| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C J Wu, X Qian, D M O'Rourk. Sustained mitogen-activated protein kinase activation is induced by transforming erbB receptor complexes. DNA and cell biology. vol 18. issue 10. 1999-11-22. PMID:10541432. |
transforming erbb complexes, including egfr homodimers, deltaegfr homodimers, and p185(neu)/egfr heterodimers, appear to induce sustained, unattenuated activation of mapk activities that may contribute to increased transformation and resistance to apoptosis in primary human glioblastoma cells. |
1999-11-22 |
2023-08-12 |
human |
| D B Reardon, J N Contessa, R B Mikkelsen, K Valerie, C Amir, P Dent, R K Schmidt-Ullric. Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells. Oncogene. vol 18. issue 33. 1999-10-15. PMID:10467423. |
modulation of egfr and mapk functions also altered overall cellular responses of growth and apoptosis. |
1999-10-15 |
2023-08-12 |
human |
| R Iwamoto, K Handa, E Mekad. Contact-dependent growth inhibition and apoptosis of epidermal growth factor (EGF) receptor-expressing cells by the membrane-anchored form of heparin-binding EGF-like growth factor. The Journal of biological chemistry. vol 274. issue 36. 1999-10-07. PMID:10464334. |
moreover, 32d cells expressing egfr mutant composed of the extracellular and the transmembrane domain of egfr and the cytoplasmic domain of erythropoietin receptor did not undergo apoptosis by co-culture with vero-h cells, indicating that the inhibitory signal induced by pro-hb-egf-expressing vero-h cells is mediated to der cells via egfr and that the cytoplasmic domain of egfr is essential for pro-hb-egf-induced apoptosis. |
1999-10-07 |
2023-08-12 |
Not clear |
| A Well. EGF receptor. The international journal of biochemistry & cell biology. vol 31. issue 6. 1999-08-05. PMID:10404636. |
the integrated biological responses to egfr signaling are pleiotropic including mitogenesis or apoptosis, enhanced cell motility, protein secretion, and differentiation or dedifferentiation. |
1999-08-05 |
2023-08-12 |
Not clear |
| M Ołdak, J Malejczy. [Signal transduction mechanisms induced by epidermal growth factor receptor (EGFR) and their role in apoptosis regulation]. Postepy higieny i medycyny doswiadczalnej. vol 53. issue 2. 1999-08-03. PMID:10355296. |
[signal transduction mechanisms induced by epidermal growth factor receptor (egfr) and their role in apoptosis regulation]. |
1999-08-03 |
2023-08-12 |
Not clear |
| M Ołdak, J Malejczy. [Signal transduction mechanisms induced by epidermal growth factor receptor (EGFR) and their role in apoptosis regulation]. Postepy higieny i medycyny doswiadczalnej. vol 53. issue 2. 1999-08-03. PMID:10355296. |
surprisingly, under certain circumstances stimulation of egfr may also result in cell growth arrest and apoptosis induction. |
1999-08-03 |
2023-08-12 |
Not clear |
| A G Korshunov, A V Golanov, R V Sycheva, I N Proni. [The prognostic importance of cancer-associated proteins and apoptosis in glioblastomas of the cerebral hemispheres]. Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko. issue 1. 1999-06-16. PMID:10335568. |
they revealed that the longevity of the hemispheres was substantially influenced by three immunobiological criteria: the proliferative potential defined as a labelling index (li) of proliferative cell nuclear antigen (pcna), the expression of intracellular domain of epidermal growth factor receptor (egfr) and the rate of apoptosis identified by isel. |
1999-06-16 |
2023-08-12 |
Not clear |
| N Sugawa, K Yamamoto, S Ueda, N Morita, M Kita, H Nishino, S Fushiki, T Okab. Function of aberrant EGFR in malignant gliomas. Brain tumor pathology. vol 15. issue 1. 1999-03-04. PMID:9879464. |
to study the relationship between the expression of this aberrant egfr and cell proliferation, as well as apoptosis in malignant gliomas, we have developed u-87mg cell transfectants that express the aberrant (mutant-type) or normal (wild-type) egfr. |
1999-03-04 |
2023-08-12 |
mouse |
| N Sugawa, K Yamamoto, S Ueda, N Morita, M Kita, H Nishino, S Fushiki, T Okab. Function of aberrant EGFR in malignant gliomas. Brain tumor pathology. vol 15. issue 1. 1999-03-04. PMID:9879464. |
these results suggest that aberrant egfr affects the malignancy of glioma by stimulating proliferation and inhibiting apoptosis. |
1999-03-04 |
2023-08-12 |
mouse |
| M Perez, B Haschke, N J Donat. Differential expression and translocation of protein tyrosine phosphatase 1B-related proteins in ME-180 tumor cells expressing apoptotic sensitivity and resistance to tumor necrosis factor: potential interaction with epidermal growth factor receptor. Oncogene. vol 18. issue 4. 1999-02-23. PMID:10023672. |
prior to the onset of apoptosis, tnf caused a significant reduction in the level of egfr tyrosine phosphorylation in sen cells but mediated only limited suppression of egfr tyrosine phosphorylation in apoptotically resistant res cells. |
1999-02-23 |
2023-08-12 |
Not clear |
| D G Beer, G D Stone. Clinical models of chemoprevention for the esophagus. Hematology/oncology clinics of North America. vol 12. issue 5. 1999-02-12. PMID:9888021. |
biomarkers of cell proliferation (e.g., pcna, ki67), cell differentiation (keratins), apoptosis, gene expression (egfr, cyclin d1, p53), and nuclear/nucleolar morphometry can be used in studies to assess the efficacy of chemopreventives to either reverse esophageal dysplastic lesions or slow their rate of progression. |
1999-02-12 |
2023-08-12 |
rat |
| M Mandal, L Adam, J Mendelsohn, R Kuma. Nuclear targeting of Bax during apoptosis in human colorectal cancer cells. Oncogene. vol 17. issue 8. 1998-10-02. PMID:9747879. |
we report that inhibition of epidermal growth factor receptor (egfr) tyrosine kinase activity and downregulation of egfr by anti-egfr mab 225 induces apoptosis in human colorectal carcinoma difi and fet cells. |
1998-10-02 |
2023-08-12 |
human |
| H Modjtahedi, K Affleck, C Stubberfield, C Dea. EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5. International journal of oncology. vol 13. issue 2. 1998-08-14. PMID:9664130. |
egfr blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma hn5. |
1998-08-14 |
2023-08-12 |
mouse |
| H Modjtahedi, K Affleck, C Stubberfield, C Dea. EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5. International journal of oncology. vol 13. issue 2. 1998-08-14. PMID:9664130. |
we conclude that egfr blockade by anti-egfr mabs or tk inhibitor influences the growth in culture of egfr overexpressing tumours by directing terminal differentiation and inducing apoptosis. |
1998-08-14 |
2023-08-12 |
mouse |
| T Kvasnicka, W Wang, H Johansson, K Sandelin, L Grimeliu. Apoptosis and growth factors in parathyroid adenomas. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 29. issue 11. 1998-04-10. PMID:9479553. |
detection rates of tgf-alpha and egfr were very high, but neither tgf-alpha nor egfr was correlated to apoptosis. |
1998-04-10 |
2023-08-12 |
Not clear |
| S W Stoll, M Benedict, R Mitra, A Hiniker, J T Elder, G Nuñe. EGF receptor signaling inhibits keratinocyte apoptosis: evidence for mediation by Bcl-XL. Oncogene. vol 16. issue 11. 1998-04-08. PMID:9580112. |
here we report that human keratinocytes undergo apoptosis when incubated with the blocking egfr monoclonal antibody 225 igg, or pd153035, a highly specific egfr tyrosine kinase inhibitor. |
1998-04-08 |
2023-08-12 |
human |
| S W Stoll, M Benedict, R Mitra, A Hiniker, J T Elder, G Nuñe. EGF receptor signaling inhibits keratinocyte apoptosis: evidence for mediation by Bcl-XL. Oncogene. vol 16. issue 11. 1998-04-08. PMID:9580112. |
endogenous mrna and protein levels of bcl-xl, a member the bcl-2 family which suppresses apoptosis, were specifically inhibited by egfr blockade. |
1998-04-08 |
2023-08-12 |
human |
| T Nagao, I Sugano, Y Ishida, M Hasegawa, O Matsuzaki, A Konno, Y Kondo, K Naga. Basal cell adenocarcinoma of the salivary glands: comparison with basal cell adenoma through assessment of cell proliferation, apoptosis, and expression of p53 and bcl-2. Cancer. vol 82. issue 3. 1998-02-19. PMID:9452259. |
eleven cases of bcac are presented here and compared with basal cell adenoma (bca) through assessment of cell proliferative activity, apoptosis, and expression of p53, bcl-2, and epidermal growth factor receptor (egfr) because these two tumors show close similarity in some cytologic and architectural characteristics. |
1998-02-19 |
2023-08-12 |
Not clear |
| C Boccafoschi, F Montefiore, M Pavesi, M Pastormerlo, P G Bett. [Cellular proliferation, expression of p53, EGFR and apoptosis index of healthy mucosa of the bladder with TCC; pre- and post-intravesical BCG immunohistochemical study]. Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica. vol 69. issue 4. 1997-12-30. PMID:9417299. |
[cellular proliferation, expression of p53, egfr and apoptosis index of healthy mucosa of the bladder with tcc; pre- and post-intravesical bcg immunohistochemical study]. |
1997-12-30 |
2023-08-12 |
Not clear |
| C Boccafoschi, F Montefiore, M Pavesi, M Pastormerlo, P G Bett. [Cellular proliferation, expression of p53, EGFR and apoptosis index of healthy mucosa of the bladder with TCC; pre- and post-intravesical BCG immunohistochemical study]. Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica. vol 69. issue 4. 1997-12-30. PMID:9417299. |
the therapeutic effects of bcg don't seem to depend exclusively on local immune response, so that according to this assertion, this immunohistochemical study had been conducted on 14 patients affected by superficial bladder cancer (pta-pt1) which aimed to value both the apoptosis and proliferation indexes and the expression of the genetic product p53 and egfr before and after the exposition of the vesical mucosa to the bcg. |
1997-12-30 |
2023-08-12 |
Not clear |