| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhao Zhang, Elena Pascuet, Pierre-Alain Hueber, Leelee Chu, Daniel G Bichet, Tang-Cheng Lee, David W Threadgill, Paul Goodye. Targeted inactivation of EGF receptor inhibits renal collecting duct development and function. Journal of the American Society of Nephrology : JASN. vol 21. issue 4. 2010-04-22. PMID:20133479. |
homozygous egfr knockout did not affect the pattern of ub arborization, but renal papillae were hypoplastic and exhibited widespread apoptosis of tubular cells. |
2010-04-22 |
2023-08-12 |
mouse |
| Caterina Carmi, Andrea Cavazzoni, Stefano Vezzosi, Fabrizio Bordi, Federica Vacondio, Claudia Silva, Silvia Rivara, Alessio Lodola, Roberta R Alfieri, Silvia La Monica, Maricla Galetti, Andrea Ardizzoni, Pier Giorgio Petronini, Marco Mo. Novel irreversible epidermal growth factor receptor inhibitors by chemical modulation of the cysteine-trap portion. Journal of medicinal chemistry. vol 53. issue 5. 2010-04-01. PMID:20151670. |
in particular, at significant lower concentrations than gefitinib (1), (2r,3r)-n-(4-(3-bromoanilino)quinazolin-6-yl)-3-(piperidin-1-ylmethyl)oxirane-2-carboxamide (6) inhibited egfr autophosphorylation and downstream signaling pathways, suppressed proliferation, and induced apoptosis in gefitinib-resistant nsclc h1975 cells, harboring the t790m mutation in egfr. |
2010-04-01 |
2023-08-12 |
Not clear |
| Qiao-Ling Wang, Ji-Min Sha. [Effects of environmental physical and chemical agents on epidermal growth factor receptor and its signal transduction]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 38. issue 3. 2010-03-30. PMID:19504644. |
epidermal growth factor receptor (egfr) is a classic protein tyrosine kinase receptor, which plays an important role in cell proliferation, survival, adhesion, differentiation and apoptosis. |
2010-03-30 |
2023-08-12 |
Not clear |
| Michel Zimmermann, Abderrahim Zouhair, David Azria, Mahmut Ozsahi. The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications. Radiation oncology (London, England). vol 1. 2010-03-22. PMID:16722544. |
blocking the egfr by a monoclonal antibody results in inhibition of the stimulation of the receptor, therefore, in inhibition of cell proliferation, enhanced apoptosis, and reduced angiogenesis, invasiveness and metastases. |
2010-03-22 |
2023-08-12 |
Not clear |
| M Steins, M Thomas, M Geissle. Erlotinib. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. vol 184. 2010-03-16. PMID:20072828. |
the epidermal growth factor receptor (egfr) has been implicated in a multiplicity of cancer-related signal transduction pathways like cellular proliferation, adhesion, migration, neoangiogenesis, and apoptosis inhibition, all of them important features of cancerogenesis and tumour progression. |
2010-03-16 |
2023-08-12 |
Not clear |
| Ho-Kee Koon, Pui-Shan Chan, Ricky Ngok-Shun Wong, Zhen-Guo Wu, Maria Li Lung, Chi-Kwong Chang, Nai-Ki Ma. Targeted inhibition of the EGFR pathways enhances Zn-BC-AM PDT-induced apoptosis in well-differentiated nasopharyngeal carcinoma cells. Journal of cellular biochemistry. vol 108. issue 6. 2010-03-11. PMID:19816982. |
targeted inhibition of the egfr pathways enhances zn-bc-am pdt-induced apoptosis in well-differentiated nasopharyngeal carcinoma cells. |
2010-03-11 |
2023-08-12 |
Not clear |
| E Maciorkowska, K Guzińska-Ustymowicz, E Ryszczuk, A Kemona, M Kaczmarsk. The EGFR expression in gastric mucosa of children infected with Helicobacter pylori. Advances in medical sciences. vol 54. issue 2. 2010-03-04. PMID:20034922. |
epidermal growth factor receptor (egfr) modulates balance between proliferation and apoptosis in gastric mucosa of the gastrointestinal tract. |
2010-03-04 |
2023-08-12 |
Not clear |
| Beate M Lichtenberger, Poi Kiang Tan, Heide Niederleithner, Napoleone Ferrara, Peter Petzelbauer, Maria Sibili. Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development. Cell. vol 140. issue 2. 2010-02-25. PMID:20141840. |
mechanistically, k5-sos upregulates vegf, flt1, and neuropilin-1 in an erk-dependent manner, thereby activating an autocrine proliferation loop, whereas egfr prevents tumor cells from apoptosis. |
2010-02-25 |
2023-08-12 |
mouse |
| Jung-Chen Su, Kuei-Li Lin, Ching-Ming Chien, Chih-Hua Tseng, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Li. Naphtho[1,2-b]furan-4,5-dione inactivates EGFR and PI3K/Akt signaling pathways in human lung adenocarcinoma A549 cells. Life sciences. vol 86. issue 5-6. 2010-02-22. PMID:20036260. |
this study was performed to elucidate whether egfr and pi3k signaling pathways are involved in nfd-induced apoptosis of human lung adenocarcinoma a549 cells. |
2010-02-22 |
2023-08-12 |
human |
| Jason Ho Ting Wong, Vivian Wai Yan Lui, Kazuo Umezawa, Yeung Ho, Elaine Yue Ling Wong, Margaret Heung Ling Ng, Suk Hang Cheng, Chi Man Tsang, Sai Wah Tsao, Anthony Tak Cheung Cha. A small molecule inhibitor of NF-kappaB, dehydroxymethylepoxyquinomicin (DHMEQ), suppresses growth and invasion of nasopharyngeal carcinoma (NPC) cells. Cancer letters. vol 287. issue 1. 2010-02-19. PMID:19560263. |
these antitumor effects were associated with induction of g(2)/m cell cycle arrest and apoptosis, and downregulation of nf-kappab target genes (egfr, cyclin d1 and survivin). |
2010-02-19 |
2023-08-12 |
Not clear |
| J Konishi, F Yi, X Chen, H Vo, D P Carbone, T P Dan. Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim. Oncogene. vol 29. issue 4. 2010-02-05. PMID:19881544. |
notch3 cooperates with the egfr pathway to modulate apoptosis through the induction of bim. |
2010-02-05 |
2023-08-12 |
Not clear |
| N H Thoennissen, J O'Kelly, D Lu, G B Iwanski, D T La, S Abbassi, A Leiter, B Karlan, R Mehta, H P Koeffle. Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway. Oncogene. vol 29. issue 2. 2010-02-01. PMID:19855437. |
the drug potently inhibited growth of er-positive (mcf-7, t47d, bt-474) and er-negative (skbr-3, mda-mb231) breast cancer cell lines, which was associated with g(0)/g(1) cell-cycle arrest, increased levels of apoptosis and reduced protein expression of human epidermal growth factor receptor (egfr), her-2, activated extracellular-regulated kinase (erk) and cyclin d1. |
2010-02-01 |
2023-08-12 |
mouse |
| Kenji Takeuchi, Fumiaki It. EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors. The FEBS journal. vol 277. issue 2. 2010-02-01. PMID:19922467. |
lung cancer cells harboring mutant egfrs become dependent on them for their survival and, consequently, undergo apoptosis following the inhibition of egfr tyrosine kinase by gefitinib. |
2010-02-01 |
2023-08-12 |
Not clear |
| Chang Hoon Le. A mechanistic study on gefitinib-induced apoptosis reveals a new link between EGFR and hTERT in breast cancers. Archives of pharmacal research. vol 32. issue 10. 2010-01-04. PMID:19898793. |
a mechanistic study on gefitinib-induced apoptosis reveals a new link between egfr and htert in breast cancers. |
2010-01-04 |
2023-08-12 |
Not clear |
| Dong-Oh Moon, Mun-Ock Kim, Moon-Soo Heo, Jae-Dong Lee, Yung Hyun Choi, Gi-Young Ki. Gefitinib induces apoptosis and decreases telomerase activity in MDA-MB-231 human breast cancer cells. Archives of pharmacal research. vol 32. issue 10. 2010-01-04. PMID:19898796. |
gefitinib is an anti-cancer drug that selectively inhibits epithelial growth factor receptor (egfr) tyrosine kinase activity and induces apoptosis in many cancer cells. |
2010-01-04 |
2023-08-12 |
human |
| Ivan Vannini, Wainer Zoli, Francesco Fabbri, Paola Ulivi, Anna Tesei, Silvia Carloni, Giovanni Brigliadori, Dino Amador. Role of efflux pump activity in lapatinib/caelyx combination in breast cancer cell lines. Anti-cancer drugs. vol 20. issue 10. 2009-12-29. PMID:19752719. |
simultaneous exposure to lapatinib and caelyx in skbr3 cell line produced an additive cytotoxic effect with dephosphorylation of her2 and egfr, an upregulation of p21, and an induction of apoptosis through dephosphorylation of bad and caspase cleavage. |
2009-12-29 |
2023-08-12 |
Not clear |
| Anthony C Faber, Danan Li, Youngchul Song, Mei-Chih Liang, Beow Y Yeap, Roderick T Bronson, Eugene Lifshits, Zhao Chen, Sauveur-Michel Maira, Carlos García-Echeverría, Kwok-Kin Wong, Jeffrey A Engelma. Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 46. 2009-12-15. PMID:19850869. |
differential induction of apoptosis in her2 and egfr addicted cancers following pi3k inhibition. |
2009-12-15 |
2023-08-12 |
Not clear |
| Anthony C Faber, Danan Li, Youngchul Song, Mei-Chih Liang, Beow Y Yeap, Roderick T Bronson, Eugene Lifshits, Zhao Chen, Sauveur-Michel Maira, Carlos García-Echeverría, Kwok-Kin Wong, Jeffrey A Engelma. Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 46. 2009-12-15. PMID:19850869. |
such cancers are "addicted" to egfr, and treatment with a tki invariably leads to down-regulation of the pi3k-akt-mtor and mek-erk signaling pathways, resulting in apoptosis. |
2009-12-15 |
2023-08-12 |
Not clear |
| Anthony C Faber, Danan Li, Youngchul Song, Mei-Chih Liang, Beow Y Yeap, Roderick T Bronson, Eugene Lifshits, Zhao Chen, Sauveur-Michel Maira, Carlos García-Echeverría, Kwok-Kin Wong, Jeffrey A Engelma. Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 46. 2009-12-15. PMID:19850869. |
in contrast to her2-amplified breast cancers, we found that pi3k-mtor inhibition did not promote substantial apoptosis in the egfr mutant lung cancers. |
2009-12-15 |
2023-08-12 |
Not clear |
| Anthony C Faber, Danan Li, Youngchul Song, Mei-Chih Liang, Beow Y Yeap, Roderick T Bronson, Eugene Lifshits, Zhao Chen, Sauveur-Michel Maira, Carlos García-Echeverría, Kwok-Kin Wong, Jeffrey A Engelma. Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 46. 2009-12-15. PMID:19850869. |
however, blocking both pi3k-mtor and mek simultaneously led to apoptosis to similar levels as the egfr tkis, suggesting that down-regulation of these pathways may account for much of the apoptosis promoted by egfr inhibition. |
2009-12-15 |
2023-08-12 |
Not clear |