| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C R Antonescu, A Kawai, D H Leung, F Lonardo, J M Woodruff, J H Healey, M Ladany. Strong association of SYT-SSX fusion type and morphologic epithelial differentiation in synovial sarcoma. Diagnostic molecular pathology : the American journal of surgical pathology, part B. vol 9. issue 1. 2000-03-29. PMID:10718206. |
apoptosis (by tunel) was rarely observed, consistent with prominent expression of the anti-apoptotic protein bcl2 in almost all cases. |
2000-03-29 |
2023-08-12 |
Not clear |
| X Deng, P Ruvolo, B Carr, W S Ma. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 4. 2000-03-23. PMID:10677502. |
bcl2 phosphorylation at ser-70 may be required for the full and potent suppression of apoptosis in il-3-dependent myeloid cells and can result from agonist activation of mitochondrial protein kinase c (pkc). |
2000-03-23 |
2023-08-12 |
Not clear |
| X Deng, P Ruvolo, B Carr, W S Ma. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 4. 2000-03-23. PMID:10677502. |
paradoxically, expression of exogenous bcl2 can protect parental cells from apoptosis induced by the potent pkc inhibitor, staurosporine (stauro). |
2000-03-23 |
2023-08-12 |
Not clear |
| X Deng, P Ruvolo, B Carr, W S Ma. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 4. 2000-03-23. PMID:10677502. |
a role for a mek/mapk as a responsible srk was implicated because the highly specific mek/mapk inhibitor, pd98059, also can only partially inhibit il-3-induced bcl2 phosphorylation, whereas the combination of pd98059 and stauro completely blocks phosphorylation and synergistically enhances apoptosis. |
2000-03-23 |
2023-08-12 |
Not clear |
| X Deng, P Ruvolo, B Carr, W S Ma. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 4. 2000-03-23. PMID:10677502. |
thus, the srks can serve to functionally link the il-3-stimulated proliferative and survival signaling pathways and, in a novel capacity, may explain how bcl2 can suppress stauro-induced apoptosis. |
2000-03-23 |
2023-08-12 |
Not clear |
| T J Moran, S Gray, C A Mikosz, S D Conze. The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer research. vol 60. issue 4. 2000-03-20. PMID:10706096. |
apoptosis is accelerated by ectopic expression of c-myc and blocked by overexpression of bcl2. |
2000-03-20 |
2023-08-12 |
human |
| M Ghosh, J Crocker, A G Morri. CD40 and Bcl2 expression in squamous cell carcinoma of the lung: correlation with apoptosis, survival, and other clinicopathological factors. The Journal of pathology. vol 189. issue 3. 2000-03-13. PMID:10547598. |
cd40 and bcl2 expression in squamous cell carcinoma of the lung: correlation with apoptosis, survival, and other clinicopathological factors. |
2000-03-13 |
2023-08-12 |
Not clear |
| M Ghosh, J Crocker, A G Morri. CD40 and Bcl2 expression in squamous cell carcinoma of the lung: correlation with apoptosis, survival, and other clinicopathological factors. The Journal of pathology. vol 189. issue 3. 2000-03-13. PMID:10547598. |
cd40 is a cell surface receptor which, when ligated, modulates apoptosis in some cell types, perhaps via activation of the expression of members of the bcl2 gene family. |
2000-03-13 |
2023-08-12 |
Not clear |
| M Ghosh, J Crocker, A G Morri. CD40 and Bcl2 expression in squamous cell carcinoma of the lung: correlation with apoptosis, survival, and other clinicopathological factors. The Journal of pathology. vol 189. issue 3. 2000-03-13. PMID:10547598. |
this study sought to determine whether expression of cd40 in a series of 134 squamous cell carcinomas (sccs) of the lung was related to apoptosis or clinical parameters, either alone or in connection with bcl2 expression. |
2000-03-13 |
2023-08-12 |
Not clear |
| M Ghosh, J Crocker, A G Morri. CD40 and Bcl2 expression in squamous cell carcinoma of the lung: correlation with apoptosis, survival, and other clinicopathological factors. The Journal of pathology. vol 189. issue 3. 2000-03-13. PMID:10547598. |
apoptosis did not correlate with cd40 expression, nor was there evidence of a co-operative or an antagonistic effect with bcl2. |
2000-03-13 |
2023-08-12 |
Not clear |
| M Ghosh, J Crocker, A G Morri. CD40 and Bcl2 expression in squamous cell carcinoma of the lung: correlation with apoptosis, survival, and other clinicopathological factors. The Journal of pathology. vol 189. issue 3. 2000-03-13. PMID:10547598. |
bcl2 expression, on the other hand, correlated significantly with the apoptosis score. |
2000-03-13 |
2023-08-12 |
Not clear |
| M Ramakrishnan, W M Liu, P A DiCroce, A Posner, J Zheng, T Kohwi-Shigematsu, T G Krontiri. Modulated binding of SATB1, a matrix attachment region protein, to the AT-rich sequence flanking the major breakpoint region of BCL2. Molecular and cellular biology. vol 20. issue 3. 2000-02-14. PMID:10629043. |
the t(14,18) chromosomal translocation that occurs in human follicular lymphoma constitutively activates the bcl2 gene and disrupts control of apoptosis. |
2000-02-14 |
2023-08-12 |
mouse |
| L Yel, S Aggarwal, S Gupt. Cartilage-hair hypoplasia syndrome: increased apoptosis of T lymphocytes is associated with altered expression of Fas (CD95), FasL (CD95L), IAP, Bax, and Bcl2. Journal of clinical immunology. vol 19. issue 6. 2000-01-28. PMID:10634217. |
cartilage-hair hypoplasia syndrome: increased apoptosis of t lymphocytes is associated with altered expression of fas (cd95), fasl (cd95l), iap, bax, and bcl2. |
2000-01-28 |
2023-08-12 |
Not clear |
| M J Keatin. Chronic lymphocytic leukemia. Seminars in oncology. vol 26. issue 5 Suppl 14. 1999-11-30. PMID:10561025. |
apoptosis dysregulation is a major feature of cll, and while no clear pattern has emerged, abnormal levels of bcl2 are common in cll and bcl2 to bax ratios are also commonly disturbed. |
1999-11-30 |
2023-08-12 |
Not clear |
| S A You, A Basu, S Halda. Potent antitumor agent proteasome inhibitors: a novel trigger for Bcl2 phosphorylation to induce apoptosis. International journal of oncology. vol 15. issue 4. 1999-11-24. PMID:10493941. |
potent antitumor agent proteasome inhibitors: a novel trigger for bcl2 phosphorylation to induce apoptosis. |
1999-11-24 |
2023-08-12 |
human |
| S A You, A Basu, S Halda. Potent antitumor agent proteasome inhibitors: a novel trigger for Bcl2 phosphorylation to induce apoptosis. International journal of oncology. vol 15. issue 4. 1999-11-24. PMID:10493941. |
the simultaneous apoptosis with bcl2 phosphorylation was evident in cancer cells challenged with the proteasome inhibitor, mg132. |
1999-11-24 |
2023-08-12 |
human |
| B Witenberg, Y Kletter, H H Kalir, Z Raviv, E Fenig, A Nagler, D Halperin, I Fabia. Ascorbic acid inhibits apoptosis induced by X irradiation in HL60 myeloid leukemia cells. Radiation research. vol 152. issue 5. 1999-11-19. PMID:10521923. |
irradiation of the cells with 1-3 gy resulted in up-regulation of expression of bcl2 without affecting the level of apoptosis. |
1999-11-19 |
2023-08-12 |
Not clear |
| B Witenberg, Y Kletter, H H Kalir, Z Raviv, E Fenig, A Nagler, D Halperin, I Fabia. Ascorbic acid inhibits apoptosis induced by X irradiation in HL60 myeloid leukemia cells. Radiation research. vol 152. issue 5. 1999-11-19. PMID:10521923. |
at higher doses of radiation, enhanced bcl2 expression did not prevent radiation-induced apoptosis. |
1999-11-19 |
2023-08-12 |
Not clear |
| B Witenberg, Y Kletter, H H Kalir, Z Raviv, E Fenig, A Nagler, D Halperin, I Fabia. Ascorbic acid inhibits apoptosis induced by X irradiation in HL60 myeloid leukemia cells. Radiation research. vol 152. issue 5. 1999-11-19. PMID:10521923. |
at higher doses of radiation, ascorbate decreased apoptosis and restored the level of bcl2 in the cells. |
1999-11-19 |
2023-08-12 |
Not clear |
| J J Jacobs, B Scheijen, J W Voncken, K Kieboom, A Berns, M van Lohuize. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes & development. vol 13. issue 20. 1999-11-15. PMID:10541554. |
we observe increased apoptosis in bmi-1(-/-) lymphoid organs, which can be rescued by deletion of ink4a-arf or overexpression of bcl2. |
1999-11-15 |
2023-08-12 |
mouse |