| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soo-Jung Park, Mi-Ju Kim, Hak-Bong Kim, Hee-Young Sohn, Jae-Ho Bae, Chi-Dug Kang, Sun-Hee Ki. Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway. Biochemical pharmacology. vol 77. issue 8. 2009-06-02. PMID:19426671. |
trichostatin a sensitizes human ovarian cancer cells to trail-induced apoptosis by down-regulation of c-flipl via inhibition of egfr pathway. |
2009-06-02 |
2023-08-12 |
human |
| Soo-Jung Park, Mi-Ju Kim, Hak-Bong Kim, Hee-Young Sohn, Jae-Ho Bae, Chi-Dug Kang, Sun-Hee Ki. Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway. Biochemical pharmacology. vol 77. issue 8. 2009-06-02. PMID:19426671. |
collectively, our data suggest that tsa-mediated sensitization of ovarian cancer cells to trail is closely correlated with down-regulation of c-flip(l) via inhibition of egfr pathway, involving caspase-dependent mitochondrial apoptosis, and combination of tsa and trail may be an effective strategy for treating trail-resistant human ovarian cancer cells. |
2009-06-02 |
2023-08-12 |
human |
| Mehdi Shakibaei, Kuzhuvelil B Harikumar, Bharat B Aggarwa. Resveratrol addiction: to die or not to die. Molecular nutrition & food research. vol 53. issue 1. 2009-05-15. PMID:19072742. |
cell killing by this stilbene may be mediated through any of numerous mechanisms that involve activation of mitochondria and of death caspases; upregulation of cyclin-dependent kinase inhibitors, tumor suppressor gene products, or death-inducing cytokines and cytokine receptors; or downregulation of cell survival proteins (survivin, cflip, ciaps, x-linked inhibitor of apoptosis protein (xiap), bcl-2, bcl-xl) or inhibition of cell survival kinases (e.g., mitogen-activiated protein kinases (mapks), akt/phosphoinositide 3-kinase (pi3k), pkc, egfr kinase) and survival transcription factors (nuclear factor-kappab (nf-kappab), activating protein 1 (ap-1), hif-1alpha, signal transducer and activator of transcription (stat3)). |
2009-05-15 |
2023-08-12 |
Not clear |
| A Z Dudek, K Lesniewski-Kmak, N J Shehadeh, O N Pandey, M Franklin, R A Kratzke, E W Greeno, P Kuma. Phase I study of bortezomib and cetuximab in patients with solid tumours expressing epidermal growth factor receptor. British journal of cancer. vol 100. issue 9. 2009-05-14. PMID:19401697. |
we hypothesised that concomitant blockade of nf-kappab and egfr signalling would overcome egfr-mediated resistance to single-agent bortezomib and induce apoptosis through two molecular pathways. |
2009-05-14 |
2023-08-12 |
Not clear |
| D Padilla, P Menéndez, M García, P Villarejo, T Cubo, D Gambí, R Pardo, J Martí. [Immunohistochemical expression of epidermal growth factor and its prognostic value for gastrointestinal stromal tumors]. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva. vol 100. issue 12. 2009-04-20. PMID:19222333. |
egfr activation plays an important role in increased cell proliferation, angiogenesis, and decreased apoptosis. |
2009-04-20 |
2023-08-12 |
Not clear |
| Sheng-Huei Yang, Ching-Ming Chien, Jung-Chen Su, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Li. Novel indoloquinoline derivative, IQDMA, inhibits STAT5 signaling associated with apoptosis in K562 cells. Journal of biochemical and molecular toxicology. vol 22. issue 6. 2009-04-08. PMID:19111001. |
taken together, these results indicate that iqdma causes significant induction of apoptosis in k562 cells via downregulation of egfr, src, bcr-abl, jak2, and stat5 signaling and modulation of p21, p27, cyclin d1, mcl-1, bcl-x(l), and vegf proteins. |
2009-04-08 |
2023-08-12 |
human |
| Patricia Sancho, Esther Bertran, Laia Caja, Irene Carmona-Cuenca, Miguel M Murillo, Isabel Fabrega. The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms. Biochimica et biophysica acta. vol 1793. issue 2. 2009-04-01. PMID:18848961. |
in summary, egfr inhibition enhances apoptosis induced by tgf-beta in fao rat hepatoma cells through an increased oxidative stress coincident with a change in the expression pattern of nox enzymes. |
2009-04-01 |
2023-08-12 |
rat |
| Antonella Muscella, Loredana Urso, Nadia Calabriso, Carla Vetrugno, Francesco Paolo Fanizzi, Carlo Storelli, Santo Marsigliant. Functions of epidermal growth factor receptor in cisplatin response of thyroid cells. Biochemical pharmacology. vol 77. issue 6. 2009-04-01. PMID:19111676. |
in conclusion, these findings supported a model in which cisplatin provokes an oxidant-induced mmp-2-dependent egfr transactivation responsible for the induction of cell apoptosis, a process ascribable to the intracellular signalling of pkc-epsilon and mapk/p38. |
2009-04-01 |
2023-08-12 |
Not clear |
| Chun-Yu Chuang, Chuan-Hsin Chang, Yi-Ling Huan. Thioredoxin mediates remodeling factors of human bronchial epithelial cells upon interaction with house dust mite-stimulated eosinophils. Inhalation toxicology. vol 21. issue 2. 2009-03-23. PMID:18800270. |
notably, beas-2b cells over-expressing trx reduced eosinophil-derived apoptosis and suppressed underlying airway remodeling via attenuation of tgf-beta1, egfr and p21(waf) and up-regulation of mmp9 expression. |
2009-03-23 |
2023-08-12 |
human |
| Jasleen Shant, Kunrong Cheng, Bernard S Marasa, Jian-Ying Wang, Jean-Pierre Raufma. Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis. Experimental cell research. vol 315. issue 3. 2009-02-27. PMID:19056378. |
both dct-induced nf-kappab nuclear translocation and attenuation of tnf-alpha-stimulated apoptosis were dependent on egfr activation. |
2009-02-27 |
2023-08-12 |
human |
| B Agaev, G Muslimov, V Iagublu, B Geĭdrik. [Effect of EGFR (epidermal growth factor receptor) inhibitors on apoptosis and cell proliferation in pancreatic cancer]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology. issue 2. 2009-02-27. PMID:19145871. |
[effect of egfr (epidermal growth factor receptor) inhibitors on apoptosis and cell proliferation in pancreatic cancer]. |
2009-02-27 |
2023-08-12 |
Not clear |
| G F Muslimo. Role of epidermal growth factor gene in the development of pancreatic cancer and efficiency of inhibitors of this gene in the treatment of pancreatic carcinoma. Bulletin of experimental biology and medicine. vol 145. issue 4. 2009-02-23. PMID:19110611. |
the effect of ag-1478 preparation (a new-generation inhibitor of egfr) on apoptosis and cell proliferation in pancreatic cancer was evaluated. |
2009-02-23 |
2023-08-12 |
Not clear |
| Monzur Rahman, Sean R Davis, Janet G Pumphrey, Jing Bao, Marion M Nau, Paul S Meltzer, Stanley Lipkowit. TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype. Breast cancer research and treatment. vol 113. issue 2. 2009-02-06. PMID:18266105. |
finally, inhibition of egfr, expressed in both trail-sensitive and trail-resistant triple-negative breast cancer cell lines, using a small molecule tyrosine kinase inhibitor (ag1478), enhanced trail-induced apoptosis in trail-sensitive cell lines but did not convert resistant cells into trail-sensitive cells. |
2009-02-06 |
2023-08-12 |
Not clear |
| Juliane Weber, Paul L McCormac. Panitumumab: in metastatic colorectal cancer with wild-type KRAS. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. vol 22. issue 6. 2009-01-12. PMID:18998757. |
binding of panitumumab to egfr reduces cell proliferation and mediator production, and induces apoptosis. |
2009-01-12 |
2023-08-12 |
human |
| Simone Boehrer, Lionel Adès, Lorenzo Galluzzi, Nicolas Tajeddine, Maximilien Tailler, Claude Gardin, Stéphane de Botton, Pierre Fenaux, Guido Kroeme. Erlotinib and gefitinib for the treatment of myelodysplastic syndrome and acute myeloid leukemia: a preclinical comparison. Biochemical pharmacology. vol 76. issue 11. 2009-01-09. PMID:18617157. |
erlotinib and gefitinib, two inhibitors of the epidermal growth factor receptor (egfr), can stimulate apoptosis and differentiation of myeloid cell lines that lack egfr, unveiling a novel, therapeutically exploitable off-target effect of tyrosine kinase inhibitors. |
2009-01-09 |
2023-08-12 |
Not clear |
| Simon Florian Preuss, Antje Weinell, Markus Molitor, Robert Semrau, Markus Stenner, Uta Drebber, Inga Wedemeyer, Thomas K Hoffmann, Orlando Guntinas-Lichius, Jens Peter Klussman. Survivin and epidermal growth factor receptor expression in surgically treated oropharyngeal squamous cell carcinoma. Head & neck. vol 30. issue 10. 2009-01-09. PMID:18704972. |
the epidermal growth factor receptor (egfr) and the inhibitor of apoptosis protein survivin play important roles in the regulation of cellular proliferation and survival in squamous cell carcinomas. |
2009-01-09 |
2023-08-12 |
Not clear |
| Andreas Dietz, Andreas Boehm, Christian Mozet, Gunnar Wichmann, Athanassios Gianni. Current aspects of targeted therapy in head and neck tumors. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 265 Suppl 1. 2009-01-06. PMID:18535834. |
epidermal growth factor receptor (egfr) is the most prominent candidate for therapeutic targeting because of its more than 90% expression rate in hnscc and influence on the regulation of proliferation, apoptosis, metastasis, angiogenesis and cell differentiation. |
2009-01-06 |
2023-08-12 |
Not clear |
| Bhuminder Singh, Matthias Schneider, Pjotr Knyazev, Axel Ullric. UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines. International journal of cancer. vol 124. issue 3. 2008-12-30. PMID:19003995. |
additionally, blocking egfr signal transactivation by bb94 led to increased apoptosis in uv-irradiated cells. |
2008-12-30 |
2023-08-12 |
Not clear |
| Eugenia Ortega, Rosa M Marti, Andree Yeramian, Anabel Sorolla, Xavier Dolcet, David Llobet, Leandro Abal, Maria Santacana, Judit Pallares, Antonio Llombart-Cussac, Xavier Matias-Gui. Targeted therapies in gynecologic cancers and melanoma. Seminars in diagnostic pathology. vol 25. issue 4. 2008-12-23. PMID:19013892. |
the most promising signaling pathways to be targeted for therapies in these tumors are the tyrosine kinase receptor (egfr, her2, c-kit), the ras/b-raf/mapk, the pi3k-mtor, and apoptosis signaling pathways. |
2008-12-23 |
2023-08-12 |
Not clear |
| Y-L Yuan, X-H Zhou, Jian Song, X-P Qiu, Jun Li, L-F Y. Dual silencing of type 1 insulin-like growth factor and epidermal growth factor receptors to induce apoptosis of nasopharyngeal cancer cells. The Journal of laryngology and otology. vol 122. issue 9. 2008-12-19. PMID:17908353. |
the epidermal growth factor receptor (egfr) and type 1 insulin-like growth factor receptor (type 1 igf receptor or igf1r) have played an important role in the growth and apoptosis of cancer. |
2008-12-19 |
2023-08-12 |
Not clear |