| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew D Burdick, Irena D Ivnitski-Steele, Fredine T Lauer, Scott W Burchie. PYK2 mediates anti-apoptotic AKT signaling in response to benzo[a]pyrene diol epoxide in mammary epithelial cells. Carcinogenesis. vol 27. issue 11. 2006-12-26. PMID:16774943. |
this work demonstrates a novel mechanism for akt activation by bpde that occurs through increased ca2+ concentration, and implicates ca2+, pyk2, egfr and akt as a potential pathway by which bpde can inhibit apoptosis and act as a promoter of carcinogenesis. |
2006-12-26 |
2023-08-12 |
human |
| Xiang-Hong Peng, Prasanthi Karna, Zehong Cao, Bing-Hua Jiang, Muxiang Zhou, Lily Yan. Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression. The Journal of biological chemistry. vol 281. issue 36. 2006-12-18. PMID:16847054. |
although increasing evidence supports a link between epidermal growth factor receptor (egfr) signaling and resistance to apoptosis, the mechanism by which the egfr signaling pathway inhibits apoptosis is not well understood. |
2006-12-18 |
2023-08-12 |
human |
| Xiang-Hong Peng, Prasanthi Karna, Zehong Cao, Bing-Hua Jiang, Muxiang Zhou, Lily Yan. Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression. The Journal of biological chemistry. vol 281. issue 36. 2006-12-18. PMID:16847054. |
our results demonstrate a novel pathway for egfr signaling-mediated apoptosis resistance in human cancer cells. |
2006-12-18 |
2023-08-12 |
human |
| Xiang-Hong Peng, Prasanthi Karna, Zehong Cao, Bing-Hua Jiang, Muxiang Zhou, Lily Yan. Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression. The Journal of biological chemistry. vol 281. issue 36. 2006-12-18. PMID:16847054. |
understanding key molecular events in egfr signaling-induced apoptosis resistance should provide new information for the development of novel therapeutic agents targeting egfr, hif-1alpha, and/or survivin. |
2006-12-18 |
2023-08-12 |
human |
| An Van Laethem, Kris Nys, Sofie Van Kelst, Sofie Claerhout, Hidenori Ichijo, Jackie R Vandenheede, Maria Garmyn, Patrizia Agostini. Apoptosis signal regulating kinase-1 connects reactive oxygen species to p38 MAPK-induced mitochondrial apoptosis in UVB-irradiated human keratinocytes. Free radical biology & medicine. vol 41. issue 9. 2006-12-05. PMID:17023263. |
the nadph oxidase antagonist diphenylene iodonium chloride and the egfr inhibitor ag1487 prevent uvb-mediated ros generation, the activation of the ask-1-p38 mapk stress response pathway, and apoptosis, evidencing the link existing between the early plasma membrane-generated ros and the activation of a lethal cascade initiated by ask-1. |
2006-12-05 |
2023-08-12 |
human |
| Marlene R Quadros, Sharon Connelly, Csaba Kari, Marc T Abrams, Eric Wickstrom, Ulrich Rodec. EGFR-dependent downregulation of Bim in epithelial cells requires MAPK and PKC-delta activities. Cancer biology & therapy. vol 5. issue 5. 2006-11-21. PMID:16582597. |
activation of the epidermal growth factor receptor (egfr) provides a measure of protection to immortalized epidermal keratinocytes (hacat cells) against apoptosis induced by diverse cellular stressors. |
2006-11-21 |
2023-08-12 |
Not clear |
| Marlene R Quadros, Sharon Connelly, Csaba Kari, Marc T Abrams, Eric Wickstrom, Ulrich Rodec. EGFR-dependent downregulation of Bim in epithelial cells requires MAPK and PKC-delta activities. Cancer biology & therapy. vol 5. issue 5. 2006-11-21. PMID:16582597. |
these results establish that egfr activation attenuates susceptibility of immortalized and malignant keratinocytes to apoptosis by post-translational control of bim-el expression through a pathway requiring pkc-delta and mek/mapk activation. |
2006-11-21 |
2023-08-12 |
Not clear |
| Hiroshi Nozawa, Takushi Tadakuma, Takeshi Ono, Masaki Sato, Sadayuki Hiroi, Kazuma Masumoto, Yasunori Sat. Small interfering RNA targeting epidermal growth factor receptor enhances chemosensitivity to cisplatin, 5-fluorouracil and docetaxel in head and neck squamous cell carcinoma. Cancer science. vol 97. issue 10. 2006-11-14. PMID:16984384. |
egfr expression, proliferation, angiogenesis and apoptosis index were evaluated by immunohistochemistry. |
2006-11-14 |
2023-08-12 |
Not clear |
| Hiroshi Nozawa, Takushi Tadakuma, Takeshi Ono, Masaki Sato, Sadayuki Hiroi, Kazuma Masumoto, Yasunori Sat. Small interfering RNA targeting epidermal growth factor receptor enhances chemosensitivity to cisplatin, 5-fluorouracil and docetaxel in head and neck squamous cell carcinoma. Cancer science. vol 97. issue 10. 2006-11-14. PMID:16984384. |
treatment with egfr sirna in combination with cisplatin, 5-fu and docetaxel enhanced chemosensitivity with a significant increase in apoptosis. |
2006-11-14 |
2023-08-12 |
Not clear |
| Susan Lanza-Jacoby, Randy Burd, Francis E Rosato, Kandace McGuire, James Little, Noel Nougbilly, Sheldon Mille. Effect of simultaneous inhibition of epidermal growth factor receptor and cyclooxygenase-2 in HER-2/neu-positive breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 12. issue 20 Pt 1. 2006-11-14. PMID:17062693. |
her-2/erbb2/neu breast tumors are frequently associated with up-regulation of cyclooxygenase (cox)-2 and activation of the epidermal growth factor receptor (egfr) pathway, which promote enhanced cell growth and resistance to apoptosis. |
2006-11-14 |
2023-08-12 |
Not clear |
| Susan Lanza-Jacoby, Randy Burd, Francis E Rosato, Kandace McGuire, James Little, Noel Nougbilly, Sheldon Mille. Effect of simultaneous inhibition of epidermal growth factor receptor and cyclooxygenase-2 in HER-2/neu-positive breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 12. issue 20 Pt 1. 2006-11-14. PMID:17062693. |
this study investigated whether simultaneously blocking both egfr and cox-2 pathways with zd1839 and celecoxib, respectively, would be more effective in inhibiting cell growth and inducing apoptosis than either agent alone. |
2006-11-14 |
2023-08-12 |
Not clear |
| Nam-Sung Moon, Luisa Di Stefano, Nicholas Dyso. A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Molecular and cellular biology. vol 26. issue 20. 2006-11-13. PMID:16954388. |
surprisingly, this pattern of apoptosis is not caused by inappropriate cell cycle progression but instead involves the action of argos, a secreted protein that negatively regulates drosophila epidermal growth factor receptor (egfr [der]) activity. |
2006-11-13 |
2023-08-12 |
drosophila_melanogaster |
| Han-Soo Kim, Ju Won Kim, Jingu Gang, Jing Wen, Sang Seok Koh, Jong Sung Koh, Hyun-Ho Chung, Si Young Son. The farnesyltransferase inhibitor, LB42708, inhibits growth and induces apoptosis irreversibly in H-ras and K-ras-transformed rat intestinal epithelial cells. Toxicology and applied pharmacology. vol 215. issue 3. 2006-11-09. PMID:16712893. |
these results suggest that lb7 causes the induction of p21(cip1/waf1) and rhob and downregulation of egfr that may serve as critical steps in the mechanism by which ftis trigger irreversible inhibitions on the cell growth and apoptosis in ras-transformed cells. |
2006-11-09 |
2023-08-12 |
rat |
| Gaelle Del Castillo, Miguel M Murillo, Alberto Alvarez-Barrientos, Esther Bertran, Margarita Fernández, Aránzazu Sánchez, Isabel Fabrega. Autocrine production of TGF-beta confers resistance to apoptosis after an epithelial-mesenchymal transition process in hepatocytes: Role of EGF receptor ligands. Experimental cell research. vol 312. issue 15. 2006-10-19. PMID:16828470. |
in summary, results suggest that an autocrine loop of tgf-beta confers resistance to apoptosis after an emt process in hepatocytes, through the increase in the expression of egfr ligands. |
2006-10-19 |
2023-08-12 |
rat |
| Claudia María Valverde, Teresa Macarulla, Esther Casado, Francisco Javier Ramos, Erika Martinelli, Josep Taberner. Novel targets in gastric and esophageal cancer. Critical reviews in oncology/hematology. vol 59. issue 2. 2006-10-05. PMID:16829119. |
in this review we describe the current status of targeted therapies in the treatment of ec and gc, including egfr inhibitors, antiangiogenic agents, cell cycle inhibitors, apoptosis promoters and matrix metalloproteinases inhibitors. |
2006-10-05 |
2023-08-12 |
Not clear |
| Ruben Garcia, Richard A Franklin, James A McCubre. Cell death of MCF-7 human breast cancer cells induced by EGFR activation in the absence of other growth factors. Cell cycle (Georgetown, Tex.). vol 5. issue 16. 2006-09-28. PMID:16861904. |
these results indicate that egfr activation by itself is not sufficient for the proliferation of breast cancer cells and suggest the existence of a mechanism that induces apoptosis upon egfr activation. |
2006-09-28 |
2023-08-12 |
human |
| Sally Järvelä, S Järvellä, H Helin, J Haapasalo, Timo Järvelä, T Järvellä, T T Junttila, K Elenius, M Tanner, H Haapasalo, J Isol. Amplification of the epidermal growth factor receptor in astrocytic tumours by chromogenic in situ hybridization: association with clinicopathological features and patient survival. Neuropathology and applied neurobiology. vol 32. issue 4. 2006-09-19. PMID:16866989. |
patients with older age (p < 0.001) and tumours with lack of p53 overexpression (p = 0.03) and higher apoptosis rate (p < 0.001) had significantly more egfr gene amplifications than their counterparts. |
2006-09-19 |
2023-08-12 |
Not clear |
| Shizhen Emily Wang, Archana Narasanna, Marianela Perez-Torres, Bin Xiang, Frederick Y Wu, Seungchan Yang, Graham Carpenter, Adi F Gazdar, Senthil K Muthuswamy, Carlos L Arteag. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer cell. vol 10. issue 1. 2006-09-11. PMID:16843263. |
knockdown of mutant her2 in h1781 lung cancer cells increased apoptosis and restored sensitivity to egfr tkis. |
2006-09-11 |
2023-08-12 |
Not clear |
| David H Johnso. Targeted therapies in combination with chemotherapy in non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 12. issue 14 Pt 2. 2006-09-08. PMID:16857827. |
by contrast, tumor cells harboring somatic mutations in egfr experience massive apoptosis when exposed to the egfr tyrosine kinase inhibitors. |
2006-09-08 |
2023-08-12 |
Not clear |
| Jutta Auberger, Judith Loeffler-Ragg, Walter Wurzer, Wolfgang Hilb. Targeted therapies in non-small cell lung cancer: proven concepts and unfulfilled promises. Current cancer drug targets. vol 6. issue 4. 2006-09-05. PMID:16848720. |
recent approaches affect the following major groups: the epidermal growth factor receptor (egfr)-family, angiogenesis, the eicosanoid pathway, the pkc/ ras/ mapk pathway, the proteasome and inducers of apoptosis. |
2006-09-05 |
2023-08-12 |
Not clear |