| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Béla Szend. [The occurrence and significance of apoptosis in tumors]. Magyar onkologia. vol 48. issue 3. 2005-05-11. PMID:15520871. |
expression of genes influencing apoptosis, such as bcl2, p53, and bax, may rather be of importance from the point of view of histological differential diagnosis. |
2005-05-11 |
2023-08-12 |
Not clear |
| Puay-Hoon Tan, Boon-Huat Bay, George Yip, Sathiyamoorthy Selvarajan, Patrick Tan, Jeanie Wu, Chee-How Lee, Kuo-Bin L. Immunohistochemical detection of Ki67 in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 18. issue 3. 2005-05-09. PMID:15578079. |
genes related to apoptosis and cell death (bcl2, map2k4, tnf10) were noted to be downregulated in tumors that disclosed >40% ki67 immunostaining (p<0.001). |
2005-05-09 |
2023-08-12 |
Not clear |
| Susanne Vetterkind, Meike Boosen, Karl-Heinz Scheidtmann, Ute Preus. Ectopic expression of Par-4 leads to induction of apoptosis in CNS tumor cell lines. International journal of oncology. vol 26. issue 1. 2005-05-02. PMID:15586236. |
induction of apoptosis by par-4 in the neural tumor cell lines is independent of endogenous bcl-2 levels and pkczeta activity, although it has been proposed that par-4 can exert its pro-apoptotic function by down-modulation of bcl2 expression and inhibition of pkczeta. |
2005-05-02 |
2023-08-12 |
human |
| Xin Fu, John R Latendresse, Levan Muskhelishvili, Betty S Blaydes, K Barry Delclo. Dietary modulation of 7,12-dimethylbenz[a]anthracene (DMBA)-induced adrenal toxicity in female Sprague-Dawley rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 43. issue 5. 2005-04-25. PMID:15778017. |
apoptosis was manifested at 24 and 36 h after dmba treatment in the zona reticularis (zr) and the zona fasciculata (zf) of the adrenal cortex; this was followed by severe hemorrhagic necrosis at 48 h. dmba-induced apoptosis, evaluated by the tunel assay, immunohistochemical analysis of activated caspase 3, and the ratio of expression of pro-apoptotic bax to anti-apoptotic bcl2, was greater in rats fed nih-31 diet relative to rats fed 5k96 diet at 24 h after treatment. |
2005-04-25 |
2023-08-12 |
rat |
| Minakshi Nihal, Nihal Ahmad, Hasan Mukhtar, Gary S Woo. Anti-proliferative and proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: possible implications for the chemoprevention of melanoma. International journal of cancer. vol 114. issue 4. 2005-04-11. PMID:15609335. |
our data suggest that egcg causes significant induction of cell cycle arrest and apoptosis of melanoma cells that is mediated via modulations in the cki-cyclin-cdk network and bcl2 family proteins. |
2005-04-11 |
2023-08-12 |
human |
| Barbara Jung, Valerie Barbier, Howard Brickner, John Welsh, Arun Fotedar, Michael McClellan. Mechanisms of sulindac-induced apoptosis and cell cycle arrest. Cancer letters. vol 219. issue 1. 2005-03-31. PMID:15694660. |
in contrast, bcl2 transgenic thymocytes are resistant to sulindac sulfide-induced apoptosis. |
2005-03-31 |
2023-08-12 |
mouse |
| Alireza Mirmohammadsadegh, Annett Baer, Sandeep Nambiar, Walter Bardenheuer, Ulrich R Hengg. Rapid identification of dysregulated genes in cutaneous malignant melanoma metastases using cDNA technology. Cells, tissues, organs. vol 177. issue 3. 2005-03-07. PMID:15388985. |
an abundance of genes was dysregulated (up-/downregulated), which involved for example the apoptosis gene growth factor receptor-bound protein 10, bcl2-associated x membrane protein, bcl2 antagonist of cell death, glutathione s-transferase theta(1) and glutathione reductase. |
2005-03-07 |
2023-08-12 |
human |
| M Vijay Kumar, Robert Shirley, Yulin Ma, Ronald W Lewi. Role of genomics-based strategies in overcoming chemotherapeutic resistance. Current pharmaceutical biotechnology. vol 5. issue 5. 2005-02-23. PMID:15544495. |
nfkappab blocked apoptosis by interfering with the function of tnfalpha/trail and/or through the activation of antiapoptotic proteins of the bcl2 family. |
2005-02-23 |
2023-08-12 |
Not clear |
| Emi K Nishimura, Scott R Granter, David E Fishe. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science (New York, N.Y.). vol 307. issue 5710. 2005-02-16. PMID:15618488. |
this process is accelerated dramatically with bcl2 deficiency, which causes selective apoptosis of melanocyte stem cells, but not of differentiated melanocytes, within the niche at their entry into the dormant state. |
2005-02-16 |
2023-08-12 |
mouse |
| Sheng-Tung Huang, Hsin-Da Tsai, Hsien-Shou Kuo, Yu-Ping Yang, Yi-Chen Peng, Yuh-Ling Li. A novel bis-aziridinylnaphthoquinone with anti-solid tumor activity in which induced apoptosis is associated with altered expression of Bcl-2 protein. Chembiochem : a European journal of chemical biology. vol 5. issue 6. 2005-02-15. PMID:15174162. |
growth arrest in hep2 cells was preceded by early induction of g(2)-m cell cycle arrest at 0.75 microm of 1 c after culture for 24 h, and was then followed by apoptosis after 60 h. this was associated with decreased expression of antiapoptotic bcl2 protein (by 78 %) upon culture with 3.0 microm of 1 c after 60 h. our results suggest that 1 c is a novel antitumor aziridinylnaphthoquinone with therapeutic potential against solid tumors. |
2005-02-15 |
2023-08-12 |
human |
| Celeste Tríbulo, Manuel J Aybar, Sara S Sánchez, Roberto Mayo. A balance between the anti-apoptotic activity of Slug and the apoptotic activity of msx1 is required for the proper development of the neural crest. Developmental biology. vol 275. issue 2. 2005-01-25. PMID:15501222. |
the protective effect of expressing slug can be reversed by expressing the apoptotic factor bax, while the apoptosis promoted by msx1 can be abolished by expressing the xenopus homologue of bcl2 (xr11). |
2005-01-25 |
2023-08-12 |
xenopus_laevis |
| Shlomit Reich-Zeliger, Judith Gan, Esther Bachar-Lustig, Yair Reisne. Tolerance induction by veto CTLs in the TCR transgenic 2C mouse model. II. Deletion of effector cells by Fas-Fas ligand apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 11. 2005-01-14. PMID:15557157. |
the protein levels of the apoptosis inhibitors flip and bcl2 in purified cd8(+)1b2(+) effector cells at different time points after mlr showed an initial up-regulation of these inhibitors, with marked reduction of flip, but not of bcl2, by 48 h after initiation of culture. |
2005-01-14 |
2023-08-12 |
mouse |
| João Carlos das Neves Pereira, Alecsander Guilharman Pereira da Silva, Fabiana Soares, Alexandre Muxfeldt Ab'Saber, Aurelino Schmidt, Olavo Ribeiro Rodrigues, Ana Garippo, Marisa Capelozzi, José Ribas Milanez de Campos, Tereza Takagaki, Fábio Biscegli Jatene, Sandro Martins, Vera Luiza Capelozz. Nuclear and environment morphometric profile in tumor size and nodal metastasis of resected typical pulmonary carcinoid. Pathology, research and practice. vol 200. issue 6. 2005-01-06. PMID:15310149. |
as the biologic behavior in lung tumors with neuroendocrine differentiation is highly dependent on cell death (apoptosis) and extracellular matrix invasion, bcl2 and extracellular matrix density have been targeted as potentially useful tumor markers. |
2005-01-06 |
2023-08-12 |
Not clear |
| Jiang-Yan Yang, David Michod, Joël Walicki, Brona M Murphy, Shailaja Kasibhatla, Seamus J Martin, Christian Widman. Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions. Molecular and cellular biology. vol 24. issue 23. 2005-01-04. PMID:15542850. |
cells can protect themselves from potentially lethal stimuli by expressing antiapoptotic factors, such as inhibitors of apoptosis, flice (caspase 8)-inhibitory proteins, and members of the bcl2 family. |
2005-01-04 |
2023-08-12 |
Not clear |
| Tian-Biao Liu, Paul W M Fedak, Richard D Weisel, Tamotsu Yasuda, Gholam Kiani, Donald A G Mickle, Zhi-Qiang Jia, Ren-Ke L. Enhanced IGF-1 expression improves smooth muscle cell engraftment after cell transplantation. American journal of physiology. Heart and circulatory physiology. vol 287. issue 6. 2005-01-03. PMID:15331370. |
one week later, igf-1-transfected smcs had increased myocardial igf-1 and vegf levels, increased bcl2 expression, limited cell apoptosis, and enhanced vessel formation in the myocardial scar compared with the two control groups (p <0.05 for all groups). |
2005-01-03 |
2023-08-12 |
rat |
| Maria Bai, Angelos Skyrlas, Niki John Agnantis, Sevasti Kamina, Panagiotis Kitsoulis, Panagiotis Kanavaro. Cluster analysis of apoptosis-associated bcl2 family proteins in diffuse large B-cell lymphomas. Relations with the apoptotic index, the proliferation profile and the B-cell differentiation immunophenotypes. Anticancer research. vol 24. issue 5A. 2004-12-10. PMID:15517919. |
in order to gain further insight into the apoptosis profile of dlbcl, 79 cases were investigated to determine whether distinct clusters of the combined expression levels of bcl2 family proteins can be identified in these lymphomas. |
2004-12-10 |
2023-08-12 |
Not clear |
| Zhen-guo Li, Mark Britton, Anders A F Sima, Joseph C Dunba. Diabetes enhances apoptosis induced by cerebral ischemia. Life sciences. vol 76. issue 3. 2004-12-08. PMID:15531378. |
24-48 hr following mca occlusion the animals were killed, the brain removed and prepared for evaluation by several indexes of apoptosis: nucleosomal dna fragmentation, tunel staining, activation of caspase-3 and alteration in the expression of bax and bcl2. |
2004-12-08 |
2023-08-12 |
rat |
| E M Lyng, M Lyons-Alcantara, P Olwell, S Ní Shuilleabháin, C Seymour, D C Cottell, C Mothersil. Ionizing radiation induces a stress response in primary cultures of rainbow trout skin. Radiation research. vol 162. issue 2. 2004-11-29. PMID:15387151. |
expression of pcna, c-myc and bcl2 was investigated as well as growth and levels of apoptosis and necrosis. |
2004-11-29 |
2023-08-12 |
Not clear |
| P Bullon, M Fioroni, G Goteri, C Rubini, M Battin. Immunohistochemical analysis of soft tissues in implants with healthy and peri-implantitis condition, and aggressive periodontitis. Clinical oral implants research. vol 15. issue 5. 2004-11-16. PMID:15355397. |
apoptosis, analysed by bcl2 and p53 immunoreactivity, was similar in the three groups. |
2004-11-16 |
2023-08-12 |
Not clear |
| Matthew D Show, Janet S Folmer, Matthew D Anway, Barry R Zirki. Testicular expression and distribution of the rat bcl2 modifying factor in response to reduced intratesticular testosterone. Biology of reproduction. vol 70. issue 4. 2004-11-02. PMID:14668207. |
the bcl2 modifying factor (bmf) is a pro-apoptotic member of the bcl2 family of apoptosis-related proteins that has been shown to initiate apoptosis in response to the loss of attachment of cells from their basal lamina (anoikis). |
2004-11-02 |
2023-08-12 |
rat |