| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Bai, N J Agnantis, A Skyrlas, E Tsanou, S Kamina, V Galani, P Kanavaro. Increased expression of the bcl6 and CD10 proteins is associated with increased apoptosis and proliferation in diffuse large B-cell lymphomas. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 16. issue 5. 2003-12-10. PMID:12748254. |
the association between increased bcl6 expression and enhanced apoptosis might be due, at least in part, to the null/low bcl2 expression because previous in vitro data showed that bcl6 overexpression induces apoptosis accompanied by bcl2 and bcl-xl downregulation. |
2003-12-10 |
2023-08-12 |
Not clear |
| M C Perianayagam, V S Balakrishnan, D Guo, B J G Pereira, B L Jabe. Quantification of Bax and Bcl2 in polymorphonuclear leukocytes from haemodialysis patients: relation to hydrogen peroxide. European journal of clinical investigation. vol 33. issue 10. 2003-12-04. PMID:14511363. |
in the present study, we explored the relation of hydrogen peroxide (h2o2) generation by polymorphonuclear cells (pmns) to the cytosolic expression of bax and bcl2 proteins and apoptosis in haemodialysis (hd) patients. |
2003-12-04 |
2023-08-12 |
Not clear |
| Tetsuhiro Tanaka, Norio Hanafusa, Julie R Ingelfinger, Takamoto Ohse, Toshiro Fujita, Masaomi Nangak. Hypoxia induces apoptosis in SV40-immortalized rat proximal tubular cells through the mitochondrial pathways, devoid of HIF1-mediated upregulation of Bax. Biochemical and biophysical research communications. vol 309. issue 1. 2003-10-16. PMID:12943686. |
temperature-sensitive sv40-immortalized rat proximal tubular cells (irptcs) showed apoptosis in 21.9+/-2.9% by hypoxia (0.2% o(2), 48h), with alterations in mitochondrial signaling such as bcl2 and caspase-9. |
2003-10-16 |
2023-08-12 |
rat |
| Yinghui Huang, Traci Tyler, Neshat Saadatmandi, Casey Lee, Per Borgstrom, Ruth A Gjerse. Enhanced tumor suppression by a p14ARF/p53 bicistronic adenovirus through increased p53 protein translation and stability. Cancer research. vol 63. issue 13. 2003-08-25. PMID:12839954. |
adp14/p53 treatment leads to an elevated bax:bcl2 ratio and induction of apoptosis in vitro and in vivo, coupled with a failure of the tumor cells to induce neovascularization in vivo. |
2003-08-25 |
2023-08-12 |
Not clear |
| Guorong Li, Claude Lambert, Anne Gentil-Perret, Christian Genin, Jacques Tostai. [Molecular and cytometric analysis of renal cell carcinoma cells. Concepts, techniques and prospects]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. vol 13. issue 1. 2003-08-01. PMID:12703348. |
the tumour's capacity for progression is related to dysregulations of the cycle (ras, pax2, tiam 1, waf/p21), division (tetracyclines, mib1, pcna, nor ag), apoptosis (bcl2, p53, cd95/apo1), and the capacities for tissue invasion (proteases), disorganization (cadherin, catenins) or nidation (icam-1, cd44). |
2003-08-01 |
2023-08-12 |
Not clear |
| H Raybaud, G Odin, A Fafet, J Santini, R A Montei. [Genic alterations in oral and head and neck squamous cell carcinomas: analysis of international literature]. Pathologie-biologie. vol 51. issue 3. 2003-07-31. PMID:12781800. |
by blocking apoptosis, the bcl2 protein seems to increase the resistance of tumours to radiotherapy and chemotherapy. |
2003-07-31 |
2023-08-12 |
Not clear |
| Sophie Meintières, Fabrice Nesslany, Marc Pallardy, Daniel Marzi. Detection of ghost cells in the standard alkaline comet assay is not a good measure of apoptosis. Environmental and molecular mutagenesis. vol 41. issue 4. 2003-07-22. PMID:12717781. |
to answer this question, we made use of two cell lines: ctll-2 cells that can enter apoptosis upon addition of apoptosis stimuli or il-2 deprivation, and ctll-2 bcl2 cells that are protected from apoptosis due to the overexpression of the apoptosis inhibitor gene bcl2. |
2003-07-22 |
2023-08-12 |
Not clear |
| Masao Set. Molecular mechanisms of lymphomagenesis through transcriptional disregulation by chromosome translocation. International journal of hematology. vol 76 Suppl 1. 2003-07-17. PMID:12430874. |
bcl2 expression from altered allele also keeps its expression at the germinal center stage where normal counterpart cells down-regulate bcl2 expression, and makes cells to resist apoptosis, leading to development of follicular lymphoma. |
2003-07-17 |
2023-08-12 |
Not clear |
| WenJing Liu, Anca Bulgaru, Missak Haigentz, C A Stein, Roman Perez-Soler, Sridhar Man. The BCL2-family of protein ligands as cancer drugs: the next generation of therapeutics. Current medicinal chemistry. Anti-cancer agents. vol 3. issue 3. 2003-07-11. PMID:12769779. |
bcl2 proteins are key mediators of the process of apoptosis and ligands to these family of proteins have been described using modern combinatorial, computational and evolutionary small molecule screening approaches. |
2003-07-11 |
2023-08-12 |
Not clear |
| WenJing Liu, Anca Bulgaru, Missak Haigentz, C A Stein, Roman Perez-Soler, Sridhar Man. The BCL2-family of protein ligands as cancer drugs: the next generation of therapeutics. Current medicinal chemistry. Anti-cancer agents. vol 3. issue 3. 2003-07-11. PMID:12769779. |
in several cases, these ligands (e.g., ha14-1, 2-methoxy antimycin a) induce apoptosis even under conditions of bcl2 overexpression and if developed preclinically will be promising anticancer agents. |
2003-07-11 |
2023-08-12 |
Not clear |
| Heng Wu, Vikas Goel, Frank G Halusk. PTEN signaling pathways in melanoma. Oncogene. vol 22. issue 20. 2003-07-07. PMID:12789288. |
in addition, agonist-induced apoptosis is mediated by pten, through the upregulation of proapoptotic machinery involving caspases and bid, and the downregulation of antiapoptotic proteins such as bcl2. |
2003-07-07 |
2023-08-12 |
human |
| X Deng, S M Kornblau, P P Ruvolo, W S Ma. Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance. Journal of the National Cancer Institute. Monographs. issue 28. 2003-07-01. PMID:11158204. |
phosphorylation of bcl2 at serine 70 is required for suppression of apoptosis in interleukin 3 (il-3)-dependent myeloid cells deprived of il-3 or treated with antileukemic drugs and can result from agonist activation of mitochondrial protein kinase c alpha (pkcalpha). |
2003-07-01 |
2023-08-12 |
Not clear |
| X Deng, S M Kornblau, P P Ruvolo, W S Ma. Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance. Journal of the National Cancer Institute. Monographs. issue 28. 2003-07-01. PMID:11158204. |
these findings indicate a novel role for erk1 and 2 as molecular links between proliferative and survival signaling and may, at least in part, explain the apparent paradox by which bcl2 may suppress staurosporine-induced apoptosis. |
2003-07-01 |
2023-08-12 |
Not clear |
| Olivia Lanvin, Paul Guglielmi, Vincent Fuentes, Valérie Gouilleux-Gruart, Cécile Mazière, Eliane Bissac, Aline Regnier, Kamel Benlagha, Fabrice Gouilleux, Kaiss Lassoue. TGF-beta1 modulates Fas (APO-1/CD95)-mediated apoptosis of human pre-B cell lines. European journal of immunology. vol 33. issue 5. 2003-06-12. PMID:12731064. |
altogether, our findings suggest that tgf-beta1 prevents fas-induced apoptosis of pre-b lines by inhibiting pi3k pathway and by enhancing expression of bcl2. |
2003-06-12 |
2023-08-12 |
human |
| C K Tan, J Yan, C Ananth, C Kau. Dexamethasone induces dendritic alteration but not apoptosis in the neurons of the hippocampus in postnatal rats. Neuroscience letters. vol 326. issue 3. 2003-06-05. PMID:12095657. |
neuronal death by apoptosis in the hippocampus was investigated by immunohistochemistry using bcl2, bax and caspase3 antibodies. |
2003-06-05 |
2023-08-12 |
rat |
| Kui Lei, Roger J Davi. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 5. 2003-05-13. PMID:12591950. |
jnk phosphorylation of bim-related members of the bcl2 family induces bax-dependent apoptosis. |
2003-05-13 |
2023-08-12 |
Not clear |
| Aruna Basu, Subrata Halda. Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis. FEBS letters. vol 538. issue 1-3. 2003-04-25. PMID:12633850. |
bcl-xl, a close homolog of bcl2, is an important regulator of apoptosis and is overexpressed in human cancer. |
2003-04-25 |
2023-08-12 |
human |
| Aurélien Olichon, Laurent Baricault, Nicole Gas, Emmanuelle Guillou, Annie Valette, Pascale Belenguer, Guy Lenaer. Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. The Journal of biological chemistry. vol 278. issue 10. 2003-04-23. PMID:12509422. |
similarly, in nih-ovcar-3 cells, the opa1 sirna induces mitochondrial fragmentation and apoptosis, the latter being inhibited by bcl2 overexpression. |
2003-04-23 |
2023-08-12 |
Not clear |
| Aruna Basu, Subrata Halda. Signal-induced site specific phosphorylation targets Bcl2 to the proteasome pathway. International journal of oncology. vol 21. issue 3. 2003-03-24. PMID:12168105. |
it is known that in contrary to phospho bcl2, native bcl2 (non-phosphoform) is unable to associate with cis-trans peptidyl prolyl isomerase pin1-a key factor to regulate the fate of phosphoforms of bcl2 and apoptosis. |
2003-03-24 |
2023-08-12 |
Not clear |
| Sophie Meintières, Armelle Biola, Marc Pallardy, Daniel Marzi. Using CTLL-2 and CTLL-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. Environmental and molecular mutagenesis. vol 41. issue 1. 2003-03-14. PMID:12552588. |
using ctll-2 and ctll-2 bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test. |
2003-03-14 |
2023-08-12 |
Not clear |