| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea B Motoyama, Nancy E Hyne. BAD: a good therapeutic target? Breast cancer research : BCR. vol 5. issue 1. 2003-05-13. PMID:12559042. |
recently described the ability of zd1839, a small-molecule inhibitor of the epidermal growth factor receptor (egfr), to induce apoptosis of mammary cells that are dependent upon growth factors for survival. |
2003-05-13 |
2023-08-12 |
Not clear |
| John W Davis, Andrew D Burdick, Fredine T Lauer, Scott W Burchie. The aryl hydrocarbon receptor antagonist, 3'methoxy-4'nitroflavone, attenuates 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent regulation of growth factor signaling and apoptosis in the MCF-10A cell line. Toxicology and applied pharmacology. vol 188. issue 1. 2003-05-07. PMID:12668121. |
previous studies have demonstrated that 2,3,7,8 tetracholorodibenzo-p-dioxin (tcdd) mimics epidermal growth factor receptor (egfr) signaling in the mcf-10a human mammary epithelial cell line and protects cells from egf withdrawal-induced apoptosis. |
2003-05-07 |
2023-08-12 |
human |
| Marcella Flinterman, Joop Gäken, Farzin Farzaneh, Mahvash Tavassol. E1A-mediated suppression of EGFR expression and induction of apoptosis in head and neck squamous carcinoma cell lines. Oncogene. vol 22. issue 13. 2003-04-23. PMID:12673202. |
e1a-mediated suppression of egfr expression and induction of apoptosis in head and neck squamous carcinoma cell lines. |
2003-04-23 |
2023-08-12 |
human |
| Marcella Flinterman, Joop Gäken, Farzin Farzaneh, Mahvash Tavassol. E1A-mediated suppression of EGFR expression and induction of apoptosis in head and neck squamous carcinoma cell lines. Oncogene. vol 22. issue 13. 2003-04-23. PMID:12673202. |
analysis of apoptosis in the scc cell lines demonstrated e1a-mediated downregulation of egfr, which was overexpressed in each of these cell lines. |
2003-04-23 |
2023-08-12 |
human |
| Marcella Flinterman, Joop Gäken, Farzin Farzaneh, Mahvash Tavassol. E1A-mediated suppression of EGFR expression and induction of apoptosis in head and neck squamous carcinoma cell lines. Oncogene. vol 22. issue 13. 2003-04-23. PMID:12673202. |
overexpression of an exogenously introduced egfr, under the control of an e1a-insensitive heterologous promoter, blocked e1a induction of apoptosis in these cells. |
2003-04-23 |
2023-08-12 |
human |
| Marcella Flinterman, Joop Gäken, Farzin Farzaneh, Mahvash Tavassol. E1A-mediated suppression of EGFR expression and induction of apoptosis in head and neck squamous carcinoma cell lines. Oncogene. vol 22. issue 13. 2003-04-23. PMID:12673202. |
therefore, e1a-mediated downregulation of egfr expression appears to be the cause, rather than a consequence of e1a-induced apoptosis in these scc cell lines. |
2003-04-23 |
2023-08-12 |
human |
| Marcella Flinterman, Joop Gäken, Farzin Farzaneh, Mahvash Tavassol. E1A-mediated suppression of EGFR expression and induction of apoptosis in head and neck squamous carcinoma cell lines. Oncogene. vol 22. issue 13. 2003-04-23. PMID:12673202. |
these findings demonstrate a novel pathway by which e1a can induce apoptosis and identify egfr as a potential target for the development of therapeutic strategies against epithelial malignancies, the majority of which have abnormal egfr expression. |
2003-04-23 |
2023-08-12 |
human |
| Sylvia S W Ng, Ming-Sound Tsao, Trudey Nicklee, David W Hedle. Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma. Molecular cancer therapeutics. vol 1. issue 10. 2003-04-07. PMID:12492110. |
the present study examined the effects of the epidermal growth factor receptor (egfr) inhibitor osi-774 ("tarceva") alone and in combination with wortmannin and/or gemcitabine on downstream signaling molecules, as well as apoptosis in primary pancreatic cancer xenografts implanted orthotopically in severely combined immunodeficient mice. |
2003-04-07 |
2023-08-12 |
mouse |
| Sylvia S W Ng, Ming-Sound Tsao, Trudey Nicklee, David W Hedle. Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma. Molecular cancer therapeutics. vol 1. issue 10. 2003-04-07. PMID:12492110. |
tumors established from two pancreatic cancer patients [ontario cancer institute pancreas number (ocip#) 2 and ocip#7] were treated with various combinations of the above three drugs and harvested for analyses of the following: the levels of phosphorylated and nonphosphorylated forms of egfr, protein kinase b (pkb/akt) and extracellular-regulated kinase (erk1/2), and the extent of apoptosis using immunofluorescence image analysis and tunel assay, respectively. |
2003-04-07 |
2023-08-12 |
mouse |
| Csaba Kari, Tung O Chan, Marlene Rocha de Quadros, Ulrich Rodec. Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage. Cancer research. vol 63. issue 1. 2003-03-27. PMID:12517767. |
by contrast, malignant tumor cells faced with inadequate cell-matrix contacts critically depend on egfr activation for survival, rendering them more susceptible to apoptosis induction by egfr blockade. |
2003-03-27 |
2023-08-12 |
Not clear |
| Csaba Kari, Tung O Chan, Marlene Rocha de Quadros, Ulrich Rodec. Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage. Cancer research. vol 63. issue 1. 2003-03-27. PMID:12517767. |
redundant control of cell survival by the egfr and extracellular matrix/cell adhesion receptors is enabled, in part, by shared signal transduction pathways that control expression and activation states of members of the bcl-2 family of apoptosis regulators. |
2003-03-27 |
2023-08-12 |
Not clear |
| Ana Cuadrado, Luis F Garcia-Fernandez, Laura Gonzalez, Yajaira Suarez, Alejandro Losada, Victoria Alcaide, Teresa Martinez, Jose Maria Fernandez-Sousa, Jose Maria Sanchez-Puelles, Alberto Muno. Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK. The Journal of biological chemistry. vol 278. issue 1. 2003-02-10. PMID:12414812. |
aplidin-induced apoptosis was only partially blocked by the general caspase inhibitor benzyloxycarbonyl-vad-fluoromethyl ketone and was also sensitive to ag1478 (an egfr inhibitor), pp2 (an src inhibitor), and sb203580 (an inhibitor of jnk and p38 mapk) in mda-mb-231 cells. |
2003-02-10 |
2023-08-12 |
mouse |
| Ana Cuadrado, Luis F Garcia-Fernandez, Laura Gonzalez, Yajaira Suarez, Alejandro Losada, Victoria Alcaide, Teresa Martinez, Jose Maria Fernandez-Sousa, Jose Maria Sanchez-Puelles, Alberto Muno. Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK. The Journal of biological chemistry. vol 278. issue 1. 2003-02-10. PMID:12414812. |
supporting a role for egfr in aplidin action, egfr-deficient mouse embryo fibroblasts underwent apoptosis upon treatment more slowly than wild-type egfr fibroblasts and also showed delayed jnk and reduced p38 mapk activation. |
2003-02-10 |
2023-08-12 |
mouse |
| Ana Cuadrado, Luis F Garcia-Fernandez, Laura Gonzalez, Yajaira Suarez, Alejandro Losada, Victoria Alcaide, Teresa Martinez, Jose Maria Fernandez-Sousa, Jose Maria Sanchez-Puelles, Alberto Muno. Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK. The Journal of biological chemistry. vol 278. issue 1. 2003-02-10. PMID:12414812. |
remarkably, aplidin also induced apoptosis and activated egfr, jnk, and p38 mapk in two cell lines (a-498 and achn) derived from human renal cancer, a neoplasia that is highly refractory to chemotherapy. |
2003-02-10 |
2023-08-12 |
mouse |
| Cara L Crowley-Weber, Claire M Payne, Mary Gleason-Guzman, George S Watts, Bernard Futscher, Caroline N Waltmire, Cheray Crowley, Katerina Dvorakova, Carol Bernstein, Mary Craven, Harinder Garewal, Harris Bernstei. Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate. Carcinogenesis. vol 23. issue 12. 2003-02-10. PMID:12507930. |
genes that may play a role in apoptosis and early stage carcinogenesis have been identified as upregulated in these cell lines, including grp78, bcl-2, nf-kappab(p50), nf-kappab(p65), thioredoxin peroxidase (peroxiredoxin) 2, peroxiredoxin 4, maspin, guanylate cyclase activating protein-1, pkczeta, egfr, ras family members, pka, pi(4,5)k, traf2 and birc1 (iap protein). |
2003-02-10 |
2023-08-12 |
human |
| Johann S de Bono, Eric K Rowinsk. Therapeutics targeting signal transduction for patients with colorectal carcinoma. British medical bulletin. vol 64. 2003-01-02. PMID:12421735. |
therapies discussed include agents targeting: (i) the epidermal growth factor receptor (egfr) family; (ii) ras via the inhibition of farnesyltransferase; (iii) raf kinase; (iv) the mitogen-activated protein kinase pathway (mapk, mek, erk); (v) akt; and (vi) the apoptosis signalling pathways including nf-kappab, bcl-2 and the trail receptor. |
2003-01-02 |
2023-08-12 |
Not clear |
| Drew L Lichtenstein, Peter Krajcsi, David J Esteban, Ann E Tollefson, William S M Wol. Adenovirus RIDbeta subunit contains a tyrosine residue that is critical for RID-mediated receptor internalization and inhibition of Fas- and TRAIL-induced apoptosis. Journal of virology. vol 76. issue 22. 2002-12-03. PMID:12388693. |
to investigate the molecular determinants of ridbeta that are involved in receptor down-regulation, mutations within the cytoplasmic tail of ridbeta were constructed and the mutant proteins were analyzed for their capacity to internalize and degrade fas and egfr and to protect cells from death receptor ligand-induced apoptosis. |
2002-12-03 |
2023-08-12 |
Not clear |
| Vita Golubovskaya, Lucia Beviglia, Li-Hui Xu, H Shelton Earp, Rolf Craven, William Canc. Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. The Journal of biological chemistry. vol 277. issue 41. 2002-11-25. PMID:12167618. |
egfr overexpression did not inhibit detachment induced by the fak c-terminal domain, but did suppress apoptosis, activating akt and erk1/2 survival pathways and inhibiting cleavage of fak, caspase-3 and -8, and poly(adp-ribose) polymerase. |
2002-11-25 |
2023-08-12 |
human |
| Vita Golubovskaya, Lucia Beviglia, Li-Hui Xu, H Shelton Earp, Rolf Craven, William Canc. Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. The Journal of biological chemistry. vol 277. issue 41. 2002-11-25. PMID:12167618. |
in addition, inhibition of fak and egfr in another breast cancer cell line (bt20) endogenously overexpressing these kinases also induced apoptosis via the same mechanism as in the egfr-overexpressing bt474 cells. |
2002-11-25 |
2023-08-12 |
human |
| Vita Golubovskaya, Lucia Beviglia, Li-Hui Xu, H Shelton Earp, Rolf Craven, William Canc. Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. The Journal of biological chemistry. vol 277. issue 41. 2002-11-25. PMID:12167618. |
the results of this study indicate that dual inhibition of fak and egfr signaling pathways can cooperatively enhance apoptosis in breast cancers. |
2002-11-25 |
2023-08-12 |
human |