| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cornelia E Protzer, Irmgard Wech, Anja C Nage. Hairless induces cell death by downregulation of EGFR signalling activity. Journal of cell science. vol 121. issue Pt 19. 2008-12-12. PMID:18765565. |
together, the results indicate that h induces apoptosis by downregulation of egfr signalling activity. |
2008-12-12 |
2023-08-12 |
drosophila_melanogaster |
| Christine A Pratilas, Aphrothiti J Hanrahan, Ensar Halilovic, Yogindra Persaud, Junichi Soh, Dhananjay Chitale, Hisayuki Shigematsu, Hiromasa Yamamoto, Ayana Sawai, Manickam Janakiraman, Barry S Taylor, William Pao, Shinichi Toyooka, Marc Ladanyi, Adi Gazdar, Neal Rosen, David B Soli. Genetic predictors of MEK dependence in non-small cell lung cancer. Cancer research. vol 68. issue 22. 2008-12-10. PMID:19010912. |
supporting its classification as a "driver" mutation in the cells in which it is expressed, mek inhibition in (v600e)braf nsclc cells led to substantial induction of apoptosis, comparable with that seen with egfr kinase inhibition in egfr mutant nsclc models. |
2008-12-10 |
2023-08-12 |
human |
| Igor Sukhotnik, Dan Shteinberg, Shani Ben Lulu, Yulia Bashenko, Jorge G Mogilner, Benno M Ure, Ron Shaoul, Arnold G Cora. Effect of transforming growth factor-alpha on enterocyte apoptosis is correlated with EGF receptor expression along the villus-crypt axis during methotrexate-induced intestinal mucositis in a rat. Apoptosis : an international journal on programmed cell death. vol 13. issue 11. 2008-12-03. PMID:18803016. |
the inhibiting effect of tgf-alpha on enterocyte apoptosis was strongly correlated with egfr expression along the villus-crypt axis. |
2008-12-03 |
2023-08-12 |
rat |
| Cong Cao, Shan Lu, Qin Jiang, Wen-Jun Wang, Xiuzu Song, Rebecca Kivlin, Brittany Wallin, Andrew Bagdasarian, Tyrone Tamakloe, Wen-Ming Chu, John Marshall, Nicola Kouttab, Aie Xu, Yinsheng Wa. EGFR activation confers protections against UV-induced apoptosis in cultured mouse skin dendritic cells. Cellular signalling. vol 20. issue 10. 2008-11-14. PMID:18644433. |
egfr activation confers protections against uv-induced apoptosis in cultured mouse skin dendritic cells. |
2008-11-14 |
2023-08-12 |
mouse |
| Cong Cao, Shan Lu, Qin Jiang, Wen-Jun Wang, Xiuzu Song, Rebecca Kivlin, Brittany Wallin, Andrew Bagdasarian, Tyrone Tamakloe, Wen-Ming Chu, John Marshall, Nicola Kouttab, Aie Xu, Yinsheng Wa. EGFR activation confers protections against UV-induced apoptosis in cultured mouse skin dendritic cells. Cellular signalling. vol 20. issue 10. 2008-11-14. PMID:18644433. |
in this study, we examined the mechanisms of activation and apoptosis of dcs after uv irradiation by focusing on epidermal growth factor receptor (egfr). |
2008-11-14 |
2023-08-12 |
mouse |
| Cong Cao, Shan Lu, Qin Jiang, Wen-Jun Wang, Xiuzu Song, Rebecca Kivlin, Brittany Wallin, Andrew Bagdasarian, Tyrone Tamakloe, Wen-Ming Chu, John Marshall, Nicola Kouttab, Aie Xu, Yinsheng Wa. EGFR activation confers protections against UV-induced apoptosis in cultured mouse skin dendritic cells. Cellular signalling. vol 20. issue 10. 2008-11-14. PMID:18644433. |
taken together, we conclude that uv induces multiple signaling pathways mediated by egfr trans-activation leading to possible maturation, apoptosis and survival, and egfr activation protects against uv-induced apoptosis in cultured mouse dendritic cells. |
2008-11-14 |
2023-08-12 |
mouse |
| Belinda Sánchez Ramírez, Yeranddy Aguiar Alpízar, Diana Rosa Hernández Fernández, Greta Garrido Hidalgo, Ailem Rabasa Capote, Rolando Pérez Rodríguez, Luis Enrique Fernánde. Anti-EGFR activation, anti-proliferative and pro-apoptotic effects of polyclonal antibodies induced by EGFR-based cancer vaccine. Vaccine. vol 26. issue 38. 2008-10-23. PMID:18672015. |
anti-egfr pab abrogated ligands-dependent egfr phosphorylation, provoking tumor cells apoptosis. |
2008-10-23 |
2023-08-12 |
mouse |
| Yi-Ling Huang, Chun-Yu Chuang, Fung-Chang Sung, Chia-Yang Che. Thioredoxin overexpression modulates remodeling factors in stress responses to cigarette smoke. Journal of toxicology and environmental health. Part A. vol 71. issue 22. 2008-10-21. PMID:18836924. |
results showed that cs stimulated ros generation and apoptosis in normal human bronchial epithelial (beas-2b) cells, and interfered with gene expression of remodeling factors, such as activation of transforming growth factor (tgf)-beta1, epidermal growth factor receptor (egfr), and cyclin-dependent kinase inhibitor (p21), but repressed matrix metalloproteinases (mmp)-9. |
2008-10-21 |
2023-08-12 |
human |
| Yi-Ling Huang, Chun-Yu Chuang, Fung-Chang Sung, Chia-Yang Che. Thioredoxin overexpression modulates remodeling factors in stress responses to cigarette smoke. Journal of toxicology and environmental health. Part A. vol 71. issue 22. 2008-10-21. PMID:18836924. |
in particular, trx-overexpressing bronchial epithelial (trx-td) cells reduced cs-induced apoptosis, and suppressed airway remodeling through attenuation of tgf-beta1, egfr, and p21 and upregulation of mmp-9 expression. |
2008-10-21 |
2023-08-12 |
human |
| H Wallerand, G Robert, J-C Bernhard, A Ravaud, J-M Ferrièr. [Targeted therapy for locally advanced and/or metastatic bladder cancer]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. vol 18. issue 7. 2008-10-17. PMID:18602599. |
overexpression of tyrosine kinase receptors, including egfr, vefgr and her2/neu, is correlated with tumour progression and activation of the phosphatidyl-inositol-3 kinase (pi-3k) pathway is involved in tumour invasion and inhibition of apoptosis. |
2008-10-17 |
2023-08-12 |
Not clear |
| Yun-Gang Zhang, Qiang Du, Wei-Gang Fang, Mu-Lan Jin, Xin-Xia Tia. Tyrphostin AG1478 suppresses proliferation and invasion of human breast cancer cells. International journal of oncology. vol 33. issue 3. 2008-10-07. PMID:18695891. |
in this study, we evaluated the effectiveness of tyrphostin ag1478, a potent and specific inhibitor of egfr tyrosine kinase, on the growth, apoptosis and invasion of breast cancer cells. |
2008-10-07 |
2023-08-12 |
human |
| Rohit Upadhyay, Meenu Jain, Shaleen Kumar, Uday Chand Ghoshal, Balraj Mitta. Interaction of EGFR 497Arg>Lys with EGF +61A>G polymorphism: modulation of risk in esophageal cancer. Oncology research. vol 17. issue 4. 2008-09-30. PMID:18773861. |
genetic polymorphisms in egfr 497arg>lys and egf +61a>g genes influence cell cycle progression, apoptosis, angiogenesis, and metastasis. |
2008-09-30 |
2023-08-12 |
Not clear |
| Alexandros Zafiropoulos, George N Tzanakaki. Decorin-mediated effects in cancer cell biology. Connective tissue research. vol 49. issue 3. 2008-09-26. PMID:18661352. |
decorin was established to directly interact with egfr and erb2, inducing protracted receptor internalization, which results in attenuation of the receptor-mediated intacellular signaling and induction of apoptosis. |
2008-09-26 |
2023-08-12 |
Not clear |
| Andriani Charpidou, Despoina Blatza, Valsamo Anagnostou, Elsa Anagnostou, Konstantinos N Syrigo. Review. EGFR mutations in non-small cell lung cancer--clinical implications. In vivo (Athens, Greece). vol 22. issue 4. 2008-09-19. PMID:18712184. |
egfr activation results in a series of downstream signaling events that mediate cancer cell growth, proliferation, motility, adhesion, invasion, apoptosis inhibition and metastasis as well as resistance to chemotherapy. |
2008-09-19 |
2023-08-12 |
Not clear |
| Masayasu Iwase, Sayaka Takaoka, Makiko Uchida, Sayaka Yoshiba, Gen Kondo, Hitoshi Watanabe, Masaru Ohashi, Masao Nagum. Epidermal growth factor receptor inhibitors enhance susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells. Oral oncology. vol 44. issue 4. 2008-09-18. PMID:17689285. |
we examined whether inhibition of egfr signaling would affect the susceptibility of oral squamous cell carcinoma (oscc) cells to fas-mediated apoptosis. |
2008-09-18 |
2023-08-12 |
Not clear |
| Masayasu Iwase, Sayaka Takaoka, Makiko Uchida, Sayaka Yoshiba, Gen Kondo, Hitoshi Watanabe, Masaru Ohashi, Masao Nagum. Epidermal growth factor receptor inhibitors enhance susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells. Oral oncology. vol 44. issue 4. 2008-09-18. PMID:17689285. |
treatment of oscc cells with an anti-egfr monoclonal antibody, c225, and an egfr tyrosine kinase inhibitor, ag1478, which target the extracellular and intracellular domains of the receptor, respectively, inhibited phosphorylation of egfr and its downstream effector molecule akt and amplified the induction of fas-mediated apoptosis. |
2008-09-18 |
2023-08-12 |
Not clear |
| Masayasu Iwase, Sayaka Takaoka, Makiko Uchida, Sayaka Yoshiba, Gen Kondo, Hitoshi Watanabe, Masaru Ohashi, Masao Nagum. Epidermal growth factor receptor inhibitors enhance susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells. Oral oncology. vol 44. issue 4. 2008-09-18. PMID:17689285. |
in oscc cells treated with egfr inhibitors, fas-mediated apoptosis was accompanied by caspase-8 activation but not bid cleavage. |
2008-09-18 |
2023-08-12 |
Not clear |
| Masayasu Iwase, Sayaka Takaoka, Makiko Uchida, Sayaka Yoshiba, Gen Kondo, Hitoshi Watanabe, Masaru Ohashi, Masao Nagum. Epidermal growth factor receptor inhibitors enhance susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells. Oral oncology. vol 44. issue 4. 2008-09-18. PMID:17689285. |
caspase-3 and -8 inhibitors reduced the effect of egfr inhibitors on fas-mediated apoptosis in oscc cells, but a caspase-9 inhibitor did not. |
2008-09-18 |
2023-08-12 |
Not clear |
| Masayasu Iwase, Sayaka Takaoka, Makiko Uchida, Sayaka Yoshiba, Gen Kondo, Hitoshi Watanabe, Masaru Ohashi, Masao Nagum. Epidermal growth factor receptor inhibitors enhance susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells. Oral oncology. vol 44. issue 4. 2008-09-18. PMID:17689285. |
these results suggest that the egfr signaling pathway may, in part, regulate fas-mediated apoptosis in oscc cells through c-flip expression. |
2008-09-18 |
2023-08-12 |
Not clear |
| E Vairaktaris, S Spyridonidou, V Papakosta, A Vylliotis, A Lazaris, D Perrea, C Yapijakis, E Patsouri. The hamster model of sequential oral oncogenesis. Oral oncology. vol 44. issue 4. 2008-09-18. PMID:18061531. |
we investigated the expression of oncogenes egfr, erbb2, erbb3, fgfr-2, fgfr-3, c-myc, n-ras, ets-1, h-ras, c-fos and c-jun, apoptosis markers bax and bcl-2, tumour suppressor genes p53 and p16, and cell proliferation marker ki-67 in the sequential stages of hamster oral oncogenesis. |
2008-09-18 |
2023-08-12 |
human |