| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Rogatsky, A B Hittelman, D Pearce, M J Garabedia. Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids. Molecular and cellular biology. vol 19. issue 7. 1999-07-22. PMID:10373553. |
using cultured human osteosarcoma cells as a model for the gr antiproliferative effect, we demonstrate that in u20s cells, gr activation leads to irreversible growth inhibition, apoptosis, and repression of bcl2. |
1999-07-22 |
2023-08-12 |
human |
| I Rogatsky, A B Hittelman, D Pearce, M J Garabedia. Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids. Molecular and cellular biology. vol 19. issue 7. 1999-07-22. PMID:10373553. |
this cytotoxic effect is mediated by gr's transcriptional repression function, since transactivation-deficient mutants and ligands still bring about apoptosis and bcl2 down-regulation. |
1999-07-22 |
2023-08-12 |
human |
| I Rogatsky, A B Hittelman, D Pearce, M J Garabedia. Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids. Molecular and cellular biology. vol 19. issue 7. 1999-07-22. PMID:10373553. |
in contrast, the antiproliferative effect of gr in saos2 cells is reversible, does not result in apoptosis or repression of bcl2, and is a function of the receptor's ability to stimulate transcription. |
1999-07-22 |
2023-08-12 |
human |
| X Zi, R Agarwa. Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 13. 1999-07-19. PMID:10377442. |
silibinin treatment of cells did not result in apoptosis and changes in p53 and bcl2, suggesting that the observed increase in cip1/p21 is a p53-independent effect that does not lead to an apoptotic cell death pathway. |
1999-07-19 |
2023-08-12 |
human |
| E J Blink, J A Trapani, D A Jan. Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis? Immunology and cell biology. vol 77. issue 3. 1999-07-08. PMID:10361252. |
in intact cells, perforin-dependent nuclear entry of granzymes precedes the nuclear events of apoptosis such as dna fragmentation and nuclear envelope breakdown; prevention of granzyme nuclear translocation through bcl2 overexpression or treatment of target cells with inhibitors of caspase activation blocks these events. |
1999-07-08 |
2023-08-12 |
Not clear |
| S Ning, S J Kno. G2/M-phase arrest and death by apoptosis of HL60 cells irradiated with exponentially decreasing low-dose-rate gamma radiation. Radiation research. vol 151. issue 6. 1999-06-17. PMID:10360785. |
to further study the role of cell death by apoptosis in the response to exponentially decreasing low-dose-rate irradiation, hl60 cells were transfected with the bcl2 proto-oncogene. |
1999-06-17 |
2023-08-12 |
human |
| S Gibson, C Widmann, G L Johnso. Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents. The Journal of biological chemistry. vol 274. issue 16. 1999-05-17. PMID:10196170. |
overexpression of anti-apoptotic bcl2 blocked mekk1 and taxol-induced apoptosis but did not block the caspase-dependent cleavage of mekk1 in response to etoposide. |
1999-05-17 |
2023-08-12 |
Not clear |
| S Gibson, C Widmann, G L Johnso. Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents. The Journal of biological chemistry. vol 274. issue 16. 1999-05-17. PMID:10196170. |
this indicates bcl2 inhibition of apoptosis is, therefore, downstream of caspase-dependent mekk1 cleavage. |
1999-05-17 |
2023-08-12 |
Not clear |
| K Imaizumi, T Morihara, Y Mori, T Katayama, M Tsuda, T Furuyama, A Wanaka, M Takeda, M Tohyam. The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein. The Journal of biological chemistry. vol 274. issue 12. 1999-04-15. PMID:10075695. |
the cell death-promoting gene dp5, which interacts with the bcl2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein. |
1999-04-15 |
2023-08-12 |
rat |
| R M Lee, G Gillet, J Burnside, S J Thomas, P Neima. Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius. Genes & development. vol 13. issue 6. 1999-04-15. PMID:10090728. |
the expression of bcl2 family cell death antagonists was examined to identify the genes that regulate bursal cell apoptosis. |
1999-04-15 |
2023-08-12 |
chicken |
| M F El Etreby, Y Liang, R W Wrenn, P V Schoenlei. Additive effect of mifepristone and tamoxifen on apoptotic pathways in MCF-7 human breast cancer cells. Breast cancer research and treatment. vol 51. issue 2. 1999-03-23. PMID:9879777. |
this inhibition of cell survival was associated with a significant increase in dna fragmentation (apoptosis), downregulation of bcl2, and induction of tgfbeta1 protein. |
1999-03-23 |
2023-08-12 |
human |
| A Basu, S Halda. The relationship between BcI2, Bax and p53: consequences for cell cycle progression and cell death. Molecular human reproduction. vol 4. issue 12. 1999-03-12. PMID:9872359. |
both bcl2 and bax are transcriptional targets for the tumour suppressor protein, p53, which induces cell cycle arrest or apoptosis in response to dna damage. |
1999-03-12 |
2023-08-12 |
Not clear |
| D A Jans, V R Sutton, P Jans, C J Froelich, J A Trapan. BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis. The Journal of biological chemistry. vol 274. issue 7. 1999-03-11. PMID:9933585. |
in this study, we examine the subcellular distribution of granzymes in the presence of perforin and the induction of apoptosis in mouse fdc-p1 myeloid and yac-1 lymphoma cells that express the proto-oncogene bcl2. |
1999-03-11 |
2023-08-12 |
mouse |
| K Oritani, Y Tomiyama, P W Kincade, K Aoyama, T Yokota, I Matsumura, Y Kanakura, K Nakajima, T Hirano, Y Matsuzaw. Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells. Blood. vol 93. issue 4. 1999-03-11. PMID:9949178. |
both stat3-activation and stat3-independent bcl2 downregulation are important for interleukin-6-induced apoptosis of 1a9-m cells. |
1999-03-11 |
2023-08-12 |
human |
| K Oritani, Y Tomiyama, P W Kincade, K Aoyama, T Yokota, I Matsumura, Y Kanakura, K Nakajima, T Hirano, Y Matsuzaw. Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells. Blood. vol 93. issue 4. 1999-03-11. PMID:9949178. |
the importance of bcl2 and stat3 on il-6-induced macrophage-differentiation and apoptosis was studied with 1a9-m cells expressing human bcl2 or a dominant-negative form of stat3, respectively. |
1999-03-11 |
2023-08-12 |
human |
| K Oritani, Y Tomiyama, P W Kincade, K Aoyama, T Yokota, I Matsumura, Y Kanakura, K Nakajima, T Hirano, Y Matsuzaw. Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells. Blood. vol 93. issue 4. 1999-03-11. PMID:9949178. |
il-6-induced apoptosis, but not macrophage-differentiation, was blocked by continuously expressed bcl2. |
1999-03-11 |
2023-08-12 |
human |
| R Homburg, A Amsterda. Polysystic ovary syndrome--loss of the apoptotic mechanism in the ovarian follicles? Journal of endocrinological investigation. vol 21. issue 9. 1999-02-23. PMID:9856409. |
further investigation of the pathogenesis of pcos is needed on the modulation of tumour suppressor and apoptosis genes such as p53, bax or the apo/fas system and the over expression of survival genes such as bcl2. |
1999-02-23 |
2023-08-12 |
Not clear |
| N Levy-Strumpf, A Kimch. Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions. Oncogene. vol 17. issue 25. 1999-02-16. PMID:9916995. |
the major challenge now is to analyse how these diverse dap gene activities constitute biochemical pathway(s) leading to programmed cell death, and what is their functional position with respect to other known positive mediators and suppressors of apoptosis such as the bcl2 and caspase family members. |
1999-02-16 |
2023-08-12 |
human |
| K Rossen, A Karabulut Thorup, K Hou-Jensen, G Krag Jacobse. BAX protein is not expressed by basal cell carcinomas. The British journal of dermatology. vol 139. issue 3. 1999-02-09. PMID:9767293. |
bax and related proteins encoded by the bcl2 gene family are involved in the regulation of apoptosis. |
1999-02-09 |
2023-08-12 |
Not clear |
| V Maguer-Satt. CML and apoptosis: the ceramide pathway. Hematology and cell therapy. vol 40. issue 5. 1999-01-26. PMID:9844818. |
finally, we observed that ceramide-induced apoptosis does not seem to implicate a bcl2 protein modulation. |
1999-01-26 |
2023-08-12 |
Not clear |