| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xingming Deng, Fengqin Gao, Tammy Flagg, W Stratford Ma. Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 1. 2004-02-25. PMID:14660795. |
bcl2 functions to suppress apoptosis and retard cell cycle entry. |
2004-02-25 |
2023-08-12 |
Not clear |
| Maria Mamani-Matsuda, Daniel Moynet, Mathieu Molimard, Hélène Ferry-Dumazet, Gérald Marit, Josy Reiffers, M Djavad Mossalayi, M Diavad Mossalay. Long-acting beta2-adrenergic formoterol and salmeterol induce the apoptosis of B-chronic lymphocytic leukaemia cells. British journal of haematology. vol 124. issue 2. 2004-02-11. PMID:14687023. |
b-cell chronic lymphocytic leukaemia (b-cll) is a neoplastic disorder characterized by defective apoptosis, cell accumulation in g0/g1, and high expression of bcl2 oncogene. |
2004-02-11 |
2023-08-12 |
Not clear |
| S Buckley, W Shi, B Driscoll, A Ferrario, K Anderson, D Warburto. BMP4 signaling induces senescence and modulates the oncogenic phenotype of A549 lung adenocarcinoma cells. American journal of physiology. Lung cellular and molecular physiology. vol 286. issue 1. 2004-02-06. PMID:12959928. |
senescent bmp4-treated cells had lower erk activation, vegf expression, and bcl2 expression than wild-type cells, consistent with a less proliferative, less angiogenic phenotype with increased susceptibility to death by apoptosis. |
2004-02-06 |
2023-08-12 |
mouse |
| Simonetta Astigiano, Patrizia Damonte, Ottavia Barbier. Inhibition of ductal morphogenesis in the mammary gland of WAP -fgf4 transgenic mice. Anatomy and embryology. vol 206. issue 6. 2004-01-20. PMID:12707773. |
we also show that regulation of apoptosis by fgf4 in the mammary gland, both during development and involution, could occur via inhibition of bcl2 expression. |
2004-01-20 |
2023-08-12 |
mouse |
| Marco Corazzari, Penny E Lovat, Serafina Oliverio, Andy D J Pearson, Mauro Piacentini, Christopher P F Redfer. Growth and DNA damage-inducible transcription factor 153 mediates apoptosis in response to fenretinide but not synergy between fenretinide and chemotherapeutic drugs in neuroblastoma. Molecular pharmacology. vol 64. issue 6. 2004-01-16. PMID:14645667. |
the stress-inducible transcription factor known as growth and dna damage (gadd)-inducible transcription factor 153 is induced in response to fenretinide and in other cell types modulates apoptosis via pro- and antiapoptotic members of the bcl2 family. |
2004-01-16 |
2023-08-12 |
Not clear |
| Ting Xi Liu, Niall G Howlett, Min Deng, David M Langenau, Karl Hsu, Jennifer Rhodes, John P Kanki, Alan D D'Andrea, A Thomas Loo. Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Developmental cell. vol 5. issue 6. 2004-01-16. PMID:14667412. |
developmental defects and increased apoptosis in fancd2-deficient zebrafish were corrected by injection of human fancd2 or zebrafish bcl2 mrna, or by knockdown of p53, indicating that in the absence of fancd2, developing tissues spontaneously undergo p53-dependent apoptosis. |
2004-01-16 |
2023-08-12 |
human |
| Peter J Hahn, Zhi-Wei Lai, Barbara Nevaldine, Ninel Schiff, Nancy C Fiore, Allen E Silverston. Bcl2-independent chromatin cleavage is a very early event during induction of apoptosis in mouse thymocytes after treatment with either dexamethasone or ionizing radiation. Radiation research. vol 160. issue 5. 2004-01-08. PMID:14565826. |
the presence of the bcl2 transgene under the control of the p56lck promoter almost completely inhibited apoptosis up to 24 h after treatment, but it had virtually no effect on the early chromatin cleavage occurring in the first 6 h. ionizing radiation induced chromatin cleavage both directly by damaging dna and indirectly with kinetics similar to the induction of chromatin cleavage by dexamethasone. |
2004-01-08 |
2023-08-12 |
mouse |
| Jin Kyu Kim, Ji Hyang Kim, Yong Dal Yoo. Evaluation of caffeine as a radioprotector in whole-body irradiated male mice. In vivo (Athens, Greece). vol 17. issue 2. 2004-01-05. PMID:12792986. |
the expression of fas antigen, p21, p53, bax and bcl2 related to radiation- induced apoptosis was comparable to that of the caffeine-untreated group. |
2004-01-05 |
2023-08-12 |
mouse |
| Wei Hu, John J Kavanag. Anticancer therapy targeting the apoptotic pathway. The Lancet. Oncology. vol 4. issue 12. 2003-12-24. PMID:14662428. |
several studies have attempted to induce apoptosis by triggering the tumour-necrosis-factor-related apoptosis-inducing ligand receptor and the bcl2 family of proteins, and others have targeted the caspases, and proteins that inhibit apoptosis. |
2003-12-24 |
2023-08-12 |
Not clear |
| Peter Liston, Wai Gin Fong, Robert G Kornelu. The inhibitors of apoptosis: there is more to life than Bcl2. Oncogene. vol 22. issue 53. 2003-12-11. PMID:14634619. |
the inhibitors of apoptosis: there is more to life than bcl2. |
2003-12-11 |
2023-08-12 |
human |
| M Bai, N J Agnantis, A Skyrlas, E Tsanou, S Kamina, V Galani, P Kanavaro. Increased expression of the bcl6 and CD10 proteins is associated with increased apoptosis and proliferation in diffuse large B-cell lymphomas. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 16. issue 5. 2003-12-10. PMID:12748254. |
the association between increased bcl6 expression and enhanced apoptosis might be due, at least in part, to the null/low bcl2 expression because previous in vitro data showed that bcl6 overexpression induces apoptosis accompanied by bcl2 and bcl-xl downregulation. |
2003-12-10 |
2023-08-12 |
Not clear |
| M C Perianayagam, V S Balakrishnan, D Guo, B J G Pereira, B L Jabe. Quantification of Bax and Bcl2 in polymorphonuclear leukocytes from haemodialysis patients: relation to hydrogen peroxide. European journal of clinical investigation. vol 33. issue 10. 2003-12-04. PMID:14511363. |
in the present study, we explored the relation of hydrogen peroxide (h2o2) generation by polymorphonuclear cells (pmns) to the cytosolic expression of bax and bcl2 proteins and apoptosis in haemodialysis (hd) patients. |
2003-12-04 |
2023-08-12 |
Not clear |
| Tetsuhiro Tanaka, Norio Hanafusa, Julie R Ingelfinger, Takamoto Ohse, Toshiro Fujita, Masaomi Nangak. Hypoxia induces apoptosis in SV40-immortalized rat proximal tubular cells through the mitochondrial pathways, devoid of HIF1-mediated upregulation of Bax. Biochemical and biophysical research communications. vol 309. issue 1. 2003-10-16. PMID:12943686. |
temperature-sensitive sv40-immortalized rat proximal tubular cells (irptcs) showed apoptosis in 21.9+/-2.9% by hypoxia (0.2% o(2), 48h), with alterations in mitochondrial signaling such as bcl2 and caspase-9. |
2003-10-16 |
2023-08-12 |
rat |
| Yinghui Huang, Traci Tyler, Neshat Saadatmandi, Casey Lee, Per Borgstrom, Ruth A Gjerse. Enhanced tumor suppression by a p14ARF/p53 bicistronic adenovirus through increased p53 protein translation and stability. Cancer research. vol 63. issue 13. 2003-08-25. PMID:12839954. |
adp14/p53 treatment leads to an elevated bax:bcl2 ratio and induction of apoptosis in vitro and in vivo, coupled with a failure of the tumor cells to induce neovascularization in vivo. |
2003-08-25 |
2023-08-12 |
Not clear |
| Guorong Li, Claude Lambert, Anne Gentil-Perret, Christian Genin, Jacques Tostai. [Molecular and cytometric analysis of renal cell carcinoma cells. Concepts, techniques and prospects]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. vol 13. issue 1. 2003-08-01. PMID:12703348. |
the tumour's capacity for progression is related to dysregulations of the cycle (ras, pax2, tiam 1, waf/p21), division (tetracyclines, mib1, pcna, nor ag), apoptosis (bcl2, p53, cd95/apo1), and the capacities for tissue invasion (proteases), disorganization (cadherin, catenins) or nidation (icam-1, cd44). |
2003-08-01 |
2023-08-12 |
Not clear |
| H Raybaud, G Odin, A Fafet, J Santini, R A Montei. [Genic alterations in oral and head and neck squamous cell carcinomas: analysis of international literature]. Pathologie-biologie. vol 51. issue 3. 2003-07-31. PMID:12781800. |
by blocking apoptosis, the bcl2 protein seems to increase the resistance of tumours to radiotherapy and chemotherapy. |
2003-07-31 |
2023-08-12 |
Not clear |
| Sophie Meintières, Fabrice Nesslany, Marc Pallardy, Daniel Marzi. Detection of ghost cells in the standard alkaline comet assay is not a good measure of apoptosis. Environmental and molecular mutagenesis. vol 41. issue 4. 2003-07-22. PMID:12717781. |
to answer this question, we made use of two cell lines: ctll-2 cells that can enter apoptosis upon addition of apoptosis stimuli or il-2 deprivation, and ctll-2 bcl2 cells that are protected from apoptosis due to the overexpression of the apoptosis inhibitor gene bcl2. |
2003-07-22 |
2023-08-12 |
Not clear |
| Masao Set. Molecular mechanisms of lymphomagenesis through transcriptional disregulation by chromosome translocation. International journal of hematology. vol 76 Suppl 1. 2003-07-17. PMID:12430874. |
bcl2 expression from altered allele also keeps its expression at the germinal center stage where normal counterpart cells down-regulate bcl2 expression, and makes cells to resist apoptosis, leading to development of follicular lymphoma. |
2003-07-17 |
2023-08-12 |
Not clear |
| WenJing Liu, Anca Bulgaru, Missak Haigentz, C A Stein, Roman Perez-Soler, Sridhar Man. The BCL2-family of protein ligands as cancer drugs: the next generation of therapeutics. Current medicinal chemistry. Anti-cancer agents. vol 3. issue 3. 2003-07-11. PMID:12769779. |
bcl2 proteins are key mediators of the process of apoptosis and ligands to these family of proteins have been described using modern combinatorial, computational and evolutionary small molecule screening approaches. |
2003-07-11 |
2023-08-12 |
Not clear |
| WenJing Liu, Anca Bulgaru, Missak Haigentz, C A Stein, Roman Perez-Soler, Sridhar Man. The BCL2-family of protein ligands as cancer drugs: the next generation of therapeutics. Current medicinal chemistry. Anti-cancer agents. vol 3. issue 3. 2003-07-11. PMID:12769779. |
in several cases, these ligands (e.g., ha14-1, 2-methoxy antimycin a) induce apoptosis even under conditions of bcl2 overexpression and if developed preclinically will be promising anticancer agents. |
2003-07-11 |
2023-08-12 |
Not clear |