| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Byung Lae Park, Lyoung Hyo Kim, Hyun Sub Cheong, Hye Young Cho, Eun Mi Kim, Hyoung Doo Shin, Yong-Sun Kim, Chaeyoung Le. Identification of variants in cyclin D1 ( CCND1) and B-Cell CLL/lymphoma 2 ( BCL2). Journal of human genetics. vol 49. issue 8. 2004-10-12. PMID:15278764. |
ccnd1 is an important cell-cycle regulatory protein associated with cell proliferation, poor prognosis and recurrence in cancer, while bcl2 is an important anti-apoptotic protein that plays a vital role in the regulation of the life span by controlling the rate of apoptosis. |
2004-10-12 |
2023-08-12 |
human |
| Refika I Pakunlu, Yang Wang, William Tsao, Vitaly Pozharov, Thomas J Cook, Tamara Mink. Enhancement of the efficacy of chemotherapy for lung cancer by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense: novel multicomponent delivery system. Cancer research. vol 64. issue 17. 2004-10-05. PMID:15342407. |
the drug delivery system includes four components: (a) liposome as a carrier, (b) dox as an inductor of apoptosis, (c) antisense oligonucleotides (asos) targeted to mrp1 mrna as a suppressor of pump resistance, and (d) asos targeted to bcl2 mrna as a suppressor of nonpump resistance. |
2004-10-05 |
2023-08-12 |
human |
| Refika I Pakunlu, Yang Wang, William Tsao, Vitaly Pozharov, Thomas J Cook, Tamara Mink. Enhancement of the efficacy of chemotherapy for lung cancer by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense: novel multicomponent delivery system. Cancer research. vol 64. issue 17. 2004-10-05. PMID:15342407. |
it was found that the proposed liposomal delivery system successfully delivered asos and dox to cell nuclei, inhibited mrp1 and bcl2 protein synthesis, and substantially increased the anticancer action of dox by stimulating the caspase-dependent pathway of apoptosis in multidrug-resistant human lung cancer cells. |
2004-10-05 |
2023-08-12 |
human |
| Liron Hirsh, Ada Dantes, Byong-Sun Suh, Yoshio Yoshida, Kumiko Hosokawa, Kimihisa Tajima, Fumikazu Kotsuji, Ofer Merimsky, Abraham Amsterda. Phosphodiesterase inhibitors as anti-cancer drugs. Biochemical pharmacology. vol 68. issue 6. 2004-09-27. PMID:15313391. |
the effect of theophylline in induction of apoptosis involved reduction of intracellular levels of bcl2. |
2004-09-27 |
2023-08-12 |
human |
| Bernd Schmeck, Ralph Gross, Phillipe Dje N'Guessan, Andreas C Hocke, Sven Hammerschmidt, Tim J Mitchell, Simone Rosseau, Norbert Suttorp, Stefan Hippenstie. Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium. Infection and immunity. vol 72. issue 9. 2004-09-24. PMID:15321985. |
overexpression of bcl2 in these cells reduced apoptosis significantly. |
2004-09-24 |
2023-08-12 |
human |
| Gabriel Gil-Góme. Measurement of changes in apoptosis and cell cycle regulatory kinase Cdk2. Methods in molecular biology (Clifton, N.J.). vol 282. 2004-09-21. PMID:15105561. |
apoptotic cdk2 activation is controlled by apoptosis regulatory proteins like p53 and bcl2 family members and correlates with degradation of its inhibitors p21cip1 and p27kip1 by activated caspases. |
2004-09-21 |
2023-08-12 |
Not clear |
| Anike Joswig, Heinz-Dieter Gabriel, Mark Kibschull, Elke Winterhage. Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways. Reproductive biology and endocrinology : RB&E. vol 1. 2004-09-08. PMID:12801416. |
in order to investigate pathways of apoptosis in mouse uterine epithelium and decidua during early pregnancy (day 4.5-7.0 post coitum), we have investigated different proteins such as tnfalpha, tnf receptor1, fas ligand, fas receptor1, bax and bcl2 as well as caspase-9 and caspase-3 using immunohistochemistry. |
2004-09-08 |
2023-08-12 |
mouse |
| Linda K Dixon, Charles C Abrams, Gavin Bowick, Lynnette C Goatley, Pen C Kay-Jackson, Dave Chapman, Elisabetta Liverani, Rebecca Nix, Rhiannon Silk, Fuquan Zhan. African swine fever virus proteins involved in evading host defence systems. Veterinary immunology and immunopathology. vol 100. issue 3-4. 2004-09-02. PMID:15207450. |
two asfv proteins, an iap and a bcl2 homologue, inhibit apoptosis in infected cells and thus facilitate production of progeny virions. |
2004-09-02 |
2023-08-12 |
Not clear |
| Sebastian Kreuz, Daniela Siegmund, Jost-Julian Rumpf, Dierk Samel, Martin Leverkus, Ottmar Janssen, Georg Häcker, Oliver Dittrich-Breiholz, Michael Kracht, Peter Scheurich, Harald Wajan. NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP. The Journal of cell biology. vol 166. issue 3. 2004-09-01. PMID:15289496. |
as nfkappab signaling is inhibited during apoptosis, fasl-induced nfkappab activation was most prominent in cells that were protected by bcl2 expression or caspase inhibitors and expressed no or minute amounts of flip. |
2004-09-01 |
2023-08-12 |
Not clear |
| Hakan Savli, Sema Sirma, Balint Nagy, Melih Aktan, Guncag Dincol, Ugur Ozbe. Real-time PCR analysis of the apoptosis related genes in ATRA treated APL t(15;17) patients. Experimental & molecular medicine. vol 35. issue 5. 2004-08-26. PMID:14646600. |
either bcl2 family or less known apoptosis related genes as wt1 will still be required to further studies in this setting. |
2004-08-26 |
2023-08-12 |
Not clear |
| Sophie Meintières, Daniel Marzi. Apoptosis may contribute to false-positive results in the in vitro micronucleus test performed in extreme osmolality, ionic strength and pH conditions. Mutation research. vol 560. issue 2. 2004-08-19. PMID:15157649. |
these cells can enter apoptosis when exposed to apoptosis stimuli or after il-2 deprivation, whereas the ctll-2 bcl2 cell line is protected from apoptosis due to the over-expression of the apoptosis inhibitor bcl2 in bcl2-transfected ctll-2 cells. |
2004-08-19 |
2023-08-12 |
Not clear |
| M A I Abou El Hassan, D C J Mastenbroek, W R Gerritsen, G Giaccone, F A E Kruy. Overexpression of Bcl2 abrogates chemo- and radiotherapy-induced sensitisation of NCI-H460 non-small-cell lung cancer cells to adenovirus-mediated expression of full-length TRAIL. British journal of cancer. vol 91. issue 1. 2004-08-06. PMID:15173860. |
further analyses revealed that adtrail induces death receptor- and mitochondria-dependent apoptosis that could be partially suppressed by bcl2 overexpression. |
2004-08-06 |
2023-08-12 |
human |
| Pradip K Majumder, Phillip G Febbo, Rachel Bikoff, Raanan Berger, Qi Xue, Louis M McMahon, Judith Manola, James Brugarolas, Timothy J McDonnell, Todd R Golub, Massimo Loda, Heidi A Lane, William R Seller. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nature medicine. vol 10. issue 6. 2004-07-28. PMID:15156201. |
induction of cell death required the mitochondrial pathway, as prostate-specific coexpression of bcl2 blocked apoptosis. |
2004-07-28 |
2023-08-12 |
mouse |
| V M Pushkarev, D V Starenki, V A Saenko, H Namba, J Kurebayashi, M D Tronko, S Yamashit. Molecular mechanisms of the effects of low concentrations of taxol in anaplastic thyroid cancer cells. Endocrinology. vol 145. issue 7. 2004-07-14. PMID:15044368. |
low doses of taxol enhanced bcl2 phosphorylation and led to its degradation observed on the background of a sustained or increasing bax level and accumulation of survivin and x-chromosome-linked inhibitor of apoptosis. |
2004-07-14 |
2023-08-12 |
human |
| Kostas V Floros, Hellinida Thomadaki, George Lallas, Nikos Katsaros, Maroulio Talieri, Andreas Scorila. Cisplatin-induced apoptosis in HL-60 human promyelocytic leukemia cells: differential expression of BCL2 and novel apoptosis-related gene BCL2L12. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033711. |
cisplatin-induced apoptosis in hl-60 human promyelocytic leukemia cells: differential expression of bcl2 and novel apoptosis-related gene bcl2l12. |
2004-06-15 |
2023-08-12 |
human |
| Kostas V Floros, Hellinida Thomadaki, George Lallas, Nikos Katsaros, Maroulio Talieri, Andreas Scorila. Cisplatin-induced apoptosis in HL-60 human promyelocytic leukemia cells: differential expression of BCL2 and novel apoptosis-related gene BCL2L12. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033711. |
in the present study, the expression of bcl2 and bcl2l12 genes during cisplatin-induced apoptosis in hl-60 leukemic cells was investigated. |
2004-06-15 |
2023-08-12 |
human |
| Alexander Egle, Alan W Harris, Philippe Bouillet, Suzanne Cor. Bim is a suppressor of Myc-induced mouse B cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 16. 2004-06-15. PMID:15079075. |
bcl2, activated by chromosomal translocation in human follicular lymphoma, promotes oncogenesis by inhibiting apoptosis. |
2004-06-15 |
2023-08-12 |
mouse |
| Regine Schneider-Stock, Christian Mawrin, Christiane Motsch, Carsten Boltze, Brigitte Peters, Roland Hartig, Peter Buhtz, Anja Giers, Astrid Rohrbeck, Bernd Freigang, Albert Roessne. Retention of the arginine allele in codon 72 of the p53 gene correlates with poor apoptosis in head and neck cancer. The American journal of pathology. vol 164. issue 4. 2004-04-29. PMID:15039212. |
apoptosis was determined immunohistochemically using antibodies against fas, fasl, p53, bcl2, and terminal deoxy-transferase-mediated dutp nick end labeling (tunel) staining. |
2004-04-29 |
2023-08-12 |
Not clear |
| Regine Schneider-Stock, Christian Mawrin, Christiane Motsch, Carsten Boltze, Brigitte Peters, Roland Hartig, Peter Buhtz, Anja Giers, Astrid Rohrbeck, Bernd Freigang, Albert Roessne. Retention of the arginine allele in codon 72 of the p53 gene correlates with poor apoptosis in head and neck cancer. The American journal of pathology. vol 164. issue 4. 2004-04-29. PMID:15039212. |
in cases of loh, there was a preferential loss of the proline allele, which was associated with an up-regulation of bcl2 and lack of co-expression of fas/fasl and, thus, impaired apoptosis (p < 0.001). |
2004-04-29 |
2023-08-12 |
Not clear |
| Sandrine Roulland, Pierre Lebailly, Yannick Lecluse, Mélanie Briand, Didier Pottier, Pascal Gauducho. Characterization of the t(14;18) BCL2-IGH translocation in farmers occupationally exposed to pesticides. Cancer research. vol 64. issue 6. 2004-04-08. PMID:15026372. |
of these, the t(14;18), which deregulates bcl2 expression and inhibits apoptosis, is the most frequent in follicular lymphoma and has been detected consistently in peripheral blood lymphocytes of healthy individuals. |
2004-04-08 |
2023-08-12 |
Not clear |