| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| George Sheng, Jun Guo, Brad W Warne. Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells. American journal of physiology. Gastrointestinal and liver physiology. vol 293. issue 3. 2007-10-11. PMID:17615176. |
additionally, epidermal growth factor receptor (egfr) activation prevents sbr-induced enterocyte apoptosis. |
2007-10-11 |
2023-08-12 |
Not clear |
| George Sheng, Jun Guo, Brad W Warne. Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells. American journal of physiology. Gastrointestinal and liver physiology. vol 293. issue 3. 2007-10-11. PMID:17615176. |
the present study aims to delineate the relationship between egfr activity and intestinal epithelial cell apoptosis. |
2007-10-11 |
2023-08-12 |
Not clear |
| George Sheng, Jun Guo, Brad W Warne. Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells. American journal of physiology. Gastrointestinal and liver physiology. vol 293. issue 3. 2007-10-11. PMID:17615176. |
treatment of model intestinal epithelial cells (riec-18) with both a selective egfr inhibitor (zd1839) and egfr small interfering rna knockdown resulted in a dramatic increase in apoptosis, accompanied by rapid phosphorylation of p38alpha. |
2007-10-11 |
2023-08-12 |
Not clear |
| George Sheng, Jun Guo, Brad W Warne. Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells. American journal of physiology. Gastrointestinal and liver physiology. vol 293. issue 3. 2007-10-11. PMID:17615176. |
these results demonstrate that that diminished egfr activity initiates the intrinsic pathway of apoptosis through p38alpha-dependent bax activation in intestinal epithelial cells. |
2007-10-11 |
2023-08-12 |
Not clear |
| George Sheng, Jun Guo, Brad W Warne. Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells. American journal of physiology. Gastrointestinal and liver physiology. vol 293. issue 3. 2007-10-11. PMID:17615176. |
these finding provide mechanistic insight into the role that egfr signaling plays in the regulation of enterocyte apoptosis following massive intestinal loss. |
2007-10-11 |
2023-08-12 |
Not clear |
| Guy Letellier, Marie-José Perez, Mokrane Yacoub, Pierre Levillain, Olivier Cussenot, Gaëlle Fromon. Epithelial phenotypes in the developing human prostate. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 55. issue 9. 2007-09-21. PMID:17478449. |
we analyzed fetal prostates for the expression of cks (5/6, 18, 19) and factors involved in proliferation and apoptosis: p63, ki67, p27, epidermal growth factor (egfr), bcl2, androgen receptor (ar). |
2007-09-21 |
2023-08-12 |
human |
| Dae Ho Lee, Geon Kook Lee, Sun-Young Kong, Myoung Chul Kook, Sun Kyung Yang, So Yeon Park, Seong Hoe Park, Bhumsuk Keam, Do Joon Park, Bo Youn Cho, Seok Won Kim, Ki-Wook Chung, Eun Sook Lee, Sun Wook Ki. Epidermal growth factor receptor status in anaplastic thyroid carcinoma. Journal of clinical pathology. vol 60. issue 8. 2007-09-10. PMID:17079354. |
in vitro studies have shown that egfr tyrosine kinase inhibitors (tkis) greatly inhibit cellular growth and induced apoptosis in the atc cell lines, while somatic mutations in the tyrosine kinase domain or an increased gene copy number are associated with increased sensitivity to tkis in non-small cell lung cancer. |
2007-09-10 |
2023-08-12 |
Not clear |
| Zhiming Mai, George L Blackburn, Jin-Rong Zho. Genistein sensitizes inhibitory effect of tamoxifen on the growth of estrogen receptor-positive and HER2-overexpressing human breast cancer cells. Molecular carcinogenesis. vol 46. issue 7. 2007-08-23. PMID:17295235. |
further determination of the molecular markers showed that tam and genistein combination synergistically induced bt-474 cell apoptosis in part by synergistic downregulation of the expression of survivin, one of the apoptotic effectors, and downregulation of egfr, her2, and eralpha expression. |
2007-08-23 |
2023-08-12 |
human |
| K J Schmitz, J Wohlschlaeger, H Alakus, J Bohr, M A Stauder, K Worm, G Winde, K W Schmid, H A Bab. Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations. Virchows Archiv : an international journal of pathology. vol 450. issue 2. 2007-08-21. PMID:17149612. |
we investigated the relationship of phospho-erk1/2 (perk1/2) and phospho-akt (pakt) with associated parameters (egfr, cox-2, cyclin-d1), proliferative activity (ki-67), and apoptosis (tunel) using immunohistochemistry. |
2007-08-21 |
2023-08-12 |
Not clear |
| Marie P Piechocki, George H Yoo, Susan K Dibbley, Fulvio Lonard. Breast cancer expressing the activated HER2/neu is sensitive to gefitinib in vitro and in vivo and acquires resistance through a novel point mutation in the HER2/neu. Cancer research. vol 67. issue 14. 2007-08-21. PMID:17638894. |
we characterized the effects of gefitinib on egfr, her2, and erbb-3 phosphorylation by western blot and determined the effects on downstream signaling through growth, survival, and stress pathways and the effect on proliferation, cell cycle, and apoptosis. |
2007-08-21 |
2023-08-12 |
Not clear |
| Jadranka Dujic, Stefan Kippenberger, Stephanie Hoffmann, Ana Ramirez-Bosca, Jaime Miquel, Joquin Diaz-Alperi, Jürgen Bereiter-Hahn, Roland Kaufmann, August Bern. Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light. The Journal of investigative dermatology. vol 127. issue 8. 2007-08-02. PMID:17410200. |
additionally, the egfr, an upstream regulator of both kinases, was inhibited indicating that apoptosis is induced by blocking survival- and proliferation-associated signal cascades at the receptor level. |
2007-08-02 |
2023-08-12 |
human |
| Shinichi Tamura, Hajime Hosoi, Yasumichi Kuwahara, Ken Kikuchi, Osamu Otabe, Moriatsu Izumi, Kunihiko Tsuchiya, Tomoko Iehara, Takahiro Gotoh, Tohru Sugimot. Induction of apoptosis by an inhibitor of EGFR in neuroblastoma cells. Biochemical and biophysical research communications. vol 358. issue 1. 2007-07-27. PMID:17482563. |
induction of apoptosis by an inhibitor of egfr in neuroblastoma cells. |
2007-07-27 |
2023-08-12 |
Not clear |
| Shinichi Tamura, Hajime Hosoi, Yasumichi Kuwahara, Ken Kikuchi, Osamu Otabe, Moriatsu Izumi, Kunihiko Tsuchiya, Tomoko Iehara, Takahiro Gotoh, Tohru Sugimot. Induction of apoptosis by an inhibitor of EGFR in neuroblastoma cells. Biochemical and biophysical research communications. vol 358. issue 1. 2007-07-27. PMID:17482563. |
we also demonstrated an egfr inhibitor induced apoptosis on neuroblastoma cells. |
2007-07-27 |
2023-08-12 |
Not clear |
| Eva M Schmelz, Hu Xu, Radha Sengupta, Jianhua Du, Sanjeev Banerjee, Fazlul H Sarkar, Arun K Rishi, Adhip P N Majumda. Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein. Cancer research. vol 67. issue 11. 2007-07-26. PMID:17545620. |
this could partly be attributed to inhibition of proliferation and stimulation of apoptosis in the intestinal mucosa and was associated with decreased activation of several egfr family members, suppression of downstream effector nuclear factor kappab and down-regulation of cyclooxygenase-2. |
2007-07-26 |
2023-08-12 |
mouse |
| Sayaka Takaoka, Masayasu Iwase, Makiko Uchida, Sayaka Yoshiba, Gen Kondo, Hitoshi Watanabe, Masaru Ohashi, Masao Nagumo, Satoru Shintan. Effect of combining epidermal growth factor receptor inhibitors and cisplatin on proliferation and apoptosis of oral squamous cell carcinoma cells. International journal of oncology. vol 30. issue 6. 2007-07-12. PMID:17487368. |
in combination with conventional anti-cancer drugs, agents that block egfr may represent an efficient means of inhibiting proliferation and inducing apoptosis in scc cells. |
2007-07-12 |
2023-08-12 |
Not clear |
| Sayaka Takaoka, Masayasu Iwase, Makiko Uchida, Sayaka Yoshiba, Gen Kondo, Hitoshi Watanabe, Masaru Ohashi, Masao Nagumo, Satoru Shintan. Effect of combining epidermal growth factor receptor inhibitors and cisplatin on proliferation and apoptosis of oral squamous cell carcinoma cells. International journal of oncology. vol 30. issue 6. 2007-07-12. PMID:17487368. |
therefore, egfr inhibitors can provide partial regulation of cisplatin-mediated apoptosis in oscc cells by modulating expression of ciap-1, xiap, bcl-2, bcl-xl, bax and bak. |
2007-07-12 |
2023-08-12 |
Not clear |
| Sayaka Takaoka, Masayasu Iwase, Makiko Uchida, Sayaka Yoshiba, Gen Kondo, Hitoshi Watanabe, Masaru Ohashi, Masao Nagumo, Satoru Shintan. Effect of combining epidermal growth factor receptor inhibitors and cisplatin on proliferation and apoptosis of oral squamous cell carcinoma cells. International journal of oncology. vol 30. issue 6. 2007-07-12. PMID:17487368. |
these results suggest that egfr inhibitors may represent a novel strategy for overcoming resistance to cisplatin-mediated apoptosis via the phosphatidylinositol 3-kinase/akt pathway. |
2007-07-12 |
2023-08-12 |
Not clear |
| R Labianca, N La Verde, M C Garassin. Development and clinical indications of cetuximab. The International journal of biological markers. vol 22. issue 1 Suppl 4. 2007-07-11. PMID:17520580. |
the egfr signaling pathways regulate cell differentiation, proliferation, migration, angiogenesis and apoptosis, all of which become deregulated in cancer cells. |
2007-07-11 |
2023-08-12 |
Not clear |
| Mark Agulnik, Gilda da Cunha Santos, David Hedley, Trudey Nicklee, Patricia Pintor Dos Reis, James Ho, Gregory R Pond, Heidi Chen, Shuo Chen, Yu Shyr, Eric Winquist, Denis Soulieres, Eric X Chen, Jeremy A Squire, Paula Marrano, Suzanne Kamel-Reid, Janet Dancey, Lillian L Siu, Ming S Tsa. Predictive and pharmacodynamic biomarker studies in tumor and skin tissue samples of patients with recurrent or metastatic squamous cell carcinoma of the head and neck treated with erlotinib. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 25. issue 16. 2007-06-12. PMID:17538163. |
levels of epidermal growth factor receptor (egfr), downstream signaling components, and markers of angiogenesis and apoptosis were evaluated to determine the relationship between correlative end points and clinical outcomes. |
2007-06-12 |
2023-08-12 |
Not clear |
| T Wada, K Hata, K Yamaguchi, K Shiozaki, K Koseki, S Moriya, T Miyag. A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells. Oncogene. vol 26. issue 17. 2007-05-31. PMID:17334392. |
ras activation by neu3 was abrogated by pp2 (src inhibitor) or ag1478 (epidermal growth factor receptor (egfr) inhibitor), and neu3 actually enhanced egf-stimulated tyrosine-phosphorylation of egfr, suggesting that the upstream targets might be tyrosine kinases including src and egfr, and the subsequent stimulation of ras cascade leads to the inhibition of cell apoptosis. |
2007-05-31 |
2023-08-12 |
human |