| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Birgit Geoerger, Nathalie Gaspar, Paule Opolon, Jackie Morizet, Pauline Devanz, Yann Lecluse, Alexander Valent, Ludovic Lacroix, Jacques Grill, Gilles Vassa. EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts. International journal of cancer. vol 123. issue 1. 2008-06-02. PMID:18386816. |
egfr tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts. |
2008-06-02 |
2023-08-12 |
Not clear |
| Lin Ji, Jack A Rot. Tumor suppressor FUS1 signaling pathway. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. vol 3. issue 4. 2008-05-27. PMID:18379348. |
here we present recent findings indicating that fus1 induces apoptosis through the activation of the intrinsic mitochondrial-dependent and apaf-1-associated pathways and inhibits the function of protein tyrosine kinases including egfr, pdgfr, akt, c-abl, and c-kit. |
2008-05-27 |
2023-08-12 |
human |
| Simone Boehrer, Lionel Adès, Thorsten Braun, Lorenzo Galluzzi, Jennifer Grosjean, Claire Fabre, Génèviève Le Roux, Claude Gardin, Antoine Martin, Stéphane de Botton, Pierre Fenaux, Guido Kroeme. Erlotinib exhibits antineoplastic off-target effects in AML and MDS: a preclinical study. Blood. vol 111. issue 4. 2008-05-21. PMID:17925489. |
erlotinib, an inhibitor of the epidermal growth factor receptor (egfr), induces differentiation, cell-cycle arrest, and apoptosis of egfr-negative myeloblasts of patients with myelodysplastic syndrome (mds) and acute myeloid leukemia (aml), as well as in egfr-negative cell lines representing these diseases (p39, kg-1, and hl 60). |
2008-05-21 |
2023-08-12 |
human |
| Conrad Ortiz, Laia Caja, Patricia Sancho, Esther Bertran, Isabel Fabrega. Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion. Biochemical pharmacology. vol 75. issue 10. 2008-05-16. PMID:18371937. |
in this work we have analysed the consequences of inhibiting the egfr in fao rat hepatoma cells, focusing the attention on autocrine growth and protection from apoptosis. |
2008-05-16 |
2023-08-12 |
rat |
| Conrad Ortiz, Laia Caja, Patricia Sancho, Esther Bertran, Isabel Fabrega. Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion. Biochemical pharmacology. vol 75. issue 10. 2008-05-16. PMID:18371937. |
treatment of cells with the combination of doxorubicin and the tyrphostin 4-(3-chloroanilino)-6,7-dimethoxyquinazoline (ag1478, a potent and specific inhibitor of egfr tyrosine kinase) potently inhibits autocrine growth and induces apoptosis. |
2008-05-16 |
2023-08-12 |
rat |
| Shyh-Dar Li, Yun-Ching Chen, Michael J Hackett, Leaf Huan. Tumor-targeted delivery of siRNA by self-assembled nanoparticles. Molecular therapy : the journal of the American Society of Gene Therapy. vol 16. issue 1. 2008-05-13. PMID:17923843. |
three daily injections (1.2 mg/kg) of sirna formulated in the targeted nps silenced the epidermal growth factor receptor (egfr) in the tumor and induced approximately 15% tumor cell apoptosis. |
2008-05-13 |
2023-08-12 |
Not clear |
| Hongxiang Hui, Manory A Fernando, Anthony P Heane. The alpha1-adrenergic receptor antagonist doxazosin inhibits EGFR and NF-kappaB signalling to induce breast cancer cell apoptosis. European journal of cancer (Oxford, England : 1990). vol 44. issue 1. 2008-04-14. PMID:18042375. |
the alpha1-adrenergic receptor antagonist doxazosin inhibits egfr and nf-kappab signalling to induce breast cancer cell apoptosis. |
2008-04-14 |
2023-08-12 |
Not clear |
| Hongxiang Hui, Manory A Fernando, Anthony P Heane. The alpha1-adrenergic receptor antagonist doxazosin inhibits EGFR and NF-kappaB signalling to induce breast cancer cell apoptosis. European journal of cancer (Oxford, England : 1990). vol 44. issue 1. 2008-04-14. PMID:18042375. |
egf- and tnfalpha treatment alone failed to block dox-mediated breast cancer apoptotic effects, but combination of egf and tnfalpha treatments completely abrogated dox-induced breast cancer cell apoptosis, indicating doxazosin inhibits both egfr and nf-kappab signalling pathways to induce breast cancer cell apoptosis. |
2008-04-14 |
2023-08-12 |
Not clear |
| Junming Xian, Yinghe Lin, Yafeng Liu, Ping Gong, Shixi Li. Signal transduction-related gene transfer leads to inhibition of proliferation and induction of differentiation in laryngeal squamous cell carcinoma in vitro. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 264. issue 12. 2008-04-10. PMID:17628821. |
fcm revealed that the proportion of apoptosis cells transfected by ad-p14arf and ad-antisense egfr increased more obviously than the control. |
2008-04-10 |
2023-08-12 |
human |
| Noriyuki Takai, Tami Ueda, Masakazu Nishida, Kaei Nasu, Hisashi Narahar. Beta-hydroxyisovalerylshikonin has a profound anti-growth activity in human endometrial and ovarian cancer cells. Gynecologic oncology. vol 109. issue 1. 2008-04-08. PMID:18234298. |
beta-hydroxyisovalerylshikonin (beta-hivs), a compound isolated from the traditional oriental medicinal herb lithospermum radix, is an atp non-competitive inhibitor of protein-tyrosine kinases, such as v-src and egfr, and it induces apoptosis in some lines of human tumor cells. |
2008-04-08 |
2023-08-12 |
human |
| Meenu Jain, Shaleen Kumar, Rohit Upadhyay, Puneeta Lal, Anu Tiwari, Uday C Ghoshal, Balraj Mitta. Influence of apoptosis (BCL2, FAS), cell cycle (CCND1) and growth factor (EGF, EGFR) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer. Cancer biology & therapy. vol 6. issue 10. 2008-04-03. PMID:17912028. |
influence of apoptosis (bcl2, fas), cell cycle (ccnd1) and growth factor (egf, egfr) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer. |
2008-04-03 |
2023-08-12 |
Not clear |
| Elisa Giovannetti, Clara Lemos, Christina Tekle, Kees Smid, Sara Nannizzi, José A Rodriguez, Simona Ricciardi, Romano Danesi, Giuseppe Giaccone, Godefridus J Peter. Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells. Molecular pharmacology. vol 73. issue 4. 2008-04-03. PMID:18187583. |
pharmacological interaction was studied using the combination index (ci) method, whereas cell cycle, apoptosis induction, and egfr, extracellular signal-regulated kinases 1 and 2, and akt phosphorylation were studied by flow cytometry, fluorescence microscopy, and enzyme-linked immunosorbent assays. |
2008-04-03 |
2023-08-12 |
Not clear |
| Elisa Giovannetti, Clara Lemos, Christina Tekle, Kees Smid, Sara Nannizzi, José A Rodriguez, Simona Ricciardi, Romano Danesi, Giuseppe Giaccone, Godefridus J Peter. Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells. Molecular pharmacology. vol 73. issue 4. 2008-04-03. PMID:18187583. |
induction of apoptosis, modulation of egfr and akt phosphorylation, and changes in the expression of critical genes involved in pemetrexed activity contribute to this synergistic interaction and support the clinical investigation of these markers. |
2008-04-03 |
2023-08-12 |
Not clear |
| Arlhee Diaz Miqueli, Rances Blanco, Beatriz Garcia, Teresita Badia, Ana E Batista, Ruby Alonso, Enrique Monter. Biological activity in vitro of anti-epidermal growth factor receptor monoclonal antibodies with different affinities. Hybridoma (2005). vol 26. issue 6. 2008-03-31. PMID:18158788. |
our findings also confirm previous evidences that blocking egfr in a431 cells by means of antibodies significantly changes tumor cell biology by promoting apoptosis while decreasing tumor cell proliferation. |
2008-03-31 |
2023-08-12 |
mouse |
| I Zlobec, T Vuong, C C Compton, A Lugli, R P Michel, S Hayashi, J R Jas. Combined analysis of VEGF and EGFR predicts complete tumour response in rectal cancer treated with preoperative radiotherapy. British journal of cancer. vol 98. issue 2. 2008-03-27. PMID:18182986. |
the aim of this study was to determine the value of epidermal growth factor receptor (egfr), vascular endothelial growth factor (vegf), p53, bcl-2 and apoptosis protease-activating factor-1 (apaf-1) as predictors of complete pathologic tumour regression in patients undergoing preoperative radiotherapy for advanced rectal cancer. |
2008-03-27 |
2023-08-12 |
Not clear |
| Jean-Pierre Raufman, Jasleen Shant, Chang Yue Guo, Sanjit Roy, Kunrong Chen. Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling. Journal of cellular physiology. vol 215. issue 2. 2008-03-25. PMID:18064605. |
to examine the role of bile acids and pi3k signaling in maintaining colon cancer cell survival, we explored the role of signaling downstream of bile acid-induced activation of the epidermal growth factor receptor (egfr) in regulating both apoptosis and proliferation of ht-29 and h508 human colon cancer cells. |
2008-03-25 |
2023-08-12 |
human |
| Vita M Golubovskaya, Christopher Virnig, William G Canc. TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR. Molecular carcinogenesis. vol 47. issue 3. 2008-03-17. PMID:17849451. |
tae226-induced apoptosis in breast cancer cells with overexpressed src or egfr. |
2008-03-17 |
2023-08-12 |
human |
| Vita M Golubovskaya, Christopher Virnig, William G Canc. TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR. Molecular carcinogenesis. vol 47. issue 3. 2008-03-17. PMID:17849451. |
we have shown previously that the dominant-negative fak, c-terminal fak-cd, caused detachment and apoptosis in human breast cancer cells, and that overexpression of an activated form of src tyrosine kinase or epidermal growth factor receptor, egfr, suppressed fak-cd induced apoptotic effects in breast cancer cells. |
2008-03-17 |
2023-08-12 |
human |
| Eleftherios Vairaktaris, Sofia Spyridonidou, Lambros Goutzanis, Antonis Vylliotis, Andreas Lazaris, Ismini Donta, Despina Perrea, Christos Yapijakis, Efstratios Patsouri. Diabetes and oral oncogenesis. Anticancer research. vol 27. issue 6B. 2008-02-12. PMID:18225590. |
the expression of egfr, erbb2, erbb3, fgfr-2, fgfr-3, c-myc, n-ras, ets-1, h-ras, c-fos and c-jun, the tumor suppressor genes p53 and p16, apoptosis markers bax and bcl-2, and the cell proliferation marker ki-67 in the sequential stages of rat oral oncogenesis was investigated. |
2008-02-12 |
2023-08-12 |
rat |
| Michael Keese, Martin Offterdinger, Christian Tischer, Andreas Girod, Piet H M Lommerse, Vugar Yagublu, Richard Magdeburg, Philippe I H Bastiaen. Quantitative imaging of apoptosis commitment in colorectal tumor cells. Differentiation; research in biological diversity. vol 75. issue 9. 2008-02-08. PMID:17511782. |
we have studied caspase-3 activation by combined dna damage induction and egfr kinase inhibition in order to identify potential egfr-mediated survival signals conferring resistance to apoptosis in human colorectal tumor cells. |
2008-02-08 |
2023-08-12 |
human |