| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Ozenne, D Dayde, E Brambilla, B Eymin, S Gazzer. p14(ARF) inhibits the growth of lung adenocarcinoma cells harbouring an EGFR L858R mutation by activating a STAT3-dependent pro-apoptotic signalling pathway. Oncogene. vol 32. issue 8. 2013-07-12. PMID:22450744. |
in this study, we demonstrate that p14(arf) promotes apoptosis in lung tumour cells harbouring the egfr l858r mutation through the accumulation of phosphorylated signal transducer and activator of transcription 3 (stat3) on tyr 705 residue, which leads to bcl-2 downregulation. |
2013-07-12 |
2023-08-12 |
Not clear |
| Xiongwei Wang, Qungen Xiao, Xihong Xing, Chunlei Tian, Huaqiu Zhang, Fei Ye, Feng Wan, Baofeng Wang, Dongsheng Guo, Ting Le. LRIG1 enhances cisplatin sensitivity of glioma cell lines. Oncology research. vol 20. issue 5-6. 2013-06-20. PMID:23581227. |
the mechanisms underlying the effect of the combined treatment of lrig1 and cddp could be that lrig1 blocked cddp-induced egfr activation and regulated the apoptosis proteins. |
2013-06-20 |
2023-08-12 |
Not clear |
| Takayuki Nakagawa, Shinji Takeuchi, Tadaaki Yamada, Hiromichi Ebi, Takako Sano, Shigeki Nanjo, Daisuke Ishikawa, Mitsuo Sato, Yoshinori Hasegawa, Yoshitaka Sekido, Seiji Yan. EGFR-TKI resistance due to BIM polymorphism can be circumvented in combination with HDAC inhibition. Cancer research. vol 73. issue 8. 2013-06-12. PMID:23382048. |
bim upregulation is required for apoptosis induction by egf receptor (egfr) tyrosine kinase inhibitors (egfr-tki) in egfr-mutant forms of non-small cell lung cancer (nsclc). |
2013-06-12 |
2023-08-12 |
Not clear |
| Hal W Hirt. Profile of erlotinib and its potential in the treatment of advanced ovarian carcinoma. OncoTargets and therapy. vol 6. 2013-06-03. PMID:23723710. |
the epidermal growth-factor receptor (egfr) is overexpressed in the majority of epithelial ovarian cancers and promotes cell proliferation, migration and invasion, and angiogenesis, as well as resistance to apoptosis. |
2013-06-03 |
2023-08-12 |
Not clear |
| Boban M Erovic, Luke Harris, Mina Jamali, David P Goldstein, Jonathan C Irish, Sylvia L Asa, Ozgur Met. Biomarkers of parathyroid carcinoma. Endocrine pathology. vol 23. issue 4. 2013-05-23. PMID:23001705. |
we constructed a tissue microarray of parathyroid carcinomas from 10 patients as well as parathyroid adenomas from 25 patients and stained the slides for 34 proteins involved in angiogenesis (platelet-derived growth factor receptor (pdgfr)-α, pdgfr-β, vascular endothelial growth factor receptor-2 (vegfr-2), and epidermal growth factor receptor (egfr)), inflammation (cyclooxygenase (cox)-1 and cox-2), cell adhesion (matrix metalloproteinase (mmp)-1, cd9, and keratin 7), cell cycle (cdc2p34, cyclin d1, retinoblastoma (rb), p27, p21, parafibromin, bmi-1, 14-3-3σ, and p53), and apoptosis (bcl-2a, mcl-1, bcl-xl, and glutathione-s-transferase-isoenzyme π (gst-π)) along with some markers of the sonic hedgehog (smo, shh, gli-1, gli-2, gli-3, and patched), mtor (akt, mammalian target of rapamycin (mtor), and forkhead box o (foxo)-1), and wnt (wisp-1, wisp-2, and β-catenin) signal transduction pathways. |
2013-05-23 |
2023-08-12 |
Not clear |
| Yang Yu, Si-Miao Fan, Yuan-Chao Ye, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejim. The tyrphostin AG1478 augments oridonin-induced A431 cell apoptosis by blockage of JNK MAPK and enhancement of oxidative stress. Free radical research. vol 46. issue 11. 2013-05-21. PMID:22881126. |
a specific epidermal growth factor receptor (egfr) inhibitor ag1478 was used to examine the relationship between egfr signal pathways and oridonin-induced apoptosis and autophagy in egfr abundant human epidermoid carcinoma a431 cells. |
2013-05-21 |
2023-08-12 |
human |
| Yang Yu, Si-Miao Fan, Yuan-Chao Ye, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejim. The tyrphostin AG1478 augments oridonin-induced A431 cell apoptosis by blockage of JNK MAPK and enhancement of oxidative stress. Free radical research. vol 46. issue 11. 2013-05-21. PMID:22881126. |
therefore, in egfr downstream pathways, jnk played a major role in preventing oridonin-induced apoptosis. |
2013-05-21 |
2023-08-12 |
human |
| Yang Yu, Si-Miao Fan, Yuan-Chao Ye, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejim. The tyrphostin AG1478 augments oridonin-induced A431 cell apoptosis by blockage of JNK MAPK and enhancement of oxidative stress. Free radical research. vol 46. issue 11. 2013-05-21. PMID:22881126. |
inhibition of egfr augmented oridonin-induced apoptosis and this was caused by enhanced oxidative stress, and jnk played a major protective role by increasing autophagy, leading to antagonising apoptosis and ros generation. |
2013-05-21 |
2023-08-12 |
human |
| Archana Thakur, Lawrence G Lum, Dana Schalk, Asfar Azmi, Sanjeev Banerjee, Fazlul H Sarkar, Ramzi Mohomma. Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells. PloS one. vol 7. issue 11. 2013-05-14. PMID:23185240. |
the effects of at-101 on cytotoxicity, early apoptosis, and granzyme b (grzb) and ifn-γ signaling pathways were evaluated during egfr bispecific antibody armed atc (aatc)-mediated killing of l3.6pl and miapaca-2 pc cells pre-sensitized with at-101. |
2013-05-14 |
2023-08-12 |
Not clear |
| Bo Zhang, Jiao Jiao, Ying Liu, Liang-Xia Guo, Bo Zhou, Gang-Qin Li, Zhu-Jun Yao, Guang-Biao Zho. Gefitinib analogue V1801 induces apoptosis of T790M EGFR-harboring lung cancer cells by up-regulation of the BH-3 only protein Noxa. PloS one. vol 7. issue 11. 2013-05-14. PMID:23185274. |
though v1801 only moderately inhibited egfr kinase activity, it markedly induced the expression of the bh3-only protein noxa, and noxa silencing significantly reduced v1801-induced apoptosis of nci-h1975 cells. |
2013-05-14 |
2023-08-12 |
mouse |
| Elżbieta Płuciennik, Magdalena Nowakowska, Wioletta I Wujcicka, Anna Sitkiewicz, Bernarda Kazanowska, Elżbieta Zielińska, Andrzej K Bednare. Genetic alterations of WWOX in Wilms' tumor are involved in its carcinogenesis. Oncology reports. vol 28. issue 4. 2013-05-09. PMID:22842668. |
we evaluated the correlation between expression of wwox and genes involved in proliferation (ki67), apoptosis (bcl2, bax), signal transduction (erbb4, erbb2, egfr), cell cycle (ccne1, ccnd1), cell adhesion (cdh1) and transcription (tp73) using real-time rt-pcr in 23 tumor samples. |
2013-05-09 |
2023-08-12 |
Not clear |
| Elżbieta Płuciennik, Magdalena Nowakowska, Wioletta I Wujcicka, Anna Sitkiewicz, Bernarda Kazanowska, Elżbieta Zielińska, Andrzej K Bednare. Genetic alterations of WWOX in Wilms' tumor are involved in its carcinogenesis. Oncology reports. vol 28. issue 4. 2013-05-09. PMID:22842668. |
in the present study we reveal that in wilms' tumors the wwox expression levels are positively associated with the process of apoptosis, signal transduction through the erbb4 pathway and egfr and negatively with the regulation of the cell cycle (by cyclin e1 and d1). |
2013-05-09 |
2023-08-12 |
Not clear |
| Chang-fu Qin, Xiao-dong Tian, Kun Hao, Yin-mo Yan. [Effects and mechanisms of combined suppression of epidermal growth factor receptor and hedgehog signaling on proliferation in pancreatic cancer cells]. Zhonghua yi xue za zhi. vol 92. issue 26. 2013-04-25. PMID:22944238. |
to explore the synergistic effects on proliferation and apoptosis by targeted suppression of epidermal growth factor receptor (egfr) in combination with blockade of hedgehog signaling pathways in pancreatic cancer cells and examine the synergistic mechanism of hedgehog and egfr signaling pathways. |
2013-04-25 |
2023-08-12 |
Not clear |
| Shunzhou Wan, David W Wright, Peter V Covene. Mechanism of drug efficacy within the EGF receptor revealed by microsecond molecular dynamics simulation. Molecular cancer therapeutics. vol 11. issue 11. 2013-04-23. PMID:22863610. |
the egf receptor (egfr) regulates important cellular processes including proliferation, differentiation, and apoptosis. |
2013-04-23 |
2023-08-12 |
Not clear |
| Stefanie Niederlechner, Christine Baird, Benjamin Petrie, Erhard Wischmeyer, Paul E Wischmeye. Epidermal growth factor receptor expression and signaling are essential in glutamine's cytoprotective mechanism in heat-stressed intestinal epithelial-6 cells. American journal of physiology. Gastrointestinal and liver physiology. vol 304. issue 5. 2013-04-23. PMID:23275616. |
we showed that hs induced a decrease in total, cytoplasmic, and nuclear egfr levels in iec-6 cells, which was prevented by gln supplementation, leading to attenuated apoptosis via egfr small interfering rna. |
2013-04-23 |
2023-08-12 |
Not clear |
| Tsuyoshi Ohta, Masahide Ohmichi, Tae Shibuya, Toshifumi Takahashi, Seiji Tsutsumi, Kazuhiro Takahashi, Hirohisa Kurach. Gefitinib (ZD1839) increases the efficacy of cisplatin in ovarian cancer cells. Cancer biology & therapy. vol 13. issue 6. 2013-04-19. PMID:22313686. |
we examined the effect of gefitinib (zd1839), a selective epidermal growth factor receptor (egfr)-tyrosine kinase inhibitor, on cytotoxicity to cisplatin, egfr downstream signaling, apoptosis and the association between the inhibition of dna repair by gefitinib and the expression of dna-dependent protein kinase (dna-pk) using three ovarian cancer cell lines. |
2013-04-19 |
2023-08-12 |
Not clear |
| Tsuyoshi Ohta, Masahide Ohmichi, Tae Shibuya, Toshifumi Takahashi, Seiji Tsutsumi, Kazuhiro Takahashi, Hirohisa Kurach. Gefitinib (ZD1839) increases the efficacy of cisplatin in ovarian cancer cells. Cancer biology & therapy. vol 13. issue 6. 2013-04-19. PMID:22313686. |
in the presence of gefitinib, cisplatin-induced growth inhibition and apoptosis were significantly enhanced in caov-3 and rmg-1 cells, which express egfr, and in a2780, which lacks egfr but expresses her-2. |
2013-04-19 |
2023-08-12 |
Not clear |
| Y Shen, M L Ren, Y H Shi, Y X Zhang, Y L Ca. Octreotide is the favorable alternative for cisplatin resistance reversal of ovarian cancer in vitro and in nude mice in vivo. European journal of gynaecological oncology. vol 33. issue 6. 2013-04-16. PMID:23327050. |
it is suggested that oct could inhibit ovarian cancer proliferation and promote apoptosis, via the cell surface sstr2, and reverse cisplatin resistance through inhibition of mrp2, egfr, and even gst-pi expressions. |
2013-04-16 |
2023-08-12 |
mouse |
| Ram Prasad, Santosh K Katiya. Bioactive phytochemical proanthocyanidins inhibit growth of head and neck squamous cell carcinoma cells by targeting multiple signaling molecules. PloS one. vol 7. issue 9. 2013-04-10. PMID:23050025. |
dietary administration of gsps (0.5%, w/w) in supplementation with ain76a control diet inhibited the growth of scc1 tumor xenografts in athymic nude mice, which was associated with: (i) inhibition of cell proliferation, (ii) induction of apoptosis of tumor xenograft cells, (iii) decreased expression of cyclins and cdks, (iv) decreased expression of egfr, and (v) increased expression of cip1/p21 and kip1/p27 proteins and their increased binding to cdks in tumor xenograft samples. |
2013-04-10 |
2023-08-12 |
mouse |
| Xiao-Hong Kang, Zhen-Ye Xu, Ya-Bin Gong, Li-Fang Wang, Zhong-Qi Wang, Ling Xu, Fei Cao, Ming-Juan Lia. Bufalin Reverses HGF-Induced Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer Cells via Blockage of Met/PI3k/Akt Pathway and Induction of Apoptosis. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-03-28. PMID:23533466. |
bufalin reverses hgf-induced resistance to egfr-tkis in egfr mutant lung cancer cells via blockage of met/pi3k/akt pathway and induction of apoptosis. |
2013-03-28 |
2023-08-12 |
Not clear |