| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Ortiz, P Justo, M P Catalán, A B Sanz, C Lorz, J Egid. Apoptotic cell death in renal injury: the rationale for intervention. Current drug targets. Immune, endocrine and metabolic disorders. vol 2. issue 2. 2003-01-28. PMID:12476791. |
death ligands and receptors, such as tumor necrosis factor and fas ligand, proapoptotic and antiapoptotic bcl2 family members and caspases have all been shown to participate in apoptosis regulation in the course of renal cell injury. |
2003-01-28 |
2023-08-12 |
Not clear |
| Bart Schouten, R Maarten Egeler, Pieter J M Leenen, Antonie H M Taminiau, Lambert J J C M van den Broek, Pancras C W Hogendoor. Expression of cell cycle-related gene products in Langerhans cell histiocytosis. Journal of pediatric hematology/oncology. vol 24. issue 9. 2003-01-21. PMID:12468913. |
the tgf-betar genes play a role in tumor suppression, whereas bcl2 inhibits apoptosis. |
2003-01-21 |
2023-08-12 |
Not clear |
| Bart Schouten, R Maarten Egeler, Pieter J M Leenen, Antonie H M Taminiau, Lambert J J C M van den Broek, Pancras C W Hogendoor. Expression of cell cycle-related gene products in Langerhans cell histiocytosis. Journal of pediatric hematology/oncology. vol 24. issue 9. 2003-01-21. PMID:12468913. |
the observed overexpression of bcl2 may play a role in the activation of p53 and p16 and/or the arrest of apoptosis. |
2003-01-21 |
2023-08-12 |
Not clear |
| Qun Wu, Paul Kirschmeier, Tish Hockenberry, Tong-Yuan Yang, Diana L Brassard, Luquan Wang, Terri McClanahan, Stuart Black, Giovanni Rizzi, Mary Lynn Musco, Asra Mirza, Suxing Li. Transcriptional regulation during p21WAF1/CIP1-induced apoptosis in human ovarian cancer cells. The Journal of biological chemistry. vol 277. issue 39. 2002-11-13. PMID:12138103. |
quantitative reverse transcription-pcr analysis revealed that the differential expression of bax, bcl2, and caspase 3 genes, specific in rad-p53-induced apoptotic cells, was not altered in rad-p21-induced apoptotic cells, suggesting p21(waf1/cip1)-induced apoptosis through a pathway distinguishable from p53-induced apoptosis. |
2002-11-13 |
2023-08-12 |
human |
| Sergey A Kaliberov, Donald J Buchsbaum, G Yancey Gillespie, David T Curiel, Waleed O Arafat, Mark Carpenter, Murray A Stackhous. Adenovirus-mediated transfer of BAX driven by the vascular endothelial growth factor promoter induces apoptosis in lung cancer cells. Molecular therapy : the journal of the American Society of Gene Therapy. vol 6. issue 2. 2002-10-04. PMID:12161185. |
bax is a death-promoting member of the bcl2 family of genes that are intimately involved in apoptosis. |
2002-10-04 |
2023-08-12 |
human |
| Maria Chiara Deregibus, Vincenzo Cantaluppi, Sophie Doublier, Maria Felice Brizzi, Ilaria Deambrosis, Adriana Albini, Giovanni Camuss. HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells. The Journal of biological chemistry. vol 277. issue 28. 2002-08-12. PMID:11994280. |
in this study we found that tat protected vincristine-treated kaposi's sarcoma cells from apoptosis and from down-regulation of several anti-apoptotic genes such as akt-1, akt-2, bcl2, bcl-xl, and insulin-like growth factor i and induced the de novo expression of the interleukin-3 gene. |
2002-08-12 |
2023-08-12 |
Not clear |
| Clemens A Schmitt, Jordan S Fridman, Meng Yang, Eugene Baranov, Robert M Hoffman, Scott W Low. Dissecting p53 tumor suppressor functions in vivo. Cancer cell. vol 1. issue 3. 2002-08-01. PMID:12086865. |
using a mouse model harboring primary, genetically modified myc-driven lymphomas, we show that disruption of apoptosis downstream of p53 by bcl2 or a dominant-negative caspase 9 confers-like p53 loss-a selective advantage, and completely alleviates pressure to inactivate p53 during lymphomagenesis. |
2002-08-01 |
2023-08-12 |
mouse |
| P Giridharan, S T Somasundaram, K Perumal, R A Vishwakarma, N P Karthikeyan, R Velmurugan, A Balakrishna. Novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase and activation of c-myc and caspases leading to apoptosis. British journal of cancer. vol 87. issue 1. 2002-07-31. PMID:12085264. |
the pure compound and the crude ethyl acetate fraction which showed anti-proliferative activities were examined for ability to target specific markers of apoptosis like bcl2, c-myc and caspases and for effects on telomerase. |
2002-07-31 |
2023-08-12 |
Not clear |
| P Giridharan, S T Somasundaram, K Perumal, R A Vishwakarma, N P Karthikeyan, R Velmurugan, A Balakrishna. Novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase and activation of c-myc and caspases leading to apoptosis. British journal of cancer. vol 87. issue 1. 2002-07-31. PMID:12085264. |
the results indicate that 7'-hydroxy-3',4',5,9,9'-pentamethoxy-3,4-methylene dioxy lignan was capable of inhibiting telomerase activity and also could inhibit bcl2 and activate caspase 3 and caspase 8 whose significance in the induction of apoptosis is well known. |
2002-07-31 |
2023-08-12 |
Not clear |
| E Farczádi, I Kaszás, M Baki, B Szend. Changes in apoptosis, mitosis, Her-2, p53 and Bcl2 expression in breast carcinomas after short-term tamoxifen treatment. Neoplasma. vol 49. issue 2. 2002-07-24. PMID:12088100. |
changes in apoptosis, mitosis, her-2, p53 and bcl2 expression in breast carcinomas after short-term tamoxifen treatment. |
2002-07-24 |
2023-08-12 |
Not clear |
| E Farczádi, I Kaszás, M Baki, B Szend. Changes in apoptosis, mitosis, Her-2, p53 and Bcl2 expression in breast carcinomas after short-term tamoxifen treatment. Neoplasma. vol 49. issue 2. 2002-07-24. PMID:12088100. |
the short-term (7 days) effect of tamoxifen on apoptosis and mitosis index, p53, bcl2 and her-2/neu/c-erb2 expression in invasive ductal mammary carcinoma was studied histologically in the diagnostic biopsy and surgically removed tumor tissue of 10 patients. |
2002-07-24 |
2023-08-12 |
Not clear |
| Peter P Ruvolo, Warren Clark, Marc Mumby, Fengqin Gao, W Stratford Ma. A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function. The Journal of biological chemistry. vol 277. issue 25. 2002-07-19. PMID:11929874. |
pp2a-resistant) gain-of-function s70e mutant bcl2 can protect cells from ceramide-induced apoptosis. |
2002-07-19 |
2023-08-12 |
Not clear |
| Gaël G McGill, Martin Horstmann, Hans R Widlund, Jinyan Du, Gabriela Motyckova, Emi K Nishimura, Yi-Ling Lin, Sridhar Ramaswamy, William Avery, Han-Fei Ding, Siobhán A Jordan, Ian J Jackson, Stanley J Korsmeyer, Todd R Golub, David E Fishe. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell. vol 109. issue 6. 2002-07-19. PMID:12086670. |
disruption of mitf in melanocytes or melanoma triggered profound apoptosis susceptible to rescue by bcl2 overexpression. |
2002-07-19 |
2023-08-12 |
mouse |
| David R Plas, Craig B Thompso. Cell metabolism in the regulation of programmed cell death. Trends in endocrinology and metabolism: TEM. vol 13. issue 2. 2002-07-16. PMID:11854022. |
here, we review the coordinated effects of growth factor withdrawal on bioenergetics and programmed cell death, and discuss the metabolic consequences of genes that prevent apoptosis, including the bcl2 family of genes and akt. |
2002-07-16 |
2023-08-12 |
Not clear |
| U Mazurek, G Bierzyńska-Macyszyn, J Gola, J Orchel, J Słowiński, T Wilczo. BCL2 and BAX mRNA concentration profile in fibrillary astrocytoma. Folia histochemica et cytobiologica. vol 39 Suppl 2. 2002-06-21. PMID:11820596. |
a high level of the bcl2 protein and the lack of apoptosis promoting protein bax are beginning to be treated as markers of cellular resistance to anti-neoplastic drugs. |
2002-06-21 |
2023-08-12 |
Not clear |
| X B Shi, P H Gumerlock, J T Muenzer, R W deVere Whit. BCL2 antisense transcripts decrease intracellular Bcl2 expression and sensitize LNCaP prostate cancer cells to apoptosis-inducing agents. Cancer biotherapy & radiopharmaceuticals. vol 16. issue 5. 2002-06-17. PMID:11776759. |
since bcl2 is believed to play a role in protecting cap cells from apoptosis, we investigated the effects of down-regulating bcl2 expression on cap cells. |
2002-06-17 |
2023-08-12 |
Not clear |
| G C Huang, S Hobbs, M Walton, R J Epstei. Dominant negative knockout of p53 abolishes ErbB2-dependent apoptosis and permits growth acceleration in human breast cancer cells. British journal of cancer. vol 86. issue 7. 2002-04-30. PMID:11953857. |
compared with parental cells, mcf7-b2 cells are characterised by upregulation of p53, p21(waf) and myc, downregulation of bcl2, and apoptosis. |
2002-04-30 |
2023-08-12 |
human |
| Erika M Gibson, Elizabeth S Henson, Jacylyn Villanueva, Spencer B Gibso. MEK kinase 1 induces mitochondrial permeability transition leading to apoptosis independent of cytochrome c release. The Journal of biological chemistry. vol 277. issue 12. 2002-04-29. PMID:11756439. |
since bcl2 regulates changes in mitochondria and blocks mekk1-induced apoptosis, we determined that bcl2 blocks mekk1-induced apoptosis when targeted to the mitochondria. |
2002-04-29 |
2023-08-12 |
mouse |
| P Kanavaros, K Stefanaki, D Rontogianni, D Papalazarou, M Sgantzos, D Arvanitis, C Vamvouka, V Gorgoulis, I Siatitsas, N J Agnantis, M Ba. Immunohistochemical expression of p53, p21/waf1, rb, p16, cyclin D1, p27, Ki67, cyclin A, cyclin B1, bcl2, bax and bak proteins and apoptotic index in normal thymus. Histology and histopathology. vol 16. issue 4. 2002-03-21. PMID:11642719. |
the expressions of bax and bak were more widespread in both the medulla and cortex, suggesting that these proteins play a broader role than bcl2 in the regulation of thymic apoptosis. |
2002-03-21 |
2023-08-12 |
Not clear |
| A Hartwich, S J Konturek, P Pierzchalski, M Zuchowicz, H Labza, P C Konturek, E Karczewska, W Bielanski, K Marlicz, T Starzynska, M Lawniczak, E G Hah. Helicobacter pylori infection, gastrin, cyclooxygenase-2, and apoptosis in colorectal cancer. International journal of colorectal disease. vol 16. issue 4. 2001-12-31. PMID:11515678. |
we conclude that colon adenocarcinoma and its resection margin overexpress gastrin, its receptors, cckb-r, and cox-2, and that hp infection may contribute to colonic cancerogenesis via overexpression of gastrin and cox-2, which may account for the stimulation of the tumor growth and the reduction in apoptosis as documented by enhanced mrna expression of anti-apoptotic bcl2 over proapoptotic bax proteins. |
2001-12-31 |
2023-08-12 |
Not clear |