| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diana Braunholz, Mohammad Saki, Franziska Niehr, Merve Öztürk, Berta Borràs Puértolas, Robert Konschak, Volker Budach, Ingeborg Tinhofe. Spheroid Culture of Head and Neck Cancer Cells Reveals an Important Role of EGFR Signalling in Anchorage Independent Survival. PloS one. vol 11. issue 9. 2017-08-10. PMID:27643613. |
the extent of apoptosis, clonogenic survival and egfr signalling under such culture conditions was evaluated. |
2017-08-10 |
2023-08-13 |
Not clear |
| Zhentao Sheng, Lijia Yu, Tianyi Zhang, Xun Pei, Xuan Li, Zhihua Zhang, Wei D. ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling. Journal of cell science. vol 129. issue 10. 2017-07-31. PMID:27056762. |
from a genetic screen in drosophila, we identified synthetic lethal interactions between mutations of fly rb (rbf) and the escrt-0 components stam and hrs we show that inactivation of escrt-0 sensitizes rbf-mutant cells to undergo apoptosis through inhibition of egfr signaling and accumulation of hid protein. |
2017-07-31 |
2023-08-13 |
drosophila_melanogaster |
| Haiquan Lu, Xinqun Li, Yang Lu, Songbo Qiu, Zhen Fa. ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis. Cancer letters. vol 381. issue 1. 2017-07-28. PMID:27450723. |
cetuximab thereby sensitized hnscc cells to reactive oxygen species (ros)-induced apoptosis and, importantly, it is independent of effective inhibition of egfr downstream signaling by cetuximab. |
2017-07-28 |
2023-08-13 |
human |
| Haiquan Lu, Xinqun Li, Yang Lu, Songbo Qiu, Zhen Fa. ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis. Cancer letters. vol 381. issue 1. 2017-07-28. PMID:27450723. |
in contrast, knockdown of egfr by sirna or inhibition of egfr kinase with gefitinib, an egfr kinase inhibitor, failed to sensitize hnscc cells to ros-induced apoptosis. |
2017-07-28 |
2023-08-13 |
human |
| Xue Wang, Nan Zheng, Jing Dong, Xuming Wang, Lijiang Liu, Jian Huan. Estrogen receptor-α36 is involved in icaritin induced growth inhibition of triple-negative breast cancer cells. The Journal of steroid biochemistry and molecular biology. vol 171. 2017-07-18. PMID:28529129. |
our study demonstrated that icartin decreased both er-α36 and egfr protein expression, and induced apoptosis in tnbc mda-mb-231 and mda-mb-453 cells. |
2017-07-18 |
2023-08-13 |
human |
| Cezary Treda, Marta Popeda, Magdalena Ksiazkiewicz, Dawid P Grzela, Maciej P Walczak, Mateusz Banaszczyk, Joanna Peciak, Ewelina Stoczynska-Fidelus, Piotr Riesk. EGFR Activation Leads to Cell Death Independent of PI3K/AKT/mTOR in an AD293 Cell Line. PloS one. vol 11. issue 5. 2017-07-07. PMID:27153109. |
there are also reports that overexpression and activation of wild-type egfr may lead to cell apoptosis. |
2017-07-07 |
2023-08-13 |
human |
| Cezary Treda, Marta Popeda, Magdalena Ksiazkiewicz, Dawid P Grzela, Maciej P Walczak, Mateusz Banaszczyk, Joanna Peciak, Ewelina Stoczynska-Fidelus, Piotr Riesk. EGFR Activation Leads to Cell Death Independent of PI3K/AKT/mTOR in an AD293 Cell Line. PloS one. vol 11. issue 5. 2017-07-07. PMID:27153109. |
ad293 cells overexpressing wild-type egfr, despite a significant proliferation increase in serum supplemented medium, underwent apoptosis after egf stimulation in serum free conditions. |
2017-07-07 |
2023-08-13 |
human |
| Cezary Treda, Marta Popeda, Magdalena Ksiazkiewicz, Dawid P Grzela, Maciej P Walczak, Mateusz Banaszczyk, Joanna Peciak, Ewelina Stoczynska-Fidelus, Piotr Riesk. EGFR Activation Leads to Cell Death Independent of PI3K/AKT/mTOR in an AD293 Cell Line. PloS one. vol 11. issue 5. 2017-07-07. PMID:27153109. |
moreover, apoptosis was not prevented by inhibiting egfr downstream proteins (pi3k, akt and mtor). |
2017-07-07 |
2023-08-13 |
human |
| Yu Nakamura, Yosuke Togashi, Hirokazu Nakahara, Shuta Tomida, Eri Banno, Masato Terashima, Hidetoshi Hayashi, Marco A de Velasco, Kazuko Sakai, Yoshihiko Fujita, Takatsugu Okegawa, Kikuo Nutahara, Suguru Hamada, Kazuto Nishi. Afatinib against Esophageal or Head-and-Neck Squamous Cell Carcinoma: Significance of Activating Oncogenic HER4 Mutations in HNSCC. Molecular cancer therapeutics. vol 15. issue 8. 2017-06-29. PMID:27207775. |
afatinib dramatically reduced the phosphorylation level of egfr or her4 and induced apoptosis in the two cell lines. |
2017-06-29 |
2023-08-13 |
Not clear |
| Elena Ciaglia, Mario Abate, Chiara Laezza, Simona Pisanti, Mario Vitale, Vincenzo Seneca, Giovanni Torelli, Silvia Franceschelli, Giuseppe Catapano, Patrizia Gazzerro, Maurizio Bifulc. Antiglioma effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, through the downregulation of epidermal growth factor receptor. International journal of cancer. vol 140. issue 4. 2017-06-23. PMID:27813087. |
ipa powerfully inhibited tumor cell growth and induced caspase-dependent apoptosis through a mechanism involving a marked accumulation of the pro-apoptotic bim protein and inhibition of egfr. |
2017-06-23 |
2023-08-13 |
mouse |
| Jiang Pi, Hua Jin, Jinhuan Jiang, Fen Yang, Huaihong Cai, Peihui Yang, Jiye Cai, Zheng W Che. Single molecule force spectroscopy for in-situ probing oridonin inhibited ROS-mediated EGF-EGFR interactions in living KYSE-150 cells. Pharmacological research. vol 119. 2017-06-19. PMID:28411855. |
oridonin was found to induce apoptosis and also reduce egfr expression in kyse-150 cells. |
2017-06-19 |
2023-08-13 |
Not clear |
| David Quintero, Jamie Carrafa, Lena Vincent, David Bermude. EGFR-targeted Chimeras of Pseudomonas ToxA released into the extracellular milieu by attenuated Salmonella selectively kill tumor cells. Biotechnology and bioengineering. vol 113. issue 12. 2017-06-15. PMID:27260220. |
in this study, we demonstrate the ability of the salmonella strain vnp20009 to produce three different forms of the pseudomonas exotoxin a (toxa) chimeric with a tumor growth factor alpha (tgfα) which results in its producing culture supernatants that are cytotoxic and induce apoptosis in egfr positive cancer cells as measured by the tetrazolium dye reduction, and rhodamine 123 and jc-10 mitochondrial depolarization assays. |
2017-06-15 |
2023-08-13 |
human |
| Yan Zhou, Yuan Li, Hong-Min Ni, Wen-Xing Ding, Hua Zhon. Nrf2 but not autophagy inhibition is associated with the survival of wild-type epidermal growth factor receptor non-small cell lung cancer cells. Toxicology and applied pharmacology. vol 310. 2017-05-31. PMID:27639429. |
in the present study, we confirmed that icotinib and gefitinib induced apoptosis in egfr mutant hcc827 but not in egfr wild-type a549 nsclc cells. |
2017-05-31 |
2023-08-13 |
Not clear |
| Jianchun Chen, Raymond C Harri. Interaction of the EGF Receptor and the Hippo Pathway in the Diabetic Kidney. Journal of the American Society of Nephrology : JASN. vol 27. issue 6. 2017-05-24. PMID:26453611. |
activation of the egf receptor (egfr) or the hippo signaling pathway can control cell proliferation, apoptosis, and differentiation, and the dysregulation of these pathways can contribute to tumorigenesis. |
2017-05-24 |
2023-08-13 |
mouse |
| Olesea Cojohari, Megan A Peppenelli, Gary C Cha. Human Cytomegalovirus Induces an Atypical Activation of Akt To Stimulate the Survival of Short-Lived Monocytes. Journal of virology. vol 90. issue 14. 2017-05-18. PMID:27147739. |
here, we show that hcmv glycoprotein gb binding to cellular epidermal growth factor receptor (egfr) during hcmv entry initiated a rapid (within 15 min) activation of the apoptosis suppressor akt, which was maintained through 72 h. the virus-induced activation of akt was more robust than that with the normal myeloid growth factor macrophage colony-stimulating factor (m-csf) and was essential for infected monocytes to bypass the 48-h viability checkpoint. |
2017-05-18 |
2023-08-13 |
human |
| Nicole M Jackson, Brian P Ceres. Protein Kinase G facilitates EGFR-mediated cell death in MDA-MB-468 cells. Experimental cell research. vol 346. issue 2. 2017-05-15. PMID:27381222. |
the epidermal growth factor receptor (egfr) is a transmembrane receptor tyrosine kinase with critical implications in cell proliferation, migration, wound healing and the regulation of apoptosis. |
2017-05-15 |
2023-08-13 |
human |
| Nicole M Jackson, Brian P Ceres. Protein Kinase G facilitates EGFR-mediated cell death in MDA-MB-468 cells. Experimental cell research. vol 346. issue 2. 2017-05-15. PMID:27381222. |
this particular cell line hyper-expresses the egfr and undergoes egfr-mediated apoptosis in response to egf ligand. |
2017-05-15 |
2023-08-13 |
human |
| Zhi-Dong Chen, Liang Xu, Kan-Kai Tang, Fang-Xiao Gong, Jing-Quan Liu, Yin Ni, Ling-Zhi Jiang, Jun Hong, Fang Han, Qian Li, Xiang-Hong Yang, Ren-Hua Sun, Shi-Jing M. NF-κB-dependent transcriptional upregulation of cyclin D1 exerts cytoprotection against hypoxic injury upon EGFR activation. Experimental cell research. vol 347. issue 1. 2017-05-15. PMID:27443256. |
here we report that epidermal growth factor receptor (egfr) activation prevents neuron-like pc12 cells apoptosis in response to hypoxia via restoring nf-κb-dependent transcriptional upregulation of cyclin d1. |
2017-05-15 |
2023-08-13 |
Not clear |
| Zhi-Dong Chen, Liang Xu, Kan-Kai Tang, Fang-Xiao Gong, Jing-Quan Liu, Yin Ni, Ling-Zhi Jiang, Jun Hong, Fang Han, Qian Li, Xiang-Hong Yang, Ren-Hua Sun, Shi-Jing M. NF-κB-dependent transcriptional upregulation of cyclin D1 exerts cytoprotection against hypoxic injury upon EGFR activation. Experimental cell research. vol 347. issue 1. 2017-05-15. PMID:27443256. |
functionally, egfr activation by egf stimulation mitigates hypoxia-induced pc12 cells apoptosis in both dose- and time-dependent manner. |
2017-05-15 |
2023-08-13 |
Not clear |
| Tung-Yi Lin, Hsien-Yeh Hsu, Wei-Hsuan Sun, Tsung-Han Wu, Shu-Ming Tsa. Induction of Cbl-dependent epidermal growth factor receptor degradation in Ling Zhi-8 suppressed lung cancer. International journal of cancer. vol 140. issue 11. 2017-05-01. PMID:28198003. |
in our study, we demonstrated that recombinant lz-8 (rlz-8), a medicinal mushroom ganoderma lucidum protein, induced cell cycle arrest and apoptosis by downregulating the expression of wild-type and mutated egfr and inhibiting egfr downstream effectors, akt and erk1/2 in lung cancer cells. |
2017-05-01 |
2023-08-13 |
mouse |