| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bettina Wagner, Anuradha Natarajan, Sabine Grünaug, Renate Kroismayr, Erwin F Wagner, Maria Sibili. Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes. The EMBO journal. vol 25. issue 4. 2006-04-14. PMID:16467848. |
the expression of many neurotrophic factors is unaltered in egfr(-/-) cortical astrocytes suggesting that neuronal loss occurs as a consequence of increased astrocyte apoptosis rather than impaired secretion of trophic factors. |
2006-04-14 |
2023-08-12 |
mouse |
| Y-Y He, J-L Huang, C F Chignel. Cleavage of epidermal growth factor receptor by caspase during apoptosis is independent of its internalization. Oncogene. vol 25. issue 10. 2006-04-13. PMID:16247443. |
here, we report that during apoptosis egfr is cleaved by activated caspase-3 or related proteases at its c-terminus domain. |
2006-04-13 |
2023-08-12 |
Not clear |
| Y-Y He, J-L Huang, C F Chignel. Cleavage of epidermal growth factor receptor by caspase during apoptosis is independent of its internalization. Oncogene. vol 25. issue 10. 2006-04-13. PMID:16247443. |
egfr internalization during apoptosis required dynamin and cholesterol since dominant-negative dynamin (k44a) or cholesterol depletion by methyl-beta-cyclodextrin prevented egfr internalization. |
2006-04-13 |
2023-08-12 |
Not clear |
| Y-Y He, J-L Huang, C F Chignel. Cleavage of epidermal growth factor receptor by caspase during apoptosis is independent of its internalization. Oncogene. vol 25. issue 10. 2006-04-13. PMID:16247443. |
a cleavage-deficient egfr mutant delayed apoptosis process. |
2006-04-13 |
2023-08-12 |
Not clear |
| Y-Y He, J-L Huang, C F Chignel. Cleavage of epidermal growth factor receptor by caspase during apoptosis is independent of its internalization. Oncogene. vol 25. issue 10. 2006-04-13. PMID:16247443. |
we conclude that the evolutionarily conserved c-terminus domain of egfr is the target of caspases and subjected to degradation during apoptosis to shut down its signaling. |
2006-04-13 |
2023-08-12 |
Not clear |
| Daniel Edmund Bryan Swinson, Kenneth John O'Byrn. Interactions between hypoxia and epidermal growth factor receptor in non-small-cell lung cancer. Clinical lung cancer. vol 7. issue 4. 2006-04-06. PMID:16512978. |
the epidermal growth factor receptor (egfr) promotes tumor cell proliferation and angiogenesis and inhibits apoptosis. |
2006-04-06 |
2023-08-12 |
Not clear |
| Barbara Burtnes. The role of cetuximab in the treatment of squamous cell cancer of the head and neck. Expert opinion on biological therapy. vol 5. issue 8. 2006-03-29. PMID:16050785. |
binding of the antibody to the egfr prevents activation of the receptor by endogenous ligands; proliferation is reduced, apoptosis enhanced, and angiogenesis, invasiveness and metastasis reduced. |
2006-03-29 |
2023-08-12 |
human |
| Lauren Coh. Mucus in chronic airway diseases: sorting out the sticky details. The Journal of clinical investigation. vol 116. issue 2. 2006-03-23. PMID:16453018. |
show, in a mouse model of chronic mucous hypersecretion, that ciliated epithelial cell apoptosis is inhibited by egfr activation, allowing il-13 to stimulate the differentiation of these cells into goblet cells, which secrete mucus. |
2006-03-23 |
2023-08-12 |
mouse |
| Jeffrey W Tyner, Edy Y Kim, Kyotaro Ide, Mark R Pelletier, William T Roswit, Jeffrey D Morton, John T Battaile, Anand C Patel, G Alexander Patterson, Mario Castro, Melanie S Spoor, Yingjian You, Steven L Brody, Michael J Holtzma. Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. The Journal of clinical investigation. vol 116. issue 2. 2006-03-23. PMID:16453019. |
this chronic switch in epithelial behavior exhibits genetic susceptibility and depends on persistent activation of egfr signaling to pi3k that prevents apoptosis of ciliated cells and on il-13 signaling that promotes transdifferentiation of ciliated to goblet cells. |
2006-03-23 |
2023-08-12 |
mouse |
| Lanxi Song, Domenico Coppola, Sandy Livingston, Doug Cress, Eric B Haur. Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells. Cancer biology & therapy. vol 4. issue 3. 2006-03-21. PMID:15753661. |
lung cancer cells overexpressing mcl-1 are less sensitive to apoptosis induced by chemotherapeutic agents, zd1839 (an inhibitor of egfr tyrosine kinase) and bcl-2 or bcl-x(l) antisense oligonucleotides. |
2006-03-21 |
2023-08-12 |
human |
| C Festuccia, P Muzi, D Millimaggi, L Biordi, G L Gravina, S Speca, A Angelucci, V Dolo, C Vicentini, M Bologn. Molecular aspects of gefitinib antiproliferative and pro-apoptotic effects in PTEN-positive and PTEN-negative prostate cancer cell lines. Endocrine-related cancer. vol 12. issue 4. 2006-03-10. PMID:16322337. |
the mapk pathway seems to be involved primarily on cell-growth modulation because dual blockade of egfr and erk1/2 phosphorylation potentiates growth inhibition (both not cell apoptosis) in pten-positive pca cells and reduced egf-mediated growth in pten-negative cells. |
2006-03-10 |
2023-08-12 |
Not clear |
| C Festuccia, P Muzi, D Millimaggi, L Biordi, G L Gravina, S Speca, A Angelucci, V Dolo, C Vicentini, M Bologn. Molecular aspects of gefitinib antiproliferative and pro-apoptotic effects in PTEN-positive and PTEN-negative prostate cancer cell lines. Endocrine-related cancer. vol 12. issue 4. 2006-03-10. PMID:16322337. |
therefore, our data suggest that the inhibition of egfr signalling can result in a significant growth reduction and in increased apoptosis in egfr-overexpressing pca cells with different modalities, which are regulated by pten status, and this may have relevance in the clinical setting of pca. |
2006-03-10 |
2023-08-12 |
Not clear |
| Hikaru Machida, Syuichi Nakajima, Naoto Shikano, Junko Nishio, Shinobu Okada, Munehiko Asayama, Makoto Shirai, Nobuo Kubot. Heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin potentiates the radiation response of tumor cells grown as monolayer cultures and spheroids by inducing apoptosis. Cancer science. vol 96. issue 12. 2006-03-10. PMID:16367912. |
however, in all three cell lines, 17aag increased radiation-induced apoptosis by reducing the expression of egfr and erbb-2 and inhibiting the phosphorylation of akt. |
2006-03-10 |
2023-08-12 |
human |
| Masahito Shimizu, Atsuko Deguchi, Andrew K Joe, Judith F Mckoy, Hisataka Moriwaki, I Bernard Weinstei. EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cells. Journal of experimental therapeutics & oncology. vol 5. issue 1. 2006-03-10. PMID:16416603. |
with a longer incubation time, 96 hours, a very low dose (1.0 microg/ml) of egcg also caused inhibition of cell growth, inhibition of activation of egfr, her2, and her3, a decrease in the levels of cox-2 and bcl-xl proteins, and apoptosis. |
2006-03-10 |
2023-08-12 |
human |
| Taghrid B El-Abaseri, Sumanth Putta, Laura A Hanse. Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor. Carcinogenesis. vol 27. issue 2. 2006-03-09. PMID:16123117. |
collectively, these results demonstrate that the uv-induced activation of egfr augments keratinocyte proliferation and suppresses apoptosis, leading to epidermal hyperplasia, associated with increased g1 cyclin expression and suppression of cdk inhibitor expression. |
2006-03-09 |
2023-08-12 |
mouse |
| Shadan Ali, Basil F El-Rayes, Fazlul H Sarkar, Philip A Phili. Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy. Molecular cancer therapeutics. vol 4. issue 12. 2006-03-02. PMID:16373709. |
the aims of this study were to determine the effects of (a) combining the epidermal growth factor receptor (egfr) blocker (erlotinib) and the cyclooxygenase-2 inhibitor (celecoxib) on cell growth and apoptosis in human pancreatic cancer cell lines, (b) baseline egfr expression on the potentiation of erlotinib-induced apoptosis by celecoxib, and (c) the effects of the combination on the expression of the cox-2, egfr, her-2/neu, and nuclear factor-kappab (nf-kappab). |
2006-03-02 |
2023-08-12 |
human |
| Shadan Ali, Basil F El-Rayes, Fazlul H Sarkar, Philip A Phili. Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy. Molecular cancer therapeutics. vol 4. issue 12. 2006-03-02. PMID:16373709. |
however, no potentiation in growth inhibition or apoptosis was observed in the miapaca cell line with low expression of the egfr. |
2006-03-02 |
2023-08-12 |
human |
| Shadan Ali, Basil F El-Rayes, Fazlul H Sarkar, Philip A Phili. Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy. Molecular cancer therapeutics. vol 4. issue 12. 2006-03-02. PMID:16373709. |
(a) celecoxib can potentiate erlotinib-induced growth inhibition and apoptosis in pancreatic cell lines, (b) high baseline egfr expression is a predictor of this potentiation, and (c) the down-regulation of egfr, cox-2, and her-2/neu expression and nf-kappab inactivation contributes to the potentiation of erlotinib by celecoxib. |
2006-03-02 |
2023-08-12 |
human |
| Ravi D Rao, Ann C Mladek, Jeffrey D Lamont, Jennie M Goble, Charles Erlichman, C David James, Jann N Sarkari. Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells. Neoplasia (New York, N.Y.). vol 7. issue 10. 2006-02-23. PMID:16242075. |
elevated epidermal growth factor receptor (egfr) and mammalian target of rapamycin (mtor) signaling are known to contribute to the malignant properties of glioblastoma multiforme (gbm), which include uncontrolled cell proliferation and evasion of apoptosis. |
2006-02-23 |
2023-08-12 |
Not clear |
| Yunfei Zhou, Song Li, Yi P Hu, Jing Wang, Jennie Hauser, Alexis N Conway, Michelle A Vinci, Lisa Humphrey, Elizabeth Zborowska, James K V Willson, Michael G Brattai. Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis. Cancer research. vol 66. issue 1. 2006-02-23. PMID:16397255. |
blockade of egfr and erbb2 by the novel dual egfr and erbb2 tyrosine kinase inhibitor gw572016 sensitizes human colon carcinoma geo cells to apoptosis. |
2006-02-23 |
2023-08-12 |
human |