| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shin-Hyung Park, Myeong-A Seong, Ho-Young Le. p38 MAPK-induced MDM2 degradation confers paclitaxel resistance through p53-mediated regulation of EGFR in human lung cancer cells. Oncotarget. vol 7. issue 7. 2016-12-20. PMID:26799187. |
erlotinib, an egfr inhibitor, also increased ptx-induced apoptosis in ptx resistant cells, which suggests a role for p38 mapk and egfr in the development of ptx resistance. |
2016-12-20 |
2023-08-13 |
mouse |
| Hongjuan Zhang, Cheng Zhan, Ji Ke, Zhiqiang Xue, Aiqun Zhang, Kaifeng Xu, Zhirong Shen, Lei Yu, Liang Che. EGFR kinase domain mutation positive lung cancers are sensitive to intrapleural perfusion with hyperthermic chemotherapy (IPHC) complete treatment. Oncotarget. vol 7. issue 3. 2016-12-13. PMID:26654941. |
hyperthermia and cisplatin synergistically downregulated the egfr protein level, leading to quenching of signal from egfr and induction of apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yusuke Nitta, Saki Shimizu, Yukiko Shishido-Hara, Kaori Suzuki, Yoshiaki Shiokawa, Motoo Nagan. Nimotuzumab enhances temozolomide-induced growth suppression of glioma cells expressing mutant EGFR in vivo. Cancer medicine. vol 5. issue 3. 2016-12-13. PMID:26778701. |
antitumor activity was tested using nude mice bearing either subcutaneous or intracerebral xenografts along with analyses of egfr phosphorylation status, proliferation, apoptosis, and vessel density. |
2016-12-13 |
2023-08-13 |
mouse |
| Bhornprom Yoysungnoen, Parvapan Bhattarakosol, Chatchawan Changtam, Suthiluk Patumra. Effects of Tetrahydrocurcumin on Tumor Growth and Cellular Signaling in Cervical Cancer Xenografts in Nude Mice. BioMed research international. vol 2016. 2016-11-10. PMID:26881213. |
cox-2, egfr, p-erk1&2, p-akt, and ki-67 expressions were measured by immunohistochemistry whereas cell apoptosis was detected by tunels method. |
2016-11-10 |
2023-08-13 |
mouse |
| Loredana Vesci, Ferdinando Maria Milazzo, Anna Maria Anastasi, Fiorella Petronzelli, Caterina Chiapparino, Valeria Carollo, Giuseppe Roscilli, Emanuele Marra, Laura Luberto, Luigi Aurisicchio, Maria Lucrezia Pacello, Luigi Giusto Spagnoli, Rita De Santi. Intra-tumor AvidinOX allows efficacy of low dose systemic biotinylated Cetuximab in a model of head and neck cancer. Oncotarget. vol 7. issue 1. 2016-11-07. PMID:26575422. |
avidinox-anchored bcet induces apoptosis and dna damage as well as specific inhibition of signaling, degradation and abrogation of nuclear translocation of egfr. |
2016-11-07 |
2023-08-13 |
mouse |
| Abu Syed Md Anisuzzaman, Abedul Haque, Mohammad Aminur Rahman, Dongsheng Wang, James R Fuchs, Selwyn Hurwitz, Yuan Liu, Gabriel Sica, Fadlo R Khuri, Zhuo Georgia Chen, Dong M Shin, A R M Ruhul Ami. Preclinical In Vitro, In Vivo, and Pharmacokinetic Evaluations of FLLL12 for the Prevention and Treatment of Head and Neck Cancers. Cancer prevention research (Philadelphia, Pa.). vol 9. issue 1. 2016-10-18. PMID:26511491. |
taken together, our results strongly suggest that flll12 is a potent curcumin analogue with more favorable pharmacokinetic properties that induces apoptosis of head and neck cancer cell lines by inhibition of survival proteins including egfr, akt, and bcl-2 and increasing of the proapoptotic protein bim. |
2016-10-18 |
2023-08-13 |
Not clear |
| Devrim Kilinc, Jefrem Schwab, Stefano Rampini, Oshoke W Ikpekha, Ashwin Thampi, Agata Blasiak, Peng Li, Robert Schwamborn, Walter Kolch, David Matallanas, Gil U Le. A microfluidic dual gradient generator for conducting cell-based drug combination assays. Integrative biology : quantitative biosciences from nano to macro. vol 8. issue 1. 2016-10-17. PMID:26569638. |
a431 epidermoid carcinoma cells, where egf induces apoptosis in a concentration-dependent manner, were simultaneously exposed to gradients of mek inhibitor and egf receptor (egfr) inhibitor. |
2016-10-17 |
2023-08-13 |
Not clear |
| Niki Karachaliou, Jordi Codony-Servat, Cristina Teixidó, Sara Pilotto, Ana Drozdowskyj, Carles Codony-Servat, Ana Giménez-Capitán, Miguel Angel Molina-Vila, Jordi Bertrán-Alamillo, Radj Gervais, Bartomeu Massuti, Teresa Morán, Margarita Majem, Enriqueta Felip, Enric Carcereny, Rosario García-Campelo, Santiago Viteri, María González-Cao, Daniela Morales-Espinosa, Alberto Verlicchi, Elisabetta Crisetti, Imane Chaib, Mariacarmela Santarpia, José Luis Ramírez, Joaquim Bosch-Barrera, Andrés Felipe Cardona, Filippo de Marinis, Guillermo López-Vivanco, José Miguel Sánchez, Alain Vergnenegre, José Javier Sánchez Hernández, Isabella Sperduti, Emilio Bria, Rafael Rosel. BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer. Scientific reports. vol 5. 2016-10-10. PMID:26639561. |
bim is a proapoptotic protein that initiates apoptosis triggered by egfr tyrosine kinase inhibitors (tki). |
2016-10-10 |
2023-08-13 |
Not clear |
| Niki Karachaliou, Jordi Codony-Servat, Cristina Teixidó, Sara Pilotto, Ana Drozdowskyj, Carles Codony-Servat, Ana Giménez-Capitán, Miguel Angel Molina-Vila, Jordi Bertrán-Alamillo, Radj Gervais, Bartomeu Massuti, Teresa Morán, Margarita Majem, Enriqueta Felip, Enric Carcereny, Rosario García-Campelo, Santiago Viteri, María González-Cao, Daniela Morales-Espinosa, Alberto Verlicchi, Elisabetta Crisetti, Imane Chaib, Mariacarmela Santarpia, José Luis Ramírez, Joaquim Bosch-Barrera, Andrés Felipe Cardona, Filippo de Marinis, Guillermo López-Vivanco, José Miguel Sánchez, Alain Vergnenegre, José Javier Sánchez Hernández, Isabella Sperduti, Emilio Bria, Rafael Rosel. BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer. Scientific reports. vol 5. 2016-10-10. PMID:26639561. |
mtor negatively regulates apoptosis and may influence response to egfr tki. |
2016-10-10 |
2023-08-13 |
Not clear |
| Youlin Deng, Junhui Zhang, Zhongliang Wang, Zhengjian Yan, Min Qiao, Jixing Ye, Qiang Wei, Jing Wang, Xin Wang, Lianggong Zhao, Shun Lu, Shengli Tang, Maryam K Mohammed, Hao Liu, Jiaming Fan, Fugui Zhang, Yulong Zou, Junyi Liao, Hongbo Qi, Rex C Haydon, Hue H Luu, Tong-Chuan He, Liangdan Tan. Antibiotic monensin synergizes with EGFR inhibitors and oxaliplatin to suppress the proliferation of human ovarian cancer cells. Scientific reports. vol 5. 2016-10-10. PMID:26639992. |
monensin acts synergistically with egfr inhibitors and oxaliplatin to inhibit cell proliferation and induce apoptosis of ovarian cancer cells. |
2016-10-10 |
2023-08-13 |
human |
| Yang-Ling Li, Yi-Ni Pan, Wen-Jue Wu, Shi-Ying Mao, Jiao Sun, Yi-Ming Zhao, Jing-Yin Dong, Da-Yong Zhang, Jian-Ping Pan, Chong Zhang, Neng-Ming Li. Evodiamine induces apoptosis and enhances apoptotic effects of erlotinib in wild-type EGFR NSCLC cells via S6K1-mediated Mcl-1 inhibition. Medical oncology (Northwood, London, England). vol 33. issue 2. 2016-10-05. PMID:26757927. |
evodiamine induces apoptosis and enhances apoptotic effects of erlotinib in wild-type egfr nsclc cells via s6k1-mediated mcl-1 inhibition. |
2016-10-05 |
2023-08-13 |
Not clear |
| Yang-Ling Li, Yi-Ni Pan, Wen-Jue Wu, Shi-Ying Mao, Jiao Sun, Yi-Ming Zhao, Jing-Yin Dong, Da-Yong Zhang, Jian-Ping Pan, Chong Zhang, Neng-Ming Li. Evodiamine induces apoptosis and enhances apoptotic effects of erlotinib in wild-type EGFR NSCLC cells via S6K1-mediated Mcl-1 inhibition. Medical oncology (Northwood, London, England). vol 33. issue 2. 2016-10-05. PMID:26757927. |
benth, we showed that evodiamine could induce anti-proliferation and apoptosis in four wild-type egfr nsclc cell lines, and combining evodiamine with erlotinib might successfully inhibit cell proliferation and survival in wild-type egfr nsclc cells, characterized as erlotinib-resistant. |
2016-10-05 |
2023-08-13 |
Not clear |
| Keizo Misumi, Jiying Sun, Aiko Kinomura, Yoshihiro Miyata, Morihito Okada, Satoshi Tashir. Enhanced gefitinib-induced repression of the epidermal growth factor receptor pathway by ataxia telangiectasia-mutated kinase inhibition in non-small-cell lung cancer cells. Cancer science. vol 107. issue 4. 2016-08-25. PMID:26825989. |
we found that the combination of an atm inhibitor, ku55933, and an egfr-tki, gefitinib, resulted in synergistic cell growth inhibition and induction of apoptosis in nsclc cell lines carrying the sensitive egfr mutation. |
2016-08-25 |
2023-08-13 |
Not clear |
| Hong Wu, Aoli Wang, Wei Zhang, Beilei Wang, Cheng Chen, Wenchao Wang, Chen Hu, Zi Ye, Zheng Zhao, Li Wang, Xixiang Li, Kailin Yu, Juan Liu, Jiaxin Wu, Xiao-E Yan, Peng Zhao, Jinhua Wang, Chu Wang, Ellen L Weisberg, Nathanael S Gray, Cai-Hong Yun, Jing Liu, Liang Chen, Qingsong Li. Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells. Oncotarget. vol 6. issue 31. 2016-08-23. PMID:26375053. |
ibrutinib strongly affected egfr mediated signaling pathways and induced apoptosis and cell cycle arrest (g0/g1) in mutant egfr but not wt egfr cells. |
2016-08-23 |
2023-08-13 |
Not clear |
| Lei Wang, Yongwei Hao, Haixia Li, Yalin Zhao, Dehui Meng, Dong Li, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang, Yun Zhan. Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles. Journal of drug targeting. vol 23. issue 9. 2016-08-22. PMID:25856302. |
this system could efficiently deliver dox and sirna into u87mg cells leading to significant cell inhibition, apoptosis and egfr silencing in vitro. |
2016-08-22 |
2023-08-13 |
mouse |
| Lei Wang, Yongwei Hao, Haixia Li, Yalin Zhao, Dehui Meng, Dong Li, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang, Yun Zhan. Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles. Journal of drug targeting. vol 23. issue 9. 2016-08-22. PMID:25856302. |
the animal study using the brain orthotopic u87mg glioma xenograft model indicated that the ang-targeted co-delivery of dox and egfr sirna resulted in not only the prolongation of the life span of the glioma-bearing mice but also an obvious cell apoptosis in glioma tissue. |
2016-08-22 |
2023-08-13 |
mouse |
| Laura K van Dijk, Otto C Boerman, Johannes H A M Kaanders, Johan Bussin. Epidermal growth factor receptor imaging in human head and neck cancer xenografts. Acta oncologica (Stockholm, Sweden). vol 54. issue 9. 2016-08-22. PMID:26248024. |
the epidermal growth factor receptor (egfr) is involved in various radiation resistance mechanisms as it steers the pathways related to dna damage repair, proliferation, hypoxia and apoptosis. |
2016-08-22 |
2023-08-13 |
human |
| Hoi Yan Ng, Josephine Mun-Yee Ko, Valen Zhuoyou Yu, Joseph Chok Yan Ip, Wei Dai, Santiago Cal, Maria Li Lun. DESC1, a novel tumor suppressor, sensitizes cells to apoptosis by downregulating the EGFR/AKT pathway in esophageal squamous cell carcinoma. International journal of cancer. vol 138. issue 12. 2016-08-18. PMID:26856390. |
desc1 also reduced egfr protein level, which was abrogated when the proteolytic function of desc1 was lost, suggesting that desc1 cleaved egfr and downregulated the egfr/akt pathway to favor apoptosis. |
2016-08-18 |
2023-08-13 |
Not clear |
| Tsun-Wen Yao, Jie Zhang, Michael Prados, William A Weiss, C David James, Theodore Nicolaide. EGFR blockade prevents glioma escape from BRAFV600E targeted therapy. Oncotarget. vol 6. issue 26. 2016-08-03. PMID:26023796. |
moreover, pharmacologic inhibition of egfr combined with inhibition of braf(v600e) to reduce growth of glioma cell lines and orthotopic glioma xenograft by decreasing tumor cell proliferation while increasing apoptosis, with resultant significant extension of animal subject survival. |
2016-08-03 |
2023-08-13 |
human |
| Georgia Arentz, Tim Chataway, Mark R Condina, Timothy J Price, Peter Hoffmann, Jennifer E Hardingha. Increased Phospho-Keratin 8 Isoforms in Colorectal Tumors Associated with EGFR Pathway Activation and Reduced Apoptosis. ISRN molecular biology. vol 2012. 2016-07-11. PMID:27398237. |
increased phospho-keratin 8 isoforms in colorectal tumors associated with egfr pathway activation and reduced apoptosis. |
2016-07-11 |
2023-08-13 |
Not clear |