| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sasmita Mishra, Jyoti P Mishra, Ashok Kuma. Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: involvement of antiapoptotic BCL2 and c-IAP1 genes. The Journal of biological chemistry. vol 282. issue 7. 2007-03-26. PMID:17158886. |
activation of jnk-dependent pathway is required for hiv viral protein r-induced apoptosis in human monocytic cells: involvement of antiapoptotic bcl2 and c-iap1 genes. |
2007-03-26 |
2023-08-12 |
human |
| Sasmita Mishra, Jyoti P Mishra, Ashok Kuma. Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: involvement of antiapoptotic BCL2 and c-IAP1 genes. The Journal of biological chemistry. vol 282. issue 7. 2007-03-26. PMID:17158886. |
furthermore vpr-(52-96)-induced apoptosis was mediated by inhibition of downstream antiapoptotic bcl2 and c-iap1 genes whose expression could be restored following pretreatment with jnk-specific inhibitors. |
2007-03-26 |
2023-08-12 |
human |
| Sasmita Mishra, Jyoti P Mishra, Ashok Kuma. Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: involvement of antiapoptotic BCL2 and c-IAP1 genes. The Journal of biological chemistry. vol 282. issue 7. 2007-03-26. PMID:17158886. |
overall the results suggest that vpr-(52-96)-activated jnk plays a key role in inducing apoptosis through the down-regulation of antiapoptotic bcl2 and c-iap1 genes. |
2007-03-26 |
2023-08-12 |
human |
| Hellinida Thomadaki, Maroulio Talieri, Andreas Scorila. Prognostic value of the apoptosis related genes BCL2 and BCL2L12 in breast cancer. Cancer letters. vol 247. issue 1. 2007-03-20. PMID:16647810. |
prognostic value of the apoptosis related genes bcl2 and bcl2l12 in breast cancer. |
2007-03-20 |
2023-08-12 |
Not clear |
| Maria Bai, Alexandra Papoudou-Bai, Nikolaos Horianopoulos, Constantina Grepi, Niki John Agnantis, Panagiotis Kanavaro. Expression of bcl2 family proteins and active caspase 3 in classical Hodgkin's lymphomas. Human pathology. vol 38. issue 1. 2007-02-15. PMID:16949642. |
this study aimed to investigate the expression of the proteins bcl2, bcl-xl, mcl1, bax, bak, bad, bid, bim, and active caspase 3, and the tunel (terminal deoxynucleotidyl transferase-mediated in situ labeling) index to gain further insight into the apoptosis profile of classical hls. |
2007-02-15 |
2023-08-12 |
Not clear |
| Jagruti H Patel, Steven B McMaho. BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis. The Journal of biological chemistry. vol 282. issue 1. 2007-02-08. PMID:17082179. |
bcl2 is a downstream effector of miz-1 essential for blocking c-myc-induced apoptosis. |
2007-02-08 |
2023-08-12 |
human |
| Jagruti H Patel, Steven B McMaho. BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis. The Journal of biological chemistry. vol 282. issue 1. 2007-02-08. PMID:17082179. |
these observations suggest that repression of bcl2 transcription is the single essential consequence of targeting the miz-1 pathway during apoptosis induction. |
2007-02-08 |
2023-08-12 |
human |
| Suniket V Fulzele, Abhijit Chatterjee, Madhu Sudhan Shaik, Tanise Jackson, Nkechi Ichite, Mandip Sing. 15-Deoxy-Delta12,14-prostaglandin J2 enhances docetaxel anti-tumor activity against A549 and H460 non-small-cell lung cancer cell lines and xenograft tumors. Anti-cancer drugs. vol 18. issue 1. 2007-01-30. PMID:17159504. |
15-deoxy-delta-prostaglandin j2+docetaxel showed a significant increase in apoptosis associated with inhibition of the bcl2 and cyclin d1 expression and overexpression of caspase and p53 pathway genes. |
2007-01-30 |
2023-08-12 |
mouse |
| Muthusamy Thangaraju, Elangovan Gopal, Pamela M Martin, Sudha Ananth, Sylvia B Smith, Puttur D Prasad, Esta Sterneck, Vadivel Ganapath. SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases. Cancer research. vol 66. issue 24. 2007-01-25. PMID:17178845. |
apoptosis induced by slc5a8/pyruvate in mcf7 cells is associated with up-regulation of p53, bax, tumor necrosis factor-related apoptosis-inducing ligand (trail), trail receptor (trailr) 1, and trailr2 and down-regulation of bcl2 and survivin. |
2007-01-25 |
2023-08-12 |
Not clear |
| Kostas V Floros, Maroulio Talieri, Andreas Scorila. Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells. Biological chemistry. vol 387. issue 12. 2007-01-24. PMID:17132110. |
the bcl2 family of genes (b-cell cll/lymphoma 2; bcl-2) plays a pivotal role in the highly regulated process of apoptosis. |
2007-01-24 |
2023-08-12 |
human |
| Wu Yin, Ni Chen, Yutao Zhang, Hao Zeng, Xueqin Chen, Yongtao He, Xiaojie Wang, Qiao Zho. Survivin nuclear labeling index: a superior biomarker in superficial urothelial carcinoma of human urinary bladder. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 19. issue 11. 2007-01-05. PMID:16892011. |
in the present study, we first systematically evaluated the expression profile of the major apoptosis regulators, including caspases (casp3, 6, 7, 8, 9, 10, and 14), iaps (survivin/birc5, ciap1, ciap2, xiap, and livin), apaf1, smac, and bcl2, as well as proliferation markers ki67 and phh3, in ta/t1 human urinary bladder urothelial carcinomas and normal urothelium samples by immunohistochemistry. |
2007-01-05 |
2023-08-12 |
human |
| Jixun Dai, Ding Chen, Roger A Jones, Laurence H Hurley, Danzhou Yan. NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region. Nucleic acids research. vol 34. issue 18. 2006-12-18. PMID:16998187. |
bcl2 protein functions as an inhibitor of cell apoptosis and has been found to be aberrantly expressed in a wide range of human diseases. |
2006-12-18 |
2023-08-12 |
human |
| Rongrong Li, Yufeng Cheng, Chengjin Ga. Enhancing radiosensitivity of Hela cells by combining transfection of bcl-2 c-myc ASODNs. Bulletin du cancer. vol 93. issue 11. 2006-12-18. PMID:17145575. |
in this study, we investigated the effect on apoptosis of hela cells by combining transfection of bcl2 and c-myc antisense oligonucleotides(asodns), and to explore the relationship between combining gene transfection and radiosensitivity of hela cells, furthermore, to seek a new method to enhance the radiosensitivity of tumor cells. |
2006-12-18 |
2023-08-12 |
Not clear |
| Rongrong Li, Yufeng Cheng, Chengjin Ga. Enhancing radiosensitivity of Hela cells by combining transfection of bcl-2 c-myc ASODNs. Bulletin du cancer. vol 93. issue 11. 2006-12-18. PMID:17145575. |
the apoptosis rate of hela cells treated with bcl2 asodn was 6.60 +/- 0.70%, c-myc asodn 10.29 +/- 0.66%, bcl2 + c-myc asodns 11.83 +/- 0.57 %, which were much higher than that of control 1.79 +/- 0.19%(p < 0.05). |
2006-12-18 |
2023-08-12 |
Not clear |
| Rongrong Li, Yufeng Cheng, Chengjin Ga. Enhancing radiosensitivity of Hela cells by combining transfection of bcl-2 c-myc ASODNs. Bulletin du cancer. vol 93. issue 11. 2006-12-18. PMID:17145575. |
combining transfection of bcl2 and c-myc asodn could more effectively induce apoptosis of hela cells, which subsequently enhanced radiosensitivity of hela cells. |
2006-12-18 |
2023-08-12 |
Not clear |
| Sung Nim Han, Oskar Adolfsson, Cheol-Koo Lee, Tomas A Prolla, Jose Ordovas, Simin Nikbin Meydan. Age and vitamin E-induced changes in gene expression profiles of T cells. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 9. 2006-12-13. PMID:17056531. |
higher gadd45 and lower bcl2 expression may contribute to increased apoptosis in old t cells. |
2006-12-13 |
2023-08-12 |
mouse |
| Yan Xia, Rachel Novak, Jennifer Lewis, Colin S Duckett, Andrew C Phillip. Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP. Molecular and cellular biochemistry. vol 286. issue 1-2. 2006-10-19. PMID:16432762. |
this implicates a role for the mitochondrial apoptotic pathway, consistent with the ability of bcl2 to block xaf1 induced apoptosis. |
2006-10-19 |
2023-08-12 |
Not clear |
| Shinzaburo Noguch. Predictive factors for response to docetaxel in human breast cancers. Cancer science. vol 97. issue 9. 2006-10-18. PMID:16805818. |
various biological parameters have been studied clinically for their ability to predict response to docetaxel, such as parameters related to: (1) efflux (p-glycoprotein) and metabolism (cyp3a4); (2) beta-tubulin (somatic mutation of beta-tubulin and changes in beta-tubulin isotypes levels); (3) cell cycle (her2, brca1 and aurora-a); and (4) apoptosis (p53, bcl2 and thioredoxin). |
2006-10-18 |
2023-08-12 |
human |
| K Rathinasamy, D Pand. Suppression of microtubule dynamics by benomyl decreases tension across kinetochore pairs and induces apoptosis in cancer cells. The FEBS journal. vol 273. issue 17. 2006-10-17. PMID:16903866. |
further, we analyzed the effects of benomyl on the signal transduction pathways in relation to mitotic block, bcl2 phosphorylation and induction of apoptosis. |
2006-10-17 |
2023-08-12 |
Not clear |
| Subhash Thalappilly, Subhashini Sadasivam, Vegesna Radha, Ghanshyam Swaru. Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis. The FEBS journal. vol 273. issue 12. 2006-09-25. PMID:16817903. |
an activated form of ipaf induced caspase 1-dependent apoptosis that was inhibited by bcl2 and also by a dominant inhibitor of caspase 9 (caspase 9s). |
2006-09-25 |
2023-08-12 |
Not clear |