| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Farczádi, I Kaszás, M Baki, B Szend. Changes in apoptosis, mitosis, Her-2, p53 and Bcl2 expression in breast carcinomas after short-term tamoxifen treatment. Neoplasma. vol 49. issue 2. 2002-07-24. PMID:12088100. |
the short-term (7 days) effect of tamoxifen on apoptosis and mitosis index, p53, bcl2 and her-2/neu/c-erb2 expression in invasive ductal mammary carcinoma was studied histologically in the diagnostic biopsy and surgically removed tumor tissue of 10 patients. |
2002-07-24 |
2023-08-12 |
Not clear |
| Peter P Ruvolo, Warren Clark, Marc Mumby, Fengqin Gao, W Stratford Ma. A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function. The Journal of biological chemistry. vol 277. issue 25. 2002-07-19. PMID:11929874. |
pp2a-resistant) gain-of-function s70e mutant bcl2 can protect cells from ceramide-induced apoptosis. |
2002-07-19 |
2023-08-12 |
Not clear |
| Gaël G McGill, Martin Horstmann, Hans R Widlund, Jinyan Du, Gabriela Motyckova, Emi K Nishimura, Yi-Ling Lin, Sridhar Ramaswamy, William Avery, Han-Fei Ding, Siobhán A Jordan, Ian J Jackson, Stanley J Korsmeyer, Todd R Golub, David E Fishe. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell. vol 109. issue 6. 2002-07-19. PMID:12086670. |
disruption of mitf in melanocytes or melanoma triggered profound apoptosis susceptible to rescue by bcl2 overexpression. |
2002-07-19 |
2023-08-12 |
mouse |
| David R Plas, Craig B Thompso. Cell metabolism in the regulation of programmed cell death. Trends in endocrinology and metabolism: TEM. vol 13. issue 2. 2002-07-16. PMID:11854022. |
here, we review the coordinated effects of growth factor withdrawal on bioenergetics and programmed cell death, and discuss the metabolic consequences of genes that prevent apoptosis, including the bcl2 family of genes and akt. |
2002-07-16 |
2023-08-12 |
Not clear |
| U Mazurek, G Bierzyńska-Macyszyn, J Gola, J Orchel, J Słowiński, T Wilczo. BCL2 and BAX mRNA concentration profile in fibrillary astrocytoma. Folia histochemica et cytobiologica. vol 39 Suppl 2. 2002-06-21. PMID:11820596. |
a high level of the bcl2 protein and the lack of apoptosis promoting protein bax are beginning to be treated as markers of cellular resistance to anti-neoplastic drugs. |
2002-06-21 |
2023-08-12 |
Not clear |
| X B Shi, P H Gumerlock, J T Muenzer, R W deVere Whit. BCL2 antisense transcripts decrease intracellular Bcl2 expression and sensitize LNCaP prostate cancer cells to apoptosis-inducing agents. Cancer biotherapy & radiopharmaceuticals. vol 16. issue 5. 2002-06-17. PMID:11776759. |
since bcl2 is believed to play a role in protecting cap cells from apoptosis, we investigated the effects of down-regulating bcl2 expression on cap cells. |
2002-06-17 |
2023-08-12 |
Not clear |
| G C Huang, S Hobbs, M Walton, R J Epstei. Dominant negative knockout of p53 abolishes ErbB2-dependent apoptosis and permits growth acceleration in human breast cancer cells. British journal of cancer. vol 86. issue 7. 2002-04-30. PMID:11953857. |
compared with parental cells, mcf7-b2 cells are characterised by upregulation of p53, p21(waf) and myc, downregulation of bcl2, and apoptosis. |
2002-04-30 |
2023-08-12 |
human |
| Erika M Gibson, Elizabeth S Henson, Jacylyn Villanueva, Spencer B Gibso. MEK kinase 1 induces mitochondrial permeability transition leading to apoptosis independent of cytochrome c release. The Journal of biological chemistry. vol 277. issue 12. 2002-04-29. PMID:11756439. |
since bcl2 regulates changes in mitochondria and blocks mekk1-induced apoptosis, we determined that bcl2 blocks mekk1-induced apoptosis when targeted to the mitochondria. |
2002-04-29 |
2023-08-12 |
mouse |
| P Kanavaros, K Stefanaki, D Rontogianni, D Papalazarou, M Sgantzos, D Arvanitis, C Vamvouka, V Gorgoulis, I Siatitsas, N J Agnantis, M Ba. Immunohistochemical expression of p53, p21/waf1, rb, p16, cyclin D1, p27, Ki67, cyclin A, cyclin B1, bcl2, bax and bak proteins and apoptotic index in normal thymus. Histology and histopathology. vol 16. issue 4. 2002-03-21. PMID:11642719. |
the expressions of bax and bak were more widespread in both the medulla and cortex, suggesting that these proteins play a broader role than bcl2 in the regulation of thymic apoptosis. |
2002-03-21 |
2023-08-12 |
Not clear |
| A Hartwich, S J Konturek, P Pierzchalski, M Zuchowicz, H Labza, P C Konturek, E Karczewska, W Bielanski, K Marlicz, T Starzynska, M Lawniczak, E G Hah. Helicobacter pylori infection, gastrin, cyclooxygenase-2, and apoptosis in colorectal cancer. International journal of colorectal disease. vol 16. issue 4. 2001-12-31. PMID:11515678. |
we conclude that colon adenocarcinoma and its resection margin overexpress gastrin, its receptors, cckb-r, and cox-2, and that hp infection may contribute to colonic cancerogenesis via overexpression of gastrin and cox-2, which may account for the stimulation of the tumor growth and the reduction in apoptosis as documented by enhanced mrna expression of anti-apoptotic bcl2 over proapoptotic bax proteins. |
2001-12-31 |
2023-08-12 |
Not clear |
| L A Kroger, G L DeNardo, P H Gumerlock, C Y Xiong, M D Winthrop, X B Shi, P C Mack, T Leshchinsky, S J DeNard. Apoptosis-related gene and protein expression in human lymphoma xenografts (Raji) after low dose rate radiation using 67Cu-2IT-BAT-Lym-1 radioimmunotherapy. Cancer biotherapy & radiopharmaceuticals. vol 16. issue 3. 2001-12-18. PMID:11471486. |
subgroups of 4-5 mice were sacrificed at 3, 6 and 24 h after therapy so that tumors could be examined for poly(adp-ribose) polymerase (parp) and dna ladder evidence for apoptosis and for bcl2, p53, p21, gadd45, tgf-beta 1 and c-myc gene and protein expression. |
2001-12-18 |
2023-08-12 |
mouse |
| P Farid, S Z Gomb, I Péter, B Szend. bcl2, p53 and bax in thyroid tumors and their relation to apoptosis. Neoplasma. vol 48. issue 4. 2001-12-10. PMID:11712682. |
bcl2, p53 and bax in thyroid tumors and their relation to apoptosis. |
2001-12-10 |
2023-08-12 |
Not clear |
| P Farid, S Z Gomb, I Péter, B Szend. bcl2, p53 and bax in thyroid tumors and their relation to apoptosis. Neoplasma. vol 48. issue 4. 2001-12-10. PMID:11712682. |
twenty five thyroid tumors were investigated by immunohistochemistry for the presence of apoptosis, expression of p53, bax and bcl2. |
2001-12-10 |
2023-08-12 |
Not clear |
| G Guasch, V Ollendorff, J P Borg, D Birnbaum, M J Pébusqu. 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways. Molecular and cellular biology. vol 21. issue 23. 2001-12-05. PMID:11689702. |
finally, fop-fgfr1 protects cells from apoptosis by survival signals including bcl2 overexpression and inactivation of caspase-9 activity. |
2001-12-05 |
2023-08-12 |
Not clear |
| R J Bold, S Virudachalam, D J McConke. BCL2 expression correlates with metastatic potential in pancreatic cancer cell lines. Cancer. vol 92. issue 5. 2001-10-04. PMID:11571724. |
dysregulation in the expression of the bcl2 gene family, the prototypic regulators of apoptosis, is a common occurrence in cancer and imparts resistance to standard triggers of apoptosis. |
2001-10-04 |
2023-08-12 |
Not clear |
| R J Bold, S Virudachalam, D J McConke. BCL2 expression correlates with metastatic potential in pancreatic cancer cell lines. Cancer. vol 92. issue 5. 2001-10-04. PMID:11571724. |
therefore, the authors sought to examine whether abnormal bcl2 gene family expression correlated with resistance to apoptosis and increased metastatic potential in pancreatic carcinoma. |
2001-10-04 |
2023-08-12 |
Not clear |
| I Contasta, P Pellegrini, A M Berghella, D Adorn. Cell cycle control in cellular homeostasis during the immune response: interactions between TH1, TH2 cytokines, and Bcl2 and p53 molecules. Cancer biotherapy & radiopharmaceuticals. vol 16. issue 1. 2001-09-13. PMID:11279799. |
expression of the bcl2 gene promotes cell survival by countering apoptosis stimuli. |
2001-09-13 |
2023-08-12 |
human |
| S J George, G D Angelini, M C Capogrossi, A H Bake. Wild-type p53 gene transfer inhibits neointima formation in human saphenous vein by modulation of smooth muscle cell migration and induction of apoptosis. Gene therapy. vol 8. issue 9. 2001-08-02. PMID:11406761. |
initial in vitro analyses demonstrated that wt p53 overexpression had no effect on smc proliferation but promoted apoptosis, which was inhibited by co-expression of bcl2 or crma. |
2001-08-02 |
2023-08-12 |
human |
| Z Dastoor, J L Dreye. Potential role of nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase in apoptosis and oxidative stress. Journal of cell science. vol 114. issue Pt 9. 2001-07-26. PMID:11309196. |
bcl2 overexpression prevents nuclear translocation of gapdh and apoptosis in untransfected cells, but not in transfected cells that overexpress gapdh-gfp. |
2001-07-26 |
2023-08-12 |
Not clear |
| S Meintières, A Biola, M Pallardy, D Marzi. Apoptosis can be a confusing factor in in vitro clastogenic assays. Mutagenesis. vol 16. issue 3. 2001-07-26. PMID:11320150. |
we used a murine cytotoxic t cell line, ctll-2 bcl2, in which a stably transfected bcl2 gene is known to protect these cells from apoptosis induced by various stimuli. |
2001-07-26 |
2023-08-12 |
Not clear |