| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Keese, Martin Offterdinger, Christian Tischer, Andreas Girod, Piet H M Lommerse, Vugar Yagublu, Richard Magdeburg, Philippe I H Bastiaen. Quantitative imaging of apoptosis commitment in colorectal tumor cells. Differentiation; research in biological diversity. vol 75. issue 9. 2008-02-08. PMID:17511782. |
using these methods, we show that egfr kinase inhibitors sensitize colorectal sw-480 tumor cells for 5-fluorouracil-induced apoptosis, indicating that egfr-mediated survival signaling contributes to apoptosis resistance via its intrinsic kinase activity. |
2008-02-08 |
2023-08-12 |
human |
| Floriana Morgillo, Maria Anna Bareschino, Roberto Bianco, Giampaolo Tortora, Fortunato Ciardiell. Primary and acquired resistance to anti-EGFR targeted drugs in cancer therapy. Differentiation; research in biological diversity. vol 75. issue 9. 2008-02-08. PMID:17608727. |
in recent years, the epidermal growth factor receptor (egfr) has been recognized as a central player and regulator of cancer cell proliferation, apoptosis and angiogenesis and, therefore, as a potentially relevant therapeutic target. |
2008-02-08 |
2023-08-12 |
Not clear |
| Wenjuan Wu, Michael S O'Reilly, Robert R Langley, Rachel Z Tsan, Cheryl H Baker, Neby Bekele, Xi Ming Tang, Amir Onn, Isaiah J Fidler, Roy S Herbs. Expression of epidermal growth factor (EGF)/transforming growth factor-alpha by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice. Molecular cancer therapeutics. vol 6. issue 10. 2008-02-07. PMID:17913856. |
antagonism of egfr signaling by treatment of mice with aee788 decreased proliferation and increased apoptosis of both tumor cells and tumor-associated endothelial cells in nci-h441 tumors but not in pc14-pe6 tumors. |
2008-02-07 |
2023-08-12 |
mouse |
| Adhip P N Majumdar, Jianhua Du, Yingjie Yu, Hu Xu, Edi Levi, Bhaumik B Patel, Arun K Rish. Cell cycle and apoptosis regulatory protein-1: a novel regulator of apoptosis in the colonic mucosa during aging. American journal of physiology. Gastrointestinal and liver physiology. vol 293. issue 6. 2008-02-06. PMID:17932228. |
although the regulatory mechanisms for the age-related rise in proliferation and reduction in apoptosis in the colonic mucosa are yet to be fully delineated, we have demonstrated that these events are associated with increased expression and activation of epithelial growth factor receptor (egfr)/erbb-1 and some of its receptor family members (egfrs), indicating their involvement in these processes. |
2008-02-06 |
2023-08-12 |
rat |
| Adhip P N Majumdar, Jianhua Du, Yingjie Yu, Hu Xu, Edi Levi, Bhaumik B Patel, Arun K Rish. Cell cycle and apoptosis regulatory protein-1: a novel regulator of apoptosis in the colonic mucosa during aging. American journal of physiology. Gastrointestinal and liver physiology. vol 293. issue 6. 2008-02-06. PMID:17932228. |
however, the downstream signaling events of egfr and/or its family members regulating age-related changes in mucosal proliferation and apoptosis remain to be delineated. |
2008-02-06 |
2023-08-12 |
rat |
| Adhip P N Majumdar, Jianhua Du, Yingjie Yu, Hu Xu, Edi Levi, Bhaumik B Patel, Arun K Rish. Cell cycle and apoptosis regulatory protein-1: a novel regulator of apoptosis in the colonic mucosa during aging. American journal of physiology. Gastrointestinal and liver physiology. vol 293. issue 6. 2008-02-06. PMID:17932228. |
we report that the age-related reduction in apoptosis in the colonic mucosa is associated with increased expression and tyrosine phosphorylation of not only egfr but also erbb-2 and erbb-3. |
2008-02-06 |
2023-08-12 |
rat |
| Stephen E D Webb, Selene K Roberts, Sarah R Needham, Christopher J Tynan, Daniel J Rolfe, Martyn D Winn, David T Clarke, Roger Barraclough, Marisa L Martin-Fernande. Single-molecule imaging and fluorescence lifetime imaging microscopy show different structures for high- and low-affinity epidermal growth factor receptors in A431 cells. Biophysical journal. vol 94. issue 3. 2008-02-05. PMID:17890389. |
epidermal growth factor (egf) receptor (egfr) modulates mitosis and apoptosis through signaling by its high-affinity (ha) and low-affinity (la) egf-binding states. |
2008-02-05 |
2023-08-12 |
Not clear |
| Khadija Rafiq, Marie Hanscom, Kristoffer Valerie, Susan F Steinberg, Abdelkarim Sabr. Novel mode for neutrophil protease cathepsin G-mediated signaling: membrane shedding of epidermal growth factor is required for cardiomyocyte anoikis. Circulation research. vol 102. issue 1. 2008-02-05. PMID:17975113. |
consistent with this effect of egfr, high level expression of wild-type egfr was sufficient to promote myocyte apoptosis. |
2008-02-05 |
2023-08-12 |
rat |
| Sanjay Goel, Manuel Hidalgo, Roman Perez-Sole. EGFR inhibitor-mediated apoptosis in solid tumors. Journal of experimental therapeutics & oncology. vol 6. issue 4. 2008-01-17. PMID:18038764. |
egfr inhibitor-mediated apoptosis in solid tumors. |
2008-01-17 |
2023-08-12 |
Not clear |
| Sanjay Goel, Manuel Hidalgo, Roman Perez-Sole. EGFR inhibitor-mediated apoptosis in solid tumors. Journal of experimental therapeutics & oncology. vol 6. issue 4. 2008-01-17. PMID:18038764. |
whereas suppressing egfr signaling may be insufficient to fully induce apoptosis, it may prime neoplastic cells for apoptosis induced by other cytotoxic stimuli. |
2008-01-17 |
2023-08-12 |
Not clear |
| Sanjay Goel, Manuel Hidalgo, Roman Perez-Sole. EGFR inhibitor-mediated apoptosis in solid tumors. Journal of experimental therapeutics & oncology. vol 6. issue 4. 2008-01-17. PMID:18038764. |
preclinical and clinical data show that inhibition of egfr, together with enhanced induction of apoptosis, may counter resistance to chemotherapy and radiation therapy, both of which have been shown to induce egfr-dependent survival responses. |
2008-01-17 |
2023-08-12 |
Not clear |
| Jing Deng, Takeshi Shimamura, Samanthi Perera, Nicole E Carlson, Dongpo Cai, Geoffrey I Shapiro, Kwok-Kin Wong, Anthony Leta. Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion. Cancer research. vol 67. issue 24. 2008-01-15. PMID:18089817. |
we identify the block in apoptosis in this cell line, and show that a novel form of erlotinib resistance is present, a block in bim up-regulation downstream of egfr inhibition. |
2008-01-15 |
2023-08-12 |
Not clear |
| Yixuan Gong, Romel Somwar, Katerina Politi, Marissa Balak, Juliann Chmielecki, Xuejun Jiang, William Pa. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS medicine. vol 4. issue 10. 2008-01-02. PMID:17927446. |
induction of bim is essential for apoptosis triggered by egfr kinase inhibitors in mutant egfr-dependent lung adenocarcinomas. |
2008-01-02 |
2023-08-12 |
Not clear |
| Daniel B Costa, Balázs Halmos, Amit Kumar, Susan T Schumer, Mark S Huberman, Titus J Boggon, Daniel G Tenen, Susumu Kobayash. BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. PLoS medicine. vol 4. issue 10. 2007-12-26. PMID:17973572. |
bim mediates egfr tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic egfr mutations. |
2007-12-26 |
2023-08-12 |
Not clear |
| Daniel B Costa, Balázs Halmos, Amit Kumar, Susan T Schumer, Mark S Huberman, Titus J Boggon, Daniel G Tenen, Susumu Kobayash. BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. PLoS medicine. vol 4. issue 10. 2007-12-26. PMID:17973572. |
the objective of this study was to identify the mechanism of egfr tki-induced apoptosis and secondary resistant mutations that affect this process. |
2007-12-26 |
2023-08-12 |
Not clear |
| Ramesh M Ray, Sujoy Bhattacharya, Leonard R Johnso. EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells. Cellular signalling. vol 19. issue 12. 2007-12-20. PMID:17825525. |
egfr plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells. |
2007-12-20 |
2023-08-12 |
Not clear |
| Ramesh M Ray, Sujoy Bhattacharya, Leonard R Johnso. EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells. Cellular signalling. vol 19. issue 12. 2007-12-20. PMID:17825525. |
in addition, inhibition of integrin beta3 activity (with rgds), src activity (with pp2), or egfr kinase activity (with ag1478), increased basal apoptosis and prevented protection conferred by either dfmo or egf. |
2007-12-20 |
2023-08-12 |
Not clear |
| Ramesh M Ray, Sujoy Bhattacharya, Leonard R Johnso. EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells. Cellular signalling. vol 19. issue 12. 2007-12-20. PMID:17825525. |
fibronectin activated the egfr, src, erks and protected cells from apoptosis. |
2007-12-20 |
2023-08-12 |
Not clear |
| M B Flinterman, J S Mymryk, P Klanrit, A F Yousef, S W Lowe, C Caldas, J Gäken, F Farzaneh, M Tavassol. p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing. Oncogene. vol 26. issue 48. 2007-11-29. PMID:17486071. |
we have recently shown that e1a protein of human adenovirus downregulates epidermal growth factor receptor (egfr) expression and induces apoptosis in head and neck (hnscc) and lung cancer cells independently of their p53 status. |
2007-11-29 |
2023-08-12 |
human |
| M B Flinterman, J S Mymryk, P Klanrit, A F Yousef, S W Lowe, C Caldas, J Gäken, F Farzaneh, M Tavassol. p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing. Oncogene. vol 26. issue 48. 2007-11-29. PMID:17486071. |
in this study, we have identified e1a12s isoform to have the highest effect on egfr suppression and induction of apoptosis in hnscc cells. |
2007-11-29 |
2023-08-12 |
human |