| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei-Zhong Ying, Huang-Ge Zhang, Paul W Sander. EGF receptor activity modulates apoptosis induced by inhibition of the proteasome of vascular smooth muscle cells. Journal of the American Society of Nephrology : JASN. vol 18. issue 1. 2007-03-14. PMID:17151333. |
egf receptor (egfr) activation produced posttranslational modifications of bad, providing the pro-survival signals that prevented apoptosis of smooth muscle cells during proteasome inhibition. |
2007-03-14 |
2023-08-12 |
Not clear |
| Dan Li, Li-jun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejim. Oridonin-induced A431 cell apoptosis partially through blockage of the Ras/Raf/ERK signal pathway. Journal of pharmacological sciences. vol 103. issue 1. 2007-03-12. PMID:17251686. |
it was found that the total tyrosine kinase activity was inhibited and the protein expressions of epidermal growth factor receptor (egfr) and phosphorylated egfr were decreased in oridonin-induced a431 cell apoptosis. |
2007-03-12 |
2023-08-12 |
human |
| Dan Li, Li-jun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejim. Oridonin-induced A431 cell apoptosis partially through blockage of the Ras/Raf/ERK signal pathway. Journal of pharmacological sciences. vol 103. issue 1. 2007-03-12. PMID:17251686. |
taken together, oridonin-induced apoptosis in a431 cells might be through blocking egfr and its downstream ras/raf/erk signal pathway. |
2007-03-12 |
2023-08-12 |
human |
| Jie Zhang, Shailaja Kalyankrishna, Marie Wislez, Nishan Thilaganathan, Babita Saigal, Wei Wei, Long Ma, Ignacio I Wistuba, Faye M Johnson, Jonathan M Kuri. SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines. The American journal of pathology. vol 170. issue 1. 2007-02-21. PMID:17200208. |
pp1 decreased phosphorylation of egfr, erbb2, and erbb3 and strikingly enhanced apoptosis by gefitinib, an egfr inhibitor. |
2007-02-21 |
2023-08-12 |
Not clear |
| Jie Zhang, Shailaja Kalyankrishna, Marie Wislez, Nishan Thilaganathan, Babita Saigal, Wei Wei, Long Ma, Ignacio I Wistuba, Faye M Johnson, Jonathan M Kuri. SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines. The American journal of pathology. vol 170. issue 1. 2007-02-21. PMID:17200208. |
hcc827 cells transfected with c-src short hairpin rna exhibited diminished phosphorylation of egfr and erbb2 and decreased sensitivity to apoptosis by pp1 or gefitinib. |
2007-02-21 |
2023-08-12 |
Not clear |
| Carlos R Estrada, Rosalyn M Adam, Samuel H Eaton, Darius J Bägli, Michael R Freema. Inhibition of EGFR signaling abrogates smooth muscle proliferation resulting from sustained distension of the urinary bladder. Laboratory investigation; a journal of technical methods and pathology. vol 86. issue 12. 2007-02-20. PMID:17043666. |
the bladders were excised and incubated in ex vivo organ culture for 4-24 h. egfr phosphorylation, dna proliferation, and the extent of apoptosis in the cultured tissues were assessed. |
2007-02-20 |
2023-08-12 |
human |
| Marina Frusić-Zlotkin, Dorin Raichenberg, Xin Wang, Michael David, Beno Michel, Yoram Milne. Apoptotic mechanism in pemphigus autoimmunoglobulins-induced acantholysis--possible involvement of the EGF receptor. Autoimmunity. vol 39. issue 7. 2007-02-20. PMID:17101500. |
in this study we investigated the involvement of the egfr and intracellular signal transduction pathways in the pv-igg-induced apoptosis. |
2007-02-20 |
2023-08-12 |
Not clear |
| Marina Frusić-Zlotkin, Dorin Raichenberg, Xin Wang, Michael David, Beno Michel, Yoram Milne. Apoptotic mechanism in pemphigus autoimmunoglobulins-induced acantholysis--possible involvement of the EGF receptor. Autoimmunity. vol 39. issue 7. 2007-02-20. PMID:17101500. |
pharmacological inactivation of the egfr and erk kinase activities, by use of specific inhibitors ag1478 and pd98059 respectively, blocked pv-igg-induced phosphorylation of egfr, erk and c-jun and cellular apoptosis, measured by flow cytometry and caspase 3 activity. |
2007-02-20 |
2023-08-12 |
Not clear |
| Marina Frusić-Zlotkin, Dorin Raichenberg, Xin Wang, Michael David, Beno Michel, Yoram Milne. Apoptotic mechanism in pemphigus autoimmunoglobulins-induced acantholysis--possible involvement of the EGF receptor. Autoimmunity. vol 39. issue 7. 2007-02-20. PMID:17101500. |
the acantholytic effect caused by pv-igg binding to cell surface receptors begins with and depends on cell surface receptor (egfr) activation of intracellular signaling pathways (erk pathway) and apoptosis induction (fasr pathway), which later lead to major cell-cell separation (acantholysis) and cell death. |
2007-02-20 |
2023-08-12 |
Not clear |
| Ashwani Rajput, Alan P Koterba, Jeffrey I Kreisberg, Jason M Foster, James K V Willson, Michael G Brattai. A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo. Cancer research. vol 67. issue 2. 2007-02-20. PMID:17234777. |
the reversal of constitutive egfr activation results in the loss of downstream mitogen-activated protein kinase and akt activation, and a reduction in xenograft size that is associated with decreased proliferation and increased apoptosis. |
2007-02-20 |
2023-08-12 |
human |
| Maher N Younes, Young Wook Park, Yasemin Dakak Yazici, Meirong Gu, Alfredo A Santillan, Xiaolin Nong, Seungwon Kim, Samar A Jasser, Adel K El-Naggar, Jeffrey N Myer. Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model. Molecular cancer therapeutics. vol 5. issue 11. 2007-02-15. PMID:17121916. |
we examined the effects of aee788 on salivary acc cell growth and apoptosis and on the phosphorylation of egfr and vegfr-2 in salivary acc cells. |
2007-02-15 |
2023-08-12 |
mouse |
| Maher N Younes, Young Wook Park, Yasemin Dakak Yazici, Meirong Gu, Alfredo A Santillan, Xiaolin Nong, Seungwon Kim, Samar A Jasser, Adel K El-Naggar, Jeffrey N Myer. Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model. Molecular cancer therapeutics. vol 5. issue 11. 2007-02-15. PMID:17121916. |
treatment of salivary acc cells with aee788, alone or in combination with chemotherapy, led to growth inhibition, induction of apoptosis, and dose-dependent inhibition of egfr and vegfr-2 phosphorylation. |
2007-02-15 |
2023-08-12 |
mouse |
| Maher N Younes, Young Wook Park, Yasemin Dakak Yazici, Meirong Gu, Alfredo A Santillan, Xiaolin Nong, Seungwon Kim, Samar A Jasser, Adel K El-Naggar, Jeffrey N Myer. Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model. Molecular cancer therapeutics. vol 5. issue 11. 2007-02-15. PMID:17121916. |
tumors of mice treated with aee788 and aee788 plus chemotherapy exhibited down-regulation of activated egfr and vegfr-2, increased tumor and endothelial cell apoptosis, and decreased microvessel density, which correlated with a decrease in the level of matrix metalloproteinase-9 and matrix metalloproteinase-2 expression and a decrease in the incidence of vascular metastasis. |
2007-02-15 |
2023-08-12 |
mouse |
| Mathias Munk, Ashfaque Ahmed Memon, Ebba Nexo, Boe Sandahl Sorense. Inhibition of the epidermal growth factor receptor in bladder cancer cells treated with the DNA-damaging drug etoposide markedly increases apoptosis. BJU international. vol 99. issue 1. 2007-02-12. PMID:17092291. |
to investigate the effect of the epidermal growth factor receptor (egfr) on the induction of apoptosis by the chemotherapeutic agent etoposide (vp16), and to examine the effect of combining vp16 with gefitinib to see if the cell-survival mechanism can be prevented. |
2007-02-12 |
2023-08-12 |
Not clear |
| Shahar Lev-Ari, Alex Starr, Akiva Vexler, Vicki Karaush, Vered Loew, Joel Greif, Eyal Fenig, Dan Aderka, Rami Ben-Yose. Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity. Anticancer research. vol 26. issue 6B. 2007-01-25. PMID:17201164. |
inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of cox-2 and egfr and inhibition of erk1/2 activity. |
2007-01-25 |
2023-08-12 |
Not clear |
| William O Ward, Don A Delker, Susan D Hester, Sheau-Fung Thai, Douglas C Wolf, James W Allen, Stephen Nesno. Transcriptional profiles in liver from mice treated with hepatotumorigenic and nonhepatotumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanil. Toxicologic pathology. vol 34. issue 7. 2007-01-23. PMID:17178688. |
triadimefon and propiconazole both altered apoptosis, cell cycle, adherens junction, calcium signaling, and egfr signaling pathways. |
2007-01-23 |
2023-08-12 |
mouse |
| Alessandra Antonello, Andrea Tarozzi, Fabiana Morroni, Andrea Cavalli, Michela Rosini, Patrizia Hrelia, Maria Laura Bolognesi, Carlo Melchiorr. Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects. Journal of medicinal chemistry. vol 49. issue 23. 2007-01-19. PMID:17154492. |
following this rationale, we designed compounds able to irreversibly block epidermal growth factor receptor (egfr), and to induce apoptosis in tumor cell lines. |
2007-01-19 |
2023-08-12 |
human |
| Alessandra Antonello, Andrea Tarozzi, Fabiana Morroni, Andrea Cavalli, Michela Rosini, Patrizia Hrelia, Maria Laura Bolognesi, Carlo Melchiorr. Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects. Journal of medicinal chemistry. vol 49. issue 23. 2007-01-19. PMID:17154492. |
the novel molecules were synthesized by combining the structural features of the egfr inhibitor pd153035 (1) and lipoic acid, which among other therapeutic effects triggers apoptosis in human cancer cells. |
2007-01-19 |
2023-08-12 |
human |
| Susumu Kobayashi, Takeshi Shimamura, Stefano Monti, Ulrich Steidl, Christopher J Hetherington, April M Lowell, Todd Golub, Matthew Meyerson, Daniel G Tenen, Geoffrey I Shapiro, Balázs Halmo. Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling. Cancer research. vol 66. issue 23. 2007-01-10. PMID:17145885. |
the gefitinib-resistant, t790m-mutant h1975 nsclc cell line undergoes prominent growth arrest and apoptosis when treated with the irreversible egfr inhibitor, cl-387,785. |
2007-01-10 |
2023-08-12 |
Not clear |
| Marvin Rubenstein, Kenning M Anderson, Paulus Tsui, Patrick Guina. Synthesis of branched antisense oligonucleotides having multiple specificities. Treatment of hormone insensitive prostate cancer. Medical hypotheses. vol 67. issue 6. 2007-01-04. PMID:16870352. |
subsequent bispecifics have been developed which target both egfr and the apoptosis regulating protein bcl-2. |
2007-01-04 |
2023-08-12 |
Not clear |