| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Lyahyai, T Goldammer, A E Beattie, P Zaragoza, I Martín-Burrie. Positional and functional characterisation of apoptosis related genes belonging to the BCL2 family in sheep. Cytogenetic and genome research. vol 109. issue 4. 2005-07-12. PMID:15905648. |
positional and functional characterisation of apoptosis related genes belonging to the bcl2 family in sheep. |
2005-07-12 |
2023-08-12 |
cattle |
| Yang Wang, Refika I Pakunlu, William Tsao, Vitaly Pozharov, Tamara Mink. Bimodal effect of hypoxia in cancer: role of hypoxia inducible factor in apoptosis. Molecular pharmaceutics. vol 1. issue 2. 2005-07-11. PMID:15832512. |
after treatment, the following processes and factors were monitored: apoptosis, cellular metabolism and viability, expression of genes encoding hif1a, von hippel-lindau tumor suppressor protein (vhl), and genes responsible for cell death induction and antiapoptotic defense (p53, bcl2, bax, and caspases 9 and 3). |
2005-07-11 |
2023-08-12 |
human |
| Yang Wang, Refika I Pakunlu, William Tsao, Vitaly Pozharov, Tamara Mink. Bimodal effect of hypoxia in cancer: role of hypoxia inducible factor in apoptosis. Molecular pharmaceutics. vol 1. issue 2. 2005-07-11. PMID:15832512. |
hypoxia induced apoptosis by upregulating the p53-, bax-, and caspase-dependent cell death pathways, while activating cellular antiapoptotic defense by the overexpression of bcl2 protein. |
2005-07-11 |
2023-08-12 |
human |
| Hensin Tsao, Arthur J Sobe. Melanoma treatment update. Dermatologic clinics. vol 23. issue 2. 2005-06-21. PMID:15837158. |
for instance, sustained expression of bcl2 has been associated with an increased resistance to apoptosis, and recently, anti-sense-mediated reduction of bcl2 levels was shown to chemosensitize patients to dacarbazine, dimethyl triazino imidazole carboxomide, or dtic. |
2005-06-21 |
2023-08-12 |
Not clear |
| Wei Ma, Dong Zhang, Yi Hou, Yong-Hai Li, Qing-Yuan Sun, Xiao-Fang Sun, Wei-Hua Wan. Reduced expression of MAD2, BCL2, and MAP kinase activity in pig oocytes after in vitro aging are associated with defects in sister chromatid segregation during meiosis II and embryo fragmentation after activation. Biology of reproduction. vol 72. issue 2. 2005-05-24. PMID:15469999. |
this study was conducted to examine expression of centromere protein b (cenpb), spindle checkpoint protein mad2 (mitotic arrest deficient protein), and antiapoptotic protein bcl2; activities of mapk (mitogen-activated protein kinase) and mitochondria distribution in pig oocytes during aging, and their relationship with sister chromatid separation during meiosis ii and embryo fragmentation and apoptosis after activation. |
2005-05-24 |
2023-08-12 |
Not clear |
| Alexandra H Minn, Christian Hafele, Anath Shale. Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis. Endocrinology. vol 146. issue 5. 2005-05-24. PMID:15705778. |
we therefore generated a stable transfected beta-cell line (ins-1) overexpressing human txnip and found that txnip overexpression induced apoptosis as assessed by bax, bcl2, caspase-3, and cleaved caspase-9 as well as hoechst staining. |
2005-05-24 |
2023-08-12 |
mouse |
| Shailja Singh, B S Dwarakanath, T Lazar Mathe. Role of topoisomerases in cytotoxicity induced by DNA ligand Hoechst-33342 and UV-C in a glioma cell line. Indian journal of experimental biology. vol 43. issue 4. 2005-05-20. PMID:15875714. |
induction of apoptosis was associated with a decline in the level of bcl2. |
2005-05-20 |
2023-08-12 |
human |
| Angel Martínez-Ramírez, Miguel Urioste, Lorenzo Melchor, David Blesa, Laura Valle, Sara Alvarez de Andrés, Klaas Kok, Maria José Calasanz, Juan Cruz Cigudosa, Javier Beníte. Analysis of myelodysplastic syndromes with complex karyotypes by high-resolution comparative genomic hybridization and subtelomeric CGH array. Genes, chromosomes & cancer. vol 42. issue 3. 2005-05-19. PMID:15611930. |
in addition, two other genes, bcl6 and bcl2, which are classically related to apoptosis and non-hodgkin lymphoma, were shown for the first time to be involved in amplification. |
2005-05-19 |
2023-08-12 |
Not clear |
| José Palacios, Emiliano Honrado, Ana Osorio, Alicia Cazorla, David Sarrió, Alicia Barroso, Sandra Rodríguez, Juan C Cigudosa, Orland Diez, Carmen Alonso, Enrique Lerma, Joaquín Dopazo, Carmen Rivas, Javier Beníte. Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers. Breast cancer research and treatment. vol 90. issue 1. 2005-05-19. PMID:15770521. |
markers analyzed included, amog others, common markers in breast cancer, such as hormone receptors, p53 and her2, along with 15 molecules involved in cell cycle regulation, such as cyclins, cyclin dependent kinases (cdk) and cdk inhibitors (cdki), apoptosis markers, such as bcl2 and active caspase 3, and two basal/myoepithelial markers (ck 5/6 and p-cadherin). |
2005-05-19 |
2023-08-12 |
Not clear |
| Kostas V Floros, Hellinida Thomadaki, Nikos Katsaros, Maroulio Talieri, Andreas Scorila. mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biological chemistry. vol 385. issue 11. 2005-05-17. PMID:15576332. |
in the case of carboplatin-induced apoptosis we detected down-regulation of bax , bcl2 and caspase-9, whereas in the case of doxorubicin, bax and bcl2 remained at control levels and caspase-9 was increased. |
2005-05-17 |
2023-08-12 |
human |
| Béla Szend. [The occurrence and significance of apoptosis in tumors]. Magyar onkologia. vol 48. issue 3. 2005-05-11. PMID:15520871. |
expression of genes influencing apoptosis, such as bcl2, p53, and bax, may rather be of importance from the point of view of histological differential diagnosis. |
2005-05-11 |
2023-08-12 |
Not clear |
| Puay-Hoon Tan, Boon-Huat Bay, George Yip, Sathiyamoorthy Selvarajan, Patrick Tan, Jeanie Wu, Chee-How Lee, Kuo-Bin L. Immunohistochemical detection of Ki67 in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 18. issue 3. 2005-05-09. PMID:15578079. |
genes related to apoptosis and cell death (bcl2, map2k4, tnf10) were noted to be downregulated in tumors that disclosed >40% ki67 immunostaining (p<0.001). |
2005-05-09 |
2023-08-12 |
Not clear |
| Susanne Vetterkind, Meike Boosen, Karl-Heinz Scheidtmann, Ute Preus. Ectopic expression of Par-4 leads to induction of apoptosis in CNS tumor cell lines. International journal of oncology. vol 26. issue 1. 2005-05-02. PMID:15586236. |
induction of apoptosis by par-4 in the neural tumor cell lines is independent of endogenous bcl-2 levels and pkczeta activity, although it has been proposed that par-4 can exert its pro-apoptotic function by down-modulation of bcl2 expression and inhibition of pkczeta. |
2005-05-02 |
2023-08-12 |
human |
| Xin Fu, John R Latendresse, Levan Muskhelishvili, Betty S Blaydes, K Barry Delclo. Dietary modulation of 7,12-dimethylbenz[a]anthracene (DMBA)-induced adrenal toxicity in female Sprague-Dawley rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 43. issue 5. 2005-04-25. PMID:15778017. |
apoptosis was manifested at 24 and 36 h after dmba treatment in the zona reticularis (zr) and the zona fasciculata (zf) of the adrenal cortex; this was followed by severe hemorrhagic necrosis at 48 h. dmba-induced apoptosis, evaluated by the tunel assay, immunohistochemical analysis of activated caspase 3, and the ratio of expression of pro-apoptotic bax to anti-apoptotic bcl2, was greater in rats fed nih-31 diet relative to rats fed 5k96 diet at 24 h after treatment. |
2005-04-25 |
2023-08-12 |
rat |
| Minakshi Nihal, Nihal Ahmad, Hasan Mukhtar, Gary S Woo. Anti-proliferative and proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: possible implications for the chemoprevention of melanoma. International journal of cancer. vol 114. issue 4. 2005-04-11. PMID:15609335. |
our data suggest that egcg causes significant induction of cell cycle arrest and apoptosis of melanoma cells that is mediated via modulations in the cki-cyclin-cdk network and bcl2 family proteins. |
2005-04-11 |
2023-08-12 |
human |
| Barbara Jung, Valerie Barbier, Howard Brickner, John Welsh, Arun Fotedar, Michael McClellan. Mechanisms of sulindac-induced apoptosis and cell cycle arrest. Cancer letters. vol 219. issue 1. 2005-03-31. PMID:15694660. |
in contrast, bcl2 transgenic thymocytes are resistant to sulindac sulfide-induced apoptosis. |
2005-03-31 |
2023-08-12 |
mouse |
| Alireza Mirmohammadsadegh, Annett Baer, Sandeep Nambiar, Walter Bardenheuer, Ulrich R Hengg. Rapid identification of dysregulated genes in cutaneous malignant melanoma metastases using cDNA technology. Cells, tissues, organs. vol 177. issue 3. 2005-03-07. PMID:15388985. |
an abundance of genes was dysregulated (up-/downregulated), which involved for example the apoptosis gene growth factor receptor-bound protein 10, bcl2-associated x membrane protein, bcl2 antagonist of cell death, glutathione s-transferase theta(1) and glutathione reductase. |
2005-03-07 |
2023-08-12 |
human |
| M Vijay Kumar, Robert Shirley, Yulin Ma, Ronald W Lewi. Role of genomics-based strategies in overcoming chemotherapeutic resistance. Current pharmaceutical biotechnology. vol 5. issue 5. 2005-02-23. PMID:15544495. |
nfkappab blocked apoptosis by interfering with the function of tnfalpha/trail and/or through the activation of antiapoptotic proteins of the bcl2 family. |
2005-02-23 |
2023-08-12 |
Not clear |
| Emi K Nishimura, Scott R Granter, David E Fishe. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science (New York, N.Y.). vol 307. issue 5710. 2005-02-16. PMID:15618488. |
this process is accelerated dramatically with bcl2 deficiency, which causes selective apoptosis of melanocyte stem cells, but not of differentiated melanocytes, within the niche at their entry into the dormant state. |
2005-02-16 |
2023-08-12 |
mouse |
| Sheng-Tung Huang, Hsin-Da Tsai, Hsien-Shou Kuo, Yu-Ping Yang, Yi-Chen Peng, Yuh-Ling Li. A novel bis-aziridinylnaphthoquinone with anti-solid tumor activity in which induced apoptosis is associated with altered expression of Bcl-2 protein. Chembiochem : a European journal of chemical biology. vol 5. issue 6. 2005-02-15. PMID:15174162. |
growth arrest in hep2 cells was preceded by early induction of g(2)-m cell cycle arrest at 0.75 microm of 1 c after culture for 24 h, and was then followed by apoptosis after 60 h. this was associated with decreased expression of antiapoptotic bcl2 protein (by 78 %) upon culture with 3.0 microm of 1 c after 60 h. our results suggest that 1 c is a novel antitumor aziridinylnaphthoquinone with therapeutic potential against solid tumors. |
2005-02-15 |
2023-08-12 |
human |