| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sophie Meintières, Armelle Biola, Marc Pallardy, Daniel Marzi. Using CTLL-2 and CTLL-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. Environmental and molecular mutagenesis. vol 41. issue 1. 2003-03-14. PMID:12552588. |
these previous studies were conducted by performing the in vitro micronucleus test in ctll-2 cells and a ctll-2 cell derivative stably transfected with the apoptosis inhibitor gene bcl2. |
2003-03-14 |
2023-08-12 |
Not clear |
| Sophie Meintières, Armelle Biola, Marc Pallardy, Daniel Marzi. Using CTLL-2 and CTLL-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. Environmental and molecular mutagenesis. vol 41. issue 1. 2003-03-14. PMID:12552588. |
in the present study, these previous observations were extended by examining micronucleus induction with a larger number of compounds in both ctll-2 and ctll-2 bcl2 cells and measuring apoptosis with annexin v-fitc. |
2003-03-14 |
2023-08-12 |
Not clear |
| Sophie Meintières, Armelle Biola, Marc Pallardy, Daniel Marzi. Using CTLL-2 and CTLL-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. Environmental and molecular mutagenesis. vol 41. issue 1. 2003-03-14. PMID:12552588. |
we were able to confirm that compounds that are only apoptogenic induced micronuclei in ctll-2 but not ctll-2 bcl2 cells, indicating that the positive responses are due to apoptosis in ctll-2 cells. |
2003-03-14 |
2023-08-12 |
Not clear |
| Sophie Meintières, Armelle Biola, Marc Pallardy, Daniel Marzi. Using CTLL-2 and CTLL-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. Environmental and molecular mutagenesis. vol 41. issue 1. 2003-03-14. PMID:12552588. |
some genotoxins (clastogens and aneugens) did not produce apoptosis by the annexin v assay and gave similar responses in ctll-2 and ctll-2 bcl2 cells. |
2003-03-14 |
2023-08-12 |
Not clear |
| Sophie Meintières, Armelle Biola, Marc Pallardy, Daniel Marzi. Using CTLL-2 and CTLL-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. Environmental and molecular mutagenesis. vol 41. issue 1. 2003-03-14. PMID:12552588. |
finally, higher responses were induced in ctll-2 cells compared to ctll-2 bcl2 cells that were treated with aneugens or clastogens that were also apoptosis inducers, suggesting that the greater response in ctll-2 cells is a consequence of both genotoxicity and apoptosis. |
2003-03-14 |
2023-08-12 |
Not clear |
| Sophie Meintières, Armelle Biola, Marc Pallardy, Daniel Marzi. Using CTLL-2 and CTLL-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. Environmental and molecular mutagenesis. vol 41. issue 1. 2003-03-14. PMID:12552588. |
the results indicate that coupling the in vitro micronucleus test in both ctll-2 and ctll-2 bcl2 cells with the measurement of apoptosis is able to distinguish the genotoxic effects of a test compound from its apoptotic potential and is able to avoid interference from apoptosis in the in vitro micronucleus test. |
2003-03-14 |
2023-08-12 |
Not clear |
| Margarita Sánchez-Beato, Abel Sánchez-Aguilera, Miguel A Piri. Cell cycle deregulation in B-cell lymphomas. Blood. vol 101. issue 4. 2003-03-13. PMID:12393483. |
most types of low-growth fraction lymphomas are initiated by molecular events resulting in the inhibition of apoptosis, such as translocations affecting bcl2, in follicular lymphoma, or bcl10 and api2/mlt1, in mucosa-associated lymphoid tissue (malt) lymphomas. |
2003-03-13 |
2023-08-12 |
human |
| L A Pasquini, M Besio Moreno, M Lopez Salon, E F Sot. Apoptosis in Schwann cell cultures is closely interrelated with the activity of the ubiquitin-proteasome proteolytic pathway. Neurochemical research. vol 27. issue 11. 2003-03-07. PMID:12512944. |
changes in the levels of ubiquitin-protein conjugates and of the ubiquitin activating enzymes, e1, as well as expression of proteins that instruct the cells to apoptosis (p53, nfkappab-ikappab, bcl2), or that participate in the control and regulation of the cell cycle, were also examined. |
2003-03-07 |
2023-08-12 |
rat |
| Haiqiang Mai, W Stratford May, Fengqin Gao, Zhaohui Jin, Xingming Den. A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis. The Journal of biological chemistry. vol 278. issue 3. 2003-02-14. PMID:12421819. |
a functional role for nicotine in bcl2 phosphorylation and suppression of apoptosis. |
2003-02-14 |
2023-08-12 |
Not clear |
| Haiqiang Mai, W Stratford May, Fengqin Gao, Zhaohui Jin, Xingming Den. A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis. The Journal of biological chemistry. vol 278. issue 3. 2003-02-14. PMID:12421819. |
furthermore, et-18-och3, a specific phospholipase c (plc) inhibitor, blocks nicotine-stimulated bcl2 phosphorylation and promotes apoptosis, suggesting that plc may be involved in nicotine activation of bcl2 kinases. |
2003-02-14 |
2023-08-12 |
Not clear |
| A Ortiz, P Justo, M P Catalán, A B Sanz, C Lorz, J Egid. Apoptotic cell death in renal injury: the rationale for intervention. Current drug targets. Immune, endocrine and metabolic disorders. vol 2. issue 2. 2003-01-28. PMID:12476791. |
death ligands and receptors, such as tumor necrosis factor and fas ligand, proapoptotic and antiapoptotic bcl2 family members and caspases have all been shown to participate in apoptosis regulation in the course of renal cell injury. |
2003-01-28 |
2023-08-12 |
Not clear |
| Bart Schouten, R Maarten Egeler, Pieter J M Leenen, Antonie H M Taminiau, Lambert J J C M van den Broek, Pancras C W Hogendoor. Expression of cell cycle-related gene products in Langerhans cell histiocytosis. Journal of pediatric hematology/oncology. vol 24. issue 9. 2003-01-21. PMID:12468913. |
the tgf-betar genes play a role in tumor suppression, whereas bcl2 inhibits apoptosis. |
2003-01-21 |
2023-08-12 |
Not clear |
| Bart Schouten, R Maarten Egeler, Pieter J M Leenen, Antonie H M Taminiau, Lambert J J C M van den Broek, Pancras C W Hogendoor. Expression of cell cycle-related gene products in Langerhans cell histiocytosis. Journal of pediatric hematology/oncology. vol 24. issue 9. 2003-01-21. PMID:12468913. |
the observed overexpression of bcl2 may play a role in the activation of p53 and p16 and/or the arrest of apoptosis. |
2003-01-21 |
2023-08-12 |
Not clear |
| Qun Wu, Paul Kirschmeier, Tish Hockenberry, Tong-Yuan Yang, Diana L Brassard, Luquan Wang, Terri McClanahan, Stuart Black, Giovanni Rizzi, Mary Lynn Musco, Asra Mirza, Suxing Li. Transcriptional regulation during p21WAF1/CIP1-induced apoptosis in human ovarian cancer cells. The Journal of biological chemistry. vol 277. issue 39. 2002-11-13. PMID:12138103. |
quantitative reverse transcription-pcr analysis revealed that the differential expression of bax, bcl2, and caspase 3 genes, specific in rad-p53-induced apoptotic cells, was not altered in rad-p21-induced apoptotic cells, suggesting p21(waf1/cip1)-induced apoptosis through a pathway distinguishable from p53-induced apoptosis. |
2002-11-13 |
2023-08-12 |
human |
| Sergey A Kaliberov, Donald J Buchsbaum, G Yancey Gillespie, David T Curiel, Waleed O Arafat, Mark Carpenter, Murray A Stackhous. Adenovirus-mediated transfer of BAX driven by the vascular endothelial growth factor promoter induces apoptosis in lung cancer cells. Molecular therapy : the journal of the American Society of Gene Therapy. vol 6. issue 2. 2002-10-04. PMID:12161185. |
bax is a death-promoting member of the bcl2 family of genes that are intimately involved in apoptosis. |
2002-10-04 |
2023-08-12 |
human |
| Maria Chiara Deregibus, Vincenzo Cantaluppi, Sophie Doublier, Maria Felice Brizzi, Ilaria Deambrosis, Adriana Albini, Giovanni Camuss. HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells. The Journal of biological chemistry. vol 277. issue 28. 2002-08-12. PMID:11994280. |
in this study we found that tat protected vincristine-treated kaposi's sarcoma cells from apoptosis and from down-regulation of several anti-apoptotic genes such as akt-1, akt-2, bcl2, bcl-xl, and insulin-like growth factor i and induced the de novo expression of the interleukin-3 gene. |
2002-08-12 |
2023-08-12 |
Not clear |
| Clemens A Schmitt, Jordan S Fridman, Meng Yang, Eugene Baranov, Robert M Hoffman, Scott W Low. Dissecting p53 tumor suppressor functions in vivo. Cancer cell. vol 1. issue 3. 2002-08-01. PMID:12086865. |
using a mouse model harboring primary, genetically modified myc-driven lymphomas, we show that disruption of apoptosis downstream of p53 by bcl2 or a dominant-negative caspase 9 confers-like p53 loss-a selective advantage, and completely alleviates pressure to inactivate p53 during lymphomagenesis. |
2002-08-01 |
2023-08-12 |
mouse |
| P Giridharan, S T Somasundaram, K Perumal, R A Vishwakarma, N P Karthikeyan, R Velmurugan, A Balakrishna. Novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase and activation of c-myc and caspases leading to apoptosis. British journal of cancer. vol 87. issue 1. 2002-07-31. PMID:12085264. |
the pure compound and the crude ethyl acetate fraction which showed anti-proliferative activities were examined for ability to target specific markers of apoptosis like bcl2, c-myc and caspases and for effects on telomerase. |
2002-07-31 |
2023-08-12 |
Not clear |
| P Giridharan, S T Somasundaram, K Perumal, R A Vishwakarma, N P Karthikeyan, R Velmurugan, A Balakrishna. Novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase and activation of c-myc and caspases leading to apoptosis. British journal of cancer. vol 87. issue 1. 2002-07-31. PMID:12085264. |
the results indicate that 7'-hydroxy-3',4',5,9,9'-pentamethoxy-3,4-methylene dioxy lignan was capable of inhibiting telomerase activity and also could inhibit bcl2 and activate caspase 3 and caspase 8 whose significance in the induction of apoptosis is well known. |
2002-07-31 |
2023-08-12 |
Not clear |
| E Farczádi, I Kaszás, M Baki, B Szend. Changes in apoptosis, mitosis, Her-2, p53 and Bcl2 expression in breast carcinomas after short-term tamoxifen treatment. Neoplasma. vol 49. issue 2. 2002-07-24. PMID:12088100. |
changes in apoptosis, mitosis, her-2, p53 and bcl2 expression in breast carcinomas after short-term tamoxifen treatment. |
2002-07-24 |
2023-08-12 |
Not clear |