| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuedong Wang, Jianping Zeng, Liang Wang, Xinjing Zhang, Zhiqian Liu, Hongyi Zhang, Jiahong Don. Overexpression of microRNA-133b is associated with the increased survival of patients with hepatocellular carcinoma after curative hepatectomy: Involvement of the EGFR/PI3K/Akt/mTOR signaling pathway. Oncology reports. vol 38. issue 1. 2018-04-06. PMID:28586051. |
moreover, the overexpression of mirna-133b inhibited cell proliferation, increased lactate dehydrogenase (ldh) activity, induced apoptosis and promoted caspase‑3/-8 activities and bax/bcl-2 protein expression in hcc cells, whereas the protein expression of epidermal growth factor receptor (egfr) was significantly decreased. |
2018-04-06 |
2023-08-13 |
Not clear |
| Xuedong Wang, Jianping Zeng, Liang Wang, Xinjing Zhang, Zhiqian Liu, Hongyi Zhang, Jiahong Don. Overexpression of microRNA-133b is associated with the increased survival of patients with hepatocellular carcinoma after curative hepatectomy: Involvement of the EGFR/PI3K/Akt/mTOR signaling pathway. Oncology reports. vol 38. issue 1. 2018-04-06. PMID:28586051. |
gw2974, an egfr inhibitor, suppressed the protein expression of egfr, inhibited cell proliferation, increased ldh activity, induced apoptosis and promoted caspase-3/-8 activities and bax/bcl-2 protein expression, downregulated pi3k, p-akt and p-mtor protein expression in the transfected hcc cells overexpressing mirna-133b. |
2018-04-06 |
2023-08-13 |
Not clear |
| Anne Nègre-Salvayre, Sandra Garoby-Salom, Audrey Swiader, Myriam Rouahi, Mélanie Pucelle, Robert Salvayr. Proatherogenic effects of 4-hydroxynonenal. Free radical biology & medicine. vol 111. 2018-04-03. PMID:28040472. |
among a variety of cellular targets, hne can modify signaling proteins involved in atherosclerotic plaque remodeling, particularly growth factor receptors (pdgfr, egfr), cell cycle proteins, mitochondrial and endoplasmic reticulum components or extracellular matrix proteins, which progressively alters smooth muscle cell proliferation, angiogenesis and induces apoptosis. |
2018-04-03 |
2023-08-13 |
Not clear |
| Andreza Conceição Véras de Aguiar Guerra, Luiz Alberto Lira Soares, Magda Rhayanny Assunção Ferreira, Aurigena Antunes de Araújo, Hugo Alexandre de Oliveira Rocha, Juliana Silva de Medeiros, Rômulo Dos Santos Cavalcante, Raimundo Fernandes de Araújo Júnio. Libidibia ferrea presents antiproliferative, apoptotic and antioxidant effects in a colorectal cancer cell line. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-04-03. PMID:28586741. |
using methodologies that involved flow cytometry, spectrophotometry and rt-qpcr assays, crude extracts of the fruits of l. ferrea (20t, 40t, 60t and 80t) were evaluated at 24h and/or 48h for: their ability to inhibit cell proliferation; induce apoptosis through bcl-2, caspase-3 and apaf-1; their antioxidant activity and effects on important targets related to cell proliferation (egfr and akt) in the ht-29 human colorectal cancer lineage. |
2018-04-03 |
2023-08-13 |
human |
| Emi Harada, Satoshi Serada, Minoru Fujimoto, Yusuke Takahashi, Tsuyoshi Takahashi, Hisashi Hara, Rie Nakatsuka, Takahito Sugase, Takahiko Nishigaki, Yurina Saito, Kosuke Hiramatsu, Satoshi Nojima, Risa Mitsuo, Tomoharu Ohkawara, Eiichi Morii, Masaki Mori, Yuichiro Doki, Yasufumi Kaneda, Tetsuji Nak. Glypican-1 targeted antibody-based therapy induces preclinical antitumor activity against esophageal squamous cell carcinoma. Oncotarget. vol 8. issue 15. 2018-03-23. PMID:28445969. |
knockdown of gpc1 decreased growth of escc cells and induced apoptosis via inhibition of egfr, akt and p44/42-mapk signaling pathways in vitro. |
2018-03-23 |
2023-08-13 |
mouse |
| Li Wang, Haifeng Li, Shiping Yang, Wenqiang Ma, Mei Liu, Shichao Guo, Jun Zhan, Hongquan Zhang, Suk Ying Tsang, Ziding Zhang, Zhaoyi Wang, Xiru Li, Yang-Dong Guo, Xiangdong L. Cyanidin-3-o-glucoside directly binds to ERα36 and inhibits EGFR-positive triple-negative breast cancer. Oncotarget. vol 7. issue 42. 2018-03-22. PMID:27655695. |
in this study, we found that cyanidin-3-o-glucoside (cy-3-glu) preferentially promotes the apoptosis of tnbc cells, which co-express the estrogen receptor alpha 36 (erα36) and the epidermal growth factor receptor (egfr). |
2018-03-22 |
2023-08-13 |
mouse |
| Xi Cheng, Bingrui Wang, Zhijian Jin, Ding Ma, Weiping Yang, Ren Zhao, Xiaoqian Jing, Baiyong Shen, Chenghong Peng, Weihua Qi. Pseudomonas aeruginosa-mannose-sensitive hemagglutinin inhibits pancreatic cancer cell proliferation and induces apoptosis via the EGFR pathway and caspase signaling. Oncotarget. vol 7. issue 47. 2018-03-20. PMID:27788491. |
pseudomonas aeruginosa-mannose-sensitive hemagglutinin inhibits pancreatic cancer cell proliferation and induces apoptosis via the egfr pathway and caspase signaling. |
2018-03-20 |
2023-08-13 |
mouse |
| Xi Cheng, Bingrui Wang, Zhijian Jin, Ding Ma, Weiping Yang, Ren Zhao, Xiaoqian Jing, Baiyong Shen, Chenghong Peng, Weihua Qi. Pseudomonas aeruginosa-mannose-sensitive hemagglutinin inhibits pancreatic cancer cell proliferation and induces apoptosis via the EGFR pathway and caspase signaling. Oncotarget. vol 7. issue 47. 2018-03-20. PMID:27788491. |
pa-msha-mediated inhibition of egfr signaling and activation of the caspase pathway may play an important role in the induction of apoptosis in pancreatic cancer cells. |
2018-03-20 |
2023-08-13 |
mouse |
| Daejin Lim, Kwang Soo Kim, Hyunju Kim, Kyong-Cheol Ko, Jae Jun Song, Jong Hyun Choi, Minsang Shin, Jung-Joon Min, Jae-Ho Jeong, Hyon E Cho. Anti-tumor activity of an immunotoxin (TGFα-PE38) delivered by attenuated Salmonella typhimurium. Oncotarget. vol 8. issue 23. 2018-03-19. PMID:28473665. |
tumor cells with high level of egfr undergo apoptosis upon treatment with tgfα-pe38. |
2018-03-19 |
2023-08-13 |
mouse |
| Patricia G Tremblay, Marc-André Sirar. Transcriptomic analysis of gene cascades involved in protein kinase A and C signaling in the KGN line of human ovarian granulosa tumor cells†. Biology of reproduction. vol 96. issue 4. 2018-03-12. PMID:28383663. |
gene associations with seven major ovarian functions were identified: prostaglandin- endoperoxide synthase 2 (ptgs2), interleukin 8 (il8), and interleukin 6 (il6) with inflammation; steroidogenic acute regulatory protein (star), cytochrome p450scc (cyp11a1), and cytochrome p450 family 19 subfamily a member 1 (cyp19a1) with steroidogenesis; vascular endothelial growth factor c (vegfc), vascular endothelial growth factor a (vegfa), and c-x-c chemokine receptor type 4 (cxcr4) with angiogenesis; amphiregulin (areg), epidermal growth factor receptor (egfr), and sprouty rtk signaling antagonist 2 (spry2) with differentiation, bcl2 associated x (bax), bcl2 like 12 (bcl2l12), and caspase 1(casp1) with apoptosis, cyclin d1 (ccnd1), cyclin b1 (ccnb1), and cyclin b2 (ccnb2) with division; and matrix metalloproteinase-1 (mmp1), matrix metallopeptidase 9 (mmp9), and timp metallopeptidase inhibitor 1 (timp1) with ovulation. |
2018-03-12 |
2023-08-13 |
human |
| Caterina Peraldo Neia, Giuliana Cavalloni, Giovanna Chiorino, Paola Ostano, Massimo Aglietta, Francesco Leon. Gene and microRNA modulation upon trabectedin treatment in a human intrahepatic cholangiocarcinoma paired patient derived xenograft and cell line. Oncotarget. vol 7. issue 52. 2018-03-09. PMID:27902465. |
in the pdx model, trabectedin affected ecm-receptor interaction, focal adhesion, complement and coagulation cascades, hedgehog, mapk, egfr signaling via pip3 pathway, and apoptosis. |
2018-03-09 |
2023-08-13 |
human |
| Giuliana Cassinelli, Enrica Favini, Laura Dal Bo, Monica Tortoreto, Marcella De Maglie, Gianpaolo Dagrada, Silvana Pilotti, Franco Zunino, Nadia Zaffaroni, Cinzia Lanz. Antitumor efficacy of the heparan sulfate mimic roneparstat (SST0001) against sarcoma models involves multi-target inhibition of receptor tyrosine kinases. Oncotarget. vol 7. issue 30. 2018-03-01. PMID:27374103. |
biochemical and histological/immunohistochemical ex vivo analyses confirmed a reduced activation of erbb4, egfr, insr, igf1r, associated with apoptosis induction and angiogenesis inhibition in a drug-treated ewing's sarcoma family tumor xenograft. |
2018-03-01 |
2023-08-13 |
human |
| Gabriella Mincione, Maria Carmela Di Marcantonio, Chiara Tarantelli, Luca Savino, Donatella Ponti, Marco Marchisio, Paola Lanuti, Silvia Sancilio, Antonella Calogero, Roberta Di Pietro, Raffaella Murar. Identification of the zinc finger 216 (ZNF216) in human carcinoma cells: a potential regulator of EGFR activity. Oncotarget. vol 7. issue 46. 2018-02-26. PMID:27732953. |
surprisingly, egf treatment of nih3t3-egfr/znf216 cells induced a significant increase of apoptosis thus indicating that znf216 could sensitize cells to egf-induced apoptosis and suggesting that it may be involved in the regulation and effects of egfr signaling. |
2018-02-26 |
2023-08-13 |
human |
| Ye Feng, Shuohui Gao, Yongjian Gao, Xuefeng Wang, Zhi Che. Anti-EGFR antibody sensitizes colorectal cancer stem-like cells to Fluorouracil-induced apoptosis by affecting autophagy. Oncotarget. vol 7. issue 49. 2018-02-23. PMID:27833077. |
together, our data suggest that egfr monoclonal antibody may sensitize csc-like crc cells to 5-fu-induced apoptosis by affecting autophagy. |
2018-02-23 |
2023-08-13 |
Not clear |
| Jung Min Song, Arunkumar Anandharaj, Pramod Upadhyaya, Ameya R Kirtane, Jong-Hyuk Kim, Kwon Ho Hong, Jayanth Panyam, Fekadu Kassi. Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors. Oncotarget. vol 7. issue 36. 2018-02-22. PMID:27458163. |
here, we showed that honokiol (2.5-7.5 μm), a bioactive compound of magnolia officinalis, differentially suppressed proliferation (up to 93%) and induced apoptosis (up to 61%) of egfr overexpressing tumorigenic bronchial cells and these effects were paralleled by downregulation of phospho-egfr, phospho-akt, phospho-stat3 and cell cycle-related proteins as early as 6-12 h post-treatment. |
2018-02-22 |
2023-08-13 |
mouse |
| Su-Hyung Lee, Jun-Won Park, Sang-Ho Woo, Du-Min Go, Hyo-Jung Kwon, Ja-June Jang, Dae-Yong Ki. Suppression of osteopontin inhibits chemically induced hepatic carcinogenesis by induction of apoptosis in mice. Oncotarget. vol 7. issue 52. 2018-02-22. PMID:27888617. |
apoptosis was significantly enhanced in opn ko mice, and was accompanied by the downregulation of epidermal growth factor receptor (egfr). |
2018-02-22 |
2023-08-13 |
mouse |
| Xin-Min Zhao, Shi-Yun Pan, Qi-Ling Huang, You-Ni Lu, Xiang-Hua Wu, Jian-Hua Chang, Zhe-Bin Liu, Xu-Wei Cai, Qi Liu, Jia-Lei Wang, Xiao-Long F. PA-MSHA in combination with EGFR tyrosine kinase inhibitor: A new strategy to overcome the drug resistance of non-small cell lung cancer cells. Oncotarget. vol 7. issue 31. 2018-02-21. PMID:27283902. |
using nsclc cell lines with differential egfr status, we examined the potency of pa-msha (pseudomonas aeruginosa-mannose-sensitive hemagglutinin) in combination with gefitinib on proliferation, apoptosis, cell cycle arrest, egfr signaling and tumor growth. |
2018-02-21 |
2023-08-13 |
mouse |
| Zheng Yang, Xiaohui Hu, Shaolin Zhang, Wen Zhang, Kin Yip Ta. Pharmacological synergism of 2,2-dichloroacetophenone and EGFR-TKi to overcome TKi-induced resistance in NSCLC cells. European journal of pharmacology. vol 815. 2018-02-08. PMID:28870456. |
in comparison with either dap or egfr-tki applied alone, the combination treatment not only further suppressed the egfr signaling in vitro and in vivo, but also significantly promoted cell apoptosis. |
2018-02-08 |
2023-08-13 |
Not clear |
| Lumin Wang, Hongfei Sun, Xiaofei Wang, Ni Hou, Lingyu Zhao, Dongdong Tong, Kang He, Yang Yang, Tusheng Song, Jun Yang, Chen Huan. EGR1 mediates miR-203a suppress the hepatocellular carcinoma cells progression by targeting HOXD3 through EGFR signaling pathway. Oncotarget. vol 7. issue 29. 2018-02-06. PMID:27244890. |
silencing hoxd3 could block transition of the g2/m phase, increase cell apoptosis, decrease the expression of cell cycle and apoptosis-related proteins, egfr, p-akt, p-erk, ccnb1, cdk1 and bcl2 by targeting egfr through egfr/akt and erk cell signaling pathways. |
2018-02-06 |
2023-08-13 |
Not clear |
| Abhilash Venugopalan, Min-Jung Lee, Gang Niu, José Medina-Echeverz, Yusuke Tomita, Martin J Lizak, Constance M Cultraro, Robert Mark Simpson, Xiaoyuan Chen, Jane B Trepel, Udayan Guh. EGFR-targeted therapy results in dramatic early lung tumor regression accompanied by imaging response and immune infiltration in EGFR mutant transgenic mouse models. Oncotarget. vol 7. issue 34. 2018-02-05. PMID:27494838. |
the imaging responses correlated with the inhibition of downstream egfr signaling, increased apoptosis, and decreased proliferation in the tumor tissues. |
2018-02-05 |
2023-08-13 |
mouse |