| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Wan. Regulation of apoptosis resistance and ontogeny of age-dependent diseases. Experimental gerontology. vol 32. issue 4-5. 1997-11-19. PMID:9315450. |
senescent human fibroblasts resist apoptosis, perhaps through the lack of key g1-phase gene expressions, also necessary for apoptosis initiation; they also lack key proteolytic activity, and maintain high levels of survival factor bcl2, reflecting a triple blockage to apoptosis. |
1997-11-19 |
2023-08-12 |
human |
| A E Frankel, P D Hall, C Burbage, J Vesely, M Willingham, K Bhalla, R J Kreitma. Modulation of the apoptotic response of human myeloid leukemia cells to a diphtheria toxin granulocyte-macrophage colony-stimulating factor fusion protein. Blood. vol 90. issue 9. 1997-11-18. PMID:9345050. |
also, the induction of apoptosis correlates with the inhibition of protein synthesis and is inversely related to the amount of intracellular antiapoptotic proteins (bcl2 and bc1xl). |
1997-11-18 |
2023-08-12 |
human |
| A E Frankel, P D Hall, C Burbage, J Vesely, M Willingham, K Bhalla, R J Kreitma. Modulation of the apoptotic response of human myeloid leukemia cells to a diphtheria toxin granulocyte-macrophage colony-stimulating factor fusion protein. Blood. vol 90. issue 9. 1997-11-18. PMID:9345050. |
similarly, the protein synthesis inhibition and apoptosis induction correlated well, except in cells overexpressing bcl2 and bclxl, in which 25- to 150-fold inhibition of apoptosis was observed. |
1997-11-18 |
2023-08-12 |
human |
| H Pan, C Yin, T Van Dyk. Apoptosis and cancer mechanisms. Cancer surveys. vol 29. 1997-11-14. PMID:9338106. |
at least two genes linked to human cancers, bcl2 and tp53, have been shown to regulate apoptosis. |
1997-11-14 |
2023-08-12 |
human |
| H Pan, C Yin, T Van Dyk. Apoptosis and cancer mechanisms. Cancer surveys. vol 29. 1997-11-14. PMID:9338106. |
cell culture studies have clearly demonstrated that tp53 can induce and bcl2 can suppress apoptosis in response to various stimuli. |
1997-11-14 |
2023-08-12 |
human |
| P Srivastava, J Russo, I H Russ. Chorionic gonadotropin inhibits rat mammary carcinogenesis through activation of programmed cell death. Carcinogenesis. vol 18. issue 9. 1997-11-13. PMID:9328178. |
our data also indicate the possibility that a cell death program dependent on the bcl2 family exists, because of the potential involvement of p53, bcl-xs and bax in apoptosis. |
1997-11-13 |
2023-08-12 |
human |
| V Chiarugi, L Magnelli, M Cinell. Complex interplay among apoptosis factors: RB, p53, E2F, TGF-beta, cell cycle inhibitors and the bcl2 gene family. Pharmacological research. vol 35. issue 4. 1997-09-29. PMID:9264039. |
complex interplay among apoptosis factors: rb, p53, e2f, tgf-beta, cell cycle inhibitors and the bcl2 gene family. |
1997-09-29 |
2023-08-12 |
Not clear |
| V Chiarugi, L Magnelli, M Cinell. Complex interplay among apoptosis factors: RB, p53, E2F, TGF-beta, cell cycle inhibitors and the bcl2 gene family. Pharmacological research. vol 35. issue 4. 1997-09-29. PMID:9264039. |
in this report, we would like to stress particularly that the p53/rb pathway and its complex, interplay with the bcl2 gene family, where paramount elements of apoptosis regulation are operating. |
1997-09-29 |
2023-08-12 |
Not clear |
| V Chiarugi, L Magnelli, M Cinell. Complex interplay among apoptosis factors: RB, p53, E2F, TGF-beta, cell cycle inhibitors and the bcl2 gene family. Pharmacological research. vol 35. issue 4. 1997-09-29. PMID:9264039. |
it is generally believed that bcl2 blocks apoptosis at the level of the activation of ice-(interleukin converting enzymes)-like proteases [1,2]. |
1997-09-29 |
2023-08-12 |
Not clear |
| O I Olopade, M O Adeyanju, A R Safa, F Hagos, R Mick, C B Thompson, W M Recan. Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases. The cancer journal from Scientific American. vol 3. issue 4. 1997-09-24. PMID:9263629. |
the bcl2 gene and its family member bcl-x as well as the tp53 genes regulate apoptosis and have been shown to have a direct effect on the sensitivity of cancer cells to radiation and chemotherapeutic agents. |
1997-09-24 |
2023-08-12 |
Not clear |
| L Mauvieux, E Macintyr. [Molecular anomalies in malignant hemopathies]. Presse medicale (Paris, France : 1983). vol 26. issue 21. 1997-08-21. PMID:9239151. |
this type of "quantitative" anomaly occurs in follicular lymphomas where b-cells overexpress the normal bcl2 protein which inhibits apoptosis, contributing to immortalization of the b done. |
1997-08-21 |
2023-08-12 |
Not clear |
| G Morris, S J DeNardo, G L DeNardo, T Leshchinsky, B Wu, P C Mack, M D Winthrop, P H Gumerloc. Decreased C-MYC and BCL2 expression correlates with methylprednisolone-mediated inhibition of Raji lymphoma growth. Biochemical and molecular medicine. vol 60. issue 2. 1997-07-07. PMID:9169090. |
the goal was to determine the modulation of expression of the oncogenes (c-myc and bcl2), the p53 pathway described above, and the apoptosis marker tgf-beta 1 in the human raji lymphoma following mp treatment. |
1997-07-07 |
2023-08-12 |
mouse |
| I Rodriguez, K Araki, K Khatib, J C Martinou, P Vassall. Mouse vaginal opening is an apoptosis-dependent process which can be prevented by the overexpression of Bcl2. Developmental biology. vol 184. issue 1. 1997-05-29. PMID:9142988. |
histologic studies of vaginal sections at the time of opening to the skin in normal mice showed, by the tunel method which detects nuclei with fragmented dna characteristic of apoptosis, that this event coincides with extensive apoptosis in the lower part of the vaginal mucosa, a process prevented in the bcl2 transgenic mice, which express bcl2 in suprabasal epithelial cells and in subepithelial cells of the vaginal mucosa. |
1997-05-29 |
2023-08-12 |
mouse |
| Q Zhan, C K Bieszczad, I Bae, A J Fornace, R W Crai. Induction of BCL2 family member MCL1 as an early response to DNA damage. Oncogene. vol 14. issue 9. 1997-04-11. PMID:9070651. |
this includes an increase in p53 (wild-type), a decrease in bcl2, a p53-dependent increase in the bcl2 family member bax, and increases in growth arrest and dna damage-inducible (gadd) genes such as gadd45; these changes occur as early events in a sequence that culminates in dna damage-induced apoptosis. |
1997-04-11 |
2023-08-12 |
human |
| Q Zhan, C K Bieszczad, I Bae, A J Fornace, R W Crai. Induction of BCL2 family member MCL1 as an early response to DNA damage. Oncogene. vol 14. issue 9. 1997-04-11. PMID:9070651. |
furthermore, while the increase in gadd45 is seen both in cells that undergo growth arrest and in cells that undergo apoptosis in response to dna damage, alterations in the profile of expression of bcl2 family members occur exclusively in cells that undergo the apoptotic response, with some family members increasing through p53-dependent (bax) and others through p53-independent (mcl1) pathways. |
1997-04-11 |
2023-08-12 |
human |
| H Pereira, S Silva, R Julião, P Garcia, F Perpétu. Prognostic markers for colorectal cancer: expression of P53 and BCL2. World journal of surgery. vol 21. issue 2. 1997-03-14. PMID:8995081. |
bcl2 is a proto-oncogene that inhibits apoptosis. |
1997-03-14 |
2023-08-12 |
Not clear |
| S Haldar, A Basu, C M Croc. Bcl2 is the guardian of microtubule integrity. Cancer research. vol 57. issue 2. 1997-02-11. PMID:9000560. |
induction of cancer cell death through phosphorylation of bcl2 thus provides an opportunity not only for more refined targeting of therapeutic drugs but for understanding of an important pathway leading to apoptosis. |
1997-02-11 |
2023-08-12 |
human |
| B J Rot. Highlights of abstracts on hormone-refractory prostate cancer presented at the 1996 annual meeting of the American Society of Clinical Oncology. Seminars in oncology. vol 23. issue 6 Suppl 14. 1997-02-04. PMID:8996577. |
bcl2 expression is increased in androgen-independent cells, which may block apoptosis, and retinoids induce transforming growth factor-beta and apoptosis in prostate cancer cell lines. |
1997-02-04 |
2023-08-12 |
Not clear |
| K A Nath, A J Croatt, S Likely, T W Behrens, D Warde. Renal oxidant injury and oxidant response induced by mercury. Kidney international. vol 50. issue 3. 1997-01-06. PMID:8872981. |
hgcl2 also induced members of the bcl family, bcl2 and bclx, genes that protect against apoptosis and oxidant injury. |
1997-01-06 |
2023-08-12 |
rat |
| L C Lee, J J Hunter, A Mujeeb, C Turck, T G Parslo. Evidence for alpha-helical conformation of an essential N-terminal region in the human Bcl2 protein. The Journal of biological chemistry. vol 271. issue 38. 1996-11-19. PMID:8798527. |
a region occupying approximately 24 amino acids near the n terminus of human bcl2 is essential for this cytoplasmic membrane protein's ability to inhibit apoptosis. |
1996-11-19 |
2023-08-12 |
human |