| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuru Luo, Ruiqi Zhang, Jing Gao, Yali Wang, Weimin Zhang, Suzhu Qin. The localization and expression of epidermal growth factor and epidermal growth factor receptor in bovine ovary during oestrous cycle. Reproduction in domestic animals = Zuchthygiene. vol 55. issue 7. 2021-01-28. PMID:32330337. |
egf has been indicated to effectively inhibit the apoptosis of follicular cells, to promote the proliferation of granulosa cells and the maturation of oocytes, and to induce ovulation process via binding to epidermal growth factor receptor (egfr). |
2021-01-28 |
2023-08-13 |
cattle |
| Samir Y Abbas, Reem A K Al-Harbi, Marwa A M Sh El-Sharie. Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study. European journal of medicinal chemistry. vol 198. 2021-01-26. PMID:32361329. |
synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with egfr inhibitory activity, apoptosis assay and molecular docking study. |
2021-01-26 |
2023-08-13 |
Not clear |
| Yun-Mei Liu, Yang Li, Rong-Fang Liu, Jie Xiao, Bin-Ning Zhou, Qi-Zhi Zhang, Jian-Xin Son. Synthesis, characterization and preliminary biological evaluation of chrysin amino acid derivatives that induce apoptosis and EGFR downregulation. Journal of Asian natural products research. vol 23. issue 1. 2021-01-21. PMID:31833411. |
synthesis, characterization and preliminary biological evaluation of chrysin amino acid derivatives that induce apoptosis and egfr downregulation. |
2021-01-21 |
2023-08-13 |
Not clear |
| E C Halvorsen, S E Franks, B J Wadsworth, B T Harbourne, R A Cederberg, C A Steer, I Martinez-Gonzalez, J Calder, W W Lockwood, K L Bennewit. IL-33 increases ST2 Oncoimmunology. vol 8. issue 2. 2021-01-12. PMID:30713780. |
dependent on the type of cancer and local microenvironment, areg may induce tumour cell proliferation, invasion, migration or resistance to apoptosis by signaling through the epidermal growth factor receptor (egfr). |
2021-01-12 |
2023-08-13 |
mouse |
| Jiaqi Zhang, Hui Liu, Wenhao Zhang, Yinfang Li, Zhigang Fan, Hua Jiang, Judong Lu. Identification of lncRNA-mRNA Regulatory Module to Explore the Pathogenesis and Prognosis of Melanoma. Frontiers in cell and developmental biology. vol 8. 2021-01-05. PMID:33392203. |
moreover, we ran cmap analysis to select a list of small molecule drugs for skcm, such as egfr inhibitor ag-490, growth factor receptor inhibitor gw-441756 and apoptosis stimulant betulinic-acid, which have shown therapeutic effect in the treatment of melanoma. |
2021-01-05 |
2023-08-13 |
Not clear |
| Miriam Sartages, Ebel Floridia, Mar García-Colomer, Cristina Iglesias, Manuel Macía, Patricia Peñas, Pierre-Olivier Couraud, Ignacio A Romero, Babette Weksler, Celia M Pombo, Juan Zalvid. High Levels of Receptor Tyrosine Kinases in CCM3-Deficient Cells Increase Their Susceptibility to Tyrosine Kinase Inhibition. Biomedicines. vol 8. issue 12. 2020-12-29. PMID:33348877. |
inhibition of egfr family members in ccm3-deficient cells does not revert the known cellular effects of lack of ccm genes, but it induces significantly more apoptosis in ccm3-deficient cells than in control cells. |
2020-12-29 |
2023-08-13 |
Not clear |
| Yasmen F Mahran, Hanan M Hassa. Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis. Oxidative medicine and cellular longevity. vol 2020. 2020-12-16. PMID:32695255. |
therefore, this study is aimed at finding out the potential nephroprotection of gl against cddp-induced nephrotoxicity in rats and the possible molecular mechanisms including the egfr downstream signaling, apoptosis, and autophagy. |
2020-12-16 |
2023-08-13 |
rat |
| Marsha-Kay N D Hutchinson, Michelle Mierzwa, Nisha J D'Silv. Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer. Oncogene. vol 39. issue 18. 2020-11-30. PMID:32157215. |
this review discusses the clinical criteria for radiation resistance in patients with head and neck cancer and summarizes how cancer cells evade radiation-mediated apoptosis by p53- and epidermal growth factor receptor (egfr)-mediated dna repair. |
2020-11-30 |
2023-08-13 |
Not clear |
| Yi-Nan Liu, Meng-Feng Tsai, Shang-Gin Wu, Tzu-Hua Chang, Tzu-Hsiu Tsai, Chien-Hung Gow, Hsin-Yi Wang, Jin-Yuan Shi. miR-146b-5p Enhances the Sensitivity of NSCLC to EGFR Tyrosine Kinase Inhibitors by Regulating the IRAK1/NF-κB Pathway. Molecular therapy. Nucleic acids. vol 22. 2020-11-25. PMID:33230450. |
ectopic expression of mir-146b-5p in egfr tki-resistant cells enhanced egfr tki-induced apoptosis. |
2020-11-25 |
2023-08-13 |
Not clear |
| Tia H Turner, Mohammad A Alzubi, J Chuck Harrel. Identification of synergistic drug combinations using breast cancer patient-derived xenografts. Scientific reports. vol 10. issue 1. 2020-11-16. PMID:32001757. |
through a series of further drug screening assays and two-drug combination testing, we identified that the combination of afatinib (epidermal growth factor receptor (egfr) inhibitor) and ym155 (inhibitor of baculoviral inhibitor of apoptosis repeat-containing 5 (birc5; survivin) expression) is synergistically cytotoxic across multiple models of basal-like tnbc and reduces pdx mammary tumor growth in vivo. |
2020-11-16 |
2023-08-13 |
Not clear |
| J C Gomez-Verjan, R Ramírez-Aldana, M U Pérez-Zepeda, R Quiroz-Baez, A Luna-López, L M Gutierrez Robled. Systems biology and network pharmacology of frailty reveal novel epigenetic targets and mechanisms. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31332237. |
significant pathways involved in frailty: apoptosis, proteolysis, muscle proliferation, and inflammation; genes as fn1, app, crebbp, egfr playing a role as hubs and bottlenecks in the interactome network and epigenetic factors as hist1h3 cluster and mir200 family were also involved. |
2020-10-26 |
2023-08-13 |
Not clear |
| Kai Zhang, Chuanxin Liu, Tiange Yang, Xinxin Li, Longyin Wei, Dongling Chen, Jiali Zhou, Yihui Yin, Xinyu Yu, Fei L. Systematically explore the potential hepatotoxic material basis and molecular mechanism of Radix Aconiti Lateralis based on the concept of toxicological evidence chain (TEC). Ecotoxicology and environmental safety. vol 205. 2020-10-23. PMID:32971455. |
it was found that 22 potential toxic components screened can affect th17 cell differentiation, jak-stat signaling pathway, glutathione metabolism, and other related pathways by regulating akt1, il2, f2, gsr, egfr and other related targets, which induces oxidative stress, metabolic disorders, cell apoptosis, immune response, and excessive release of inflammatory factors, eventually inducing liver damage in rats. |
2020-10-23 |
2023-08-13 |
rat |
| Haiquan Lu, Yang Lu, Yangyiran Xie, Songbo Qiu, Xinqun Li, Zhen Fa. Rational combination with PDK1 inhibition overcomes cetuximab resistance in head and neck squamous cell carcinoma. JCI insight. vol 4. issue 19. 2020-10-13. PMID:31578313. |
we found that combination of pdk1 knockdown or inhibition by dichloroacetic acid (dca) with asct2 knockdown or with cetuximab treatment induced ros overproduction and apoptosis in hnscc cells, and this effect was independent of effective inhibition of egfr downstream pathways but could be lessened by n-acetyl cysteine, an anti-oxidative agent. |
2020-10-13 |
2023-08-13 |
Not clear |
| Thomas Sarazin, Guillaume Collin, Emilie Buache, Laurence Van Gulick, Céline Charpentier, Christine Terryn, Hamid Morjani, Charles Sab. Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model. Frontiers in oncology. vol 10. 2020-10-06. PMID:33014812. |
in the present work we evaluated the impact of collagen aging on lung carcinoma cells response to erlotinib-induced cytotoxicity and apoptosis, and on epidermal growth factor receptor (egfr) expression and phosphorylation. |
2020-10-06 |
2023-08-13 |
rat |
| Qin-Fang Deng, B O Su, Yin-Min Zhao, Liang Tang, Jie Zhang, Cai-Cun Zho. Integrin β1-mediated acquired gefitinib resistance in non-small cell lung cancer cells occurs via the phosphoinositide 3-kinase-dependent pathway. Oncology letters. vol 11. issue 1. 2020-10-01. PMID:26870244. |
cell cycle progression and apoptosis were analyzed by flow cytometry, while western blotting was used to evaluate the expression of egfr, phosphorylated (phospho)-egfr, protein kinase b (akt), phospho-akt, extracellular signal-regulated kinase (erk) and phospho-erk. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yanxia Zhang, Yan Xue, Yan Liu, Guodong Song, Guofeng Lv, Yongqiang Wang, Yijiang Wang, Xiang Li, Leiying Yan. MicroRNA-146a expression inhibits the proliferation and promotes the apoptosis of bronchial smooth muscle cells in asthma by directly targeting the epidermal growth factor receptor. Experimental and therapeutic medicine. vol 12. issue 2. 2020-10-01. PMID:27446287. |
the mechanism underlying the mir-146a-induced promotion of bsmc apoptosis may be its direct targeting of epidermal growth factor receptor (egfr), which affects downstream signaling pathways. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yanxia Zhang, Yan Xue, Yan Liu, Guodong Song, Guofeng Lv, Yongqiang Wang, Yijiang Wang, Xiang Li, Leiying Yan. MicroRNA-146a expression inhibits the proliferation and promotes the apoptosis of bronchial smooth muscle cells in asthma by directly targeting the epidermal growth factor receptor. Experimental and therapeutic medicine. vol 12. issue 2. 2020-10-01. PMID:27446287. |
in conclusion, mir-146a expression in asthma inhibits the proliferation and promotes the apoptosis of bsmcs by direct targeting of egfr. |
2020-10-01 |
2023-08-13 |
Not clear |
| Tae-Gul Lee, Eun-Hui Jeong, Il Jae Min, Seo Yun Kim, Hye-Ryoun Kim, Cheol Hyeon Ki. Altered expression of cellular proliferation, apoptosis and the cell cycle-related genes in lung cancer cells with acquired resistance to EGFR tyrosine kinase inhibitors. Oncology letters. vol 14. issue 2. 2020-10-01. PMID:28781659. |
altered expression of cellular proliferation, apoptosis and the cell cycle-related genes in lung cancer cells with acquired resistance to egfr tyrosine kinase inhibitors. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ping Zhou, Jian Hu, Xiaoqin Wang, Jingyuan Wang, Yong Zhang, Cong Wan. Epidermal growth factor receptor expression affects proliferation and apoptosis in non-small cell lung cancer cells via the extracellular signal-regulated kinase/microRNA 200a signaling pathway. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29552158. |
downregulating mir200a expression significantly suppressed proliferation and promoted apoptosis and caspase (casp)3 and casp9 function in the a549 cells and significantly inhibited egfr and p-erk protein expression in the a549 cells, compared with the beas-2b cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ping Zhou, Jian Hu, Xiaoqin Wang, Jingyuan Wang, Yong Zhang, Cong Wan. Epidermal growth factor receptor expression affects proliferation and apoptosis in non-small cell lung cancer cells via the extracellular signal-regulated kinase/microRNA 200a signaling pathway. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29552158. |
the results of the present study indicated that downregulating mir200a significantly suppressed proliferation and promoted apoptosis in a549 cells via the regulation of the egfr and erk 1/2 signaling pathways. |
2020-10-01 |
2023-08-13 |
Not clear |