| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hye Sook Chon, Wei Hu, John J Kavanag. Targeted therapies in gynecologic cancers. Current cancer drug targets. vol 6. issue 4. 2006-09-05. PMID:16848724. |
several promising drugs targeting tyrosine kinases (egfr and her-2/neu), mtor, raf kinase, proteasome, and histone deacetylases, as well as drugs affecting apoptosis and mitosis, are under development for clinical application. |
2006-09-05 |
2023-08-12 |
human |
| E P Moiseeva, L H Fox, L M Howells, L A F Temple, M M Manso. Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment. Apoptosis : an international journal on programmed cell death. vol 11. issue 5. 2006-08-18. PMID:16532375. |
i3c significantly reduced levels of epidermal growth factor receptor (egfr) in mda-mb-468 after 6 h and in mda-mb-231 and hbl100 cells after 30 h. downregulation of egfr in mda-mb468 and mda-mb-231 cells using an egfr inhibitor resulted in apoptosis. |
2006-08-18 |
2023-08-12 |
human |
| E P Moiseeva, L H Fox, L M Howells, L A F Temple, M M Manso. Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment. Apoptosis : an international journal on programmed cell death. vol 11. issue 5. 2006-08-18. PMID:16532375. |
therefore, i3c-induced egfr reduction in these cells is likely to be responsible for i3c-induced apoptosis. |
2006-08-18 |
2023-08-12 |
human |
| Hiroshi Ariyama, Baoli Qin, Eishi Baba, Risa Tanaka, Kenji Mitsugi, Mine Harada, Shuji Nakan. Gefitinib, a selective EGFR tyrosine kinase inhibitor, induces apoptosis through activation of Bax in human gallbladder adenocarcinoma cells. Journal of cellular biochemistry. vol 97. issue 4. 2006-08-14. PMID:16229013. |
gefitinib, a selective egfr tyrosine kinase inhibitor, induces apoptosis through activation of bax in human gallbladder adenocarcinoma cells. |
2006-08-14 |
2023-08-12 |
human |
| Amy L Howes, Shigeki Miyamoto, John W Adams, Elizabeth A Woodcock, Joan Heller Brow. Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy. Journal of molecular and cellular cardiology. vol 40. issue 5. 2006-08-14. PMID:16466740. |
egfr activation appears to be required for galphaq-mediated protection since inhibition of src or egfr rendered cells susceptible to 2dog-induced apoptosis. |
2006-08-14 |
2023-08-12 |
rat |
| Josefa Castillo, Elena Erroba, María J Perugorría, Mónica Santamaría, David C Lee, Jesús Prieto, Matías A Avila, Carmen Berasai. Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells. Cancer research. vol 66. issue 12. 2006-08-10. PMID:16778186. |
indeed, interference with endogenous ar production resulted in reduced constitutive egfr signaling, inhibition of cell proliferation, anchorage-independent growth, and enhanced apoptosis. |
2006-08-10 |
2023-08-12 |
human |
| Lanxi Song, Mark Morris, Tapan Bagui, Francis Y Lee, Richard Jove, Eric B Haur. Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer research. vol 66. issue 11. 2006-07-27. PMID:16740687. |
in cells with egfr mutation that are dependent on egfr for survival, dasatinib reduces cell viability through the induction of apoptosis while having minimal apoptotic effect on cell lines with wild-type (wt) egfr. |
2006-07-27 |
2023-08-12 |
human |
| A P G Crijns, E W Duiker, S de Jong, P H B Willemse, A G J van der Zee, E G E de Vrie. Molecular prognostic markers in ovarian cancer: toward patient-tailored therapy. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 16 Suppl 1. 2006-07-26. PMID:16515584. |
the prognostic role of key components of apoptotic and prosurvival pathways such as p53, egfr, and her2 has been extensively studied because resistance to chemotherapy is often caused by failure of tumor cells to go into apoptosis. |
2006-07-26 |
2023-08-12 |
Not clear |
| Arun K Rishi, Liyue Zhang, Yingjie Yu, Yan Jiang, Jyoti Nautiyal, Anil Wali, Joseph A Fontana, Edi Levi, Adhip P N Majumda. Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor. The Journal of biological chemistry. vol 281. issue 19. 2006-07-18. PMID:16543231. |
epidermal growth factor receptor (egfr)-related protein (errp), a pan-erbb inhibitor, inhibits egfr and stimulates apoptosis. |
2006-07-18 |
2023-08-12 |
Not clear |
| Arun K Rishi, Liyue Zhang, Yingjie Yu, Yan Jiang, Jyoti Nautiyal, Anil Wali, Joseph A Fontana, Edi Levi, Adhip P N Majumda. Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor. The Journal of biological chemistry. vol 281. issue 19. 2006-07-18. PMID:16543231. |
treatments of cells with errp or iressa (an egfr tyrosine kinase inhibitor) results in elevated carp-1 levels, whereas antisense-dependent depletion of carp-1 causes inhibition of apoptosis by errp. |
2006-07-18 |
2023-08-12 |
Not clear |
| Ilaria Bellezza, Sergio Bracarda, Claudia Caserta, Alba Minell. Targeting of EGFR tyrosine kinase by ZD1839 ("Iressa") in androgen-responsive prostate cancer in vitro. Molecular genetics and metabolism. vol 88. issue 2. 2006-06-27. PMID:16487738. |
therefore, egfr can regulate multiple processes, i.e., gene expression, cellular proliferation, angiogenesis, and inhibition of apoptosis, which contribute to the development of malignancy. |
2006-06-27 |
2023-08-12 |
human |
| Li Bai, Rong Zhu, Zhihong Chen, Lei Gao, Xin Zhang, Xiangdong Wang, Chunxue Ba. Potential role of short hairpin RNA targeting epidermal growth factor receptor in growth and sensitivity to drugs of human lung adenocarcinoma cells. Biochemical pharmacology. vol 71. issue 8. 2006-04-25. PMID:16442503. |
the effect of shrna targeting egfr on tumor cell growth was assessed by colony formation assay, cell cycle and apoptosis by flow cytometry, and the responsiveness of hlac lines to cytotoxic drugs by 3-[4,5-dimethylthiozol-2yl]-2,5-diphenyltetrazolium bromide [mtt] assay. |
2006-04-25 |
2023-08-12 |
human |
| Li Bai, Rong Zhu, Zhihong Chen, Lei Gao, Xin Zhang, Xiangdong Wang, Chunxue Ba. Potential role of short hairpin RNA targeting epidermal growth factor receptor in growth and sensitivity to drugs of human lung adenocarcinoma cells. Biochemical pharmacology. vol 71. issue 8. 2006-04-25. PMID:16442503. |
vector-based shrna against egfr caused g1 arrest, induced apoptosis, and subsequently increased the sensitivity to cisplatin, doxorubicin and paclitaxel by about four- to seven-fold in both hlac lines. |
2006-04-25 |
2023-08-12 |
human |
| John G Shelton, Linda S Steelman, Steven L Abrams, Edmund R White, Shaw M Akula, Fred E Bertrand, Richard A Franklin, James A McCubre. Effects of endogenous epidermal growth factor receptor signaling on DNA synthesis and ERK activation in a cytokine-dependent hematopoietic cell line. Cell cycle (Georgetown, Tex.). vol 4. issue 6. 2006-04-24. PMID:15908804. |
ligation of the egfr results in the activation of many downstream signaling pathways which have profound effects on cell cycle progression and the prevention of apoptosis. |
2006-04-24 |
2023-08-12 |
Not clear |
| John G Shelton, Linda S Steelman, Steven L Abrams, Edmund R White, Shaw M Akula, Fred E Bertrand, Richard A Franklin, James A McCubre. Effects of endogenous epidermal growth factor receptor signaling on DNA synthesis and ERK activation in a cytokine-dependent hematopoietic cell line. Cell cycle (Georgetown, Tex.). vol 4. issue 6. 2006-04-24. PMID:15908804. |
likewise, the egfr inhibitor ag1478 induced apoptosis in egfr positive fdc-p1 cells but not egfr negative fl5.12 cells. |
2006-04-24 |
2023-08-12 |
Not clear |
| John G Shelton, Linda S Steelman, Steven L Abrams, Edmund R White, Shaw M Akula, Richard A Franklin, Fred E Bertrand, Martin McMahon, James A McCubre. Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines. Cell cycle (Georgetown, Tex.). vol 4. issue 6. 2006-04-24. PMID:15917660. |
conditional egfr promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines. |
2006-04-24 |
2023-08-12 |
human |
| John G Shelton, Linda S Steelman, Steven L Abrams, Edmund R White, Shaw M Akula, Richard A Franklin, Fred E Bertrand, Martin McMahon, James A McCubre. Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines. Cell cycle (Georgetown, Tex.). vol 4. issue 6. 2006-04-24. PMID:15917660. |
treatment of v-erbb:er cells with the egfr inhibitor ag1478 efficiently induced apoptosis. |
2006-04-24 |
2023-08-12 |
human |
| John G Shelton, Linda S Steelman, Steven L Abrams, Edmund R White, Shaw M Akula, Richard A Franklin, Fred E Bertrand, Martin McMahon, James A McCubre. Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines. Cell cycle (Georgetown, Tex.). vol 4. issue 6. 2006-04-24. PMID:15917660. |
induction of apoptosis and prevention of cell cycle progression by the egfr inhibitor were only observed when the cells were grown in response to v-erbb:er activation demonstrating specificity. |
2006-04-24 |
2023-08-12 |
human |
| Bettina Wagner, Anuradha Natarajan, Sabine Grünaug, Renate Kroismayr, Erwin F Wagner, Maria Sibili. Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes. The EMBO journal. vol 25. issue 4. 2006-04-14. PMID:16467848. |
here, we show that egfr signaling controls cortical degeneration by regulating cortical astrocyte apoptosis. |
2006-04-14 |
2023-08-12 |
mouse |
| Bettina Wagner, Anuradha Natarajan, Sabine Grünaug, Renate Kroismayr, Erwin F Wagner, Maria Sibili. Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes. The EMBO journal. vol 25. issue 4. 2006-04-14. PMID:16467848. |
whereas egfr(-/-) midbrain astrocytes are unaffected, mutant cortical astrocytes display increased apoptosis mediated by an akt-caspase-dependent mechanism and are unable to support neuronal survival. |
2006-04-14 |
2023-08-12 |
mouse |