| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Tsujii, R N DuBoi. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. vol 83. issue 3. 1996-01-24. PMID:8521479. |
rie-s cells were resistant to butyrate-induced apoptosis, had elevated bcl2 protein expression, and reduced transforming growth factor beta 2 receptor levels. |
1996-01-24 |
2023-08-12 |
rat |
| C M Knudson, K S Tung, W G Tourtellotte, G A Brown, S J Korsmeye. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science (New York, N.Y.). vol 270. issue 5233. 1995-11-07. PMID:7569956. |
bax, a heterodimeric partner of bcl2, counters bcl2 and promotes apoptosis in gain-of-function experiments. |
1995-11-07 |
2023-08-12 |
mouse |
| G T William. Role of apoptosis in the immune system. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 72. issue 11-12. 1995-10-05. PMID:7654316. |
failure of such a fundamental process would be expected to have serious consequences and we have been particularly involved in analysing the role of inappropriate suppression of apoptosis by the bcl2 family of genes both in oncogenesis in the immune system and in the development of cancer cell resistance to therapy. |
1995-10-05 |
2023-08-12 |
Not clear |
| H E Eliot, M M Borner, B K Sinh. Differential oncogene expression and susceptibility to apoptosis in the human leukemia HL60 cell lines: implications for etoposide resistance. Anticancer research. vol 15. issue 3. 1995-09-20. PMID:7645949. |
the level of bcl2 oncogene was similar in both cell lines; however, treatment with vp-16 resulted in a time- and dose-dependent degradation of the genomic dna into oligo-sized dna only in the sensitive cells, indicating that differential expressions of oncogenes (c-myc, c-jun, and c-fos) and susceptibility to apoptosis may play important roles in the sensitivity and resistance to vp-16 in hl60 cells. |
1995-09-20 |
2023-08-12 |
human |
| C Chiao, A M Carothers, D Grunberger, G Solomon, G A Preston, J C Barret. Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. Cancer research. vol 55. issue 16. 1995-09-07. PMID:7543016. |
furthermore, bcl2, which protects cells from oxidative stress, had a protective effect against cape-induced apoptosis in wt3a cells. |
1995-09-07 |
2023-08-12 |
rat |
| S Kumar, D L White, S Takai, S Turczynowicz, C A Juttner, T P Hughe. Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms. Human genetics. vol 95. issue 6. 1995-07-26. PMID:7789948. |
overexpression of nedd2 in cultured mammalian cells induces apoptosis that can be blocked by proto-oncogene bcl2. |
1995-07-26 |
2023-08-12 |
mouse |
| M J Allday, A Sinclair, G Parker, D H Crawford, P J Farrel. Epstein-Barr virus efficiently immortalizes human B cells without neutralizing the function of p53. The EMBO journal. vol 14. issue 7. 1995-05-30. PMID:7729416. |
although the levels of bcl2 protein and bax mrna appear unaltered by the activation of p53, within 24 h the majority of cells undergo apoptosis. |
1995-05-30 |
2023-08-12 |
human |
| J A Herrero, P Mathew, C V Pay. LMP-1 activates NF-kappa B by targeting the inhibitory molecule I kappa B alpha. Journal of virology. vol 69. issue 4. 1995-04-10. PMID:7884865. |
lmp-1 induces the expression of bcl2, an oncogene which protects cells from apoptosis, as well as of genes encoding other proteins involved in cell regulation and growth control. |
1995-04-10 |
2023-08-12 |
Not clear |
| C J Larse. [The BCL2 gene, prototype of a gene family that controls programmed cell death (apoptosis)]. Annales de genetique. vol 37. issue 3. 1995-03-09. PMID:7847793. |
[the bcl2 gene, prototype of a gene family that controls programmed cell death (apoptosis)]. |
1995-03-09 |
2023-08-12 |
Not clear |
| C J Larse. [The BCL2 gene, prototype of a gene family that controls programmed cell death (apoptosis)]. Annales de genetique. vol 37. issue 3. 1995-03-09. PMID:7847793. |
some members of the bcl2 family (bcl-2 alpha, bcl-xl) inhibit apoptosis, whereas some other (bax, bclxs) induce it. |
1995-03-09 |
2023-08-12 |
Not clear |
| K M Anderson, J E Harris, P Bonom. Potential applications of apoptosis in modifying the biological behavior of therapeutically refractory cancers. Medical hypotheses. vol 43. issue 4. 1995-03-02. PMID:7838002. |
recent information about apoptosis or programmed cell death, the anti-apoptotic gene, bcl2, its interaction with reactive oxygen species and the role of these agents in senescence and apoptosis, suggests a discussion of their relationships could be of interest. |
1995-03-02 |
2023-08-12 |
Not clear |
| B K Sinha, H Yamazaki, H M Eliot, E Schneider, M M Borner, P M O'Conno. Relationships between proto-oncogene expression and apoptosis induced by anticancer drugs in human prostate tumor cells. Biochimica et biophysica acta. vol 1270. issue 1. 1995-02-21. PMID:7827130. |
these studies, taken together, suggest that a differential susceptibility to apoptosis and chemosensitivity may be related to altered levels of bcl2 and/or oncogene overexpression in pc3(r) cells. |
1995-02-21 |
2023-08-12 |
human |
| J Klefstrom, I Västrik, E Saksela, J Valle, M Eilers, K Alital. c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha. The EMBO journal. vol 13. issue 22. 1994-12-22. PMID:7957110. |
the c-myc and tnf-induced apoptosis was inhibited by ectopic expression of the bcl2 oncoprotein and by the free oxygen radical scavenging enzyme mn superoxide dismutase. |
1994-12-22 |
2023-08-12 |
human |
| N Sakai, Y Ogiso, H Fujita, H Watari, T Koike, N Kuzumak. Induction of apoptosis by a dominant negative H-RAS mutant (116Y) in K562 cells. Experimental cell research. vol 215. issue 1. 1994-12-02. PMID:7957661. |
among them, the bcl2 gene is considered to be an important gene that inhibits apoptosis. |
1994-12-02 |
2023-08-12 |
human |
| N Sakai, Y Ogiso, H Fujita, H Watari, T Koike, N Kuzumak. Induction of apoptosis by a dominant negative H-RAS mutant (116Y) in K562 cells. Experimental cell research. vol 215. issue 1. 1994-12-02. PMID:7957661. |
these results directly indicate that the ras gene as well as the bcl2 gene has an ability to suppress apoptosis. |
1994-12-02 |
2023-08-12 |
human |
| W S May, P G Tyler, T Ito, D K Armstrong, K A Qatsha, N E Davidso. Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis. The Journal of biological chemistry. vol 269. issue 43. 1994-11-23. PMID:7929424. |
interleukin-3 and bryostatin-1 mediate hyperphosphorylation of bcl2 alpha in association with suppression of apoptosis. |
1994-11-23 |
2023-08-12 |
Not clear |
| J A Pietenpol, N Papadopoulos, S Markowitz, J K Willson, K W Kinzler, B Vogelstei. Paradoxical inhibition of solid tumor cell growth by bcl2. Cancer research. vol 54. issue 14. 1994-08-16. PMID:8033089. |
the bcl2 gene product has been demonstrated to prevent apoptosis and provide a selective growth advantage to many cell types. |
1994-08-16 |
2023-08-12 |
Not clear |
| L Naumovski, M L Clear. Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells. Blood. vol 83. issue 8. 1994-05-26. PMID:8161792. |
bcl2 inhibits apoptosis associated with terminal differentiation of hl-60 myeloid leukemia cells. |
1994-05-26 |
2023-08-12 |
Not clear |
| L Naumovski, M L Clear. Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells. Blood. vol 83. issue 8. 1994-05-26. PMID:8161792. |
the bcl2 protein inhibits apoptosis (programmed cell death) induced by a variety of noxious stimuli. |
1994-05-26 |
2023-08-12 |
Not clear |
| L Naumovski, M L Clear. Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells. Blood. vol 83. issue 8. 1994-05-26. PMID:8161792. |
bcl2 protein levels decrease during differentiation of myeloid cells into granulocytes that subsequently undergo apoptosis, but the potential role of bcl2 in coupling survival and differentiation remains undefined. |
1994-05-26 |
2023-08-12 |
Not clear |