| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anthony C Faber, Ryan B Corcoran, Hiromichi Ebi, Lecia V Sequist, Belinda A Waltman, Euiheon Chung, Joao Incio, Subba R Digumarthy, Sarah F Pollack, Youngchul Song, Alona Muzikansky, Eugene Lifshits, Sylvie Roberge, Erik J Coffman, Cyril H Benes, Henry L Gómez, José Baselga, Carlos L Arteaga, Miguel N Rivera, Dora Dias-Santagata, Rakesh K Jain, Jeffrey A Engelma. BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors. Cancer discovery. vol 1. issue 4. 2012-11-21. PMID:22145099. |
surprisingly, pretreatment rna levels of the bh3-only pro-apoptotic bim strongly predicted the capacity of egfr, her2, and pi3k inhibitors to induce apoptosis in egfr-mutant, her2-amplified, and pik3ca-mutant cancers, respectively, but bim levels did not predict responsiveness to standard chemotherapies. |
2012-11-21 |
2023-08-12 |
Not clear |
| Yu-Chin Lin, Meng-Hsuan Wu, Tzu-Tang Wei, Shu-Hui Chuang, Kuen-Feng Chen, Ann-Lii Cheng, Ching-Chow Che. Degradation of epidermal growth factor receptor mediates dasatinib-induced apoptosis in head and neck squamous cell carcinoma cells. Neoplasia (New York, N.Y.). vol 14. issue 6. 2012-11-13. PMID:22787428. |
here, we disclose that egfr degradation mediated dasatinib-induced apoptosis in head and neck squamous cell carcinoma (hnscc) cells. |
2012-11-13 |
2023-08-12 |
Not clear |
| Yu-Chin Lin, Meng-Hsuan Wu, Tzu-Tang Wei, Shu-Hui Chuang, Kuen-Feng Chen, Ann-Lii Cheng, Ching-Chow Che. Degradation of epidermal growth factor receptor mediates dasatinib-induced apoptosis in head and neck squamous cell carcinoma cells. Neoplasia (New York, N.Y.). vol 14. issue 6. 2012-11-13. PMID:22787428. |
increased egfr activation by ligand administration rescued cells from dasatinib-induced apoptosis, whereas inhibition of egfr enhanced its apoptotic effect. |
2012-11-13 |
2023-08-12 |
Not clear |
| Yu-Chin Lin, Meng-Hsuan Wu, Tzu-Tang Wei, Shu-Hui Chuang, Kuen-Feng Chen, Ann-Lii Cheng, Ching-Chow Che. Degradation of epidermal growth factor receptor mediates dasatinib-induced apoptosis in head and neck squamous cell carcinoma cells. Neoplasia (New York, N.Y.). vol 14. issue 6. 2012-11-13. PMID:22787428. |
in conclusion, degradation of egfr is a novel mechanism responsible for dasatinib-induced apoptosis in hnscc cells. |
2012-11-13 |
2023-08-12 |
Not clear |
| Guillem Ramis, Elena Thomàs-Moyà, Silvia Fernández de Mattos, José Rodríguez, Priam Villalong. EGFR inhibition in glioma cells modulates Rho signaling to inhibit cell motility and invasion and cooperates with temozolomide to reduce cell growth. PloS one. vol 7. issue 6. 2012-11-08. PMID:22701710. |
flow cytometric analyses confirm that egfr inhibition does not induce apoptosis in glioma cells, leading to cell cycle arrest in g(1). |
2012-11-08 |
2023-08-12 |
human |
| Mikihito Kajiya, Isao Ichimonji, Christine Min, Tongbo Zhu, Jun-O Jin, Qing Yu, Soulafa A Almazrooa, Seunghee Cha, Toshihisa Kawa. Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation. Molecular pharmacology. vol 82. issue 1. 2012-10-29. PMID:22511543. |
carbachol (cch), a muscarinic receptor-specific agonist, abrogated tumor necrosis factor α/interferon γ-induced apoptosis through pathways involving caspase 3/7, but its cytoprotective effect was decreased by a m3r antagonist, a mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (erk) inhibitor, a phosphatidylinositol 3-kinase/akt inhibitor, or an epidermal growth factor receptor (egfr) inhibitor. |
2012-10-29 |
2023-08-12 |
human |
| Misbah H Khan, Murad Alam, Simon Yo. Epidermal growth factor receptor inhibitors in the treatment of nonmelanoma skin cancers. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. vol 37. issue 9. 2012-10-24. PMID:21615602. |
the phosphorylation of egfr activates multiple biological processes, including apoptosis, differentiation, cellular proliferation, motility, invasion, adhesion, dna repair, and survival. |
2012-10-24 |
2023-08-12 |
Not clear |
| Yuji Sakuma, Yukiko Yamazaki, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Shoichi Matsukuma, Shiro Koizume, Yohei Miyag. NF-κB signaling is activated and confers resistance to apoptosis in three-dimensionally cultured EGFR-mutant lung adenocarcinoma cells. Biochemical and biophysical research communications. vol 423. issue 4. 2012-10-22. PMID:22695117. |
epidermal growth factor receptor (egfr)-mutant lung adenocarcinoma cells in suspension undergo apoptosis to a greater extent than adherent cells in a monolayer when egfr autophosphorylation is inhibited by egfr tyrosine kinase inhibitors (tkis). |
2012-10-22 |
2023-08-12 |
Not clear |
| Yuji Sakuma, Yukiko Yamazaki, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Shoichi Matsukuma, Shiro Koizume, Yohei Miyag. NF-κB signaling is activated and confers resistance to apoptosis in three-dimensionally cultured EGFR-mutant lung adenocarcinoma cells. Biochemical and biophysical research communications. vol 423. issue 4. 2012-10-22. PMID:22695117. |
since the microenvironment of cells cultured in a monolayer are substantially different to that of cells existing in three-dimension (3d) in vivo, we assessed whether two egfr-mutant lung adenocarcinoma cell lines, hcc827 and h1975, were more resistant to egfr tki-induced apoptosis when cultured in a 3d extracellular matrix (ecm) as compared with in suspension. |
2012-10-22 |
2023-08-12 |
Not clear |
| Yuji Sakuma, Yukiko Yamazaki, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Shoichi Matsukuma, Shiro Koizume, Yohei Miyag. NF-κB signaling is activated and confers resistance to apoptosis in three-dimensionally cultured EGFR-mutant lung adenocarcinoma cells. Biochemical and biophysical research communications. vol 423. issue 4. 2012-10-22. PMID:22695117. |
moreover, the inhibition of nf-κb with pharmacological inhibitors enhanced egfr tki-induced apoptosis in 3d-cultured egfr-mutant cells. |
2012-10-22 |
2023-08-12 |
Not clear |
| Galina E Morozevich, Nadezda I Kozlova, Natalia A Ushakova, Marina E Preobrazhenskaya, Albert E Berma. Integrin α5β1 simultaneously controls EGFR-dependent proliferation and Akt-dependent pro-survival signaling in epidermoid carcinoma cells. Aging. vol 4. issue 5. 2012-10-17. PMID:22626691. |
we demonstrated that pharmacological inhibition of epidermal growth factor receptor (egfr) significantly affected proliferation of a431 human cells by inducing the g0/g1 cell cycle arrest, whereas shrna-mediated depletion of α5 subunit of α5β1 integrin led to a similar type of cell cycle arrest followed by significant apoptosis. |
2012-10-17 |
2023-08-12 |
human |
| Simona Tavolari, Alessandra Munarini, Gianluca Storci, Stefan Laufer, Pasquale Chieco, Tiziana Guarnier. The decrease of cell membrane fluidity by the non-steroidal anti-inflammatory drug Licofelone inhibits epidermal growth factor receptor signalling and triggers apoptosis in HCA-7 colon cancer cells. Cancer letters. vol 321. issue 2. 2012-10-09. PMID:22343320. |
such phenomenon was associated with the block of egfr kinase activity and of its downstream targets, the p44-42 mitogen-activated protein kinase (mapk) and akt cascades, whose inhibitions were found to induce apoptosis in hca-7 cells. |
2012-10-09 |
2023-08-12 |
Not clear |
| Noriyuki Takai, Tami Ueda, Masakazu Nishida, Kaei Nasu, Hisashi Narahar. Anti-neoplastic effect of β-hydroxyisovalerylshikonin on a human choriocarcinoma cell line. Molecular medicine reports. vol 3. issue 3. 2012-10-02. PMID:21472272. |
β-hydroxyisovalerylshikonin (β-hivs), a compound isolated from the traditional asian medicinal herb lithospermum radix, is an atp non-competitive inhibitor of protein-tyrosine kinases such as v-src and egfr, and has been shown to induce apoptosis in several human tumor cell lines. |
2012-10-02 |
2023-08-12 |
human |
| M Prewett, P Rockwell, C Rose, N Goldstei. Anti-tumor and cell cycle responses in KB cells treated with a chimeric anti-EGFR monoclonal antibody in combination with cisplatin. International journal of oncology. vol 9. issue 2. 2012-10-02. PMID:21541503. |
the egfr appears to play an important role in regulating cell growth during tumorigenesis and blockade of the egfr/ligand interaction may be a means of inducing cell cytotoxicity, terminal differentiation, or apoptosis. |
2012-10-02 |
2023-08-12 |
human |
| Hongzheng Zhang, Sujin Yun, Thil D Batuwangala, Michael Steward, Steve D Holmes, Lin Pan, Mourad Tighiouart, Hyung Ju C Shin, Lydia Koenig, Wungki Park, Daniel Rycroft, Sreenivas Nannapaneni, Yuxiang Wang, Zhuo Georgia Chen, Dong M Shi. A dual-targeting antibody against EGFR-VEGF for lung and head and neck cancer treatment. International journal of cancer. vol 131. issue 4. 2012-08-31. PMID:21918971. |
dt-igg suppressed tu212 and a549 cell growth, inhibited egfr activation and induced apoptosis as effectively as cetuximab, and neutralized vegf as effectively as bevacizumab. |
2012-08-31 |
2023-08-12 |
human |
| Neelu Puri, Ravi Salgi. Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer. Journal of carcinogenesis. vol 7. 2012-08-27. PMID:19240370. |
c-met and egfr receptors are widely expressed on cancer cells; they are implicated in the development and progression of cancer through a plethora of effects on cell cycle progression, apoptosis, motility and metastasis and are potential targets for combination therapy. |
2012-08-27 |
2023-08-12 |
Not clear |
| Jian-Ping Zhou, Xin Chen, Shan Feng, Shi-Dong Luo, You-Li Pan, Lei Zhong, Pan Ji, Ze-Rong Wang, Shuang Ma, Lin-Li Li, Yu-Quan Wei, Sheng-Yong Yan. Systems biology modeling reveals a possible mechanism of the tumor cell death upon oncogene inactivation in EGFR addicted cancers. PloS one. vol 6. issue 12. 2012-08-27. PMID:22194952. |
in this account, we developed a mathematic model of epidermal growth factor receptor (egfr) associated signaling network, which involves egfr-driving proliferation/pro-survival signaling pathways ras/extracellular-signal-regulated kinase (erk) and phosphoinositol-3 kinase (pi3k)/akt, and pro-apoptotic signaling pathway apoptosis signal-regulating kinase 1 (ask1)/p38. |
2012-08-27 |
2023-08-12 |
Not clear |
| Ting Lan, Yongchang Chen, Jianrong Sang, Yan Wu, Ying Wang, Lu Jiang, Yan Ta. Type II cGMP-dependent protein kinase inhibits EGF-induced MAPK/JNK signal transduction in breast cancer cells. Oncology reports. vol 27. issue 6. 2012-08-27. PMID:22427012. |
the results showed that egf treatment increased the phosphorylation of egfr, the binding between grb2 and sos1, the activation of ras, and the phosphorylation/activation of mkk7, jnk and c-jun, but decreased the apoptosis of the cells. |
2012-08-27 |
2023-08-12 |
human |
| Hussein A N Al-Wadei, Mohammad F Ullah, Mohammed H Al-Wade. Intercepting neoplastic progression in lung malignancies via the beta adrenergic (β-AR) pathway: implications for anti-cancer drug targets. Pharmacological research. vol 66. issue 1. 2012-08-27. PMID:22487140. |
the stimulation of the β-adrenergic receptor by lifestyle and environmental factors, as well as a preexisting risk for neoplasm, activates downstream effector molecules (adenylyl cyclase/camp/pka/creb) concomitant to the transactivation of related pathways (egfr) that lead to pro-oncogenic signaling; this β-adrenergic pathway thereby encourages cancer growth by evasion of apoptosis, invasion, angiogenesis, and metastasis. |
2012-08-27 |
2023-08-12 |
human |
| Kequan Zhou, Julian J Raffou. Potential anticancer properties of grape antioxidants. Journal of oncology. vol 2012. 2012-08-24. PMID:22919383. |
the use of grape antioxidants are promising against a broad range of cancer cells by targeting epidermal growth factor receptor (egfr) and its downstream pathways, inhibiting over-expression of cox-2 and prostaglandin e2 receptors, or modifying estrogen receptor pathways, resulting in cell cycle arrest and apoptosis. |
2012-08-24 |
2023-08-12 |
human |