| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Floriana Morgillo, Elena D'Aiuto, Teresa Troiani, Erika Martinelli, Tina Cascone, Raffaele De Palma, Michele Orditura, Ferdinando De Vita, Fortunato Ciardiell. Antitumor activity of bortezomib in human cancer cells with acquired resistance to anti-epidermal growth factor receptor tyrosine kinase inhibitors. Lung cancer (Amsterdam, Netherlands). vol 71. issue 3. 2011-10-04. PMID:20619923. |
in contrast, bortezomib, a proteasome inhibitor, induced a significant inhibition of cancer cell growth and an increase in apoptosis in egfr inhibitor-resistant cancer cells as compared to treatment with ly294002, a pi3k inhibitor, suggesting that, in addition to interference with akt signalling, other mechanisms are involved in the pro-apoptotic effects of bortezomib. |
2011-10-04 |
2023-08-12 |
mouse |
| Floriana Morgillo, Elena D'Aiuto, Teresa Troiani, Erika Martinelli, Tina Cascone, Raffaele De Palma, Michele Orditura, Ferdinando De Vita, Fortunato Ciardiell. Antitumor activity of bortezomib in human cancer cells with acquired resistance to anti-epidermal growth factor receptor tyrosine kinase inhibitors. Lung cancer (Amsterdam, Netherlands). vol 71. issue 3. 2011-10-04. PMID:20619923. |
bortezomib treatment activated endoplasmic reticulum (er) stress-mediated apoptosis, as demonstrated by the induction of gadd153, an er stress-inducible transcription factor, and of the death receptor dr5, in egfr inhibitor-resistant cells, but not in parental cells. |
2011-10-04 |
2023-08-12 |
mouse |
| Ivan S Donev, Wei Wang, Tadaaki Yamada, Qi Li, Shinji Takeuchi, Kunio Matsumoto, Takao Yamori, Yasuhiko Nishioka, Saburo Sone, Seiji Yan. Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 17. issue 8. 2011-09-30. PMID:21220474. |
transient pi3k inhibition induces apoptosis and overcomes hgf-mediated resistance to egfr-tkis in egfr mutant lung cancer. |
2011-09-30 |
2023-08-12 |
Not clear |
| Victoria J Muir, Sohita Dhillo. Erlotinib: as maintenance monotherapy in non-small-cell lung cancer. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. vol 25. issue 3. 2011-09-30. PMID:21513367. |
inhibition of egfr tyrosine kinase results in the disruption of processes involved in cancer growth and development, including cell migration, proliferation, angiogenesis, and apoptosis. |
2011-09-30 |
2023-08-12 |
Not clear |
| Masahito Shimizu, Seiji Adachi, Muneyuki Masuda, Osamu Kozawa, Hisataka Moriwak. Cancer chemoprevention with green tea catechins by targeting receptor tyrosine kinases. Molecular nutrition & food research. vol 55. issue 6. 2011-09-27. PMID:21538846. |
(-)-epigallocatechin-3-gallate (egcg), the major catechin in green tea, inhibits cell proliferation and induces apoptosis in various types of cancer cells, including colorectal cancer and hepatocellular carcinoma cells, by blocking the activation of the epidermal growth factor receptor (egfr) family of rtks. |
2011-09-27 |
2023-08-12 |
human |
| Liping Xu, Shuping Yin, Sanjeev Banerjee, Fazlul Sarkar, Kaladhar B Redd. Enhanced anticancer effect of the combination of cisplatin and TRAIL in triple-negative breast tumor cells. Molecular cancer therapeutics. vol 10. issue 3. 2011-09-21. PMID:21252285. |
specific inhibition of egfr and/or p63 protein in tnbc cells by small interfering rna (sirna) does not increase trail-induced apoptosis. |
2011-09-21 |
2023-08-12 |
mouse |
| William C S Cho, Andrew S C Chow, Joseph S K A. MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1. RNA biology. vol 8. issue 1. 2011-09-12. PMID:21289483. |
our findings provided new insight into the complex regulating pathway comprising of mir-145, egfr, nudt1 and other unknown factors which function in cell proliferation but not in apoptosis. |
2011-09-12 |
2023-08-12 |
human |
| Fang Yan, Hanwei Cao, Timothy L Cover, M Kay Washington, Yan Shi, LinShu Liu, Rupesh Chaturvedi, Richard M Peek, Keith T Wilson, D Brent Pol. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. The Journal of clinical investigation. vol 121. issue 6. 2011-08-17. PMID:21606592. |
activation of egfr by p40 was required for inhibition of cytokine-induced apoptosis in intestinal epithelial cells in vitro and ex vivo. |
2011-08-17 |
2023-08-12 |
mouse |
| Fang Yan, Hanwei Cao, Timothy L Cover, M Kay Washington, Yan Shi, LinShu Liu, Rupesh Chaturvedi, Richard M Peek, Keith T Wilson, D Brent Pol. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. The Journal of clinical investigation. vol 121. issue 6. 2011-08-17. PMID:21606592. |
furthermore, p40 activation of egfr was required for ameliorating colon epithelial cell apoptosis and chronic inflammation in oxazolone-induced colitis. |
2011-08-17 |
2023-08-12 |
mouse |
| Francesca Bruzzese, Alessandra Leone, Monia Rocco, Carmine Carbone, Geny Piro, Michele Caraglia, Elena Di Gennaro, Alfredo Budillo. HDAC inhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ErbB receptor expression and reverting EMT. Journal of cellular physiology. vol 226. issue 9. 2011-08-17. PMID:21660961. |
we demonstrated that the histone deacetylase inhibitor vorinostat in combination with the egfr tyrosine kinase inhibitor gefitinib induced synergistic inhibition of proliferation, migration, and invasion as well as induction of apoptosis in scchn cells, including cells resistant to gefitinib. |
2011-08-17 |
2023-08-12 |
Not clear |
| Shuping Xu, Zhang Weihu. Loss of EGFR induced autophagy sensitizes hormone refractory prostate cancer cells to adriamycin. The Prostate. vol 71. issue 11. 2011-08-08. PMID:21656832. |
in the present study we investigated whether the anti-autophagic function of egfr may contribute to resistance of hormone-refractory prostate cancer cells to chemotherapeutic-induced apoptosis. |
2011-08-08 |
2023-08-12 |
Not clear |
| Jordan A Krall, Elsa M Beyer, Gavin MacBeat. High- and low-affinity epidermal growth factor receptor-ligand interactions activate distinct signaling pathways. PloS one. vol 6. issue 1. 2011-08-02. PMID:21264347. |
as the stat proteins are involved in many cellular responses including proliferation, migration and apoptosis, these results assign a function to low-affinity interactions that has been omitted from computational models of egfr signaling. |
2011-08-02 |
2023-08-12 |
Not clear |
| You-Gui Li, Dong-Feng Ji, Shi Zhong, Jian-Xun Zhu, Shi Chen, Gui-Yan H. Anti-tumor effects of proteoglycan from Phellinus linteus by immunomodulating and inhibiting Reg IV/EGFR/Akt signaling pathway in colorectal carcinoma. International journal of biological macromolecules. vol 48. issue 3. 2011-07-19. PMID:21262260. |
rt-pcr analysis suggested that p1-induced ht-29 apoptosis appeared to be associated with a decrease in the levels of expression of reg iv and egfr. |
2011-07-19 |
2023-08-12 |
mouse |
| Kyung-Soo Chun, Robert Langenbac. The prostaglandin E2 receptor, EP2, regulates survivin expression via an EGFR/STAT3 pathway in UVB-exposed mouse skin. Molecular carcinogenesis. vol 50. issue 6. 2011-07-19. PMID:21268125. |
uvb-induced epidermal apoptosis in cox-2-/- mice was reduced by butaprost and egfr inhibition blocked butaprost’s protective effects. |
2011-07-19 |
2023-08-12 |
mouse |
| Pornthip Waiwut, Myoung-Sook Shin, Akiko Inujima, Yue Zhou, Keiichi Koizumi, Ikuo Saiki, Hiroaki Sakura. Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways. Molecular and cellular biochemistry. vol 350. issue 1-2. 2011-07-15. PMID:21188622. |
gomisin n enhances tnf-α-induced apoptosis via inhibition of the nf-κb and egfr survival pathways. |
2011-07-15 |
2023-08-12 |
Not clear |
| Pornthip Waiwut, Myoung-Sook Shin, Akiko Inujima, Yue Zhou, Keiichi Koizumi, Ikuo Saiki, Hiroaki Sakura. Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways. Molecular and cellular biochemistry. vol 350. issue 1-2. 2011-07-15. PMID:21188622. |
we have recently reported that tak1 regulates phosphorylation of egfr at ser-1046/7 through p38 mapk, which cooperates with nf-κb in tnf-α-induced apoptosis. |
2011-07-15 |
2023-08-12 |
Not clear |
| Pornthip Waiwut, Myoung-Sook Shin, Akiko Inujima, Yue Zhou, Keiichi Koizumi, Ikuo Saiki, Hiroaki Sakura. Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways. Molecular and cellular biochemistry. vol 350. issue 1-2. 2011-07-15. PMID:21188622. |
the findings suggested that gomisin n enhanced tnf-α-induced apoptosis by suppressing of nf-κb and egfr signaling pathways. |
2011-07-15 |
2023-08-12 |
Not clear |
| Ming-Chieh Shun, Weiping Yu, Sook-Kyung Park, Bob G Sanders, Kimberly Klin. Downregulation of Epidermal Growth Factor Receptor Expression Contributes to alpha-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines. Journal of oncology. vol 2010. 2011-07-14. PMID:20224651. |
in this study, we investigated the effects of alpha-tea on the expression of epidermal growth factor receptor (egfr) family members, erbb1, 2 and 3, and the role of erbb 2 and 3 in alpha-tea-induced apoptosis and suppression of akt, flip and survivin in the cisplatin-sensitive (a2780s) and -resistant (a2780/cp70r) human ovarian cancer cell lines. |
2011-07-14 |
2023-08-12 |
human |
| Radha Munagala, Farrukh Aqil, Ramesh C Gupt. Promising molecular targeted therapies in breast cancer. Indian journal of pharmacology. vol 43. issue 3. 2011-07-14. PMID:21713084. |
several other targeted agents currently under evaluation in preclinical and clinical trials include inhibitors of epidermal growth factor receptor (egfr), dual egfr and her2 inhibitors, vegf/vegfr inhibitors, and agents that interfere with crucial signaling pathways such as pi3k/akt/mtor and ras/mek/erk; agents against other tyrosine kinases such as src, insulin-like growth factor (igf)/igf-receptor (igfr); agents that promote apoptosis such as poly adp ribose polymerase inhibitors; agents that target invasion and metastasis such as matrix metalloproteinases inhibitors and others. |
2011-07-14 |
2023-08-12 |
human |
| M Wasif Sai. Does erlotinib restore chemosensitivity to chemotherapy in pancreatic cancer? A case series. Anticancer research. vol 31. issue 3. 2011-06-21. PMID:21498735. |
in preclinical models, exposure of pancreatic cancer cell lines to an epidermal growth factor receptor (egfr) tyrosine kinase inhibitor plus gemcitabine suggested enhanced cytotoxicity of gemcitabine and induced apoptosis in tumor cells. |
2011-06-21 |
2023-08-12 |
Not clear |