| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Malte Kriegs, Ulla Kasten-Pisula, Britta Riepen, Konstantin Hoffer, Nina Struve, Laura Myllynen, Friederike Braig, Mascha Binder, Thorsten Rieckmann, Reidar Grénman, Cordula Petersen, Ekkehard Dikomey, Kai Rothkam. Radiosensitization of HNSCC cells by EGFR inhibition depends on the induction of cell cycle arrests. Oncotarget. vol 7. issue 29. 2018-01-30. PMID:27281611. |
because egfr targeting in combination with radiotherapy is used to treat head and neck squamous cell carcinomas (hnscc) which are predominantly p53 mutated, we tested the effects of egfr targeting on cellular radiosensitivity, proliferation, apoptosis, dna repair and cell cycle control using a large panel of hnscc cell lines. |
2018-01-30 |
2023-08-13 |
Not clear |
| Tiening Zhang, Xun Cai, Qi Li, Peng Xue, Zhixiao Chen, Xiao Dong, Ying Xu. Hsa-miR-875-5p exerts tumor suppressor function through down-regulation of EGFR in colorectal carcinoma (CRC). Oncotarget. vol 7. issue 27. 2018-01-15. PMID:27302926. |
taken together, our results demonstrated that mir-875-5p played a pivotal role on crc through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic egfr. |
2018-01-15 |
2023-08-13 |
Not clear |
| Vijayalakshmi Thamilselvan, Mani Menon, Gary S Stein, Fred Valeriote, Sivagnanam Thamilselva. Combination of Carmustine and Selenite Inhibits EGFR Mediated Growth Signaling in Androgen-Independent Prostate Cancer Cells. Journal of cellular biochemistry. vol 118. issue 12. 2018-01-02. PMID:28430389. |
therefore, in this study, we investigated whether the combination of carmustine and selenite could inhibit egfr mediated growth signaling and induce apoptosis in androgen independent-ar negative prostate cancer cells. |
2018-01-02 |
2023-08-13 |
Not clear |
| Vijayalakshmi Thamilselvan, Mani Menon, Gary S Stein, Fred Valeriote, Sivagnanam Thamilselva. Combination of Carmustine and Selenite Inhibits EGFR Mediated Growth Signaling in Androgen-Independent Prostate Cancer Cells. Journal of cellular biochemistry. vol 118. issue 12. 2018-01-02. PMID:28430389. |
overall, our findings demonstrated that the combination of carmustine and selenite treatment dramatically inhibits egfr signaling, proliferation, and induces apoptosis in aipc cells, suggesting a potential candidate for the treatment of crpc. |
2018-01-02 |
2023-08-13 |
Not clear |
| Xia Li, Xing-Xing Fan, Ze-Bo Jiang, Wings Ty Loo, Xiao-Jun Yao, Elaine Lai-Han Leung, Louis Wc Chow, Liang Li. Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway. Pharmacological research. vol 115. 2017-12-27. PMID:27864022. |
the enhancement of ros generation in h1650 and h1975 gefitinib-resistant nsclc cells leads to impairment of growth and induction of apoptosis, whereas modulation of egfr degradation and its downstream signalling pathways by shikonin contributes to its anti-tumour properties in h1975 gefitinib-resistant nsclc cells (with t790m and l858r activating mutations). |
2017-12-27 |
2023-08-13 |
Not clear |
| Qing-Shan Yang, Li-Peng Jiang, Chun-Yan He, Yu-Na Tong, Yuan-Yuan Li. Up-Regulation of MicroRNA-133a Inhibits the MEK/ERK Signaling Pathway to Promote Cell Apoptosis and Enhance Radio-Sensitivity by Targeting EGFR in Esophageal Cancer In Vivo and In Vitro. Journal of cellular biochemistry. vol 118. issue 9. 2017-12-26. PMID:27933650. |
up-regulation of microrna-133a inhibits the mek/erk signaling pathway to promote cell apoptosis and enhance radio-sensitivity by targeting egfr in esophageal cancer in vivo and in vitro. |
2017-12-26 |
2023-08-13 |
human |
| Qing-Shan Yang, Li-Peng Jiang, Chun-Yan He, Yu-Na Tong, Yuan-Yuan Li. Up-Regulation of MicroRNA-133a Inhibits the MEK/ERK Signaling Pathway to Promote Cell Apoptosis and Enhance Radio-Sensitivity by Targeting EGFR in Esophageal Cancer In Vivo and In Vitro. Journal of cellular biochemistry. vol 118. issue 9. 2017-12-26. PMID:27933650. |
this study aims to explore how microrna-133a (mir-133a) affects cell apoptosis and radio-sensitivity by targeting egfr via regulating mek/erk pathway in esophageal cancer (ec). |
2017-12-26 |
2023-08-13 |
human |
| Qing-Shan Yang, Li-Peng Jiang, Chun-Yan He, Yu-Na Tong, Yuan-Yuan Li. Up-Regulation of MicroRNA-133a Inhibits the MEK/ERK Signaling Pathway to Promote Cell Apoptosis and Enhance Radio-Sensitivity by Targeting EGFR in Esophageal Cancer In Vivo and In Vitro. Journal of cellular biochemistry. vol 118. issue 9. 2017-12-26. PMID:27933650. |
compared with the blank and nc groups, the mir-133a mimic and si-egfr groups exhibited increased cell apoptosis rate but decreased egfr, p-mek1/2, and p-erk1/2 protein expressions; while opposite trend was observed in the mir-133a inhibitors group. |
2017-12-26 |
2023-08-13 |
human |
| Qing-Shan Yang, Li-Peng Jiang, Chun-Yan He, Yu-Na Tong, Yuan-Yuan Li. Up-Regulation of MicroRNA-133a Inhibits the MEK/ERK Signaling Pathway to Promote Cell Apoptosis and Enhance Radio-Sensitivity by Targeting EGFR in Esophageal Cancer In Vivo and In Vitro. Journal of cellular biochemistry. vol 118. issue 9. 2017-12-26. PMID:27933650. |
compared with the mir-133a inhibitors group, the mir-133a inhibitors + si-egfr group presented reduced cell survival rate, egfr, p-mek1/2, and p-erk1/2 protein expressions but increased cell apoptosis rate. |
2017-12-26 |
2023-08-13 |
human |
| Qing-Shan Yang, Li-Peng Jiang, Chun-Yan He, Yu-Na Tong, Yuan-Yuan Li. Up-Regulation of MicroRNA-133a Inhibits the MEK/ERK Signaling Pathway to Promote Cell Apoptosis and Enhance Radio-Sensitivity by Targeting EGFR in Esophageal Cancer In Vivo and In Vitro. Journal of cellular biochemistry. vol 118. issue 9. 2017-12-26. PMID:27933650. |
these results indicated that mir-133a could inhibit the mek/erk pathway to promote cell apoptosis and enhance radio-sensitivity by targeting egfr in ec. |
2017-12-26 |
2023-08-13 |
human |
| Kirstine Jacobsen, Jordi Bertran-Alamillo, Miguel Angel Molina, Cristina Teixidó, Niki Karachaliou, Martin Haar Pedersen, Josep Castellví, Mónica Garzón, Carles Codony-Servat, Jordi Codony-Servat, Ana Giménez-Capitán, Ana Drozdowskyj, Santiago Viteri, Martin R Larsen, Ulrik Lassen, Enriqueta Felip, Trever G Bivona, Henrik J Ditzel, Rafael Rosel. Convergent Akt activation drives acquired EGFR inhibitor resistance in lung cancer. Nature communications. vol 8. issue 1. 2017-12-26. PMID:28871105. |
combined treatment with an egfr tyrosine kinase inhibitor and akt inhibitor causes apoptosis and synergistic growth inhibition in multiple egfr tyrosine kinase inhibitor-resistant non-small-cell lung cancer models. |
2017-12-26 |
2023-08-13 |
Not clear |
| Huixing Chen, Lan Zhou, Xiaorong Wu, Rongbing Li, Jiling Wen, Jianjun Sha, Xiaofei We. The PI3K/AKT pathway in the pathogenesis of prostate cancer. Frontiers in bioscience (Landmark edition). vol 21. 2017-12-19. PMID:27100493. |
inflammatory cytokines (ccr9, il-6, and tlr3) regulate pi3k/akt signaling during apoptosis of pca cells, and pi3k/akt signaling participates with androgen-, 1alpha,25(oh)2-vitamin d3-, and prostaglandin-associated mechanisms and is regulated by erbb, egfr, and the her family during cell growth. |
2017-12-19 |
2023-08-13 |
Not clear |
| Cuicui Zhu, Qingyi Zhu, Zhaomeng Wu, Yingying Yin, Dan Kang, Shan Lu, Ping Li. Isorhapontigenin induced cell growth inhibition and apoptosis by targeting EGFR-related pathways in prostate cancer. Journal of cellular physiology. vol 233. issue 2. 2017-11-21. PMID:28422286. |
in this study, we found for the first time that iso apparently induced cell growth inhibition and apoptosis by targeting egfr and its downstream signal pathways in prostate cancer (pca) cells both in vitro and in vivo, whereas no obviously effect on normal prostate cells. |
2017-11-21 |
2023-08-13 |
mouse |
| Nicole Tegtmeyer, Matthias Neddermann, Carmen Isabell Asche, Steffen Backer. Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA. Molecular microbiology. vol 105. issue 3. 2017-11-16. PMID:28508421. |
here we review the signal transmission by translocated caga on multiple receptor kinases (c-met and egfr) and non-receptor kinases (src, abl, csk, apkc, par1, pi3k, akt, fak, gsk-3, jak, pak1, pak2 and map kinases), manipulating a selection of fundamental processes in the human gastric epithelium such as cell adhesion, polarity, proliferation, motility, receptor endocytosis, cytoskeletal rearrangements, apoptosis, inflammation and cell cycle progression. |
2017-11-16 |
2023-08-13 |
human |
| Pilar Diz Taín, Ana López González, Andrés García-Palom. [Mechanism of action and preclinical development of afatinib]. Medicina clinica. vol 146 Suppl 1. 2017-11-09. PMID:27426242. |
covalent attachment to cysteine residues in the catalytic domain of egfr, her2 and erbb4 inhibits the tyrosine kinase activity (tkis) of these receptors, decreasing auto- and transphosphorylation between erbb dimers, and thus blocking the activity of downstream signalling pathways related to growth and apoptosis suppression. |
2017-11-09 |
2023-08-13 |
Not clear |
| Baoman Li, Shuang Qi, Guangfeng Sun, Li Yang, Jidong Han, Yue Zhu, Maosheng Xi. Leptin suppresses adenosine triphosphate-induced impairment of spinal cord astrocytes. Journal of neuroscience research. vol 94. issue 10. 2017-11-03. PMID:27316329. |
in this study, we found that 1) prolonged leptin treatment suppressed the atp-stimulated release of aa and pge2 from cultured spinal cord astrocytes; 2) leptin elevated the expression of caveolin-1 (cav-1) via the jak2/stat3 signaling pathway; 3) cav-1 blocked the interaction between src and egfr, thereby inhibiting the phosphorylation of egfr and cpla2 and attenuating the release of aa or pge2; 4) pretreatment with leptin decreased ;he level of apoptosis and the release of interleukin-6 from cocultured neurons and astrocytes; and 5) leptin improved the recovery of locomotion in mice after sci. |
2017-11-03 |
2023-08-13 |
mouse |
| Su-Mi Kim, Yun-Hee Rhee, Jong-Soo Ki. The Anticancer Effects of Radachlorin-mediated Photodynamic Therapy in the Human Endometrial Adenocarcinoma Cell Line HEC-1-A. Anticancer research. vol 37. issue 11. 2017-10-31. PMID:29061808. |
we investigated the effect of photodynamic therapy (pdt) using radachlorin on invasion, vascular formation and apoptosis by targeting epidermal growth factor receptor (egfr)/vascular endothelial growth factor receptor 2 (vegfr2) signaling pathways in the hec-1-a endometrial adenocarcinoma cell line. |
2017-10-31 |
2023-08-13 |
human |
| Xiaoqing Guo, Yue Meng, Xiaotong Sheng, Yuan Guan, Fenglei Zhang, Zhen Han, Yuying Kang, Guihua Tai, Yifa Zhou, Hairong Chen. Tunicamycin enhances human colon cancer cells to TRAIL-induced apoptosis by JNK-CHOP-mediated DR5 upregulation and the inhibition of the EGFR pathway. Anti-cancer drugs. vol 28. issue 1. 2017-10-19. PMID:27603596. |
tunicamycin enhances human colon cancer cells to trail-induced apoptosis by jnk-chop-mediated dr5 upregulation and the inhibition of the egfr pathway. |
2017-10-19 |
2023-08-13 |
human |
| Yongfei Chen, Jiaxin Wu, Aoli Wang, Ziping Qi, Taoshan Jiang, Cheng Chen, Fengming Zou, Chen Hu, Wei Wang, Hong Wu, Zhenquan Hu, Wenchao Wang, Beilei Wang, Li Wang, Tao Ren, Shanchun Zhang, Qingsong Liu, Jing Li. Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC. European journal of medicinal chemistry. vol 139. 2017-10-16. PMID:28850922. |
in the cellular context it strongly affected egfr and alk mediated signaling pathways, induced apoptosis and arrested cell cycle at g0/g1 phase. |
2017-10-16 |
2023-08-13 |
Not clear |
| b' Ksymena Urbanek, Marta Lesiak, Daniel Krakowian, Halina Koryciak-Komarska, Wirginia Likus, Piotr Czekaj, Damian Kusz, Aleksander L Siero\\xc5\\x8. Notch signaling pathway and gene expression profiles during early in vitro differentiation of liver-derived mesenchymal stromal cells to osteoblasts. Laboratory investigation; a journal of technical methods and pathology. vol 97. issue 10. 2017-10-11. PMID:28805807.' |
these early changes in activation of the notch signaling pathway were correlated with the transcription of several genes linked to osteogenesis, such as bmps, mmps, and egfr, and with the regulation of cell cycle and apoptosis. |
2017-10-11 |
2023-08-13 |
rat |