| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K M Anderson, J E Harris, P Bonom. Potential applications of apoptosis in modifying the biological behavior of therapeutically refractory cancers. Medical hypotheses. vol 43. issue 4. 1995-03-02. PMID:7838002. |
recent information about apoptosis or programmed cell death, the anti-apoptotic gene, bcl2, its interaction with reactive oxygen species and the role of these agents in senescence and apoptosis, suggests a discussion of their relationships could be of interest. |
1995-03-02 |
2023-08-12 |
Not clear |
| B K Sinha, H Yamazaki, H M Eliot, E Schneider, M M Borner, P M O'Conno. Relationships between proto-oncogene expression and apoptosis induced by anticancer drugs in human prostate tumor cells. Biochimica et biophysica acta. vol 1270. issue 1. 1995-02-21. PMID:7827130. |
these studies, taken together, suggest that a differential susceptibility to apoptosis and chemosensitivity may be related to altered levels of bcl2 and/or oncogene overexpression in pc3(r) cells. |
1995-02-21 |
2023-08-12 |
human |
| J Klefstrom, I Västrik, E Saksela, J Valle, M Eilers, K Alital. c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha. The EMBO journal. vol 13. issue 22. 1994-12-22. PMID:7957110. |
the c-myc and tnf-induced apoptosis was inhibited by ectopic expression of the bcl2 oncoprotein and by the free oxygen radical scavenging enzyme mn superoxide dismutase. |
1994-12-22 |
2023-08-12 |
human |
| N Sakai, Y Ogiso, H Fujita, H Watari, T Koike, N Kuzumak. Induction of apoptosis by a dominant negative H-RAS mutant (116Y) in K562 cells. Experimental cell research. vol 215. issue 1. 1994-12-02. PMID:7957661. |
among them, the bcl2 gene is considered to be an important gene that inhibits apoptosis. |
1994-12-02 |
2023-08-12 |
human |
| N Sakai, Y Ogiso, H Fujita, H Watari, T Koike, N Kuzumak. Induction of apoptosis by a dominant negative H-RAS mutant (116Y) in K562 cells. Experimental cell research. vol 215. issue 1. 1994-12-02. PMID:7957661. |
these results directly indicate that the ras gene as well as the bcl2 gene has an ability to suppress apoptosis. |
1994-12-02 |
2023-08-12 |
human |
| W S May, P G Tyler, T Ito, D K Armstrong, K A Qatsha, N E Davidso. Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis. The Journal of biological chemistry. vol 269. issue 43. 1994-11-23. PMID:7929424. |
interleukin-3 and bryostatin-1 mediate hyperphosphorylation of bcl2 alpha in association with suppression of apoptosis. |
1994-11-23 |
2023-08-12 |
Not clear |
| J A Pietenpol, N Papadopoulos, S Markowitz, J K Willson, K W Kinzler, B Vogelstei. Paradoxical inhibition of solid tumor cell growth by bcl2. Cancer research. vol 54. issue 14. 1994-08-16. PMID:8033089. |
the bcl2 gene product has been demonstrated to prevent apoptosis and provide a selective growth advantage to many cell types. |
1994-08-16 |
2023-08-12 |
Not clear |
| L Naumovski, M L Clear. Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells. Blood. vol 83. issue 8. 1994-05-26. PMID:8161792. |
bcl2 inhibits apoptosis associated with terminal differentiation of hl-60 myeloid leukemia cells. |
1994-05-26 |
2023-08-12 |
Not clear |
| L Naumovski, M L Clear. Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells. Blood. vol 83. issue 8. 1994-05-26. PMID:8161792. |
the bcl2 protein inhibits apoptosis (programmed cell death) induced by a variety of noxious stimuli. |
1994-05-26 |
2023-08-12 |
Not clear |
| L Naumovski, M L Clear. Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells. Blood. vol 83. issue 8. 1994-05-26. PMID:8161792. |
bcl2 protein levels decrease during differentiation of myeloid cells into granulocytes that subsequently undergo apoptosis, but the potential role of bcl2 in coupling survival and differentiation remains undefined. |
1994-05-26 |
2023-08-12 |
Not clear |
| L Naumovski, M L Clear. Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells. Blood. vol 83. issue 8. 1994-05-26. PMID:8161792. |
to ascertain the relationship between decreasing bcl2 levels and the onset of apoptosis in differentiating myeloid cells, bcl2 was hyperexpressed in the hl-60 cell line after retroviral gene transfer. |
1994-05-26 |
2023-08-12 |
Not clear |
| L Naumovski, M L Clear. Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells. Blood. vol 83. issue 8. 1994-05-26. PMID:8161792. |
these studies show that the survival-enhancing properties of bcl2 counteract programmed cell death that accompanies terminal differentiation; however, bcl2 has no significant effect on differentiation itself, suggesting that apoptosis and differentiation are regulated independently in myeloid cells. |
1994-05-26 |
2023-08-12 |
Not clear |
| R Silvestrini, S Veneroni, M G Daidone, E Benini, P Boracchi, M Mezzetti, G Di Fronzo, F Rilke, U Verones. The Bcl-2 protein: a prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients. Journal of the National Cancer Institute. vol 86. issue 7. 1994-04-20. PMID:8133533. |
the bcl-2 gene (also known as bcl2) encodes for a mitochondrial protein thought to prevent apoptosis of normal cells. |
1994-04-20 |
2023-08-12 |
Not clear |
| A J Wagner, M B Small, N Ha. Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2. Molecular and cellular biology. vol 13. issue 4. 1993-04-20. PMID:8455620. |
to further examine myc-induced apoptosis, we coexpressed the proto-oncogene bcl2, which has been shown to block apoptosis in other systems, with c-myc in serum-deprived rat 1a fibroblasts. |
1993-04-20 |
2023-08-12 |
rat |
| A J Wagner, M B Small, N Ha. Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2. Molecular and cellular biology. vol 13. issue 4. 1993-04-20. PMID:8455620. |
here we report that ectopic expression of bcl2 specifically blocks apoptosis induced by constitutive c-myc expression. |
1993-04-20 |
2023-08-12 |
rat |
| E S Alnemri, N M Robertson, T F Fernandes, C M Croce, G Litwac. Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 16. 1992-09-15. PMID:1502141. |
this result is consistent with the reported protective effect of bcl2 against apoptosis in mammalian lymphocytes and suggests a conserved function in evolution. |
1992-09-15 |
2023-08-11 |
human |
| D M Hockenbery, M Zutter, W Hickey, M Nahm, S J Korsmeye. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proceedings of the National Academy of Sciences of the United States of America. vol 88. issue 16. 1991-09-18. PMID:1871110. |
bcl2's function as an antidote to apoptosis may confer longevity to progenitor and effector cells in these tissues. |
1991-09-18 |
2023-08-11 |
mouse |