| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C D'Sa-Eipper, J R Leonard, G Putcha, T S Zheng, R A Flavell, P Rakic, K Kuida, K A Rot. DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3. Development (Cambridge, England). vol 128. issue 1. 2001-02-22. PMID:11092819. |
neural precursor cell apoptosis was also unaffected by targeted disruptions of bclx and bcl2, and unlike neurotrophic factor-deprivation-induced neuronal apoptosis, was not associated with a detectable loss of cytochrome c from mitochondria. |
2001-02-22 |
2023-08-12 |
mouse |
| C Paul, A P Arrig. Comparison of the protective activities generated by two survival proteins: Bcl-2 and Hsp27 in L929 murine fibroblasts exposed to menadione or staurosporine. Experimental gerontology. vol 35. issue 6-7. 2001-01-11. PMID:11053666. |
hence, despite some similar cellular effects resulting from their expression, bcl2 and hsp27 polypeptides protect against oxidative stress and apoptosis with different efficiencies and by using different mechanisms. |
2001-01-11 |
2023-08-12 |
Not clear |
| S Sengupta, J L Vonesch, C Waltzinger, H Zheng, B Wasyly. Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells. The EMBO journal. vol 19. issue 22. 2001-01-04. PMID:11080152. |
we found that dexamethasone-activated endogenous and exogenous gr inhibit p53-dependent functions, including transactivation, up- (bax and p21(waf1/cip1)) and down- (bcl2) regulation of endogenous genes, cell cycle arrest and apoptosis. |
2001-01-04 |
2023-08-12 |
Not clear |
| M A Brantley, J W Harbou. Deregulation of the Rb and p53 pathways in uveal melanoma. The American journal of pathology. vol 157. issue 6. 2001-01-04. PMID:11106551. |
strong cytoplasmic staining was observed for bcl2, which can inhibit both p53-dependent and -independent apoptosis. |
2001-01-04 |
2023-08-12 |
Not clear |
| B Jansen, V Wacheck, E Heere-Ress, H Schlagbauer-Wadl, C Hoeller, T Lucas, M Hoermann, U Hollenstein, K Wolff, H Pehamberge. Chemosensitisation of malignant melanoma by BCL2 antisense therapy. Lancet (London, England). vol 356. issue 9243. 2000-12-14. PMID:11095261. |
antisense oligonucleotides (aso) targeted against bcl2 mrna decreased bcl2 protein concentrations, increased tumour-cell apoptosis, and led to tumour responses in a mouse xenotransplantation model when combined with systemic dacarbazine. |
2000-12-14 |
2023-08-12 |
mouse |
| S A Amundson, T G Myers, D Scudiero, S Kitada, J C Reed, A J Fornac. An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer research. vol 60. issue 21. 2000-11-30. PMID:11085534. |
conversely, bax and bcl2, two other genes associated with regulation of apoptosis, showed no overall correlation with drug sensitivities. |
2000-11-30 |
2023-08-12 |
human |
| S H Park, H N Cho, S J Lee, T H Kim, Y Lee, Y M Park, Y J Lee, C K Cho, S Y Yoo, Y S Le. Hsp25-induced radioresistance is associated with reduction of death by apoptosis: involvement of Bcl2 and the cell cycle. Radiation research. vol 154. issue 4. 2000-11-03. PMID:11023606. |
hsp25-induced radioresistance is associated with reduction of death by apoptosis: involvement of bcl2 and the cell cycle. |
2000-11-03 |
2023-08-12 |
Not clear |
| L R Kellan. Preclinical perspectives on platinum resistance. Drugs. vol 59 Suppl 4. 2000-10-16. PMID:10864225. |
resistance may also be mediated through alterations in proteins involved in programmed cell death (apoptosis) such as p53 and the bcl2 family. |
2000-10-16 |
2023-08-12 |
Not clear |
| H Kovar, G Jug, D Printz, S Bartl, G Schmid, J Wesierska-Gade. Characterization of distinct consecutive phases in non-genotoxic p53-induced apoptosis of Ewing tumor cells and the rate-limiting role of caspase 8. Oncogene. vol 19. issue 36. 2000-10-02. PMID:10962570. |
expression of bcl2 only partially suppressed caspase activation but blocked apoptosis. |
2000-10-02 |
2023-08-12 |
Not clear |
| A Fayyazi, B Eichmeyer, A Soruri, S Schweyer, J Herms, P Schwarz, H J Radzu. Apoptosis of macrophages and T cells in tuberculosis associated caseous necrosis. The Journal of pathology. vol 191. issue 4. 2000-09-12. PMID:10918217. |
these results suggest that caseation is strongly associated with apoptosis of macrophages and t lymphocytes; that the onset of apoptosis in macrophages may be promoted by the lack of bcl2 and the abundance of bax; and that activation-induced cell death (aicd) may be responsible for the apoptosis of t cells. |
2000-09-12 |
2023-08-12 |
Not clear |
| D Dai, B C Moulton, T F Ogl. Regression of the decidualized mesometrium and decidual cell apoptosis are associated with a shift in expression of Bcl2 family members. Biology of reproduction. vol 63. issue 1. 2000-08-24. PMID:10859259. |
regression of the decidualized mesometrium and decidual cell apoptosis are associated with a shift in expression of bcl2 family members. |
2000-08-24 |
2023-08-12 |
rat |
| D Dai, B C Moulton, T F Ogl. Regression of the decidualized mesometrium and decidual cell apoptosis are associated with a shift in expression of Bcl2 family members. Biology of reproduction. vol 63. issue 1. 2000-08-24. PMID:10859259. |
the purpose of this study was to determine whether regression of the decidua basalis (db), which begins on day 14 of pregnancy in the rat, results from an intrinsic program of apoptosis regulated by bax and bcl2. |
2000-08-24 |
2023-08-12 |
rat |
| D Dai, B C Moulton, T F Ogl. Regression of the decidualized mesometrium and decidual cell apoptosis are associated with a shift in expression of Bcl2 family members. Biology of reproduction. vol 63. issue 1. 2000-08-24. PMID:10859259. |
expression of bax and bcl2 and the incidence of apoptosis were evaluated throughout gestation by western blot analysis and detection of dna fragments. |
2000-08-24 |
2023-08-12 |
rat |
| S M Kornblau, H T Vu, P Ruvolo, Z Estrov, S O'Brien, J Cortes, H Kantarjian, M Andreeff, W S Ma. BAX and PKCalpha modulate the prognostic impact of BCL2 expression in acute myelogenous leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 4. 2000-08-03. PMID:10778970. |
these results suggest that expression levels of proteins that affect the functional status of bcl2 modify the prognostic impact of bcl2 and suggest that the role of apoptosis in different cases of aml varies independently in the different cytogenetic subgroups. |
2000-08-03 |
2023-08-12 |
Not clear |
| P W Moye, W L Blalock, P E Hoyle, F Chang, R A Franklin, C Weinstein-Oppenheimer, M Pearce, L Steelman, M McMahon, J A McCubre. Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells. Leukemia. vol 14. issue 6. 2000-07-10. PMID:10865973. |
these cells will be useful in furthering our understanding of the roles of the raf and bcl2 oncoproteins in hematopoietic cell growth, cell cycle progression and prevention of apoptosis. |
2000-07-10 |
2023-08-12 |
Not clear |
| W L Blalock, P W Moye, F Chang, M Pearce, L S Steelman, M McMahon, J A McCubre. Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells. Leukemia. vol 14. issue 6. 2000-07-10. PMID:10865974. |
these conditionally transformed cells will be useful in furthering our understanding of the roles mek1 and bcl2 play in the prevention of apoptosis in hematopoietic cells. |
2000-07-10 |
2023-08-12 |
human |
| A J Watson, D M Pritchar. Lessons from genetically engineered animal models. VII. Apoptosis in intestinal epithelium: lessons from transgenic and knockout mice. American journal of physiology. Gastrointestinal and liver physiology. vol 278. issue 1. 2000-06-16. PMID:10644554. |
knockout studies have shown that spontaneous apoptosis is independent of p53 and bax in both small and large intestine, whereas bcl2 only regulates spontaneous apoptosis in the colon. |
2000-06-16 |
2023-08-12 |
mouse |
| A J Watson, D M Pritchar. Lessons from genetically engineered animal models. VII. Apoptosis in intestinal epithelium: lessons from transgenic and knockout mice. American journal of physiology. Gastrointestinal and liver physiology. vol 278. issue 1. 2000-06-16. PMID:10644554. |
in contrast, knockout studies have demonstrated that both p53 and bcl2 are important regulators of stress-induced apoptosis but that there are significant differences between early and late time points. |
2000-06-16 |
2023-08-12 |
mouse |
| E Giarnieri, C Nagar, C Valli, E Brunetti, M B Palmieri, A Vecchion. BCL2 and BAX expression in hyperplastic and dysplastic rectal polyps. Hepato-gastroenterology. vol 47. issue 31. 2000-03-30. PMID:10690601. |
members of the gene family that includes bcl2 and bax are functionally antagonists in the apoptosis process and they have been observed in normal and neoplastic tissues. |
2000-03-30 |
2023-08-12 |
Not clear |
| C R Antonescu, A Kawai, D H Leung, F Lonardo, J M Woodruff, J H Healey, M Ladany. Strong association of SYT-SSX fusion type and morphologic epithelial differentiation in synovial sarcoma. Diagnostic molecular pathology : the American journal of surgical pathology, part B. vol 9. issue 1. 2000-03-29. PMID:10718206. |
apoptosis was analyzed immunohistochemically with bax and bcl2 antibodies and by the tunel method. |
2000-03-29 |
2023-08-12 |
Not clear |