| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Iain R Hutcheson, Janice M Knowlden, Helen E Jones, Rajpal S Burmi, Richard A McClelland, Denise Barrow, Julia M W Gee, Robert I Nicholso. Inductive mechanisms limiting response to anti-epidermal growth factor receptor therapy. Endocrine-related cancer. vol 13 Suppl 1. 2007-05-29. PMID:17259562. |
aberrant epidermal growth factor receptor (egfr) signalling, a key feature of a variety of human malignancies, can drive a range of mechanisms underlying tumour growth and progression, including increased cell proliferation, angiogenesis, metastasis and decreased apoptosis. |
2007-05-29 |
2023-08-12 |
human |
| Wu Zhang, Michael Gordon, Heinz-Josef Len. Novel approaches to treatment of advanced colorectal cancer with anti-EGFR monoclonal antibodies. Annals of medicine. vol 38. issue 8. 2007-05-11. PMID:17438669. |
egfr overexpression is known to be involved in carcinogenic processes, such as cell proliferation, apoptosis, angiogenesis and metastasis. |
2007-05-11 |
2023-08-12 |
human |
| Johann Riedemann, Muhammad Sohail, Valentine M Macaula. Dual silencing of the EGF and type 1 IGF receptors suggests dominance of IGF signaling in human breast cancer cells. Biochemical and biophysical research communications. vol 355. issue 3. 2007-05-08. PMID:17320820. |
transient igf1r knockdown induced enhanced phosphorylation of the egfr and its effectors jnk, erks and stat5, but this did not prevent apoptosis induction and inhibition of clonogenic survival following igf1r knockdown. |
2007-05-08 |
2023-08-12 |
human |
| Xiao Li, Quan Pu, Cassandra Beckham, Joachim H Dee. [Expression of epidermal growth factor receptor and its relationship to apoptosis in myelodysplastic syndromes]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. vol 24. issue 1. 2007-05-04. PMID:12679005. |
to explore the expression of epidermal growth factor receptor (egfr) in hematopoietic cells and investigate its relationship to apoptosis in myelodysplastic syndrome (mds) patients. |
2007-05-04 |
2023-08-12 |
Not clear |
| Yuqing Liu, Ronnie T P Poon, Weibin Shao, Xiaoli Sun, Hui Chen, Tsz Wai Kok, Sheung Tat Fa. Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma. Cancer letters. vol 248. issue 1. 2007-05-04. PMID:16837130. |
egfr inhibitors also induced tumor cells to undergo apoptosis. |
2007-05-04 |
2023-08-12 |
human |
| Sreenath V Sharma, Daphne W Bell, Jeffrey Settleman, Daniel A Habe. Epidermal growth factor receptor mutations in lung cancer. Nature reviews. Cancer. vol 7. issue 3. 2007-05-01. PMID:17318210. |
we review the results of genetic, biochemical and clinical studies focused on somatic mutations of egfr that are associated with the phenomenon of oncogene addiction, describing 'oncogenic shock' as a mechanistic explanation for the apoptosis that follows the acute treatment of susceptible cells with kinase inhibitors. |
2007-05-01 |
2023-08-12 |
Not clear |
| Xiaorong Zhao, Wentao Dai, Huifen Zhu, Yue Zhang, Limin Cao, Qing Ye, Ping Lei, Guanxin She. Epidermal growth factor (EGF) induces apoptosis in a transfected cell line expressing EGF receptor on its membrane. Cell biology international. vol 30. issue 8. 2007-04-27. PMID:16750403. |
high concentrations of egf induced both egfr expression and apoptosis in a dose-dependent manner. |
2007-04-27 |
2023-08-12 |
human |
| Xiang-bai Wu, Kai-xiong Tao, Guo-bin Wang, Yuan Tian, Jing-hui Zhang, Dao-da Che. [Double sites short hairpin RNAs targeting epidermal growth factor receptor to promote colon cancer cells apoptosis and enhance 5-fluorouracil chemotherapy effect]. Zhonghua wai ke za zhi [Chinese journal of surgery]. vol 44. issue 11. 2007-04-26. PMID:16836928. |
to investigate the differences about rna interference (rnai) technique which focuses on single or multiple sites to suppress colon cancer lovo cell line's epidermal growth factor receptor (egfr) mrna and protein expression, induce cell apoptosis and enhance 5-fluorouracil (5-fu) sensitivity. |
2007-04-26 |
2023-08-12 |
Not clear |
| Laia Caja, Conrad Ortiz, Esther Bertran, Miguel M Murillo, M Jesús Miró-Obradors, Evangelina Palacios, Isabel Fabrega. Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis. Cellular signalling. vol 19. issue 4. 2007-04-18. PMID:17055226. |
in this work we show that tgf-beta plays a dual role in regulating apoptosis in fao rat hepatoma cells, since, in addition to its pro-apoptotic effect, tgf-beta also activates survival signals, such as akt, the epidermal growth factor receptor (egfr) being required for its activation. |
2007-04-18 |
2023-08-12 |
rat |
| Patricia D Schley, David N Brindley, Catherine J Fiel. (n-3) PUFA alter raft lipid composition and decrease epidermal growth factor receptor levels in lipid rafts of human breast cancer cells. The Journal of nutrition. vol 137. issue 3. 2007-04-17. PMID:17311938. |
to determine the mechanism by which the (n-3) fatty acids (fa) eicosapentaenoic acid (epa) and docosahexaenoic acid (dha) decrease proliferation and induce apoptosis in mda-mb-231 human breast cancer cells, we examined the effects of epa and dha on the lipid composition of lipid rafts as well as epidermal growth factor receptor (egfr) raft localization and phosphorylation. |
2007-04-17 |
2023-08-12 |
human |
| Patricia D Schley, David N Brindley, Catherine J Fiel. (n-3) PUFA alter raft lipid composition and decrease epidermal growth factor receptor levels in lipid rafts of human breast cancer cells. The Journal of nutrition. vol 137. issue 3. 2007-04-17. PMID:17311938. |
as sustained activation of the egfr and p38 mapk has been associated with apoptosis in human breast cancer cells, our results indicate that (n-3) fa modify the lipid composition of membrane rafts and alter egfr signaling in a way that decreases the growth of breast tumors. |
2007-04-17 |
2023-08-12 |
human |
| N Calonghi, E Pagnotta, C Parolin, C Mangano, M L Bolognesi, C Melchiorre, L Masott. A new EGFR inhibitor induces apoptosis in colon cancer cells. Biochemical and biophysical research communications. vol 354. issue 2. 2007-04-10. PMID:17227671. |
a new egfr inhibitor induces apoptosis in colon cancer cells. |
2007-04-10 |
2023-08-12 |
human |
| Xiangbai Wu, Yongzhi Deng, Guobin Wang, Kaixiong Ta. Combining siRNAs at two different sites in the EGFR to suppress its expression, induce apoptosis, and enhance 5-fluorouracil sensitivity of colon cancer cells. The Journal of surgical research. vol 138. issue 1. 2007-04-05. PMID:17169374. |
combining sirnas at two different sites in the egfr to suppress its expression, induce apoptosis, and enhance 5-fluorouracil sensitivity of colon cancer cells. |
2007-04-05 |
2023-08-12 |
Not clear |
| Xiangbai Wu, Yongzhi Deng, Guobin Wang, Kaixiong Ta. Combining siRNAs at two different sites in the EGFR to suppress its expression, induce apoptosis, and enhance 5-fluorouracil sensitivity of colon cancer cells. The Journal of surgical research. vol 138. issue 1. 2007-04-05. PMID:17169374. |
the epidermal growth factor receptor (egfr) has played an important role in the growth and apoptosis of colon cancer. |
2007-04-05 |
2023-08-12 |
Not clear |
| Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura, Toshiyuki Kozuki, Akiko Hisamoto, Hideki Katayama, Nagio Takigawa, Nobukazu Fujimoto, Keiichi Fujiwara, Hiroshi Ueoka, Mitsune Tanimot. Gefitinib induces premature senescence in non-small cell lung cancer cells with or without EGFR gene mutation. Oncology reports. vol 17. issue 2. 2007-03-29. PMID:17203166. |
though higher concentration of gefitinib (10 microm) induced extensive apoptosis in two cell lines (egfr-mutated pc-9 cells and egfr wild- type ebc-2/r cells), clinically relevant concentrations of gefitinib (1 microm) induced prominent premature senescence instead of apoptosis in these cells. |
2007-03-29 |
2023-08-12 |
Not clear |
| Elena P Moiseeva, Raimond Heukers, Margaret M Manso. EGFR and Src are involved in indole-3-carbinol-induced death and cell cycle arrest of human breast cancer cells. Carcinogenesis. vol 28. issue 2. 2007-03-26. PMID:16956907. |
inhibition of egfr by specific inhibitors pd153035 or zd1839 increased susceptibility to i3c-induced apoptosis of mcf7, mda-mb-468 and mda-mb-231 cells. |
2007-03-26 |
2023-08-12 |
human |
| Seema Dwivedi, Abha Sharma, Brad Patrick, Rajendra Sharma, Yogesh C Awasth. Role of 4-hydroxynonenal and its metabolites in signaling. Redox report : communications in free radical research. vol 12. issue 1. 2007-03-23. PMID:17263900. |
protein kinase c, adenylate cyclase) predict that certain constitutive levels of hne may be needed for normal cell functions - lowering of this constitutive hne level in cells promotes proliferative machinery while an increase in this level promotes apoptotic signaling; (ii) hne is a common denominator in stress-induced apoptosis caused by h(2)o(2), superoxide, uv, heat or oxidant chemicals such as doxorubicin; and (iii) hne can modulate ligand-independent signaling by membrane receptors such as egfr or fas (cd95) and may act as a sensor of external stimuli for eliciting stress-response. |
2007-03-23 |
2023-08-12 |
Not clear |
| Doron Ginsber. EGFR signaling inhibits E2F1-induced apoptosis in vivo: implications for cancer therapy. Science's STKE : signal transduction knowledge environment. vol 2007. issue 371. 2007-03-23. PMID:17264315. |
egfr signaling inhibits e2f1-induced apoptosis in vivo: implications for cancer therapy. |
2007-03-23 |
2023-08-12 |
human |
| Doron Ginsber. EGFR signaling inhibits E2F1-induced apoptosis in vivo: implications for cancer therapy. Science's STKE : signal transduction knowledge environment. vol 2007. issue 371. 2007-03-23. PMID:17264315. |
a recent study reveals epidermal growth factor receptor (egfr) signaling to be one such variable, as egfr signaling cooperates with rb in inhibiting e2f1-induced apoptosis. |
2007-03-23 |
2023-08-12 |
human |
| Marissa Shrader, Maria Simona Pino, Laura Lashinger, Menashe Bar-Eli, Liana Adam, Colin P N Dinney, David J McConke. Gefitinib reverses TRAIL resistance in human bladder cancer cell lines via inhibition of AKT-mediated X-linked inhibitor of apoptosis protein expression. Cancer research. vol 67. issue 4. 2007-03-15. PMID:17308080. |
together, our results show that egfr pathway activation limits trail-induced apoptosis via an akt- and xiap-dependent mechanism in egfr-dependent human bladder cancer cells, providing the conceptual framework for a further evaluation of the combination in relevant preclinical in vivo models. |
2007-03-15 |
2023-08-12 |
human |