| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I A Siddiqui, A Malik, V M Adhami, M Asim, B B Hafeez, S Sarfaraz, H Mukhta. Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis. Oncogene. vol 27. issue 14. 2008-04-16. PMID:17998943. |
first, apoptosis induction was accompanied by the upregulation of poly(adp-ribose) polymerase cleavage and modulation of pro- and antiapoptotic bcl2 family of proteins. |
2008-04-16 |
2023-08-12 |
human |
| Chandramani Pathak, Yogesh K Jaiswal, Manjula Vinaya. Possible involvement of queuine in regulation of cell proliferation. BioFactors (Oxford, England). vol 29. issue 4. 2008-04-14. PMID:18057548. |
like other proto-oncogenes bcl2 is known to involve in cell survival by inhibiting apoptosis. |
2008-04-14 |
2023-08-12 |
mouse |
| Meenu Jain, Shaleen Kumar, Rohit Upadhyay, Puneeta Lal, Anu Tiwari, Uday C Ghoshal, Balraj Mitta. Influence of apoptosis (BCL2, FAS), cell cycle (CCND1) and growth factor (EGF, EGFR) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer. Cancer biology & therapy. vol 6. issue 10. 2008-04-03. PMID:17912028. |
influence of apoptosis (bcl2, fas), cell cycle (ccnd1) and growth factor (egf, egfr) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer. |
2008-04-03 |
2023-08-12 |
Not clear |
| Babli Halder, Udayan Bhattacharya, Sibabrata Mukhopadhyay, Ashok K Gir. Molecular mechanism of black tea polyphenols induced apoptosis in human skin cancer cells: involvement of Bax translocation and mitochondria mediated death cascade. Carcinogenesis. vol 29. issue 1. 2008-03-31. PMID:17984116. |
our intricate investigations on apoptosis also explained that tf and tr augmented bax:bcl2 ratio, up-regulated the expression of p53 as well as p21 and inhibited phosphorylation of the cell survival protein akt. |
2008-03-31 |
2023-08-12 |
human |
| Noömi Lombaert, Dominique Lison, Paul Van Hummelen, Micheline Kirsch-Volder. In vitro expression of hard metal dust (WC-Co)--responsive genes in human peripheral blood mononucleated cells. Toxicology and applied pharmacology. vol 227. issue 2. 2008-03-31. PMID:18078969. |
quantitative rt-pcr data for a selection of the most strongly modulated genes (hmox1, hspa1a, hspa1l, bnip3, bnip3l, adora2b, mt3, pla2g7, tnfaip6), and some additionally chosen apoptosis related genes (bcl2, bax, fas, fasl, tnfalpha), confirmed the microarray data after wc-co exposure and demonstrated limited differences between the co-containing compounds. |
2008-03-31 |
2023-08-12 |
human |
| S Nagel, C Meyer, H Quentmeier, M Kaufmann, H G Drexler, R A F MacLeo. MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines. Leukemia. vol 22. issue 3. 2008-03-27. PMID:18079734. |
mef2c consistently inhibits expression of nr4a1/nur77, which regulates apoptosis via bcl2 transformation. |
2008-03-27 |
2023-08-12 |
Not clear |
| C Ploner, J Rainer, H Niederegger, M Eduardoff, A Villunger, S Geley, R Kofle. The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia. Leukemia. vol 22. issue 2. 2008-03-26. PMID:18046449. |
the bcl2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia. |
2008-03-26 |
2023-08-12 |
Not clear |
| Yan-Yi Wang, Xingming Deng, Lijun Xu, Fengqin Gao, Tammy Flagg, W Stratford Ma. Bcl2 enhances induced hematopoietic differentiation of murine embryonic stem cells. Experimental hematology. vol 36. issue 2. 2008-03-25. PMID:18023519. |
bcl2's effect on induced-hematopoietic differentiation of es cells does not result from either decreased apoptosis or a reduced number of cells. |
2008-03-25 |
2023-08-12 |
Not clear |
| Klaus Steger, Jochen Wilhelm, Lutz Konrad, Thomas Stalf, Robert Greb, Thorsten Diemer, Sabine Kliesch, Martin Bergmann, Wolfgang Weidne. Both protamine-1 to protamine-2 mRNA ratio and Bcl2 mRNA content in testicular spermatids and ejaculated spermatozoa discriminate between fertile and infertile men. Human reproduction (Oxford, England). vol 23. issue 1. 2008-03-12. PMID:18003625. |
as sperm dna integrity is known to be linked with dna fragmentation and apoptosis, we investigated whether the protamine ratio or bcl2 content represent a reliable biomarker to discriminate fertile and infertile men. |
2008-03-12 |
2023-08-12 |
mouse |
| Narendra Wajapeyee, Ryan W Serra, Xiaochun Zhu, Meera Mahalingam, Michael R Gree. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell. vol 132. issue 3. 2008-03-06. PMID:18267069. |
apoptosis results from igfbp7-mediated upregulation of bnip3l, a proapoptotic bcl2 family protein. |
2008-03-06 |
2023-08-12 |
mouse |
| Bettina Gerstner, Tara M DeSilva, Kerstin Genz, Amy Armstrong, Felix Brehmer, Rachael L Neve, Ursula Felderhoff-Mueser, Joseph J Volpe, Paul A Rosenber. Hyperoxia causes maturation-dependent cell death in the developing white matter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 5. 2008-02-19. PMID:18234901. |
overexpression of bcl2 (homo sapiens b-cell chronic lymphocytic leukemia/lymphoma 2) significantly reduced apoptosis. |
2008-02-19 |
2023-08-12 |
rat |
| Claus Schertel, Barbara Conrad. C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions. Development (Cambridge, England). vol 134. issue 20. 2008-02-15. PMID:17881492. |
we present evidence that lin-35 promotes germ cell apoptosis by repressing the expression of ced-9, an anti-apoptotic c. elegans gene that is orthologous to the human proto-oncogene bcl2. |
2008-02-15 |
2023-08-12 |
human |
| Abbes Belkhiri, Altaf A Dar, Alexander Zaika, Mark Kelley, Wael El-Rifa. t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism. Cancer research. vol 68. issue 2. 2008-02-14. PMID:18199533. |
using 20 micromol/l ceramide treatment as a model for induction of apoptosis in ags cancer cells, we found that expression of t-darpp led to an increase in bcl2 protein levels and blocked the activation of caspase-3 and caspase-9. |
2008-02-14 |
2023-08-12 |
Not clear |
| Eli E Bar, Duncan Stearn. New developments in medulloblastoma treatment: the potential of a cyclopamine-lovastatin combination. Expert opinion on investigational drugs. vol 17. issue 2. 2008-02-14. PMID:18230052. |
this review explores the relationship between cholesterol and cancer in light of a recent study that demonstrated that the hedgehog (hh) antagonist cyclopamine blocked expression of the hh pathway targets ptch1 and gli1, lowered bcl2 levels and increased apoptosis in medulloblastoma cells. |
2008-02-14 |
2023-08-12 |
human |
| Atossa Shaltouki, Margot Freer, Yu Mei, Crystal M Weyma. Increased expression of the pro-apoptotic Bcl2 family member PUMA is required for mitochondrial release of cytochrome C and the apoptosis associated with skeletal myoblast differentiation. Apoptosis : an international journal on programmed cell death. vol 12. issue 12. 2008-01-30. PMID:17879164. |
increased expression of the pro-apoptotic bcl2 family member puma is required for mitochondrial release of cytochrome c and the apoptosis associated with skeletal myoblast differentiation. |
2008-01-30 |
2023-08-12 |
Not clear |
| Hiroki Suemoto, Yasuteru Muragaki, Katsuhiro Nishioka, Misako Sato, Akira Ooshima, Shunji Itoh, Ikuji Hatamura, Michitaka Ozaki, Attila Braun, Erika Gustafsson, Reinhard Fässle. Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. Developmental biology. vol 312. issue 2. 2008-01-23. PMID:17997399. |
our conclusion is supported (i) by sirna-mediated depletion of stat3 in trps1-deficient chondrocytes, which normalized the expression of cyclin d1 and bcl2, (ii) by overexpression of trps1 in atdc5 chondrocytes, which diminished stat3 levels and increased proliferation and apoptosis, and (iii) by mutational analysis of the gata-binding sites in the stat3 gene, which revealed that their integrity is critical for the direct association with trps1 and for trps1-mediated repression of stat3. |
2008-01-23 |
2023-08-12 |
mouse |
| William C S Ch. OncomiRs: the discovery and progress of microRNAs in cancers. Molecular cancer. vol 6. 2008-01-04. PMID:17894887. |
for example, mir-15 and mir-16 induce apoptosis by targeting bcl2. |
2008-01-04 |
2023-08-12 |
human |
| Qun Li, Jun Re. Influence of cardiac-specific overexpression of insulin-like growth factor 1 on lifespan and aging-associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression. Aging cell. vol 6. issue 6. 2007-12-31. PMID:17973971. |
pro- and anti-apoptotic proteins including bax, p53, pp53, bcl2, omi/htra2, apoptosis repressor with caspase recruitment domain (arc) and x-linked inhibitor of apoptosis protein (xiap) were assessed by western blot. |
2007-12-31 |
2023-08-12 |
mouse |
| Gabriele Sass, Noula Dattu Shembade, Florian Haimerl, Nicolas Lamoureux, Said Hashemolhosseini, Andrea Tannapfel, Gisa Tieg. TNF pretreatment interferes with mitochondrial apoptosis in the mouse liver by A20-mediated down-regulation of Bax. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 10. 2007-12-27. PMID:17982095. |
our results show that pretreatment with tnf, or application of small-interfering rna directed against the proapoptotic bcl2 family member bax, interfered with the onset of mitochondrial apoptosis in vivo. |
2007-12-27 |
2023-08-12 |
mouse |
| Bianca P Gomez, Rebecca B Riggins, Ayesha N Shajahan, Uwe Klimach, Aifen Wang, Anatasha C Crawford, Yuelin Zhu, Alan Zwart, Mingyue Wang, Robert Clark. Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 14. 2007-12-26. PMID:17660348. |
data from gene expression microarray analyses imply that xbp1(s) acts through regulation of the expression of er, the antiapoptotic gene bcl2, and several other genes associated with control of the cell cycle and apoptosis. |
2007-12-26 |
2023-08-12 |
human |