| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tong-Hong Wang, Chin-Chuan Chen, Kuo-Yen Huang, Ya-Min Shih, Chi-Yuan Che. High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 64. 2020-03-02. PMID:31454652. |
high levels of egfr prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells. |
2020-03-02 |
2023-08-13 |
Not clear |
| Habib Zarredar, Safar Farajnia, Khalil Ansarin, Behzad Baradaran, Maryam Aria, Milad Asad. Synergistic Effect of Novel EGFR Inhibitor AZD8931 and p38α siRNA in Lung Adenocarcinoma Cancer Cells. Anti-cancer agents in medicinal chemistry. vol 19. issue 5. 2020-02-27. PMID:30827261. |
the aim of this study was to investigate the combined effect of p38 αspecific sirna and egfr inhibitor on apoptosis and proliferation of a549 lung cancer cell line. |
2020-02-27 |
2023-08-13 |
Not clear |
| Zheng Wang, Xue Wu, Yan-Ni Liang, Li Wang, Zhong-Xing Song, Jian-Li Liu, Zhi-Shu Tan. Cordycepin Induces Apoptosis and Inhibits Proliferation of Human Lung Cancer Cell Line H1975 via Inhibiting the Phosphorylation of EGFR. Molecules (Basel, Switzerland). vol 21. issue 10. 2020-02-25. PMID:27689974. |
cordycepin induces apoptosis and inhibits proliferation of human lung cancer cell line h1975 via inhibiting the phosphorylation of egfr. |
2020-02-25 |
2023-08-13 |
human |
| Bai Yuquan, Tang Hexiao, Wan Laiyi, Pan Gaofeng, Zhou Xuefeng, Xu Ming, Wei Yanhong, Zhang Li, Zhao Jinpin. Interaction between epidermal growth factor receptor and interleukin-6 receptor in NSCLC progression. Journal of cellular biochemistry. vol 120. issue 1. 2020-02-25. PMID:30132982. |
furthermore, the effect of egf and il-6 on biological behavior of lung cancer cells (cell proliferation, invasion, cycle, and apoptosis) and the expression of egfr, gp130, p-protein kinase b (p-akt), and p-p44/42 mitogen-activated protein kinase (p-p44/42 mapk) was significantly stronger compared with other treatment groups (all p < 0.05). |
2020-02-25 |
2023-08-13 |
Not clear |
| Ge Yan, Mohamed E M Saeed, Sebastian Foersch, Jose Schneider, Wilfried Roth, Thomas Effert. Relationship between EGFR expression and subcellular localization with cancer development and clinical outcome. Oncotarget. vol 10. issue 20. 2020-02-25. PMID:30956774. |
epidermal growth factor receptor (egfr) as a prevalent oncogene regulates proliferation, apoptosis and differentiation and thereby contributes to carcinogenesis. |
2020-02-25 |
2023-08-13 |
Not clear |
| Sherwin Jack, Kayalvizhi Madhivanan, Swetha Ramadesikan, Sneha Subramanian, Daniel F Edwards, Bennett D Elzey, Deepika Dhawan, Andrew McCluskey, Erin M Kischuk, Alexander R Loftis, Nicholas Truex, Michael Santos, Mike Lu, Amy Rabideau, Bradley Pentelute, John Collier, Hristos Kaimakliotis, Michael Koch, Timothy L Ratliff, Deborah W Knapp, Ruben C Aguila. A novel, safe, fast and efficient treatment for Her2-positive and negative bladder cancer utilizing an EGF-anthrax toxin chimera. International journal of cancer. vol 146. issue 2. 2020-02-19. PMID:31584195. |
therefore, we used an egf-conjugated anthrax toxin that after targeting egfr was internalized and triggered apoptosis in exposed bladder cancer cells. |
2020-02-19 |
2023-08-13 |
Not clear |
| Toshimitsu Yamaoka, Satoru Arata, Mayumi Homma, Tetsuya Homma, Sojiro Kusumoto, Koichi Ando, Ryou Manabe, Yasunari Kishino, Motoi Ohba, Junji Tsurutani, Masafumi Takimoto, Tohru Ohmori, Hironori Sagar. Blockade of EGFR Activation Promotes TNF-Induced Lung Epithelial Cell Apoptosis and Pulmonary Injury. International journal of molecular sciences. vol 20. issue 16. 2020-02-04. PMID:31426531. |
blockade of egfr activation promotes tnf-induced lung epithelial cell apoptosis and pulmonary injury. |
2020-02-04 |
2023-08-13 |
mouse |
| Toshimitsu Yamaoka, Satoru Arata, Mayumi Homma, Tetsuya Homma, Sojiro Kusumoto, Koichi Ando, Ryou Manabe, Yasunari Kishino, Motoi Ohba, Junji Tsurutani, Masafumi Takimoto, Tohru Ohmori, Hironori Sagar. Blockade of EGFR Activation Promotes TNF-Induced Lung Epithelial Cell Apoptosis and Pulmonary Injury. International journal of molecular sciences. vol 20. issue 16. 2020-02-04. PMID:31426531. |
hence, we aimed to test the hypothesis that egfr tyrosine kinase activity regulates tnf-mediated bronchial epithelial cell survival, and that inhibition of egfr activity increases tnf-induced lung epithelial cell apoptosis. |
2020-02-04 |
2023-08-13 |
mouse |
| Toshimitsu Yamaoka, Satoru Arata, Mayumi Homma, Tetsuya Homma, Sojiro Kusumoto, Koichi Ando, Ryou Manabe, Yasunari Kishino, Motoi Ohba, Junji Tsurutani, Masafumi Takimoto, Tohru Ohmori, Hironori Sagar. Blockade of EGFR Activation Promotes TNF-Induced Lung Epithelial Cell Apoptosis and Pulmonary Injury. International journal of molecular sciences. vol 20. issue 16. 2020-02-04. PMID:31426531. |
in this model, gefitinib, an egfr-tki, enhanced lung epithelial cell apoptosis and lymphocytic inflammation, indicating that egfr tyrosine kinase prevents tnf-induced lung injury. |
2020-02-04 |
2023-08-13 |
mouse |
| Ha-Na Oh, Mee-Hyun Lee, Eunae Kim, Goo Yoon, Jung-Il Chae, Jung-Hyun Shi. Licochalcone B inhibits growth and induces apoptosis of human non-small-cell lung cancer cells by dual targeting of EGFR and MET. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 63. 2020-01-21. PMID:31323446. |
licochalcone b inhibits growth and induces apoptosis of human non-small-cell lung cancer cells by dual targeting of egfr and met. |
2020-01-21 |
2023-08-13 |
human |
| Ming-Peng Long, Hui-Li Wang, Yong-Bin Luo, Jia-Hui Yan. Targeting ROR1 inhibits epithelial to mesenchymal transition in human lung adenocarcinoma via mTOR signaling pathway. International journal of clinical and experimental pathology. vol 11. issue 10. 2020-01-21. PMID:31949551. |
we and others have shown that the roles of ror1 include inhibiting apoptosis, potentiating egfr signaling, and inducing proliferation in lung cancer, but the roles and mechanisms of ror1 in lung adenocarcinoma metastasis have not been elucidated. |
2020-01-21 |
2023-08-13 |
human |
| Ping Chen, Shou-De Zhang, Yi Lin, Jiang Cao, Jia Chen, Bei-Bei Yan. The construction and characterization of a novel adenovirus vector of artificial microRNA targeting EGFR. International journal of clinical and experimental pathology. vol 12. issue 6. 2020-01-17. PMID:31934019. |
to construct a recombinant adenovirus with artificial microrna targeting the epidermal growth factor receptor (egfr) to inhibit the proliferation and induce the apoptosis of tumor cells. |
2020-01-17 |
2023-08-13 |
Not clear |
| Jian-Bo Fan, Wei Liu, Xin-Hui Zhu, Sheng-Yu Cui, Zhi-Ming Cui, Jian-Ning Zha. microRNA-7 inhibition protects human osteoblasts from dexamethasone via activation of epidermal growth factor receptor signaling. Molecular and cellular biochemistry. vol 460. issue 1-2. 2020-01-13. PMID:31313024. |
in ob-6, hfob1.19, and primary human osteoblasts, mir-7 depletion by a lentiviral antagomir-7 construct (lv-antagomir-7) increased egfr expression and downstream akt activation, protecting cells from dex-induced viability reduction, cell death, and apoptosis. |
2020-01-13 |
2023-08-13 |
human |
| Jian Xu, Guo-Yuan Zhu, Dai Cao, Hao Pan, Ying-Wei L. Gossypol overcomes EGFR-TKIs resistance in non-small cell lung cancer cells by targeting YAP/TAZ and EGFR Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 115. 2020-01-06. PMID:31055235. |
in the current study, we found that gossypol inhibited cell growth and induced apoptosis in h1975 cells harboring egfr |
2020-01-06 |
2023-08-13 |
Not clear |
| Tobias Reiff, Zeus A Antonello, Esther Ballesta-Illán, Laura Mira, Salvador Sala, Maria Navarro, Luis M Martinez, Maria Domingue. Notch and EGFR regulate apoptosis in progenitor cells to ensure gut homeostasis in Drosophila. The EMBO journal. vol 38. issue 21. 2020-01-06. PMID:31566767. |
notch and egfr regulate apoptosis in progenitor cells to ensure gut homeostasis in drosophila. |
2020-01-06 |
2023-08-13 |
drosophila_melanogaster |
| Hyungjoo Kim, Donghwan Jeon, Sunhwa Oh, KeeSoo Nam, Seogho Son, Myung Chan Gye, Incheol Shi. Titanium dioxide nanoparticles induce apoptosis by interfering with EGFR signaling in human breast cancer cells. Environmental research. vol 175. 2019-12-30. PMID:31112848. |
titanium dioxide nanoparticles induce apoptosis by interfering with egfr signaling in human breast cancer cells. |
2019-12-30 |
2023-08-13 |
human |
| Belgin Sever, Mehlika Dilek Altıntop, Mohamed O Radwan, Ahmet Özdemir, Masami Otsuka, Mikako Fujita, Halil I Ciftc. Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors. European journal of medicinal chemistry. vol 182. 2019-12-30. PMID:31493743. |
the results indicated that compounds 3f and 3q induced apoptosis in both cell lines and showed significant egfr inhibitory activity with ic |
2019-12-30 |
2023-08-13 |
human |
| Ke Li, Fangzheng Zhou, Yu Zhou, Sheng Zhang, Qianwen Li, Zhenyu Li, Li Liu, Gang Wu, Rui Men. Quinalizarin, a specific CK2 inhibitor, can reduce icotinib resistance in human lung adenocarcinoma cell lines. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173177. |
quinalizarin inhibited proliferation and promoted apoptosis in the cells with the egfr wild‑type and resistant mutations, and the addition of quinalizarin to icotinib partially restored their sensitivity to icotinib. |
2019-12-23 |
2023-08-13 |
human |
| Martin Siegemund, Felix Schneider, Meike Hutt, Oliver Seifert, Ines Müller, Dagmar Kulms, Klaus Pfizenmaier, Roland E Konterman. IgG-single-chain TRAIL fusion proteins for tumour therapy. Scientific reports. vol 8. issue 1. 2019-12-20. PMID:29773864. |
the binding specificity to egfr and death receptors was retained in all igg-sctrail formats and translated into high antigen-specific bioactivity on egfr-positive colo205, hct116 and wm1366 tumour cell lines, with or without sensitization to apoptosis by bortezomib. |
2019-12-20 |
2023-08-13 |
Not clear |
| Haibing Xian, Weineng Feng, Jiren Zhan. Schizandrin A enhances the efficacy of gefitinib by suppressing IKKβ/NF-κB signaling in non-small cell lung cancer. European journal of pharmacology. vol 855. 2019-12-20. PMID:31028739. |
in this study, we discovered that schizandrin a (sch a), a lignin compound isolated from schisandra chinesnesis, could synergize with the egfr receptor inhibitor gefitinib to inhibit cell growth, induce cell cycle arrest and apoptosis of hcc827/gr cells. |
2019-12-20 |
2023-08-13 |
Not clear |