| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R A Gjerset, S Lebedeva, A Haghighi, S T Turla, D Mercol. Inhibition of the Jun kinase pathway blocks DNA repair, enhances p53-mediated apoptosis and promotes gene amplification. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 10. issue 8. 1999-10-26. PMID:10470854. |
moreover, the mutant c-jun clones exhibit increased apoptosis and elevated bax:bcl2 ratios on expression of wild-type p53. |
1999-10-26 |
2023-08-12 |
Not clear |
| T F Ogle, D Dai, P Georg. Progesterone-regulated determinants of stromal cell survival and death in uterine decidua are linked to protein kinase C activity. Steroids. vol 64. issue 9. 1999-10-26. PMID:10503720. |
the expression of epidermal growth factor receptor (egf-r) and bcl2 was used as an indicator of stromal cell proliferation/survival, whereas bax and the occurrence of apoptosis provided an index of cell death. |
1999-10-26 |
2023-08-12 |
rat |
| B Krishnamoorthy, W Renner, A Balakrishna. Apoptosis induced by filarial parasitic sheath protein in HEp 2 cell lines blocked by ectopic expression of bcl 2. Cell biology international. vol 22. issue 7-8. 1999-10-12. PMID:10452816. |
hep2 bcl2 cells do not undergo apoptosis on exposure to filarial sheath protein, indicating that filarial protein-induced apoptosis in epithelial cells proceeds via a pathway, inhibitable by overexpression of bcl 2. |
1999-10-12 |
2023-08-12 |
human |
| C Ihling, T Szombathy, K Nampoothiri, J Haendeler, F Beyersdorf, M Uhl, A M Zeiher, H E Schaefe. Cystic medial degeneration of the aorta is associated with p53 accumulation, Bax upregulation, apoptotic cell death, and cell proliferation. Heart (British Cardiac Society). vol 82. issue 3. 1999-10-07. PMID:10455077. |
to address a potential role for p53, bcl2 associated protein x (bax), and apoptosis in the processes associated with cell turnover during cystic medial degeneration (cmd) of the aorta. |
1999-10-07 |
2023-08-12 |
Not clear |
| M Korabiowska, U Brinck, I Ruschenburg, T Schlott, M Droese, J Stachur. Bcl2 and Bax expression in naevi and melanomas and their relation to ploidy status and proliferation. Polish journal of pathology : official journal of the Polish Society of Pathologists. vol 50. issue 1. 1999-08-25. PMID:10412270. |
twenty-five naevi, 53 primary melanomas, 36 melanoma metastases were stained immunohistochemically for the presence of bcl2, bax and ki-67 antigen in order to define the relation between apoptosis regulators and proliferative activity. |
1999-08-25 |
2023-08-12 |
Not clear |
| P P Ruvolo, X Deng, T Ito, B K Carr, W S Ma. Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. The Journal of biological chemistry. vol 274. issue 29. 1999-08-19. PMID:10400650. |
using a genetic approach, the gain-of-function s70e bcl2 mutation, which mimics phosphorylation, fails to undergo apoptosis even with the addition of high doses of ceramide (ic50 > 50 microm). |
1999-08-19 |
2023-08-12 |
Not clear |
| P Carmeliet, M G Lampugnani, L Moons, F Breviario, V Compernolle, F Bono, G Balconi, R Spagnuolo, B Oosthuyse, M Dewerchin, A Zanetti, A Angellilo, V Mattot, D Nuyens, E Lutgens, F Clotman, M C de Ruiter, A Gittenberger-de Groot, R Poelmann, F Lupu, J M Herbert, D Collen, E Dejan. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. vol 98. issue 2. 1999-08-13. PMID:10428027. |
deficiency or truncation of ve-cadherin induced endothelial apoptosis and abolished transmission of the endothelial survival signal by vegf-a to akt kinase and bcl2 via reduced complex formation with vegf receptor-2, beta-catenin, and phosphoinositide 3 (pi3)-kinase. |
1999-08-13 |
2023-08-12 |
mouse |
| G Quash, G Fournet, C Raffin, J Chantepie, Y Michal, J Gore, U Reicher. A thioester analogue of an amino acetylenic aldehyde is a suicide inhibitor of aldehyde dehydrogenase and an inducer of apoptosis in mouse lymphoid cells overexpressing the bcl2 gene. Advances in experimental medicine and biology. vol 463. 1999-08-11. PMID:10352674. |
a thioester analogue of an amino acetylenic aldehyde is a suicide inhibitor of aldehyde dehydrogenase and an inducer of apoptosis in mouse lymphoid cells overexpressing the bcl2 gene. |
1999-08-11 |
2023-08-12 |
mouse |
| V Radha, C Sudhakar, G Swaru. Induction of p53 dependent apoptosis upon overexpression of a nuclear protein tyrosine phosphatase. FEBS letters. vol 453. issue 3. 1999-08-05. PMID:10405166. |
ptp-s2 induced apoptosis was inhibited by antiapoptotic protein bcl2 and certain inhibitors of caspases. |
1999-08-05 |
2023-08-12 |
human |
| F Labat-Moleur, O Chabre, C Guillermet, P Chaffanjon, F Blumet-Rondeu, A Bauchet, B Franc, E Brambilla, I Bachelot, J E Dumont, A Negoesc. Graves-Basedow disease goiter: a model of Bax-Bcl2 regulated apoptosis. Thyroid : official journal of the American Thyroid Association. vol 9. issue 5. 1999-07-22. PMID:10365680. |
our observations suggest that the initiation of apoptosis corresponds to a loss of cellular cohesion, a drop in bcl2 expression, and a delocalization of bax from a putative golgi storage location to a mitochondrial distribution. |
1999-07-22 |
2023-08-12 |
Not clear |
| I Rogatsky, A B Hittelman, D Pearce, M J Garabedia. Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids. Molecular and cellular biology. vol 19. issue 7. 1999-07-22. PMID:10373553. |
using cultured human osteosarcoma cells as a model for the gr antiproliferative effect, we demonstrate that in u20s cells, gr activation leads to irreversible growth inhibition, apoptosis, and repression of bcl2. |
1999-07-22 |
2023-08-12 |
human |
| I Rogatsky, A B Hittelman, D Pearce, M J Garabedia. Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids. Molecular and cellular biology. vol 19. issue 7. 1999-07-22. PMID:10373553. |
this cytotoxic effect is mediated by gr's transcriptional repression function, since transactivation-deficient mutants and ligands still bring about apoptosis and bcl2 down-regulation. |
1999-07-22 |
2023-08-12 |
human |
| I Rogatsky, A B Hittelman, D Pearce, M J Garabedia. Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids. Molecular and cellular biology. vol 19. issue 7. 1999-07-22. PMID:10373553. |
in contrast, the antiproliferative effect of gr in saos2 cells is reversible, does not result in apoptosis or repression of bcl2, and is a function of the receptor's ability to stimulate transcription. |
1999-07-22 |
2023-08-12 |
human |
| X Zi, R Agarwa. Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 13. 1999-07-19. PMID:10377442. |
silibinin treatment of cells did not result in apoptosis and changes in p53 and bcl2, suggesting that the observed increase in cip1/p21 is a p53-independent effect that does not lead to an apoptotic cell death pathway. |
1999-07-19 |
2023-08-12 |
human |
| E J Blink, J A Trapani, D A Jan. Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis? Immunology and cell biology. vol 77. issue 3. 1999-07-08. PMID:10361252. |
in intact cells, perforin-dependent nuclear entry of granzymes precedes the nuclear events of apoptosis such as dna fragmentation and nuclear envelope breakdown; prevention of granzyme nuclear translocation through bcl2 overexpression or treatment of target cells with inhibitors of caspase activation blocks these events. |
1999-07-08 |
2023-08-12 |
Not clear |
| S Ning, S J Kno. G2/M-phase arrest and death by apoptosis of HL60 cells irradiated with exponentially decreasing low-dose-rate gamma radiation. Radiation research. vol 151. issue 6. 1999-06-17. PMID:10360785. |
to further study the role of cell death by apoptosis in the response to exponentially decreasing low-dose-rate irradiation, hl60 cells were transfected with the bcl2 proto-oncogene. |
1999-06-17 |
2023-08-12 |
human |
| S Gibson, C Widmann, G L Johnso. Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents. The Journal of biological chemistry. vol 274. issue 16. 1999-05-17. PMID:10196170. |
overexpression of anti-apoptotic bcl2 blocked mekk1 and taxol-induced apoptosis but did not block the caspase-dependent cleavage of mekk1 in response to etoposide. |
1999-05-17 |
2023-08-12 |
Not clear |
| S Gibson, C Widmann, G L Johnso. Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents. The Journal of biological chemistry. vol 274. issue 16. 1999-05-17. PMID:10196170. |
this indicates bcl2 inhibition of apoptosis is, therefore, downstream of caspase-dependent mekk1 cleavage. |
1999-05-17 |
2023-08-12 |
Not clear |
| K Imaizumi, T Morihara, Y Mori, T Katayama, M Tsuda, T Furuyama, A Wanaka, M Takeda, M Tohyam. The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein. The Journal of biological chemistry. vol 274. issue 12. 1999-04-15. PMID:10075695. |
the cell death-promoting gene dp5, which interacts with the bcl2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein. |
1999-04-15 |
2023-08-12 |
rat |
| R M Lee, G Gillet, J Burnside, S J Thomas, P Neima. Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius. Genes & development. vol 13. issue 6. 1999-04-15. PMID:10090728. |
the expression of bcl2 family cell death antagonists was examined to identify the genes that regulate bursal cell apoptosis. |
1999-04-15 |
2023-08-12 |
chicken |