| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saghir Akhtar, Bindu Chandrasekhar, Sreeja Attur, Mariam H M Yousif, Ibrahim F Bente. On the nanotoxicity of PAMAM dendrimers: Superfect® stimulates the EGFR-ERK1/2 signal transduction pathway via an oxidative stress-dependent mechanism in HEK 293 cells. International journal of pharmaceutics. vol 448. issue 1. 2013-11-11. PMID:23538097. |
the egfr is an important signaling cascade that regulates cell growth, differentiation, migration, survival and apoptosis. |
2013-11-11 |
2023-08-12 |
human |
| Xiaodong Mu, Ye Zhang, Xiujuan Qu, Kezuo Hou, Jian Kang, Xuejun Hu, Yunpeng Li. Ubiquitin ligase Cbl-b is involved in icotinib (BPI-2009H)-induced apoptosis and G1 phase arrest of EGFR mutation-positive non-small-cell lung cancer. BioMed research international. vol 2013. 2013-11-11. PMID:23586056. |
ubiquitin ligase cbl-b is involved in icotinib (bpi-2009h)-induced apoptosis and g1 phase arrest of egfr mutation-positive non-small-cell lung cancer. |
2013-11-11 |
2023-08-12 |
Not clear |
| Melissa Oliveira-Cunha, William G Newman, Ajith K Siriwarden. Epidermal growth factor receptor in pancreatic cancer. Cancers. vol 3. issue 2. 2013-11-11. PMID:24212772. |
although several combinations of egfr inhibitors with chemotherapy demonstrate inhibition of tumor-induced angiogenesis, tumor cell apoptosis and regression in xenograft models, these benefits remain to be confirmed. |
2013-11-11 |
2023-08-12 |
human |
| T Yamada, S Takeuchi, N Fujita, A Nakamura, W Wang, Q Li, M Oda, T Mitsudomi, Y Yatabe, Y Sekido, J Yoshida, M Higashiyama, M Noguchi, H Uehara, Y Nishioka, S Sone, S Yan. Akt kinase-interacting protein1, a novel therapeutic target for lung cancer with EGFR-activating and gatekeeper mutations. Oncogene. vol 32. issue 37. 2013-11-08. PMID:23045273. |
silencing of aki1 induced apoptosis of egfr mutant lung cancer cells. |
2013-11-08 |
2023-08-12 |
Not clear |
| W-T Kuo, G-C Dong, C-H Yao, J-Y Huang, F-H Li. Evaluation of adhesion force and binding affinity of phytohemagglutinin erythroagglutinating to EGF receptor on human lung cancer cells. Current medicinal chemistry. vol 20. issue 19. 2013-11-08. PMID:23394551. |
pha-e is a natural product extracted from red kidney beans, and it has been reported to induce cell apoptosis by blocking egfr in lung cancer cells. |
2013-11-08 |
2023-08-12 |
human |
| Rong-Jane Chen, Shang-Jie Tsai, Chi-Tang Ho, Min-Hsiung Pan, Yuan-Soon Ho, Chih-Hsiung Wu, Ying-Jan Wan. Chemopreventive effects of pterostilbene on urethane-induced lung carcinogenesis in mice via the inhibition of EGFR-mediated pathways and the induction of apoptosis and autophagy. Journal of agricultural and food chemistry. vol 60. issue 46. 2013-11-04. PMID:23113763. |
the results indicate that the pterostilbene-mediated chemopreventive effects in vivo were a result of the inhibition of epidermal growth factor receptor (egfr) and its downstream pathways, leading to retarded cell cycle progression, and of the induction of apoptosis and autophagy during urethane-induced lung tumorigenesis. |
2013-11-04 |
2023-08-12 |
mouse |
| Abhishek Chandra, Shenghui Lan, Ji Zhu, Valerie A Siclari, Ling Qi. Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response 2 (EGR2) expression. The Journal of biological chemistry. vol 288. issue 28. 2013-09-27. PMID:23720781. |
here we demonstrate that activation of egfr increases the number of osteoprogenitors by promoting cell proliferation and suppressing either serum depletion-induced or tnfα-induced apoptosis mainly through the mapk/erk pathway. |
2013-09-27 |
2023-08-12 |
mouse |
| Gang Chen, Ijeoma Adaku Umelo, Shasha Lv, Erik Teugels, Karel Fostier, Peter Kronenberger, Alex Dewaele, Jan Sadones, Caroline Geers, Jacques De Grèv. miR-146a inhibits cell growth, cell migration and induces apoptosis in non-small cell lung cancer cells. PloS one. vol 8. issue 3. 2013-09-24. PMID:23555954. |
in functional experiments, mir-146a suppressed cell growth, induced cellular apoptosis and inhibited egfr downstream signaling in five nsclc cell lines (h358, h1650, h1975, hcc827 and h292). |
2013-09-24 |
2023-08-12 |
human |
| E Sanchez-Guerrero, S R Jo, B H Chong, L M Khachigia. EGFR and the complexity of receptor crosstalk in the cardiovascular system. Current molecular medicine. vol 13. issue 1. 2013-09-20. PMID:23116266. |
considerable experimental evidence suggests that the uncontrolled expression of egfr contributes to tumorigenesis through inhibition of apoptosis, angiogenesis, anchorage-independent growth and tumor-associated inflammation. |
2013-09-20 |
2023-08-12 |
human |
| Gang Chen, Alfiah Noor, Peter Kronenberger, Erik Teugels, Ijeoma Adaku Umelo, Jacques De Grèv. Synergistic effect of afatinib with su11274 in non-small cell lung cancer cells resistant to gefitinib or erlotinib. PloS one. vol 8. issue 3. 2013-09-17. PMID:23527257. |
the combination of egfr sirna plus c-met sirna enhanced cell growth inhibition, apoptosis induction and inhibition of downstream signaling in egfr tki resistant h358, h1650 and h1975 cells, despite the absence of activity of the c-met sirna alone. |
2013-09-17 |
2023-08-12 |
Not clear |
| C Li, X Zhang, L Cheng, L Dai, F Xu, J Zhang, H Tian, X Chen, G Shi, Y Li, T Du, S Zhang, Y Wei, H Den. RNA interference targeting human FAK and EGFR suppresses human non-small-cell lung cancer xenograft growth in nude mice. Cancer gene therapy. vol 20. issue 2. 2013-09-03. PMID:23328701. |
knockdown of fak and egfr expression significantly inhibited cell proliferation and induced cell apoptosis of a549 lung cancer cells in vitro. |
2013-09-03 |
2023-08-12 |
mouse |
| C Li, X Zhang, L Cheng, L Dai, F Xu, J Zhang, H Tian, X Chen, G Shi, Y Li, T Du, S Zhang, Y Wei, H Den. RNA interference targeting human FAK and EGFR suppresses human non-small-cell lung cancer xenograft growth in nude mice. Cancer gene therapy. vol 20. issue 2. 2013-09-03. PMID:23328701. |
fak and egfr dual silencing also significantly decreased microvessel density, tumor cell proliferation and increased the level of apoptosis in tumor cells. |
2013-09-03 |
2023-08-12 |
mouse |
| Yosef Levi, Iris Barshack, Kamila Avivi, Dalia Bar-ILan, Mordechai Gutman, Dan Aderka, Raanan Berger, Rinat Yacob. [Correlation between the presence of Kras mutation and the presence of the proteins epiregulin and amphiregulin in colon cancer tissue]. Harefuah. vol 152. issue 6. 2013-08-26. PMID:23885463. |
these monoclonal antibodies are directed against egfr and influence cell division, attachment, angiogenesis, migration and apoptosis. |
2013-08-26 |
2023-08-12 |
Not clear |
| Chun Han, Zhangjian Huang, Chao Zheng, Ledong Wan, Lianwen Zhang, Sixun Peng, Ke Ding, Hongbin Ji, Jide Tian, Yihua Zhan. Novel hybrids of (phenylsulfonyl)furoxan and anilinopyrimidine as potent and selective epidermal growth factor receptor inhibitors for intervention of non-small-cell lung cancer. Journal of medicinal chemistry. vol 56. issue 11. 2013-08-20. PMID:23668441. |
furthermore, 12k induced apoptosis of h1975 and hcc827 cells more strongly than wz4002 (1), inhibited egfr downstream signaling in h1975 cells, and suppressed the nuclear factor-κb activation in h1975 cells, while 1 had no significant effects under the same conditions. |
2013-08-20 |
2023-08-12 |
mouse |
| Shishir Shishodi. Molecular mechanisms of curcumin action: gene expression. BioFactors (Oxford, England). vol 39. issue 1. 2013-08-05. PMID:22996381. |
curcumin regulates the expression of inflammatory cytokines (e.g., tnf, il-1), growth factors (e.g., vegf, egf, fgf), growth factor receptors (e.g., egfr, her-2, ar), enzymes (e.g., cox-2, lox, mmp9, mapk, mtor, akt), adhesion molecules (e.g., elam-1, icam-1, vcam-1), apoptosis related proteins (e.g., bcl-2, caspases, dr, fas), and cell cycle proteins (e.g., cyclin d1). |
2013-08-05 |
2023-08-12 |
Not clear |
| Hiromitsu Michikoshi, Takahiro Nakamura, Katsuya Sakai, Yoshinori Suzuki, Eri Adachi, Seiichi Matsugo, Kunio Matsumot. α-Lipoic acid-induced inhibition of proliferation and met phosphorylation in human non-small cell lung cancer cells. Cancer letters. vol 335. issue 2. 2013-07-30. PMID:23507559. |
a phospho-receptor tyrosine kinase array and cell cycle analysis indicated that α-la decreased tyrosine phosphorylation levels of egfr, erbb2, and met, and this was associated with an inhibition in the cell-cycle transition from the g1 phase to the s phase without inducing apoptosis. |
2013-07-30 |
2023-08-12 |
human |
| Neil E Bhola, Maria L Freilino, Sonali C Joyce, Malabika Sen, Sufi M Thomas, Anirban Sahu, Andre Cassell, Ching-Shih Chen, Jennifer R Grandi. Antitumor mechanisms of targeting the PDK1 pathway in head and neck cancer. Molecular cancer therapeutics. vol 11. issue 6. 2013-07-22. PMID:22491800. |
blockade of pdk1 with a small molecule inhibitor (ar-12) abrogated hnscc growth, induced apoptosis, and enhanced the antiproliferative effects of egfr tyrosine kinase inhibitors in vitro. |
2013-07-22 |
2023-08-12 |
Not clear |
| E Giovannetti, M Labots, H Dekker, E Galvani, J S W Lind, R Sciarrillo, R Honeywell, E F Smit, H M Verheul, G J Peter. Molecular mechanisms and modulation of key pathways underlying the synergistic interaction of sorafenib with erlotinib in non-small-cell-lung cancer (NSCLC) cells. Current pharmaceutical design. vol 19. issue 5. 2013-07-22. PMID:22973961. |
pharmacologic interaction was studied using mtt/srb assays and the combination index (ci) method, while effects on egfr, erk1/2 and akt phosphorylation, cell cycle and apoptosis were studied with western-blot, elisa, and flow cytometry. |
2013-07-22 |
2023-08-12 |
Not clear |
| Sun-Young Lee, Seok Joon Shin, Ho-Shik Ki. ERK1/2 activation mediated by the nutlin‑3‑induced mitochondrial translocation of p53. International journal of oncology. vol 42. issue 3. 2013-07-16. PMID:23314357. |
taking the above findings into account, it can be concluded that nutlin-3 activates erk1/2 prior to egfr phosphorylation via ros generation following the mitochondrial translocation of p53 and that nutlin-3-induced erk1/2 activation may play a role in protecting u2os cells from p53-dependent apoptosis, constituting a negative feedback loop for p53-induced apoptosis. |
2013-07-16 |
2023-08-12 |
human |
| R Mezzapelle, U Miglio, O Rena, A Paganotti, S Allegrini, J Antona, F Molinari, M Frattini, G Monga, O Alabiso, R Boldorin. Mutation analysis of the EGFR gene and downstream signalling pathway in histologic samples of malignant pleural mesothelioma. British journal of cancer. vol 108. issue 8. 2013-07-15. PMID:23558893. |
mutations of the egfr gene or its downstream effectors may cause constitutive activation leading to cell proliferation, and the inhibition of apoptosis and metastases. |
2013-07-15 |
2023-08-12 |
Not clear |