| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M B Flinterman, J S Mymryk, P Klanrit, A F Yousef, S W Lowe, C Caldas, J Gäken, F Farzaneh, M Tavassol. p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing. Oncogene. vol 26. issue 48. 2007-11-29. PMID:17486071. |
using deletion mutants of e1a12s we have shown that interaction of e1a with p400, but not p300 or prb, is required for egfr suppression and apoptosis. |
2007-11-29 |
2023-08-12 |
human |
| M B Flinterman, J S Mymryk, P Klanrit, A F Yousef, S W Lowe, C Caldas, J Gäken, F Farzaneh, M Tavassol. p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing. Oncogene. vol 26. issue 48. 2007-11-29. PMID:17486071. |
inhibition of p400 by short hairpin rna confirmed that hnscc cells with reduced p400 expression were less sensitive to e1a-induced suppression of egfr and apoptosis. |
2007-11-29 |
2023-08-12 |
human |
| M B Flinterman, J S Mymryk, P Klanrit, A F Yousef, S W Lowe, C Caldas, J Gäken, F Farzaneh, M Tavassol. p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing. Oncogene. vol 26. issue 48. 2007-11-29. PMID:17486071. |
in summary, this study identifies p400 as an important mediator of e1a-induced downregulation of egfr and apoptosis. |
2007-11-29 |
2023-08-12 |
human |
| Xia Xiao, Jiangxue Wu, Xiaofeng Zhu, Peng Zhao, Jinlin Zhou, Quentin Qiang Liu, Limin Zheng, Musheng Zeng, Ranyi Liu, Wenlin Huan. Induction of cell cycle arrest and apoptosis in human nasopharyngeal carcinoma cells by ZD6474, an inhibitor of VEGFR tyrosine kinase with additional activity against EGFR tyrosine kinase. International journal of cancer. vol 121. issue 9. 2007-11-27. PMID:17631646. |
induction of cell cycle arrest and apoptosis in human nasopharyngeal carcinoma cells by zd6474, an inhibitor of vegfr tyrosine kinase with additional activity against egfr tyrosine kinase. |
2007-11-27 |
2023-08-12 |
mouse |
| Arthur Edwards, Jiannong Li, Peter Atadja, Kapil Bhalla, Eric B Haur. Effect of the histone deacetylase inhibitor LBH589 against epidermal growth factor receptor-dependent human lung cancer cells. Molecular cancer therapeutics. vol 6. issue 9. 2007-11-27. PMID:17876048. |
lbh589 selectively depleted proteins important in signaling cascades in cell lines harboring egfr kinase mutations, such as egfr, stat3, and akt, and these cells underwent apoptosis following exposure to lbh589. |
2007-11-27 |
2023-08-12 |
human |
| Arthur Edwards, Jiannong Li, Peter Atadja, Kapil Bhalla, Eric B Haur. Effect of the histone deacetylase inhibitor LBH589 against epidermal growth factor receptor-dependent human lung cancer cells. Molecular cancer therapeutics. vol 6. issue 9. 2007-11-27. PMID:17876048. |
conversely, lbh589 had little effect on apoptosis in cells not dependent on egfr for survival, no changes were identified in the expression of egfr or other survival proteins, and the predominant effect was cell cycle arrest rather than apoptosis. |
2007-11-27 |
2023-08-12 |
human |
| Arthur Edwards, Jiannong Li, Peter Atadja, Kapil Bhalla, Eric B Haur. Effect of the histone deacetylase inhibitor LBH589 against epidermal growth factor receptor-dependent human lung cancer cells. Molecular cancer therapeutics. vol 6. issue 9. 2007-11-27. PMID:17876048. |
based on these results, lbh589 can acetylate hsp90, deplete egfr and other key survival signaling proteins, and trigger apoptosis only in lung cancer cells harboring egfr mutations. |
2007-11-27 |
2023-08-12 |
human |
| Zhiwei Yu, Titus J Boggon, Susumu Kobayashi, Cheng Jin, Patrick C Ma, Afshin Dowlati, Jeffrey A Kern, Daniel G Tenen, Balázs Halmo. Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies. Cancer research. vol 67. issue 21. 2007-11-27. PMID:17974985. |
these variants showed uninhibited cell growth, reduced apoptosis, and persistent egfr activation in the presence of cl-387,785 as compared with parental h1975 cells, thus confirming their role in resistance. |
2007-11-27 |
2023-08-12 |
Not clear |
| Wenjuan Wu, Amir Onn, Takeshi Isobe, Satoshi Itasaka, Robert R Langley, Tomoaki Shitani, Keiko Shibuya, Ritsuko Komaki, Anderson J Ryan, Isaiah J Fidler, Roy S Herbst, Michael S O'Reill. Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade. Molecular cancer therapeutics. vol 6. issue 2. 2007-11-09. PMID:17308046. |
in vitro, zd6474 inhibited egfr, vegfr2, mitogen-activated protein kinase and akt phosphorylation, egf- and vegf-induced proliferation, and endothelial cell tube formation and also induced apoptosis. |
2007-11-09 |
2023-08-12 |
mouse |
| Rita Nahta, Linda X H Yuan, Yi Du, Francisco J Estev. Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling. Molecular cancer therapeutics. vol 6. issue 2. 2007-11-09. PMID:17308062. |
in the current study, we show that the dual epidermal growth factor receptor (egfr)/human egfr-2 (her2) kinase inhibitor lapatinib induces apoptosis in trastuzumab-resistant cells derived from the her2-overexpressing skbr3 breast cancer line. |
2007-11-09 |
2023-08-12 |
Not clear |
| Mike Failly, Serdar Korur, Viviane Egler, Jean-Louis Boulay, Maria Maddalena Lino, Roland Imber, Adrian Merl. Combination of sublethal concentrations of epidermal growth factor receptor inhibitor and microtubule stabilizer induces apoptosis of glioblastoma cells. Molecular cancer therapeutics. vol 6. issue 2. 2007-11-09. PMID:17308073. |
however, complete blockade of egfr activation does not result in apoptosis in human glioblastoma cells, suggesting additional cross-talk between downstream pathways. |
2007-11-09 |
2023-08-12 |
mouse |
| Mike Failly, Serdar Korur, Viviane Egler, Jean-Louis Boulay, Maria Maddalena Lino, Roland Imber, Adrian Merl. Combination of sublethal concentrations of epidermal growth factor receptor inhibitor and microtubule stabilizer induces apoptosis of glioblastoma cells. Molecular cancer therapeutics. vol 6. issue 2. 2007-11-09. PMID:17308073. |
blocking egfr with aee788 in combination with sublethal concentrations of the microtubule stabilizer patupilone also induced apoptosis and reduced cell proliferation in glioblastoma cells, accompanied by reduced akt and erk activity. |
2007-11-09 |
2023-08-12 |
mouse |
| M A Bareschino, C Schettino, T Troiani, E Martinelli, F Morgillo, F Ciardiell. Erlotinib in cancer treatment. Annals of oncology : official journal of the European Society for Medical Oncology. vol 18 Suppl 6. 2007-11-07. PMID:17591829. |
the signaling pathways of egfr is involved in cancer cell proliferation, apoptosis, angiogenesis, invasions and metastasis. |
2007-11-07 |
2023-08-12 |
Not clear |
| Amit K Das, Mitsuo Sato, Michael D Story, Michael Peyton, Robert Graves, Stella Redpath, Luc Girard, Adi F Gazdar, Jerry W Shay, John D Minna, Chaitanya S Nirod. Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation. Cancer research. vol 66. issue 19. 2007-11-06. PMID:17018617. |
we show that the majority of mutant egfr nsclcs, including those that contain the secondary gefitinib resistance t790m mutation, exhibit characteristics consistent with a radiosensitive phenotype, which include delayed dna repair kinetics, defective ir-induced arrest in dna synthesis or mitosis, and pronounced increases in apoptosis or micronuclei. |
2007-11-06 |
2023-08-12 |
human |
| F Gregory Buchanan, Vijay Holla, Sharada Katkuri, Pranathi Matta, Raymond N DuBoi. Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer. Cancer research. vol 67. issue 19. 2007-10-31. PMID:17909047. |
together, these findings suggest that the inhibition of both cox-2 and egfr may provide a better therapeutic strategy than either single agent through a combination of decreased cellular proliferation and prostaglandin signaling as well as increased apoptosis. |
2007-10-31 |
2023-08-12 |
mouse |
| Yang Lu, Xinqun Li, Ke Liang, Rodney Luwor, Zahid H Siddik, Gordon B Mills, John Mendelsohn, Zhen Fa. Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab. Cancer research. vol 67. issue 17. 2007-10-30. PMID:17804738. |
compared with parental difi cells that express high levels of egfr and in which cetuximab induces apoptosis, the cetuximab-resistant difi5 cells showed markedly lower protein levels of egfr, an increased association of egfr with cbl, and an increased ubiquitination of egfr. |
2007-10-30 |
2023-08-12 |
Not clear |
| Yang Lu, Xinqun Li, Ke Liang, Rodney Luwor, Zahid H Siddik, Gordon B Mills, John Mendelsohn, Zhen Fa. Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab. Cancer research. vol 67. issue 17. 2007-10-30. PMID:17804738. |
most importantly, inhibition of src kinase activity with pp2 reversed the resistance of difi5 cells to cetuximab-induced apoptosis without affecting the levels of egfr in the cells. |
2007-10-30 |
2023-08-12 |
Not clear |
| Susan C Kiley, Robert L Chevalie. Species differences in renal Src activity direct EGF receptor regulation in life or death response to EGF. American journal of physiology. Renal physiology. vol 293. issue 3. 2007-10-29. PMID:17626154. |
src-specific inhibitor pp2 and egfr kinase inhibitor ag1478 decreased egf-induced apoptosis in mouse ptc by 74% (p < 0.001) and 70% (p < 0.001), respectively. |
2007-10-29 |
2023-08-12 |
mouse |
| Miran Seo, Mi-Jeong Lee, Jin Hee Heo, Yun-Il Lee, Yeni Kim, So-Young Kim, Eun-So Lee, Yong-Sung Juhn. G Protein betagamma subunits augment UVB-induced apoptosis by stimulating the release of soluble heparin-binding epidermal growth factor from human keratinocytes. The Journal of biological chemistry. vol 282. issue 34. 2007-10-11. PMID:17548351. |
moreover, uvb-induced apoptosis was reduced by inhibiting egfr or p38. |
2007-10-11 |
2023-08-12 |
human |
| Miran Seo, Mi-Jeong Lee, Jin Hee Heo, Yun-Il Lee, Yeni Kim, So-Young Kim, Eun-So Lee, Yong-Sung Juhn. G Protein betagamma subunits augment UVB-induced apoptosis by stimulating the release of soluble heparin-binding epidermal growth factor from human keratinocytes. The Journal of biological chemistry. vol 282. issue 34. 2007-10-11. PMID:17548351. |
we conclude that gbetagamma mediates uvb-induced human keratinocyte apoptosis by augmenting the ectodomain shedding of hb-egf, which sequentially activates egfr and p38. |
2007-10-11 |
2023-08-12 |
human |