| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R A Canuto, G Muzio, R A Salvo, M Maggiora, A Trombetta, J Chantepie, G Fournet, U Reichert, G Quas. The effect of a novel irreversible inhibitor of aldehyde dehydrogenases 1 and 3 on tumour cell growth and death. Chemico-biological interactions. vol 130-132. issue 1-3. 2001-05-10. PMID:11306045. |
as a follow up to the work previously reported on s-methyl 4-amino-4-methylpent-2-ynethioate, a synthetic suicide inhibitor of aldh1, which induced bcl2 overexpressing cells into apoptosis and exhibited an ed50 of 400 microm, a novel broad spectrum inhibitor of aldh1 and aldh3 was synthesised. |
2001-05-10 |
2023-08-12 |
rat |
| S Y Sun, P Yue, J Y Zhou, Y Wang, H R Choi Kim, R Lotan, G S W. Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells. Biochemical and biophysical research communications. vol 280. issue 3. 2001-03-29. PMID:11162590. |
overexpression of bcl2 blocks tnf-related apoptosis-inducing ligand (trail)-induced apoptosis in human lung cancer cells. |
2001-03-29 |
2023-08-12 |
human |
| S Y Sun, P Yue, J Y Zhou, Y Wang, H R Choi Kim, R Lotan, G S W. Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells. Biochemical and biophysical research communications. vol 280. issue 3. 2001-03-29. PMID:11162590. |
however, overexpression of bcl2 blocked trail-induced apoptosis in h460 cells, which correlated with the bcl2 protein levels. |
2001-03-29 |
2023-08-12 |
human |
| S Y Sun, P Yue, J Y Zhou, Y Wang, H R Choi Kim, R Lotan, G S W. Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells. Biochemical and biophysical research communications. vol 280. issue 3. 2001-03-29. PMID:11162590. |
moreover, inhibition of trail-mediated cytochrome c release and caspase 7 activation by bcl2 correlated with the inability of parp to be cleaved and the inability of the bcl2 transfectants to undergo apoptosis. |
2001-03-29 |
2023-08-12 |
human |
| S Y Sun, P Yue, J Y Zhou, Y Wang, H R Choi Kim, R Lotan, G S W. Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells. Biochemical and biophysical research communications. vol 280. issue 3. 2001-03-29. PMID:11162590. |
thus, these results suggest that bcl2 can serve an anti-apoptotic function during trail-dependent apoptosis by inhibiting the release of cytochrome c and activation of caspase 7, thereby blocking caspase 7-dependent cleavage of cellular substrates. |
2001-03-29 |
2023-08-12 |
human |
| V Vlaeminck-Guillem, M d'Herbomez-Boidein, M Decoulx, J L Wémea. [Apoptosis and the thyroid: the Fas pathway]. Presse medicale (Paris, France : 1983). vol 30. issue 2. 2001-03-29. PMID:11244819. |
thyroid-infiltrating lymphocytes are resistant to apoptosis by overexpressing the antiapoptotic protein bcl2. |
2001-03-29 |
2023-08-12 |
Not clear |
| B Krishnamoorthy, K Narayanan, S Miyamoto, A Balakrishna. Epithelial cells release proinflammatory cytokines and undergo c-Myc-induced apoptosis on exposure to filarial parasitic sheath protein-Bcl2 mediates rescue by activating c-H-Ras. In vitro cellular & developmental biology. Animal. vol 36. issue 8. 2001-03-01. PMID:11149753. |
our earlier studies, in vitro, conclusively prove that filarial parasitic sheath proteins induce apoptosis in hep2 cells, an epithelial cell line, by a pathway inhibitable by bcl2. |
2001-03-01 |
2023-08-12 |
human |
| B Krishnamoorthy, K Narayanan, S Miyamoto, A Balakrishna. Epithelial cells release proinflammatory cytokines and undergo c-Myc-induced apoptosis on exposure to filarial parasitic sheath protein-Bcl2 mediates rescue by activating c-H-Ras. In vitro cellular & developmental biology. Animal. vol 36. issue 8. 2001-03-01. PMID:11149753. |
the present findings provide evidence that c-myc activation triggers apoptosis in hep2 cells and that it is also responsible for the burst of abortive proliferation at 6 d of treatment of hep2 bcl2 cells that overexpress bcl2, with filarial parasitic sheath protein, demonstrating the interplay between the two genes c-myc and bcl2, wherein bcl2 acts by restoring the prosurvival signal to c-myc and keeping its apoptotic tendency in check. |
2001-03-01 |
2023-08-12 |
human |
| B Krishnamoorthy, K Narayanan, S Miyamoto, A Balakrishna. Epithelial cells release proinflammatory cytokines and undergo c-Myc-induced apoptosis on exposure to filarial parasitic sheath protein-Bcl2 mediates rescue by activating c-H-Ras. In vitro cellular & developmental biology. Animal. vol 36. issue 8. 2001-03-01. PMID:11149753. |
this study also indicates that bcl2 upregulates c-h-ras, engaging ras to bring about the suppression of apoptosis through protein tyrosine kinase elevation, thus promoting the survival of the hep2 bcl2 cells. |
2001-03-01 |
2023-08-12 |
human |
| C D'Sa-Eipper, J R Leonard, G Putcha, T S Zheng, R A Flavell, P Rakic, K Kuida, K A Rot. DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3. Development (Cambridge, England). vol 128. issue 1. 2001-02-22. PMID:11092819. |
members of the bcl2 and caspase families regulate neuronal responsiveness to trophic factor withdrawal; however, their involvement in dna damage-induced neuronal apoptosis is less clear. |
2001-02-22 |
2023-08-12 |
mouse |
| C D'Sa-Eipper, J R Leonard, G Putcha, T S Zheng, R A Flavell, P Rakic, K Kuida, K A Rot. DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3. Development (Cambridge, England). vol 128. issue 1. 2001-02-22. PMID:11092819. |
neural precursor cell apoptosis was also unaffected by targeted disruptions of bclx and bcl2, and unlike neurotrophic factor-deprivation-induced neuronal apoptosis, was not associated with a detectable loss of cytochrome c from mitochondria. |
2001-02-22 |
2023-08-12 |
mouse |
| C Paul, A P Arrig. Comparison of the protective activities generated by two survival proteins: Bcl-2 and Hsp27 in L929 murine fibroblasts exposed to menadione or staurosporine. Experimental gerontology. vol 35. issue 6-7. 2001-01-11. PMID:11053666. |
hence, despite some similar cellular effects resulting from their expression, bcl2 and hsp27 polypeptides protect against oxidative stress and apoptosis with different efficiencies and by using different mechanisms. |
2001-01-11 |
2023-08-12 |
Not clear |
| S Sengupta, J L Vonesch, C Waltzinger, H Zheng, B Wasyly. Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells. The EMBO journal. vol 19. issue 22. 2001-01-04. PMID:11080152. |
we found that dexamethasone-activated endogenous and exogenous gr inhibit p53-dependent functions, including transactivation, up- (bax and p21(waf1/cip1)) and down- (bcl2) regulation of endogenous genes, cell cycle arrest and apoptosis. |
2001-01-04 |
2023-08-12 |
Not clear |
| M A Brantley, J W Harbou. Deregulation of the Rb and p53 pathways in uveal melanoma. The American journal of pathology. vol 157. issue 6. 2001-01-04. PMID:11106551. |
strong cytoplasmic staining was observed for bcl2, which can inhibit both p53-dependent and -independent apoptosis. |
2001-01-04 |
2023-08-12 |
Not clear |
| B Jansen, V Wacheck, E Heere-Ress, H Schlagbauer-Wadl, C Hoeller, T Lucas, M Hoermann, U Hollenstein, K Wolff, H Pehamberge. Chemosensitisation of malignant melanoma by BCL2 antisense therapy. Lancet (London, England). vol 356. issue 9243. 2000-12-14. PMID:11095261. |
antisense oligonucleotides (aso) targeted against bcl2 mrna decreased bcl2 protein concentrations, increased tumour-cell apoptosis, and led to tumour responses in a mouse xenotransplantation model when combined with systemic dacarbazine. |
2000-12-14 |
2023-08-12 |
mouse |
| S A Amundson, T G Myers, D Scudiero, S Kitada, J C Reed, A J Fornac. An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer research. vol 60. issue 21. 2000-11-30. PMID:11085534. |
conversely, bax and bcl2, two other genes associated with regulation of apoptosis, showed no overall correlation with drug sensitivities. |
2000-11-30 |
2023-08-12 |
human |
| S H Park, H N Cho, S J Lee, T H Kim, Y Lee, Y M Park, Y J Lee, C K Cho, S Y Yoo, Y S Le. Hsp25-induced radioresistance is associated with reduction of death by apoptosis: involvement of Bcl2 and the cell cycle. Radiation research. vol 154. issue 4. 2000-11-03. PMID:11023606. |
hsp25-induced radioresistance is associated with reduction of death by apoptosis: involvement of bcl2 and the cell cycle. |
2000-11-03 |
2023-08-12 |
Not clear |
| L R Kellan. Preclinical perspectives on platinum resistance. Drugs. vol 59 Suppl 4. 2000-10-16. PMID:10864225. |
resistance may also be mediated through alterations in proteins involved in programmed cell death (apoptosis) such as p53 and the bcl2 family. |
2000-10-16 |
2023-08-12 |
Not clear |
| H Kovar, G Jug, D Printz, S Bartl, G Schmid, J Wesierska-Gade. Characterization of distinct consecutive phases in non-genotoxic p53-induced apoptosis of Ewing tumor cells and the rate-limiting role of caspase 8. Oncogene. vol 19. issue 36. 2000-10-02. PMID:10962570. |
expression of bcl2 only partially suppressed caspase activation but blocked apoptosis. |
2000-10-02 |
2023-08-12 |
Not clear |
| A Fayyazi, B Eichmeyer, A Soruri, S Schweyer, J Herms, P Schwarz, H J Radzu. Apoptosis of macrophages and T cells in tuberculosis associated caseous necrosis. The Journal of pathology. vol 191. issue 4. 2000-09-12. PMID:10918217. |
these results suggest that caseation is strongly associated with apoptosis of macrophages and t lymphocytes; that the onset of apoptosis in macrophages may be promoted by the lack of bcl2 and the abundance of bax; and that activation-induced cell death (aicd) may be responsible for the apoptosis of t cells. |
2000-09-12 |
2023-08-12 |
Not clear |