| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liu Hong, Yu Han, Lubi Brai. The role of epidermal growth factor receptor in prognosis and treatment of gastric cancer. Expert review of gastroenterology & hepatology. vol 8. issue 1. 2014-09-22. PMID:24410474. |
egf receptor (egfr) plays important roles in gastric carcinogenesis by regulation of cell cycle, angiogenesis and apoptosis. |
2014-09-22 |
2023-08-12 |
Not clear |
| Yong-Qian Jiang, Zhi-Xiang Zhou, You-Lin J. Suppression of EGFR-STAT3 signaling inhibits tumorigenesis in a lung cancer cell line. International journal of clinical and experimental medicine. vol 7. issue 8. 2014-09-18. PMID:25232393. |
egfr and stat3 protein expression, cell apoptosis rate, cell proliferation, cell invasion, and cell division were analyzed and compared. |
2014-09-18 |
2023-08-13 |
Not clear |
| Hong-jie Huang, Fei-yun Ping, Ji-an Hu, Shi-fang Zha. [Effects of epidermal growth factor receptor gene silencing mediated by short hairpin RNA on proliferation and apoptosis of human tongue carcinoma cells]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. vol 44. issue 6. 2014-09-11. PMID:19953957. |
to investigate the effects of epidermal growth factor receptor (egfr) gene silencing mediated by short hairpin rna (shrna) on proliferation and apoptosis of human tongue carcinoma cells. |
2014-09-11 |
2023-08-12 |
human |
| M Steins, M Thomas, M Geissle. Erlotinib. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. vol 201. 2014-09-08. PMID:24756788. |
the epidermal growth factor receptor (egfr) has been implicated in a multiplicity of cancer-related signal transduction pathways such as cellular proliferation, adhesion, migration, neoangiogenesis and apoptosis inhibition, all of them are important features of cancerogenesis and tumour progression. |
2014-09-08 |
2023-08-13 |
Not clear |
| Shanqun Li, Zilong Liu, Fen Zhu, Xiaohong Fan, Xiaodan Wu, Heng Zhao, Liyan Jian. Curcumin lowers erlotinib resistance in non-small cell lung carcinoma cells with mutated EGF receptor. Oncology research. vol 21. issue 3. 2014-08-15. PMID:24512728. |
furthermore, curcumin significantly increased the cytotoxicity of erlotinib to erlotinib-resistant nsclc cells, enhanced erlotinib-induced apoptosis, downregulated the expressions of egfr, p-egfr, and survivin, and inhibited the nf-κb activation in erlotinib-resistant nsclc cells. |
2014-08-15 |
2023-08-12 |
mouse |
| Leila Zarepoor, Jenifer T Lu, Claire Zhang, Wenqing Wu, Dion Lepp, Lindsay Robinson, Janitha Wanasundara, Steve Cui, Sébastien Villeneuve, Bourlaye Fofana, Rong Tsao, Geoffrey A Wood, Krista A Powe. Dietary flaxseed intake exacerbates acute colonic mucosal injury and inflammation induced by dextran sodium sulfate. American journal of physiology. Gastrointestinal and liver physiology. vol 306. issue 12. 2014-08-15. PMID:24763556. |
dietary fs exacerbated dss-induced acute colitis, as indicated by a heightened disease activity index and an increase in colonic injury and inflammatory biomarkers [histological damage, apoptosis, myeloperoxidase, inflammatory cytokines (il-6 and il-1β), and nf-κb signaling-related genes (nfkb1, ccl5, bcl2a1a, egfr, relb, birc3, and atf1)]. |
2014-08-15 |
2023-08-13 |
mouse |
| Jinhua Chen, Wenfang Wang, Hongyuan Wang, Xinyong Liu, Xiuli Gu. Combination treatment of ligustrazine piperazine derivate DLJ14 and adriamycin inhibits progression of resistant breast cancer through inhibition of the EGFR/PI3K/Akt survival pathway and induction of apoptosis. Drug discoveries & therapeutics. vol 8. issue 1. 2014-08-14. PMID:24647156. |
the expression of proteins in the epidermal growth factor receptor (egfr)/phosphatidylinositol-3 kinase (pi3k)/akt survival pathway and mitochondrial-mediated apoptosis pathway were measured by western blotting analysis. |
2014-08-14 |
2023-08-12 |
human |
| Rupesh Chaturvedi, Mohammad Asim, M Blanca Piazuelo, Fang Yan, Daniel P Barry, Johanna Carolina Sierra, Alberto G Delgado, Salisha Hill, Robert A Casero, Luis E Bravo, Ricardo L Dominguez, Pelayo Correa, D Brent Polk, M Kay Washington, Kristie L Rose, Kevin L Schey, Douglas R Morgan, Richard M Peek, Keith T Wilso. Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage. Gastroenterology. vol 146. issue 7. 2014-07-21. PMID:24530706. |
because epidermal growth factor receptor (egfr) activation can regulate apoptosis, we determined its role in smox-mediated effects. |
2014-07-21 |
2023-08-12 |
Not clear |
| Maria Ait-Tihyaty, Zakaria Rachid, Anne-Laure Larroque-Lombard, Bertrand J Jean-Claud. ZRX1, the first EGFR inhibitor-capecitabine based combi-molecule, requires carboxylesterase-mediated hydrolysis for optimal activity. Investigational new drugs. vol 31. issue 6. 2014-07-08. PMID:23959266. |
however, when ces was present, zrx1 induced an increase in egfr inhibition, tp expression, dna damage and apoptosis. |
2014-07-08 |
2023-08-12 |
Not clear |
| Ji-Young Song, Choung-Soo Kim, Je-Hwan Lee, Se Jin Jang, Sang-wook Lee, Jung Jin Hwang, Chulsoo Lim, Gilnam Lee, Jeongbeob Seo, Suk Young Cho, Jene Cho. Dual inhibition of MEK1/2 and EGFR synergistically induces caspase-3-dependent apoptosis in EGFR inhibitor-resistant lung cancer cells via BIM upregulation. Investigational new drugs. vol 31. issue 6. 2014-07-08. PMID:24068620. |
dual inhibition of mek1/2 and egfr synergistically induces caspase-3-dependent apoptosis in egfr inhibitor-resistant lung cancer cells via bim upregulation. |
2014-07-08 |
2023-08-12 |
Not clear |
| Ji-Young Song, Choung-Soo Kim, Je-Hwan Lee, Se Jin Jang, Sang-wook Lee, Jung Jin Hwang, Chulsoo Lim, Gilnam Lee, Jeongbeob Seo, Suk Young Cho, Jene Cho. Dual inhibition of MEK1/2 and EGFR synergistically induces caspase-3-dependent apoptosis in EGFR inhibitor-resistant lung cancer cells via BIM upregulation. Investigational new drugs. vol 31. issue 6. 2014-07-08. PMID:24068620. |
egfr tyrosine kinase inhibitors (tkis) such as gefitinib induce apoptosis of cancer cells, but prolonged treatment is often associated with acquired resistance. |
2014-07-08 |
2023-08-12 |
Not clear |
| Sandeep Sreevalsan, Stephen Saf. The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells. Molecular cancer therapeutics. vol 12. issue 11. 2014-07-07. PMID:24030632. |
2,3-dihydro-5-methyl-3-([morpholinyl]methyl)pyrollo(1,2,3-de)-1,4-benzoxazinyl]-[1-naphthaleny]methanone [win 55,212-2, (win)] is a synthetic cannabinoid that inhibits rko, ht-29, and sw480 cell growth, induced apoptosis, and downregulated expression of survivin, cyclin d1, egf receptor (egfr), vegf, and its receptor (vegfr1). |
2014-07-07 |
2023-08-12 |
Not clear |
| Kobra Omidfar, Fatemeh Sadat Amjad Zanjani, Arghavan Golbaz Hagh, Maedeh Darziani Azizi, Seyed Javad Rasouli, Susan Kashania. Efficient growth inhibition of EGFR over-expressing tumor cells by an anti-EGFR nanobody. Molecular biology reports. vol 40. issue 12. 2014-07-02. PMID:24052234. |
monoclonal antibodies targeting egfr could control the tumor cell growth, proliferation, and apoptosis by suppressing the signal transduction pathways. |
2014-07-02 |
2023-08-12 |
human |
| Ronan Shaughnessy, Claudio Retamal, Claudia Oyanadel, Andrés Norambuena, Alejandro López, Marcela Bravo-Zehnder, Fabian J Montecino, Claudia Metz, Andrea Soza, Alfonso Gonzále. Epidermal growth factor receptor endocytic traffic perturbation by phosphatidate phosphohydrolase inhibition: new strategy against cancer. The FEBS journal. vol 281. issue 9. 2014-06-23. PMID:24597955. |
prolonged treatments with a low concentration of pap inhibitors, although without detectable endocytic effects, still counteracted cell proliferation, induced apoptosis and decreased anchorage-independent growth of cells bearing egfr oncogenic influences. |
2014-06-23 |
2023-08-12 |
Not clear |
| Flávia Andressa Pidone Ribeiro, Juliana Noguti, Celina Tizuko Fujiyama Oshima, Daniel Araki Ribeir. Effective targeting of the epidermal growth factor receptor (EGFR) for treating oral cancer: a promising approach. Anticancer research. vol 34. issue 4. 2014-06-15. PMID:24692681. |
overexpression of egfr results in a poor prognosis in oral cancer and its activation is associated with the malignant phenotype, inhibition of apoptosis and increased metastatic potential. |
2014-06-15 |
2023-08-13 |
Not clear |
| Jungeun Kim, Ying Zhang, Michael Skalski, Josie Hayes, Benjamin Kefas, David Schiff, Benjamin Purow, Sarah Parsons, Sean Lawler, Roger Abounade. microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma. Cancer research. vol 74. issue 5. 2014-06-03. PMID:24425048. |
microrna-148a is a prognostic oncomir that targets mig6 and bim to regulate egfr and apoptosis in glioblastoma. |
2014-06-03 |
2023-08-12 |
human |
| Jungeun Kim, Ying Zhang, Michael Skalski, Josie Hayes, Benjamin Kefas, David Schiff, Benjamin Purow, Sarah Parsons, Sean Lawler, Roger Abounade. microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma. Cancer research. vol 74. issue 5. 2014-06-03. PMID:24425048. |
two direct targets of mir-148a were identified, the egf receptor (egfr) regulator mig6 and the apoptosis regulator bim, which rescue experiments showed were essential to mediate the oncogenic activity of mir-148a. |
2014-06-03 |
2023-08-12 |
human |
| Yongqing Hou, Lei Wang, Dan Yi, Binying Ding, Xing Chen, Qingjing Wang, Huiling Zhu, Yulan Liu, Yulong Yin, Joshua Gong, Guoyao W. Dietary supplementation with tributyrin alleviates intestinal injury in piglets challenged with intrarectal administration of acetic acid. The British journal of nutrition. vol 111. issue 10. 2014-05-28. PMID:24506942. |
collectively, these results indicate that dietary supplementation with 0·1 % tbu alleviates aca-induced intestinal injury possibly by inhibiting apoptosis, promoting tight-junction formation and activating egfr signalling. |
2014-05-28 |
2023-08-12 |
Not clear |
| Elżbieta Płuciennik, Katarzyna Kośla, Katarzyna Wójcik-Krowiranda, Andrzej Bieńkiewicz, Andrzej K Bednare. The WWOX tumor suppressor gene in endometrial adenocarcinoma. International journal of molecular medicine. vol 32. issue 6. 2014-05-27. PMID:24126431. |
quantitative pcr was used to assess the correlation between the expression levels of wwox and the genes involved in the proliferation (mki67), apoptosis (bax, bcl2), signal transduction (egfr), cell cycle (ccne1, ccnd1), cell adhesion (cdh1) and transcription regulation (tp73, ncor1). |
2014-05-27 |
2023-08-12 |
Not clear |
| Jie Gao, Huaiwen Chen, Yongsheng Yu, Jinjing Song, Hao Song, Xiao Su, Wei Li, Xin Tong, Weizhu Qian, Hao Wang, Jianxin Dai, Yajun Gu. Inhibition of hepatocellular carcinoma growth using immunoliposomes for co-delivery of adriamycin and ribonucleotide reductase M2 siRNA. Biomaterials. vol 34. issue 38. 2014-05-21. PMID:24060417. |
adr-rrm2-tlpd delivered adr and rrm2 sirna to egfr overexpressing hcc cells specifically and efficiently both in vitro and in vivo, resulting in enhanced therapeutic effects (cytotoxicity, apoptosis and senescence-inducing activity) compared with single-drug loaded or non-targeted controls, including adr-nc-tlpd (targeted lpd co-delivering adr and negative control sirna), rrm2-tlpd (targeted lpd delivering rrm2 sirna) and adr-rrm2-ntlpd (non-targeted lpd co-delivering adr and rrm2 sirna). |
2014-05-21 |
2023-08-12 |
mouse |