| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suresh Palanivel, Olli Yli-Harja, Meenakshisundaram Kandhavel. Alkylamino Phenol Derivative Induces Apoptosis by Inhibiting EGFR Signaling Pathway in Breast Cancer Cells. Anti-cancer agents in medicinal chemistry. vol 20. issue 7. 2021-05-19. PMID:32053080. |
alkylamino phenol derivative induces apoptosis by inhibiting egfr signaling pathway in breast cancer cells. |
2021-05-19 |
2023-08-13 |
human |
| Chang Liu, Li-Qian Xuan, Kai Li, Zhuo Feng, Chan Lv, Xing-Jia Li, Xiao-Dan Ji, Rong Wan, Jie She. Shikonin Inhibits Cholangiocarcinoma Cell Line QBC939 by Regulating Apoptosis, Proliferation, and Invasion. Cell transplantation. vol 30. 2021-05-17. PMID:33508949. |
moreover, annexin v/pi assay and transwell invasion assay results indicated that shikonin induced apoptosis and invasion inhibitory probably due to upregulation of caspase-3 and caspase-8 expression and downregulation of mmp-9 and egfr expression in a concentration-dependent fashion. |
2021-05-17 |
2023-08-13 |
Not clear |
| Chang Liu, Li-Qian Xuan, Kai Li, Zhuo Feng, Chan Lv, Xing-Jia Li, Xiao-Dan Ji, Rong Wan, Jie She. Shikonin Inhibits Cholangiocarcinoma Cell Line QBC939 by Regulating Apoptosis, Proliferation, and Invasion. Cell transplantation. vol 30. 2021-05-17. PMID:33508949. |
shikonin could enhance apoptosis and inhibit proliferation and invasion of qbc939 cells; such biological behaviors mainly occurred via upregulating the expression of caspase-3 and caspase-8 and downregulating the expression of mmp-9 and egfr. |
2021-05-17 |
2023-08-13 |
Not clear |
| Guohai Zhang, Liangping Li, Jingai Bi, Yiming Wu, Erguang L. Targeting DNA and mutant p53 by a naphthalimide derivative, NA20, exhibits selective inhibition in gastric tumorigenesis by blocking mutant p53-EGFR signaling pathway. European journal of pharmacology. vol 887. 2021-05-14. PMID:32950500. |
na20 bound to dna and p53 identified by a combination of drug tracking, dna relaxation assay and coimmunoprecipitation-mass spectrometry (coip-ms) detection, which led to the p21 activation and the suppression of egfr signal cascading, thereby evoking cell cycle arrest and cell apoptosis, finally leading to cancer cell inhibition both in vitro and in vivo. |
2021-05-14 |
2023-08-13 |
Not clear |
| Ranran Chen, Yuanjian Huang, Lu Wang, Jiahui Zhou, Yuqian Tan, Chaofan Peng, Peng Yang, Wen Peng, Jie Li, Qiou Gu, Yuchen Sheng, Yan Wang, Guoqiang Shao, Qing Zhang, Yueming Su. Cetuximab functionalization strategy for combining active targeting and antimigration capacities of a hybrid composite nanoplatform applied to deliver 5-fluorouracil: toward colorectal cancer treatment. Biomaterials science. vol 9. issue 6. 2021-05-14. PMID:33538278. |
furthermore, delivery of 5-fu by using this nanoplatform can remarkably induce cytotoxicity, cell cycle arrest, and cell apoptosis for crc cells with high egfr expression. |
2021-05-14 |
2023-08-13 |
Not clear |
| Yuhong Jiang, Xin Zhuo, Xiujuan Fu, Yue Wu, Canquan Ma. Targeting PAR2 Overcomes Gefitinib Resistance in Non-Small-Cell Lung Cancer Cells Through Inhibition of EGFR Transactivation. Frontiers in pharmacology. vol 12. 2021-05-13. PMID:33967759. |
par2 inhibition notably enhanced gefitinib to modulate egfr transactivation, cell viability, migration and apoptosis in gefitinib-sensitive and-resistant nsclc cells, suggesting its reversal effects in gefitinib resistance. |
2021-05-13 |
2023-08-13 |
Not clear |
| Xiaoming Lin, Guangfei Wang, Ping Liu, Lei Han, Tong Wang, Kaili Chen, Yonglin Ga. Gallic acid suppresses colon cancer proliferation by inhibiting SRC and EGFR phosphorylation. Experimental and therapeutic medicine. vol 21. issue 6. 2021-05-13. PMID:33968169. |
the aim of the present study was to investigate the effects of gallic acid (ga) on the proliferation and apoptosis of colon cancer cells and to further clarify the mechanism of ga function associated with src and egfr phosphorylation. |
2021-05-13 |
2023-08-13 |
Not clear |
| Giovanna Schiavone, Samantha Epistolio, Vittoria Martin, Francesca Molinari, Jessica Barizzi, Luca Mazzucchelli, Milo Frattini, Luciano Wannesso. Functional and clinical significance of ROR1 in lung adenocarcinoma. BMC cancer. vol 20. issue 1. 2021-05-10. PMID:33172431. |
ror1 was shown to inhibit apoptosis, potentiate egfr signaling and reported to be overexpressed and associated with poor prognosis in several tumor models. |
2021-05-10 |
2023-08-13 |
Not clear |
| Y-L Zhao, B-Q Yuan, G-S She. Mechanism of RET gene mediated EGFR signaling pathway on epithelial-mesenchymal transition, proliferation and apoptosis of papillary thyroid carcinoma cells. European review for medical and pharmacological sciences. vol 24. issue 15. 2021-05-04. PMID:32767330. |
mechanism of ret gene mediated egfr signaling pathway on epithelial-mesenchymal transition, proliferation and apoptosis of papillary thyroid carcinoma cells. |
2021-05-04 |
2023-08-13 |
Not clear |
| Y-L Zhao, B-Q Yuan, G-S She. Mechanism of RET gene mediated EGFR signaling pathway on epithelial-mesenchymal transition, proliferation and apoptosis of papillary thyroid carcinoma cells. European review for medical and pharmacological sciences. vol 24. issue 15. 2021-05-04. PMID:32767330. |
to explore the mechanism of ret gene mediated egfr signaling pathway on the epithelial-mesenchymal transition (emt), proliferation and apoptosis of papillary thyroid carcinoma (ptc) cells. |
2021-05-04 |
2023-08-13 |
Not clear |
| Jie He, Zhihui Zhou, Xin Sun, Zunhua Yang, Pengwu Zheng, Shan Xu, Wufu Zh. The new opportunities in medicinal chemistry of fourth-generation EGFR inhibitors to overcome C797S mutation. European journal of medicinal chemistry. vol 210. 2021-04-22. PMID:33243531. |
epidermal growth factor receptor (egfr) is a receptor for epithelial growth factor (egf) cell proliferation and signaling, which is related to the inhibition of tumor cell proliferation, angiogenesis, tumor invasion, metastasis, and apoptosis. |
2021-04-22 |
2023-08-13 |
Not clear |
| Parvaneh Maleki, Hamid Gourabi, Mohammad Tahmaseb, Afsaneh Golkar-Narenji, Masood Bazrga. Lapatinib Decreases the Preimplantation Aneuploidy Rate of in vitro Fertilized Mouse Embryos without Affecting Completion of Preimplantation Development. Cytogenetic and genome research. vol 160. issue 11-12. 2021-04-16. PMID:33176309. |
lapatinib simultaneously inhibits egfr and her2, leading to apoptosis. |
2021-04-16 |
2023-08-13 |
mouse |
| Kyu Sic You, Yong Weon Yi, Jeonghee Cho, Yeon-Sun Seon. Dual Inhibition of AKT and MEK Pathways Potentiates the Anti-Cancer Effect of Gefitinib in Triple-Negative Breast Cancer Cells. Cancers. vol 13. issue 6. 2021-04-08. PMID:33801977. |
with drug combination screenings, we found that the triple combination of the protein kinase inhibitors (pkis) of the epidermal growth factor receptor (egfr), v-akt murine thymoma viral oncogene homolog (akt), and mapk/erk kinase (mek) is effective in inducing apoptosis in tnbc cells. |
2021-04-08 |
2023-08-13 |
rat |
| Hao Tang, Chaohui Duan, Zhizhou Kuang, Ruo-Pan Huan. Analyzing Signaling Pathways Using Antibody Arrays. Methods in molecular biology (Clifton, N.J.). vol 2237. 2021-03-26. PMID:33237422. |
this array-based system features a nitrocellulose membrane or glass slide solid support, spotted with antibodies targeting key proteins of major signaling pathways, including rtk, egfr, mapk, akt, apoptosis, tgfb, jak/stat, nfkb, and insulin receptor pathways. |
2021-03-26 |
2023-08-13 |
human |
| Noha H Amin, Mohammed T Elsaadi, Shimaa S Zaki, Hamdy M Abdel-Rahma. Design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as EGFR inhibitors and apoptosis inducers. Bioorganic chemistry. vol 105. 2021-03-19. PMID:33074119. |
design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as egfr inhibitors and apoptosis inducers. |
2021-03-19 |
2023-08-13 |
Not clear |
| Ha-Na Oh, Mee-Hyun Lee, Eunae Kim, Ah-Won Kwak, Goo Yoon, Seung-Sik Cho, Kangdong Liu, Jung-Il Chae, Jung-Hyun Shi. Licochalcone D Induces ROS-Dependent Apoptosis in Gefitinib-Sensitive or Resistant Lung Cancer Cells by Targeting EGFR and MET. Biomolecules. vol 10. issue 2. 2021-03-16. PMID:32070026. |
licochalcone d induces ros-dependent apoptosis in gefitinib-sensitive or resistant lung cancer cells by targeting egfr and met. |
2021-03-16 |
2023-08-13 |
Not clear |
| Cai-Feng Li, Feng-Rong Zhang, Na Zhu, Jian-Zhi Cui, Shi-Huan Tang, Zhi-Yong L. [Network pharmacology study of Yi medicine Jinweitai Capsules in treating gastrointestinal diseases]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 4. 2021-03-02. PMID:33645091. |
jinweitai capsules may exert an effect in the treatment of acute and chronic gastritis, gastric and duodenal ulcers, and chronic colitis by acting on akt1, egfr, ptpn11 and other targets in 15 signal pathways relating to cell inflammation and immunity, cell proliferation and apoptosis, helicobacter pylori infection, and gastrointestinal tract. |
2021-03-02 |
2023-08-13 |
Not clear |
| Yu Wakabayashi, Takeshi Masuda, Kazunori Fujitaka, Taku Nakashima, Joe Okumoto, Kiyofumi Shimoji, Yoshifumi Nishimura, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Shinichiro Ohshimo, Hironobu Hamada, Noboru Hattor. Clinical significance of BIM deletion polymorphism in chemoradiotherapy for non-small cell lung cancer. Cancer science. vol 112. issue 1. 2021-03-01. PMID:33103296. |
bim deletion polymorphism induces the suppression of apoptosis resulting from epidermal growth factor (egfr)-tyrosine kinase inhibitors in egfr-mutated nsclc patients. |
2021-03-01 |
2023-08-13 |
Not clear |
| Mahelet Mamo, I Chae Ye, Josh W DiGiacomo, Je Yeon Park, Bradley Downs, Daniele M Gilke. Hypoxia Alters the Response to Anti-EGFR Therapy by Regulating EGFR Expression and Downstream Signaling in a DNA Methylation-Specific and HIF-Dependent Manner. Cancer research. vol 80. issue 22. 2021-02-12. PMID:33023947. |
the egfr, a member of the erbb (avian erythroblastosis oncogene b) family of receptors that play a role in cell proliferation, invasion, metastasis, and apoptosis, was induced in seven of the 31 breast cancer cell lines by hypoxia. |
2021-02-12 |
2023-08-13 |
Not clear |
| Jia Jin, Leiping Wang, Zhonghua Tao, Jian Zhang, Fangfang Lv, Junning Cao, Xichun H. PDGFD induces ibrutinib resistance of diffuse large B‑cell lymphoma through activation of EGFR. Molecular medicine reports. vol 21. issue 5. 2021-02-08. PMID:32186759. |
following interference with pdgfd expression in ibrutinib‑resistant dlbcl cells, the ic50 value of ibrutinib decreased, the rate of apoptosis increased and egfr expression decreased. |
2021-02-08 |
2023-08-13 |
Not clear |