| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R K Srivastava, A R Srivastava, S J Korsmeyer, M Nesterova, Y S Cho-Chung, D L Long. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Molecular and cellular biology. vol 18. issue 6. 1998-06-17. PMID:9584191. |
these microtubule-damaging drugs caused growth arrest in g2-m phase of the cell cycle and had no effect on p53 induction, suggesting that hyperphosphorylation mediated inactivation of bcl2 and apoptosis without the involvement of p53. |
1998-06-17 |
2023-08-12 |
Not clear |
| B Helpa. [Prognostic factors of prostatic carcinoma]. Der Pathologe. vol 19. issue 1. 1998-06-01. PMID:9541941. |
dna cytometry, immunohistochemical analysis with ki67/mib1 or molecular pathological studies with the tumor suppressor gene p53 or apoptosis suppressing oncoprotein bcl2 and the density of blood capillaries may be helpful as additional prognostic factors, but only together with the results of the primary histological section. |
1998-06-01 |
2023-08-12 |
Not clear |
| J D Norton, G T Atherto. Coupling of cell growth control and apoptosis functions of Id proteins. Molecular and cellular biology. vol 18. issue 4. 1998-05-21. PMID:9528806. |
id3-induced apoptosis was mediated at least in part through p53-independent mechanisms and could be efficiently rescued by bcl2, bclxl, and the basic helix-loop-helix protein e47, which is known to oppose the functions of id3 in vivo through the formation of stable heterodimers. |
1998-05-21 |
2023-08-12 |
rat |
| J D Norton, G T Atherto. Coupling of cell growth control and apoptosis functions of Id proteins. Molecular and cellular biology. vol 18. issue 4. 1998-05-21. PMID:9528806. |
the extent of apoptosis induced by loss- and gain-of-function id3 mutants and by wild-type id3 either alone or in combination with the bcl2, bclxl, and e47 genes was invariably correlated with the relative magnitude of cell cycle s phase promotion. |
1998-05-21 |
2023-08-12 |
rat |
| S Haldar, A Basu, C M Croc. Serine-70 is one of the critical sites for drug-induced Bcl2 phosphorylation in cancer cells. Cancer research. vol 58. issue 8. 1998-05-21. PMID:9563469. |
taxoids and other microtubule-damaging drugs are known to induce bcl2 phosphorylation at the g2-m phase of the cell cycle, with concomitant apoptosis in malignant cells derived from a variety of human malignancies, including leukemia, lymphoma, and breast and prostate cancer. |
1998-05-21 |
2023-08-12 |
human |
| S Haldar, A Basu, C M Croc. Serine-70 is one of the critical sites for drug-induced Bcl2 phosphorylation in cancer cells. Cancer research. vol 58. issue 8. 1998-05-21. PMID:9563469. |
we have investigated the ability of another antineoplastic drug, dolastatin 10, in inducing bcl2 phosphorylation and apoptosis. |
1998-05-21 |
2023-08-12 |
human |
| T J Kipp. Signal transduction pathways and mechanisms of apoptosis in CLL B-lymphocytes: their role in CLL pathogenesis. Hematology and cell therapy. vol 39 Suppl 1. 1998-04-09. PMID:9471058. |
the session on signal transduction pathways and mechanisms of apoptosis in cll b-lymphocytes addressed the nature of immunoglobulin expression in chronic lymphocytic leukemia, signal transduction in b lymphocytes, as well as in chronic lymphocytic leukemia, the control of apoptosis by members of the bcl2 family, and the nature of the human immunoglobulin repertoire expressed by b cells of normal adults. |
1998-04-09 |
2023-08-12 |
human |
| S Veronese, F A Mauri, O Caffo, M Scaioli, D Aldovini, G Perrone, E Galligioni, C Doglioni, P Dalla Palma, M Barbaresch. Bax immunohistochemical expression in breast carcinoma: a study with long term follow-up. International journal of cancer. vol 79. issue 1. 1998-03-17. PMID:9495351. |
bax and bcl2 are functionally antagonistic proteins which control apoptosis, whose expression in human tumours could be of prognostic value. |
1998-03-17 |
2023-08-12 |
human |
| D H Chung, F Zhang, F Chen, W P McLaughlin, M Ljungma. Butyrate attenuates BCLX(L) expression in human fibroblasts and acts in synergy with ionizing radiation to induce apoptosis. Radiation research. vol 149. issue 2. 1998-02-19. PMID:9457899. |
in this study we investigated what effect the differentiation agent butyrate had on the cellular levels of the apoptosis regulators bcl2, bclx(l) and bax and on radiation-induced apoptosis. |
1998-02-19 |
2023-08-12 |
human |
| B W Parker, G Kaur, W Nieves-Neira, M Taimi, G Kohlhagen, T Shimizu, M D Losiewicz, Y Pommier, E A Sausville, A M Senderowic. Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. Blood. vol 91. issue 2. 1998-02-11. PMID:9427698. |
a relation of p53, bcl2, or bax protein levels to apoptosis in sudhl4 was not appreciated. |
1998-02-11 |
2023-08-12 |
Not clear |
| E Wan. Regulation of apoptosis resistance and ontogeny of age-dependent diseases. Experimental gerontology. vol 32. issue 4-5. 1997-11-19. PMID:9315450. |
senescent human fibroblasts resist apoptosis, perhaps through the lack of key g1-phase gene expressions, also necessary for apoptosis initiation; they also lack key proteolytic activity, and maintain high levels of survival factor bcl2, reflecting a triple blockage to apoptosis. |
1997-11-19 |
2023-08-12 |
human |
| A E Frankel, P D Hall, C Burbage, J Vesely, M Willingham, K Bhalla, R J Kreitma. Modulation of the apoptotic response of human myeloid leukemia cells to a diphtheria toxin granulocyte-macrophage colony-stimulating factor fusion protein. Blood. vol 90. issue 9. 1997-11-18. PMID:9345050. |
also, the induction of apoptosis correlates with the inhibition of protein synthesis and is inversely related to the amount of intracellular antiapoptotic proteins (bcl2 and bc1xl). |
1997-11-18 |
2023-08-12 |
human |
| A E Frankel, P D Hall, C Burbage, J Vesely, M Willingham, K Bhalla, R J Kreitma. Modulation of the apoptotic response of human myeloid leukemia cells to a diphtheria toxin granulocyte-macrophage colony-stimulating factor fusion protein. Blood. vol 90. issue 9. 1997-11-18. PMID:9345050. |
similarly, the protein synthesis inhibition and apoptosis induction correlated well, except in cells overexpressing bcl2 and bclxl, in which 25- to 150-fold inhibition of apoptosis was observed. |
1997-11-18 |
2023-08-12 |
human |
| H Pan, C Yin, T Van Dyk. Apoptosis and cancer mechanisms. Cancer surveys. vol 29. 1997-11-14. PMID:9338106. |
at least two genes linked to human cancers, bcl2 and tp53, have been shown to regulate apoptosis. |
1997-11-14 |
2023-08-12 |
human |
| H Pan, C Yin, T Van Dyk. Apoptosis and cancer mechanisms. Cancer surveys. vol 29. 1997-11-14. PMID:9338106. |
cell culture studies have clearly demonstrated that tp53 can induce and bcl2 can suppress apoptosis in response to various stimuli. |
1997-11-14 |
2023-08-12 |
human |
| P Srivastava, J Russo, I H Russ. Chorionic gonadotropin inhibits rat mammary carcinogenesis through activation of programmed cell death. Carcinogenesis. vol 18. issue 9. 1997-11-13. PMID:9328178. |
our data also indicate the possibility that a cell death program dependent on the bcl2 family exists, because of the potential involvement of p53, bcl-xs and bax in apoptosis. |
1997-11-13 |
2023-08-12 |
human |
| V Chiarugi, L Magnelli, M Cinell. Complex interplay among apoptosis factors: RB, p53, E2F, TGF-beta, cell cycle inhibitors and the bcl2 gene family. Pharmacological research. vol 35. issue 4. 1997-09-29. PMID:9264039. |
complex interplay among apoptosis factors: rb, p53, e2f, tgf-beta, cell cycle inhibitors and the bcl2 gene family. |
1997-09-29 |
2023-08-12 |
Not clear |
| V Chiarugi, L Magnelli, M Cinell. Complex interplay among apoptosis factors: RB, p53, E2F, TGF-beta, cell cycle inhibitors and the bcl2 gene family. Pharmacological research. vol 35. issue 4. 1997-09-29. PMID:9264039. |
in this report, we would like to stress particularly that the p53/rb pathway and its complex, interplay with the bcl2 gene family, where paramount elements of apoptosis regulation are operating. |
1997-09-29 |
2023-08-12 |
Not clear |
| V Chiarugi, L Magnelli, M Cinell. Complex interplay among apoptosis factors: RB, p53, E2F, TGF-beta, cell cycle inhibitors and the bcl2 gene family. Pharmacological research. vol 35. issue 4. 1997-09-29. PMID:9264039. |
it is generally believed that bcl2 blocks apoptosis at the level of the activation of ice-(interleukin converting enzymes)-like proteases [1,2]. |
1997-09-29 |
2023-08-12 |
Not clear |
| O I Olopade, M O Adeyanju, A R Safa, F Hagos, R Mick, C B Thompson, W M Recan. Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases. The cancer journal from Scientific American. vol 3. issue 4. 1997-09-24. PMID:9263629. |
the bcl2 gene and its family member bcl-x as well as the tp53 genes regulate apoptosis and have been shown to have a direct effect on the sensitivity of cancer cells to radiation and chemotherapeutic agents. |
1997-09-24 |
2023-08-12 |
Not clear |