not clear |
| Guiying Li, Chang Han, Lihong Xu, Kyu Lim, Kumiko Isse, Tong W. Cyclooxygenase-2 prevents fas-induced liver injury through up-regulation of epidermal growth factor receptor. Hepatology (Baltimore, Md.). vol 50. issue 3. 2009-09-18. PMID:19585617. |
pretreatment with a cox-2 inhibitor (ns-398) or an egfr inhibitor (ag1478) exacerbated jo2-mediated liver injury and hepatocyte apoptosis. |
2009-09-18 |
2023-08-12 |
mouse |
| S Loew, U Schmidt, A Unterberg, M-E Halatsc. The epidermal growth factor receptor as a therapeutic target in glioblastoma multiforme and other malignant neoplasms. Anti-cancer agents in medicinal chemistry. vol 9. issue 6. 2009-09-18. PMID:19601750. |
as the intracellular tyrosine kinase of the egfr activates signalling cascades leading to cell proliferation, angiogenesis and inhibition of apoptosis, the egfr represents an attractive target in cancer therapy. |
2009-09-18 |
2023-08-12 |
Not clear |
| Q Sun, L Ming, S M Thomas, Y Wang, Z G Chen, R L Ferris, J R Grandis, L Zhang, J Y. PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells. Oncogene. vol 28. issue 24. 2009-09-16. PMID:19421143. |
puma mediates egfr tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells. |
2009-09-16 |
2023-08-12 |
Not clear |
| Q Sun, L Ming, S M Thomas, Y Wang, Z G Chen, R L Ferris, J R Grandis, L Zhang, J Y. PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells. Oncogene. vol 28. issue 24. 2009-09-16. PMID:19421143. |
our results suggest that puma induction through p73 represents a new mechanism of egfr inhibitor-induced apoptosis, and provide potential ways for enhancing and predicting the sensitivity to egfr-targeted therapies in hnscc. |
2009-09-16 |
2023-08-12 |
Not clear |
| Annika Sommerfeld, Roland Reinehr, Dieter Häussinge. Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis. The Journal of biological chemistry. vol 284. issue 33. 2009-09-14. PMID:19553664. |
bile acids have been reported to induce epidermal growth factor receptor (egfr) activation and subsequent proliferation of activated hepatic stellate cells (hsc), but the underlying mechanisms and whether quiescent hsc are also a target for bile acid-induced proliferation or apoptosis remained unclear. |
2009-09-14 |
2023-08-12 |
rat |
| Ji-Young Song, Sang-Wook Lee, Joon Pio Hong, Sung Eun Chang, Han Choe, Jene Cho. Epidermal growth factor competes with EGF receptor inhibitors to induce cell death in EGFR-overexpressing tumor cells. Cancer letters. vol 283. issue 2. 2009-09-04. PMID:19380191. |
by contrast, egf may also stimulate apoptosis in tumor cells, depending on egfr and her2 (erbb-2) expression levels. |
2009-09-04 |
2023-08-12 |
Not clear |
| Liang Qiao, Benjamin C Y Won. Targeting apoptosis as an approach for gastrointestinal cancer therapy. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. vol 12. issue 3. 2009-08-25. PMID:19278896. |
apoptosis can be induced by many different approaches including activating cell surface death receptors (for example, fas, trail and tnf receptors), inhibiting cell survival signaling (such as egfr, mapk and pi3k), altering apoptosis threshold by modulating pro-apoptotic and anti-apoptotic members of the bcl-2 family, down-regulating anti-apoptosis proteins (such as xiap, survivin and c-iap2), and using other pro-apoptotic agents. |
2009-08-25 |
2023-08-12 |
Not clear |