| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshimitsu Yamaoka, Fang Yan, Hanwei Cao, Stuart S Hobbs, Rebecca S Dise, Wei Tong, D Brent Pol. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 33. 2008-09-16. PMID:18701712. |
activation of egfr, erbb2, akt, src, and apoptosis were determined in vivo and in vitro. |
2008-09-16 |
2023-08-12 |
mouse |
| Toshimitsu Yamaoka, Fang Yan, Hanwei Cao, Stuart S Hobbs, Rebecca S Dise, Wei Tong, D Brent Pol. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 33. 2008-09-16. PMID:18701712. |
tnf stimulated egfr phosphorylation in young adult mouse colon epithelial cells, and loss of egfr expression or inhibition of kinase activity increased tnf-induced apoptosis, which was prevented in wt but not by kinase-inactive egfr expression. |
2008-09-16 |
2023-08-12 |
mouse |
| Toshimitsu Yamaoka, Fang Yan, Hanwei Cao, Stuart S Hobbs, Rebecca S Dise, Wei Tong, D Brent Pol. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 33. 2008-09-16. PMID:18701712. |
similarly, tnf injection stimulated apoptosis in egfr-kinase-defective mice (egfr(wa2)) compared with wt mice. |
2008-09-16 |
2023-08-12 |
mouse |
| Tacghee Yi, Hye-Lim Lee, Ji-Hoon Cha, Soo-Il Ko, Hye-Jin Kim, Hong-In Shin, Kyung-Mi Woo, Hyun-Mo Ryoo, Gwan-Shik Kim, Jeong-Hwa Bae. Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signaling. Journal of cellular physiology. vol 217. issue 2. 2008-09-12. PMID:18543257. |
in addition, egfr inhibition in differentiated osteoclasts caused apoptosis through caspase activation. |
2008-09-12 |
2023-08-12 |
Not clear |
| Tacghee Yi, Hye-Lim Lee, Ji-Hoon Cha, Soo-Il Ko, Hye-Jin Kim, Hong-In Shin, Kyung-Mi Woo, Hyun-Mo Ryoo, Gwan-Shik Kim, Jeong-Hwa Bae. Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signaling. Journal of cellular physiology. vol 217. issue 2. 2008-09-12. PMID:18543257. |
inhibition of the phosphoinositide-3 kinase (pi3k)-akt/pkb pathway and subsequent activation of bad and caspases-9 and -3 may be responsible for the egfr inhibition-induced apoptosis. |
2008-09-12 |
2023-08-12 |
Not clear |
| Vihren Kolev, Anna Mandinova, Juan Guinea-Viniegra, Bing Hu, Karine Lefort, Chiara Lambertini, Victor Neel, Reinhard Dummer, Erwin F Wagner, G Paolo Dott. EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nature cell biology. vol 10. issue 8. 2008-09-09. PMID:18604200. |
suppression of notch signalling in cancer cells counteracts the differentiation-inducing effects of egfr inhibitors while, at the same time, synergizing with these compounds in induction of apoptosis. |
2008-09-09 |
2023-08-12 |
mouse |
| Cong Cao, Shan Lu, Alex Sowa, Rebecca Kivlin, Ashley Amaral, Wenming Chu, Hui Yang, Wen Di, Yinsheng Wa. Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs. Cancer letters. vol 266. issue 2. 2008-08-27. PMID:18400375. |
activation of egfr signaling pathway is involved in increased cell proliferation, angiogenesis, metastasis and decreased apoptosis. |
2008-08-27 |
2023-08-12 |
Not clear |
| Preetha Anand, Chitra Sundaram, Sonia Jhurani, Ajaikumar B Kunnumakkara, Bharat B Aggarwa. Curcumin and cancer: an "old-age" disease with an "age-old" solution. Cancer letters. vol 267. issue 1. 2008-08-27. PMID:18462866. |
curcumin is a diferuloylmethane derived from the indian spice, turmeric (popularly called "curry powder") that has been shown to interfere with multiple cell signaling pathways, including cell cycle (cyclin d1 and cyclin e), apoptosis (activation of caspases and down-regulation of antiapoptotic gene products), proliferation (her-2, egfr, and ap-1), survival (pi3k/akt pathway), invasion (mmp-9 and adhesion molecules), angiogenesis (vegf), metastasis (cxcr-4) and inflammation (nf-kappab, tnf, il-6, il-1, cox-2, and 5-lox). |
2008-08-27 |
2023-08-12 |
Not clear |
| Tina Cascone, Maria Pia Morelli, Floriana Morgillo, Woo-Young Kim, Gabriella Rodolico, Stefano Pepe, Giampaolo Tortora, Liberato Berrino, Ho-Young Lee, John V Heymach, Fortunato Ciardiell. Synergistic anti-proliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells. Journal of cellular physiology. vol 216. issue 3. 2008-08-26. PMID:18381602. |
a significant synergistic growth inhibitory effect was observed with the combination of bortezomib and each egfr inhibitor in all cell lines (combination index, ci, range 0.10-0.55), which was accompanied by a significant induction in apoptosis by the combined treatment with bortezomib, cetuximab and vandetanib. |
2008-08-26 |
2023-08-12 |
human |
| Tina Cascone, Maria Pia Morelli, Floriana Morgillo, Woo-Young Kim, Gabriella Rodolico, Stefano Pepe, Giampaolo Tortora, Liberato Berrino, Ho-Young Lee, John V Heymach, Fortunato Ciardiell. Synergistic anti-proliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells. Journal of cellular physiology. vol 216. issue 3. 2008-08-26. PMID:18381602. |
in contrast, overexpression of a constitutively active p-akt protected a549 cells by cell growth inhibition and apoptosis following treatment with bortezomib and egfr inhibitors. |
2008-08-26 |
2023-08-12 |
human |
| Shadan Ali, Sanjeev Banerjee, Aamir Ahmad, Bassel F El-Rayes, Philip A Philip, Fazlul H Sarka. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Molecular cancer therapeutics. vol 7. issue 6. 2008-08-22. PMID:18566242. |
we found significant reduction in cell viability by both 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and clonogenic assays, induction of apoptosis, down-regulation of egfr phosphorylation, nf-kappab dna-binding activity, and expression of antiapoptotic genes in bxpc-3 cells when treated with the combination of erlotinib and b-dim compared with either agent alone. |
2008-08-22 |
2023-08-12 |
Not clear |
| Sven Diederichs, Stephanie Jung, S Michael Rothenberg, Gromoslaw A Smolen, Barbara G Mlody, Daniel A Habe. Coexpression of Argonaute-2 enhances RNA interference toward perfect match binding sites. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 27. 2008-08-08. PMID:18591665. |
whereas multiple empirically designed shrna constructs exhibited highly divergent efficiencies in mediating egfr knockdown and cell killing, coexpression of ago2 resulted in uniform and highly specific target gene suppression and apoptosis in egfr-dependent cells. |
2008-08-08 |
2023-08-12 |
Not clear |
| S Sebastian, A Azzariti, R Accardi, D Conti, B Pilato, R LaCalamita, L Porcelli, G M Simone, S Tommasi, M Tommasino, A Paradis. Validation of gefitinib effectiveness in a broad panel of head and neck squamous carcinoma cells. International journal of molecular medicine. vol 21. issue 6. 2008-07-23. PMID:18506376. |
in this study, we tested for gefitinib effectiveness in a broad panel of 12 newly established hnscc cell lines, investigating its ability to reduce cell growth, to induce apoptosis and to modulate cell cycle and various egfr pathway-related targets. |
2008-07-23 |
2023-08-12 |
human |
| Matthew Wagener, Xiaochun Zhang, Humberto G Villarreal, Larry Levy, Pamela Allen, Shujun Shentu, Bingliang Fang, Sunil Krishnan, Joe Y Chang, M Rex Cheun. Effect of combining anti-epidermal growth factor receptor antibody C225 and radiation on DU145 prostate cancer. Oncology reports. vol 19. issue 5. 2008-07-22. PMID:18425360. |
flow cytometric analysis suggested that mostly necrotic cell death resulted from the egfr inhibition or irradiation, although there may be some apoptosis. |
2008-07-22 |
2023-08-12 |
mouse |
| Jorge Ducongé, Nelson Merino, Dalia Alvarez, Irene Beausoleil, Eduardo Fernández-Sánchez, Leyanis Rodríguez, Alastair D Bur. Kinetics of monoclonal anti-epidermal growth factor receptor antibody (IOR EGF/r3)-induced apoptosis in human carcinoma bearing nude mice. Puerto Rico health sciences journal. vol 27. issue 1. 2008-07-15. PMID:18450231. |
we have studied the kinetic pattern of apoptosis induction in h125 human lung carcinoma xenografts after treatment with the monoclonal antibody (mab) anti-epidermal growth factor receptor (egfr) ior egf/r3. |
2008-07-15 |
2023-08-12 |
mouse |
| Ziqiu Wang, Meifang Wang, Brian I Car. Integrin alpha5-induced EGFR activation by prothrombin triggers hepatocyte apoptosis via the JNK signaling pathway. Journal of cellular physiology. vol 216. issue 2. 2008-07-08. PMID:18330891. |
integrin alpha5-induced egfr activation by prothrombin triggers hepatocyte apoptosis via the jnk signaling pathway. |
2008-07-08 |
2023-08-12 |
rat |
| Ziqiu Wang, Meifang Wang, Brian I Car. Integrin alpha5-induced EGFR activation by prothrombin triggers hepatocyte apoptosis via the JNK signaling pathway. Journal of cellular physiology. vol 216. issue 2. 2008-07-08. PMID:18330891. |
the data suggest that integrin-related egfr activation by prothrombin can induce cell growth inhibition and apoptosis via an egfr-jnk signaling pathway. |
2008-07-08 |
2023-08-12 |
rat |
| Claudio Festuccia, Giovanni Luca Gravina, Paola Muzi, Danilo Millimaggi, Vincenza Dolo, Carlo Vicentini, Mauro Bologn. Akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors. The Prostate. vol 68. issue 9. 2008-07-03. PMID:18361408. |
akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with egfr tyrosine kinase inhibitors. |
2008-07-03 |
2023-08-12 |
human |
| Yu-Chieh Wang, Samuel K Kulp, Dasheng Wang, Chih-Cheng Yang, Aaron M Sargeant, Jui-Hsiang Hung, Yoko Kashida, Mamoru Yamaguchi, Geen-Dong Chang, Ching-Shih Che. Targeting endoplasmic reticulum stress and Akt with OSU-03012 and gefitinib or erlotinib to overcome resistance to epidermal growth factor receptor inhibitors. Cancer research. vol 68. issue 8. 2008-06-10. PMID:18413750. |
the osu-03012/egfr inhibitor combination induced pronounced apoptosis in h1155 and h23 cells, but not in a549 cells, suggesting a correlation between drug sensitivity and basal phospho-akt levels independently of egfr expression status. |
2008-06-10 |
2023-08-12 |
mouse |
| Toshimitsu Tanaka, Anupama Munshi, Colin Brooks, Jenny Liu, Marvette L Hobbs, Raymond E Mey. Gefitinib radiosensitizes non-small cell lung cancer cells by suppressing cellular DNA repair capacity. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 14. issue 4. 2008-06-03. PMID:18281562. |
overexpression of the epidermal growth factor receptor (egfr) promotes unregulated growth, inhibits apoptosis, and likely contributes to clinical radiation resistance of non-small cell lung cancer (nsclc). |
2008-06-03 |
2023-08-12 |
Not clear |