| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyungjoo Kim, Donghwan Jeon, Sunhwa Oh, KeeSoo Nam, Seogho Son, Myung Chan Gye, Incheol Shi. Titanium dioxide nanoparticles induce apoptosis by interfering with EGFR signaling in human breast cancer cells. Environmental research. vol 175. 2019-12-30. PMID:31112848. |
titanium dioxide nanoparticles induce apoptosis by interfering with egfr signaling in human breast cancer cells. |
2019-12-30 |
2023-08-13 |
human |
| Belgin Sever, Mehlika Dilek Altıntop, Mohamed O Radwan, Ahmet Özdemir, Masami Otsuka, Mikako Fujita, Halil I Ciftc. Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors. European journal of medicinal chemistry. vol 182. 2019-12-30. PMID:31493743. |
the results indicated that compounds 3f and 3q induced apoptosis in both cell lines and showed significant egfr inhibitory activity with ic |
2019-12-30 |
2023-08-13 |
human |
| Ke Li, Fangzheng Zhou, Yu Zhou, Sheng Zhang, Qianwen Li, Zhenyu Li, Li Liu, Gang Wu, Rui Men. Quinalizarin, a specific CK2 inhibitor, can reduce icotinib resistance in human lung adenocarcinoma cell lines. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173177. |
quinalizarin inhibited proliferation and promoted apoptosis in the cells with the egfr wild‑type and resistant mutations, and the addition of quinalizarin to icotinib partially restored their sensitivity to icotinib. |
2019-12-23 |
2023-08-13 |
human |
| Martin Siegemund, Felix Schneider, Meike Hutt, Oliver Seifert, Ines Müller, Dagmar Kulms, Klaus Pfizenmaier, Roland E Konterman. IgG-single-chain TRAIL fusion proteins for tumour therapy. Scientific reports. vol 8. issue 1. 2019-12-20. PMID:29773864. |
the binding specificity to egfr and death receptors was retained in all igg-sctrail formats and translated into high antigen-specific bioactivity on egfr-positive colo205, hct116 and wm1366 tumour cell lines, with or without sensitization to apoptosis by bortezomib. |
2019-12-20 |
2023-08-13 |
Not clear |
| Haibing Xian, Weineng Feng, Jiren Zhan. Schizandrin A enhances the efficacy of gefitinib by suppressing IKKβ/NF-κB signaling in non-small cell lung cancer. European journal of pharmacology. vol 855. 2019-12-20. PMID:31028739. |
in this study, we discovered that schizandrin a (sch a), a lignin compound isolated from schisandra chinesnesis, could synergize with the egfr receptor inhibitor gefitinib to inhibit cell growth, induce cell cycle arrest and apoptosis of hcc827/gr cells. |
2019-12-20 |
2023-08-13 |
Not clear |
| Remah Ali, Wells Brown, Stephen Connor Purdy, V Jo Davisson, Michael K Wend. Biased signaling downstream of epidermal growth factor receptor regulates proliferative versus apoptotic response to ligand. Cell death & disease. vol 9. issue 10. 2019-12-13. PMID:30250119. |
along these lines, an egfr mutant that is defective in endocytosis is unable to elicit stat1 phosphorylation and apoptosis. |
2019-12-13 |
2023-08-13 |
Not clear |
| Remah Ali, Wells Brown, Stephen Connor Purdy, V Jo Davisson, Michael K Wend. Biased signaling downstream of epidermal growth factor receptor regulates proliferative versus apoptotic response to ligand. Cell death & disease. vol 9. issue 10. 2019-12-13. PMID:30250119. |
pharmacologic blockade of erk1/2 signaling through the use of the allosteric mek1/2 inhibitor, trametinib, dramatically biases downstream egfr signaling toward a stat1-dominated event, resulting in enhanced egf-induced apoptosis in metastatic bc cells. |
2019-12-13 |
2023-08-13 |
Not clear |
| Angela M Ohm, Trisiani Affandi, Mary E Reylan. EGF receptor and PKCδ kinase activate DNA damage-induced pro-survival and pro-apoptotic signaling via biphasic activation of ERK and MSK1 kinases. The Journal of biological chemistry. vol 294. issue 12. 2019-12-13. PMID:30679314. |
in contrast, the second phase of erk→msk1 activation drove apoptosis and required protein kinase cδ (pkcδ) but not egfr. |
2019-12-13 |
2023-08-13 |
Not clear |
| Weiyi Xia, Libo Wang, Dongyi Yu, Xing Mu, Xin Zho. Lidocaine inhibits the progression of retinoblastoma in vitro and in vivo by modulating the miR‑520a‑3p/EGFR axis. Molecular medicine reports. vol 20. issue 2. 2019-12-11. PMID:31173241. |
furthermore, compared with treatment with lidocaine alone, the combination of transfection with mir‑520a‑3p inhibitor and lidocaine treatment significantly decreased the expression of mir‑520a‑3p, increased egfr expression, promoted rb cell proliferation and reduced the apoptosis of cells in vitro, and increased tumor volume and weight in vivo. |
2019-12-11 |
2023-08-13 |
human |
| Weiyi Xia, Libo Wang, Dongyi Yu, Xing Mu, Xin Zho. Lidocaine inhibits the progression of retinoblastoma in vitro and in vivo by modulating the miR‑520a‑3p/EGFR axis. Molecular medicine reports. vol 20. issue 2. 2019-12-11. PMID:31173241. |
the results indicated that lidocaine reduced the proliferation and induced the apoptosis of rb cells by decreasing egfr expression via the upregulation of mir‑520a‑3p, suggesting that the mir‑520a‑3p/egfr axis may be a novel therapeutic target in the treatment of rb. |
2019-12-11 |
2023-08-13 |
human |
| Habib Zarredar, Shadi Pashapour, Khalil Ansarin, Majid Khalili, Roghayyeh Baghban, Safar Farajni. Combination therapy with KRAS siRNA and EGFR inhibitor AZD8931 suppresses lung cancer cell growth in vitro. Journal of cellular physiology. vol 234. issue 2. 2019-12-10. PMID:30132854. |
this article is dedicated to evaluating the synergistic effect of a novel egfr inhibitor azd8931 and kras small interfering rna (sirna) on the proliferation and apoptosis of lung adenocarcinoma cancer cells. |
2019-12-10 |
2023-08-13 |
human |
| Habib Zarredar, Shadi Pashapour, Khalil Ansarin, Majid Khalili, Roghayyeh Baghban, Safar Farajni. Combination therapy with KRAS siRNA and EGFR inhibitor AZD8931 suppresses lung cancer cell growth in vitro. Journal of cellular physiology. vol 234. issue 2. 2019-12-10. PMID:30132854. |
the cytotoxic effects of kras sirna and te egfr inhibitor were determined usingmtt assay, and induction of apoptosis was determined by facs analysis. |
2019-12-10 |
2023-08-13 |
human |
| Habib Zarredar, Shadi Pashapour, Khalil Ansarin, Majid Khalili, Roghayyeh Baghban, Safar Farajni. Combination therapy with KRAS siRNA and EGFR inhibitor AZD8931 suppresses lung cancer cell growth in vitro. Journal of cellular physiology. vol 234. issue 2. 2019-12-10. PMID:30132854. |
the results also indicated that the silencing of kras and egfr has synergistic effects on the induction of apoptosis on the a549 cells. these results indicated that kras and egfr might play important roles in the progression of lung cancer and could be potential therapeutic targets for treatment of lung cancer. |
2019-12-10 |
2023-08-13 |
human |
| D L Sheela, A Narayanankutty, P A Nazeem, A C Raghavamenon, S R Muthangaparambi. Lauric acid induce cell death in colon cancer cells mediated by the epidermal growth factor receptor downregulation: An in silico and in vitro study. Human & experimental toxicology. vol 38. issue 7. 2019-12-02. PMID:30942101. |
the study thus concludes that the anticancer activity of la may be partially mediated by the downregulation of egfr signalling and consequent reduction in cell viability through apoptosis. |
2019-12-02 |
2023-08-13 |
human |
| Y-Z Dong, T H. Effects of miR-143 overexpression on proliferation, apoptosis, EGFR and downstream signaling pathways in PC9/GR cell line. European review for medical and pharmacological sciences. vol 22. issue 6. 2019-11-25. PMID:29630116. |
effects of mir-143 overexpression on proliferation, apoptosis, egfr and downstream signaling pathways in pc9/gr cell line. |
2019-11-25 |
2023-08-13 |
Not clear |
| Y-Z Dong, T H. Effects of miR-143 overexpression on proliferation, apoptosis, EGFR and downstream signaling pathways in PC9/GR cell line. European review for medical and pharmacological sciences. vol 22. issue 6. 2019-11-25. PMID:29630116. |
this study aimed to examine the effect of mir-143 in pc9/gr cell line on the proliferation, apoptosis, egfr and downstream signal pathways. |
2019-11-25 |
2023-08-13 |
Not clear |
| G Blackledge, S Averbuch, A Kay, J Barto. Anti-EGF receptor therapy. Prostate cancer and prostatic diseases. vol 3. issue 4. 2019-11-20. PMID:12497082. |
the epidermal growth factor receptor (egfr) signalling pathway contributes to a number of processes important to tumour progression, including cell proliferation, apoptosis, angiogenesis and metastatic spread. |
2019-11-20 |
2023-08-12 |
human |
| R Labianca, N La Verde, M C Garassin. Development and clinical indications of cetuximab. The International journal of biological markers. vol 22. issue 4. 2019-11-20. PMID:28207113. |
the egfr signaling pathways regulate cell differentiation, proliferation, migration, angiogenesis and apoptosis, all of which become deregulated in cancer cells. |
2019-11-20 |
2023-08-13 |
Not clear |
| Wei Teng, Chunguang Qiu, Zhaohui He, Guoliang Wang, Yongliang Xue, Xuezhi Hu. Linc00152 suppresses apoptosis and promotes migration by sponging miR-4767 in vascular endothelial cells. Oncotarget. vol 8. issue 49. 2019-11-20. PMID:29156700. |
moreover, blocking mir-4767 rescued the decrease of bcl2l12 and egfr caused by linc00152 knockdown, as well as the changes in cell apoptosis and migration. |
2019-11-20 |
2023-08-13 |
human |
| Sen Zhang, Yonghong Fu, Dongjie Wang, Jing Wan. Icotinib enhances lung cancer cell radiosensitivity in vitro and in vivo by inhibiting MAPK/ERK and AKT activation. Clinical and experimental pharmacology & physiology. 2019-11-20. PMID:29770473. |
cell apoptosis was also analyzed by flow cytometry, while western blotting was performed to examine the activation of egfr and its downstream kinases in h1650 cells after icotinib and radiation treatment. |
2019-11-20 |
2023-08-13 |
Not clear |