| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| István Kenesse. [Study of motogenic signal in human melanoma cells]. Magyar onkologia. vol 55. issue 1. 2011-06-21. PMID:21617791. |
egfr and c-met showed constitutive activity in human melanoma cells, and their inhibition in vitro caused decreased proliferation, migration and elevated apoptosis. |
2011-06-21 |
2023-08-12 |
mouse |
| Greta Garrido, Ilia A Tikhomirov, Ailem Rabasa, Eric Yang, Elías Gracia, Normando Iznaga, Luis E Fernández, Tania Crombet, Robert S Kerbel, Rolando Pére. Bivalent binding by intermediate affinity of nimotuzumab: a contribution to explain antibody clinical profile. Cancer biology & therapy. vol 11. issue 4. 2011-06-14. PMID:21150278. |
cetuximab decreased the cell viability and induced apoptosis for all the tested cell lines, effects which did not depend on egfr expression level. |
2011-06-14 |
2023-08-12 |
Not clear |
| Xinyu Cao, Hu Zhu, Francis Ali-Osman, Hui-Wen L. EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis. Molecular cancer. vol 10. 2011-06-13. PMID:21388543. |
egfr and egfrviii undergo stress- and egfr kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of egfr-driven antagonism of apoptosis. |
2011-06-13 |
2023-08-12 |
human |
| Martin B Steins, Niels Reinmuth, Helge Bischoff, Markus Kindermann, Michael Thoma. Targeting the epidermal growth factor receptor in non-small cell lung cancer. Onkologie. vol 33. issue 12. 2011-05-04. PMID:21124044. |
the epidermal growth factor receptor (egfr) has been implicated in a multiplicity of cancer-related signal transduction pathways like cellular proliferation, adhesion, migration, neoangiogenesis and apoptosis inhibition, all of them important features of cancerogenesis and tumour progression. |
2011-05-04 |
2023-08-12 |
Not clear |
| Maria Martinou, Efstathia Giannopoulou, Georgia Malatara, Andreas A Argyriou, Haralabos P Kalofonos, Dimitrios Kardamaki. Ionizing radiation affects epidermal growth factor receptor signalling and metalloproteinase secretion in glioma cells. Cancer genomics & proteomics. vol 8. issue 1. 2011-04-27. PMID:21289335. |
the effect of different doses of x(-)rays on apoptosis, proliferation, epidermal growth factor receptor (egfr) and matrix metalloproteinase (mmp-2) expression was investigated in a human glioblastoma cell line. |
2011-04-27 |
2023-08-12 |
human |
| Miyun Oh, Jeong-Yeon Lee, Dong-Hui Shin, Ji-Hye Park, Tingting Oian, Hyun-Jun Kim, Sung-Dae Cho, Seung-Hyun Oh, Young Ki Min, Gu Kon. The in vitro and in vivo anti-tumor effect of KO-202125, a sauristolactam derivative, as a novel epidermal growth factor receptor inhibitor in human breast cancer. Cancer science. vol 102. issue 3. 2011-04-11. PMID:21205071. |
ko-202125 showed more effective growth inhibition and apoptosis induction than gefitinib, a representative egfr inhibitor, in various egfr-overexpressing human cancers including estrogen receptor (er)-negative mda-mb-231 human breast cancer cells. |
2011-04-11 |
2023-08-12 |
mouse |
| Hai Zhu, Xiaojing Pan, Haiyan Qi, Xuechun Wang, Sichuan Hou, Baojian Han, Zhijun Liu, Luo X. Troglitazone attenuates epidermal growth factor receptor signaling independently of peroxisome proliferator-activated receptor in PC-3 cells. Oncology reports. vol 25. issue 1. 2011-04-06. PMID:21109961. |
we studied the effects of tgz on proliferation, growth arrest and apoptosis in pc-3 prostate carcinoma cells and its interaction with the signaling pathways of the activated efg receptor (egfr). |
2011-04-06 |
2023-08-12 |
Not clear |
| Xiuwei Zhu, Xiaobo Zhou, Michael T Lewis, Ling Xia, Stephen Won. Cancer stem cell, niche and EGFR decide tumor development and treatment response: A bio-computational simulation study. Journal of theoretical biology. vol 269. issue 1. 2011-03-30. PMID:20969880. |
moreover, (1) the cancer stem cell niche is, considered by modeling its effect on division patterns (symmetric or asymmetric) of cscs, and (2) the egfr signaling pathway is integrated by modeling its role in cell proliferation, apoptosis. |
2011-03-30 |
2023-08-12 |
Not clear |
| J C Su, K L Lin, C M Chien, C H Tseng, Y L Chen, L S Chang, S R Li. Furano-1,2-naphthoquinone inhibits EGFR signaling associated with G2/M cell cycle arrest and apoptosis in A549 cells. Cell biochemistry and function. vol 28. issue 8. 2011-02-22. PMID:21104938. |
furano-1,2-naphthoquinone inhibits egfr signaling associated with g2/m cell cycle arrest and apoptosis in a549 cells. |
2011-02-22 |
2023-08-12 |
Not clear |
| J C Su, K L Lin, C M Chien, C H Tseng, Y L Chen, L S Chang, S R Li. Furano-1,2-naphthoquinone inhibits EGFR signaling associated with G2/M cell cycle arrest and apoptosis in A549 cells. Cell biochemistry and function. vol 28. issue 8. 2011-02-22. PMID:21104938. |
the combined treatment of fnq with ag1478 (a specific egfr inhibitor) significantly enhanced the g(2)/m arrest and apoptosis, and also led to up-regulation in bax, p53, p21, p27, release of mitochondrial cytochrome c, and down-regulation of bcl-2, xiap, survivin, cyclin a, cyclin b, cdk1, and cdk2 in a549 cells. |
2011-02-22 |
2023-08-12 |
Not clear |
| Raj Kumar, Sowmyalakshmi Srinivasan, Pallab Pahari, Jürgen Rohr, Chendil Damodara. Activating stress-activated protein kinase-mediated cell death and inhibiting epidermal growth factor receptor signaling: a promising therapeutic strategy for prostate cancer. Molecular cancer therapeutics. vol 9. issue 9. 2011-02-17. PMID:20736346. |
treatment with psoralidin, however, inhibited both constitutive and egf-induced egfr activation and simultaneously triggered sapk signaling, resulting in the induction of apoptosis in aipc cells. |
2011-02-17 |
2023-08-12 |
mouse |
| Deric L Wheeler, Emily F Dunn, Paul M Harar. Understanding resistance to EGFR inhibitors-impact on future treatment strategies. Nature reviews. Clinical oncology. vol 7. issue 9. 2011-02-02. PMID:20551942. |
following ligand binding, egfr stimulates downstream cell signaling cascades that influence cell proliferation, apoptosis, migration, survival and complex processes, including angiogenesis and tumorigenesis. |
2011-02-02 |
2023-08-12 |
human |
| Pedro A Martínez-Carpio, Mario A Trelle. The role of epidermal growth factor receptor in photodynamic therapy: a review of the literature and proposal for future investigation. Lasers in medical science. vol 25. issue 6. 2011-01-28. PMID:20535519. |
the epidermal growth factor receptor (egfr) pathway seems to be an important contributor to the antiproliferative response to photodynamic therapy (pdt), in terms of cell death, apoptosis and tumour destruction. |
2011-01-28 |
2023-08-12 |
Not clear |
| Pedro A Martínez-Carpio, Mario A Trelle. The role of epidermal growth factor receptor in photodynamic therapy: a review of the literature and proposal for future investigation. Lasers in medical science. vol 25. issue 6. 2011-01-28. PMID:20535519. |
pdt was found to result in a time-dependent reduction of egfr expression, inhibition of tyrosine phosphorylation and induction of apoptosis during the regression of tumours. |
2011-01-28 |
2023-08-12 |
Not clear |
| Dinesh Kumar Agrawal, Pushpesh Kumar Mishr. Curcumin and its analogues: potential anticancer agents. Medicinal research reviews. vol 30. issue 5. 2011-01-27. PMID:20027668. |
it has been shown to interfere with multiple cell signaling pathways, including apoptosis (activation of caspases and downregulation of antiapoptotic gene products), proliferation (her-2, egfr, and ap-1), angiogenesis (vegf), and inflammation (nf-kappab, tnf, il-6, il-1, cox-2, and 5-lox). |
2011-01-27 |
2023-08-12 |
Not clear |
| Atsushi Suzuki, Sayaka Sekiya, Eriko Gunshima, Setsuko Fujii, Hideki Taniguch. EGF signaling activates proliferation and blocks apoptosis of mouse and human intestinal stem/progenitor cells in long-term monolayer cell culture. Laboratory investigation; a journal of technical methods and pathology. vol 90. issue 10. 2011-01-20. PMID:20714325. |
in both embryonic and adult mouse intestines, egfr and egf were expressed in immature epithelial cells and adjacent fibroblasts, respectively, and egf signaling was essential to activate proliferation and inhibit apoptosis of intestinal stem/progenitor cells. |
2011-01-20 |
2023-08-12 |
mouse |
| Kunio Okamoto, Isamu Okamoto, Wataru Okamoto, Kaoru Tanaka, Ken Takezawa, Kiyoko Kuwata, Haruka Yamaguchi, Kazuto Nishio, Kazuhiko Nakagaw. Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations. Cancer research. vol 70. issue 24. 2011-01-20. PMID:21159653. |
role of survivin in egfr inhibitor-induced apoptosis in non-small cell lung cancers positive for egfr mutations. |
2011-01-20 |
2023-08-12 |
human |
| Kunio Okamoto, Isamu Okamoto, Wataru Okamoto, Kaoru Tanaka, Ken Takezawa, Kiyoko Kuwata, Haruka Yamaguchi, Kazuto Nishio, Kazuhiko Nakagaw. Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations. Cancer research. vol 70. issue 24. 2011-01-20. PMID:21159653. |
the molecular mechanism by which epidermal growth factor receptor-tyrosine kinase inhibitors (egfr-tki) induce apoptosis in non-small cell-lung cancer (nsclc) cells that are positive for activating mutations of the egfr remains unclear. |
2011-01-20 |
2023-08-12 |
human |
| Kunio Okamoto, Isamu Okamoto, Wataru Okamoto, Kaoru Tanaka, Ken Takezawa, Kiyoko Kuwata, Haruka Yamaguchi, Kazuto Nishio, Kazuhiko Nakagaw. Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations. Cancer research. vol 70. issue 24. 2011-01-20. PMID:21159653. |
our results indicate that downregulation of survivin plays a pivotal role in gefitinib-induced apoptosis in egfr mutation-positive nsclc cells. |
2011-01-20 |
2023-08-12 |
human |
| Siddik Sarkar, Abhijit Mazumdar, Rupesh Dash, Devanand Sarkar, Paul B Fisher, Mahitosh Manda. ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells. Cancer biology & therapy. vol 9. issue 8. 2011-01-06. PMID:20139705. |
zd6474, a dual tyrosine kinase inhibitor of egfr and vegfr-2, inhibits mapk/erk and akt/pi3-k and induces apoptosis in breast cancer cells. |
2011-01-06 |
2023-08-12 |
human |