| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masahiro Seike, Akiteru Goto, Tetsuya Okano, Elise D Bowman, Aaron J Schetter, Izumi Horikawa, Ewy A Mathe, Jin Jen, Ping Yang, Haruhiko Sugimura, Akihiko Gemma, Shoji Kudoh, Carlo M Croce, Curtis C Harri. MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 29. 2009-08-25. PMID:19597153. |
in the never-smoker-derived lung adenocarcinoma cell line h3255 with mutant egfr and high levels of p-egfr and mir-21, antisense inhibition of mir-21 enhanced ag1478-induced apoptosis. |
2009-08-25 |
2023-08-12 |
Not clear |
| Masahiro Seike, Akiteru Goto, Tetsuya Okano, Elise D Bowman, Aaron J Schetter, Izumi Horikawa, Ewy A Mathe, Jin Jen, Ping Yang, Haruhiko Sugimura, Akihiko Gemma, Shoji Kudoh, Carlo M Croce, Curtis C Harri. MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 29. 2009-08-25. PMID:19597153. |
in a never-smoker-derived adenocarcinoma cell line h441 with wild-type egfr, the antisense mir-21 not only showed the additive effect with ag1478 but also induced apoptosis by itself. |
2009-08-25 |
2023-08-12 |
Not clear |
| Beata Zahorowska, Philip J Crowe, Jia-Lin Yan. Combined therapies for cancer: a review of EGFR-targeted monotherapy and combination treatment with other drugs. Journal of cancer research and clinical oncology. vol 135. issue 9. 2009-08-21. PMID:19533170. |
the epidermal growth factor receptor (egfr) was the first receptor to be proposed for targeted cancer therapy, having been found to be commonly overexpressed in a range of solid tumors and play a role in cancer cell proliferation, apoptosis, angiogenesis, invasion and metastasis. |
2009-08-21 |
2023-08-12 |
Not clear |
| Yunching Chen, Joyeeta Sen, Surendar Reddy Bathula, Qi Yang, Raffaella Fittipaldi, Leaf Huan. Novel cationic lipid that delivers siRNA and enhances therapeutic effect in lung cancer cells. Molecular pharmaceutics. vol 6. issue 3. 2009-08-06. PMID:19267451. |
although the sirna delivered by lpd-peg-aa containing either dotap or dsgla could effectively silence egfr expression, a synergistic cell killing effect in promoting cellular apoptosis was only observed with dsgla. |
2009-08-06 |
2023-08-12 |
human |
| Yunching Chen, Joyeeta Sen, Surendar Reddy Bathula, Qi Yang, Raffaella Fittipaldi, Leaf Huan. Novel cationic lipid that delivers siRNA and enhances therapeutic effect in lung cancer cells. Molecular pharmaceutics. vol 6. issue 3. 2009-08-06. PMID:19267451. |
three daily injections (0.6 mg/kg) of sirna formulated in the lpd-peg-aa containing either dotap or dsgla could effectively silence the epidermal growth factor receptor (egfr) in the tumor, but the formulation containing dsgla could induce more cellular apoptosis. |
2009-08-06 |
2023-08-12 |
human |
| O O Ogunwobi, I L P Beale. Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and Tgfalpha mediated transactivation of the epidermal growth factor receptor. British journal of biomedical science. vol 65. issue 3. 2009-08-05. PMID:18986098. |
leptin stimulates proliferation and inhibits apoptosis in oac cells but the mechanisms are not fully elucidated, transactivation of the epidermal growth factor receptor (egfr) is an important signalling mechanism for g-protein-coupled receptors, but the relationship with leptin-type receptors has not been examined and the authors hypothesise that leptin-induced proliferation involves egfr signalling. |
2009-08-05 |
2023-08-12 |
human |
| Insiya Jafferji, Mark Bain, Christine King, John H Sinclai. Inhibition of epidermal growth factor receptor (EGFR) expression by human cytomegalovirus correlates with an increase in the expression and binding of Wilms' Tumour 1 protein to the EGFR promoter. The Journal of general virology. vol 90. issue Pt 7. 2009-07-30. PMID:19321755. |
taken together, our observations suggest that hcmv-mediated repression of egfr expression results from a virus-mediated increase in cellular wt1, a known pleiotropic regulator of mitogenesis, apoptosis and differentiation. |
2009-07-30 |
2023-08-12 |
human |
| Marvin Rubenstein, Paulus Tsui, Patrick Guina. Multigene targeting of signal transduction pathways for the treatment of breast and prostate tumors: comparison between combination therapies employing bispecific oligonucleotides with either Rapamycin or Paclitaxel. Medical oncology (Northwood, London, England). vol 26. issue 2. 2009-07-23. PMID:18686047. |
targeted proteins, associated with different signal transduction pathways, have included transforming growth factor-alpha [tgf-alpha (mr(1))], its binding site the epidermal growth factor receptor [egfr (mr(2))] sharing sequence homology to the breast cancer prognostic marker her-2/neu, an apoptosis inhibiting protein [bcl-2 (mr(4))], and the androgen receptor [ar (mr(5))]. |
2009-07-23 |
2023-08-12 |
Not clear |
| Ravi Salgi. Role of c-Met in cancer: emphasis on lung cancer. Seminars in oncology. vol 36. issue 2 Suppl 1. 2009-07-16. PMID:19393836. |
protein tyrosine kinases, such as egfr and c-met, are a family of oncogenes that regulate important cellular processes, such as differentiation, proliferation, cell cycle, motility, and apoptosis. |
2009-07-16 |
2023-08-12 |
human |
| Malini Krishnamoorthy, Jamie Heimburg-Molinaro, Ana M Bargo, Rachel J Nash, Rodney J Nas. Heparin binding epidermal growth factor-like growth factor and PD169316 prevent apoptosis in mouse embryonic stem cells. Journal of biochemistry. vol 145. issue 2. 2009-07-15. PMID:19010935. |
hb-egf and the p38 inhibitor pd169316 act in a pro-survival manner by perturbing phosphorylation of egfr y-1173, suggesting its importance in inducing apoptosis. |
2009-07-15 |
2023-08-12 |
mouse |
| Richard J Santen, Ping Fan, Zhenguo Zhang, Yongde Bao, Robert X-D Song, Wei Yu. Estrogen signals via an extra-nuclear pathway involving IGF-1R and EGFR in tamoxifen-sensitive and -resistant breast cancer cells. Steroids. vol 74. issue 7. 2009-07-13. PMID:19138696. |
during the process of development of tamoxifen resistance this pathway is up-regulated with increased sensitivity to activate egfr for cell growth and protection against apoptosis. |
2009-07-13 |
2023-08-12 |
Not clear |
| Lei Li, Ye Gao, Linlin Zhang, Jin Zeng, Dalin He, Yi Su. Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma. Cancer letters. vol 272. issue 1. 2009-07-07. PMID:18723275. |
our results indicated that silibinin effectively inhibits the renal cancer carcinoma caki-1 cell proliferation and induces apoptosis through inhibiting the activation of egfr and erk and the expression of survivin, up-regulating the expression of p53 and triggering the cascades of caspase pathways. |
2009-07-07 |
2023-08-12 |
Not clear |
| Wenqing Qi, Larry S Cooke, Amy Stejskal, Christopher Riley, Kimiko Della Croce, Jose W Saldanha, David Bearss, Daruka Mahadeva. MP470, a novel receptor tyrosine kinase inhibitor, in combination with Erlotinib inhibits the HER family/PI3K/Akt pathway and tumor growth in prostate cancer. BMC cancer. vol 9. 2009-07-07. PMID:19432987. |
however, erlotinib, an egfr tyrosine kinase inhibitor, has less effect on proliferation and apoptosis in prostate cancer cell lines. |
2009-07-07 |
2023-08-12 |
Not clear |
| Jianjian Dai, Daoxin Ma, Shaolei Zang, Dongmei Guo, Xun Qu, Jingjing Ye, Chunyan J. Cross-talk between Notch and EGFR signaling in human breast cancer cells. Cancer investigation. vol 27. issue 5. 2009-06-18. PMID:19219656. |
notch and epidermal growth factor receptor (egfr) signaling play critical roles in cell proliferation, differentiation, and apoptosis, and thereby may contribute to the development of breast cancer. |
2009-06-18 |
2023-08-12 |
human |
| Anna Gates, Simon Hohenester, M Sawkat Anwer, Cynthia R L Webste. cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 beta/alpha in rat hepatocytes. American journal of physiology. Gastrointestinal and liver physiology. vol 296. issue 4. 2009-06-17. PMID:19196950. |
maximal camp-gef-mediated akt phosphorylation as well as protection from bile acid-induced apoptosis requires activation of src-tyk and the egfr. |
2009-06-17 |
2023-08-12 |
rat |
| Jaume Capdevila, Elena Elez, Teresa Macarulla, Francisco Javier Ramos, Manuel Ruiz-Echarri, Josep Taberner. Anti-epidermal growth factor receptor monoclonal antibodies in cancer treatment. Cancer treatment reviews. vol 35. issue 4. 2009-06-15. PMID:19269105. |
the phosphorylation of egfr activates multiple biological processes including apoptosis, differentiation, cellular proliferation, motility, invasion, adhesion, dna repair and survival. |
2009-06-15 |
2023-08-12 |
Not clear |
| Silke Kaulfuss, Peter Burfeind, Jochen Gaedcke, Jens-Gerd Schar. Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis. Molecular cancer therapeutics. vol 8. issue 4. 2009-06-08. PMID:19372555. |
an increased rate of apoptosis was associated with sirna-mediated silencing of igf-ir and egfr as assessed by activation of caspase-3/caspase-7. |
2009-06-08 |
2023-08-12 |
human |
| Silke Kaulfuss, Peter Burfeind, Jochen Gaedcke, Jens-Gerd Schar. Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis. Molecular cancer therapeutics. vol 8. issue 4. 2009-06-08. PMID:19372555. |
the combined knockdown of both egfr and igf-ir decreased cell proliferation and induced cell apoptosis more effectively than did silencing of either receptor alone. |
2009-06-08 |
2023-08-12 |
human |
| Silke Kaulfuss, Peter Burfeind, Jochen Gaedcke, Jens-Gerd Schar. Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis. Molecular cancer therapeutics. vol 8. issue 4. 2009-06-08. PMID:19372555. |
comparable effects on cell proliferation and apoptosis were observed after single and combinational treatment of cells by the igf-ir tyrosine kinase inhibitor nvp-aew541 and/or the egfr tyrosine kinase inhibitor erlotinib. |
2009-06-08 |
2023-08-12 |
human |
| Hong Liu, Liang Li, Xing-Qi Li, Xiu-Jun Liu, Yong-Su Zhe. Enediyne lidamycin enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitor, gefitinib, in epidermoid carcinoma A431 cells and lung carcinoma H460 cells. Anti-cancer drugs. vol 20. issue 1. 2009-06-04. PMID:19342999. |
ldm plus gefitinib showed potentiation of antiproliferative activity and apoptosis induction, which were associated with downregulation of egfr signaling pathway and nuclear factor-kappa b expression, and the increase of cleaved poly (adenosine diphosphate-ribose) polymerase in the two cell lines, although to a lesser degree in h460 cells. |
2009-06-04 |
2023-08-12 |
human |