| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Dai, B C Moulton, T F Ogl. Regression of the decidualized mesometrium and decidual cell apoptosis are associated with a shift in expression of Bcl2 family members. Biology of reproduction. vol 63. issue 1. 2000-08-24. PMID:10859259. |
regression of the decidualized mesometrium and decidual cell apoptosis are associated with a shift in expression of bcl2 family members. |
2000-08-24 |
2023-08-12 |
rat |
| D Dai, B C Moulton, T F Ogl. Regression of the decidualized mesometrium and decidual cell apoptosis are associated with a shift in expression of Bcl2 family members. Biology of reproduction. vol 63. issue 1. 2000-08-24. PMID:10859259. |
the purpose of this study was to determine whether regression of the decidua basalis (db), which begins on day 14 of pregnancy in the rat, results from an intrinsic program of apoptosis regulated by bax and bcl2. |
2000-08-24 |
2023-08-12 |
rat |
| D Dai, B C Moulton, T F Ogl. Regression of the decidualized mesometrium and decidual cell apoptosis are associated with a shift in expression of Bcl2 family members. Biology of reproduction. vol 63. issue 1. 2000-08-24. PMID:10859259. |
expression of bax and bcl2 and the incidence of apoptosis were evaluated throughout gestation by western blot analysis and detection of dna fragments. |
2000-08-24 |
2023-08-12 |
rat |
| S M Kornblau, H T Vu, P Ruvolo, Z Estrov, S O'Brien, J Cortes, H Kantarjian, M Andreeff, W S Ma. BAX and PKCalpha modulate the prognostic impact of BCL2 expression in acute myelogenous leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 4. 2000-08-03. PMID:10778970. |
these results suggest that expression levels of proteins that affect the functional status of bcl2 modify the prognostic impact of bcl2 and suggest that the role of apoptosis in different cases of aml varies independently in the different cytogenetic subgroups. |
2000-08-03 |
2023-08-12 |
Not clear |
| P W Moye, W L Blalock, P E Hoyle, F Chang, R A Franklin, C Weinstein-Oppenheimer, M Pearce, L Steelman, M McMahon, J A McCubre. Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells. Leukemia. vol 14. issue 6. 2000-07-10. PMID:10865973. |
these cells will be useful in furthering our understanding of the roles of the raf and bcl2 oncoproteins in hematopoietic cell growth, cell cycle progression and prevention of apoptosis. |
2000-07-10 |
2023-08-12 |
Not clear |
| W L Blalock, P W Moye, F Chang, M Pearce, L S Steelman, M McMahon, J A McCubre. Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells. Leukemia. vol 14. issue 6. 2000-07-10. PMID:10865974. |
these conditionally transformed cells will be useful in furthering our understanding of the roles mek1 and bcl2 play in the prevention of apoptosis in hematopoietic cells. |
2000-07-10 |
2023-08-12 |
human |
| A J Watson, D M Pritchar. Lessons from genetically engineered animal models. VII. Apoptosis in intestinal epithelium: lessons from transgenic and knockout mice. American journal of physiology. Gastrointestinal and liver physiology. vol 278. issue 1. 2000-06-16. PMID:10644554. |
knockout studies have shown that spontaneous apoptosis is independent of p53 and bax in both small and large intestine, whereas bcl2 only regulates spontaneous apoptosis in the colon. |
2000-06-16 |
2023-08-12 |
mouse |
| A J Watson, D M Pritchar. Lessons from genetically engineered animal models. VII. Apoptosis in intestinal epithelium: lessons from transgenic and knockout mice. American journal of physiology. Gastrointestinal and liver physiology. vol 278. issue 1. 2000-06-16. PMID:10644554. |
in contrast, knockout studies have demonstrated that both p53 and bcl2 are important regulators of stress-induced apoptosis but that there are significant differences between early and late time points. |
2000-06-16 |
2023-08-12 |
mouse |
| E Giarnieri, C Nagar, C Valli, E Brunetti, M B Palmieri, A Vecchion. BCL2 and BAX expression in hyperplastic and dysplastic rectal polyps. Hepato-gastroenterology. vol 47. issue 31. 2000-03-30. PMID:10690601. |
members of the gene family that includes bcl2 and bax are functionally antagonists in the apoptosis process and they have been observed in normal and neoplastic tissues. |
2000-03-30 |
2023-08-12 |
Not clear |
| C R Antonescu, A Kawai, D H Leung, F Lonardo, J M Woodruff, J H Healey, M Ladany. Strong association of SYT-SSX fusion type and morphologic epithelial differentiation in synovial sarcoma. Diagnostic molecular pathology : the American journal of surgical pathology, part B. vol 9. issue 1. 2000-03-29. PMID:10718206. |
apoptosis was analyzed immunohistochemically with bax and bcl2 antibodies and by the tunel method. |
2000-03-29 |
2023-08-12 |
Not clear |
| C R Antonescu, A Kawai, D H Leung, F Lonardo, J M Woodruff, J H Healey, M Ladany. Strong association of SYT-SSX fusion type and morphologic epithelial differentiation in synovial sarcoma. Diagnostic molecular pathology : the American journal of surgical pathology, part B. vol 9. issue 1. 2000-03-29. PMID:10718206. |
apoptosis (by tunel) was rarely observed, consistent with prominent expression of the anti-apoptotic protein bcl2 in almost all cases. |
2000-03-29 |
2023-08-12 |
Not clear |
| X Deng, P Ruvolo, B Carr, W S Ma. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 4. 2000-03-23. PMID:10677502. |
bcl2 phosphorylation at ser-70 may be required for the full and potent suppression of apoptosis in il-3-dependent myeloid cells and can result from agonist activation of mitochondrial protein kinase c (pkc). |
2000-03-23 |
2023-08-12 |
Not clear |
| X Deng, P Ruvolo, B Carr, W S Ma. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 4. 2000-03-23. PMID:10677502. |
paradoxically, expression of exogenous bcl2 can protect parental cells from apoptosis induced by the potent pkc inhibitor, staurosporine (stauro). |
2000-03-23 |
2023-08-12 |
Not clear |
| X Deng, P Ruvolo, B Carr, W S Ma. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 4. 2000-03-23. PMID:10677502. |
a role for a mek/mapk as a responsible srk was implicated because the highly specific mek/mapk inhibitor, pd98059, also can only partially inhibit il-3-induced bcl2 phosphorylation, whereas the combination of pd98059 and stauro completely blocks phosphorylation and synergistically enhances apoptosis. |
2000-03-23 |
2023-08-12 |
Not clear |
| X Deng, P Ruvolo, B Carr, W S Ma. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 4. 2000-03-23. PMID:10677502. |
thus, the srks can serve to functionally link the il-3-stimulated proliferative and survival signaling pathways and, in a novel capacity, may explain how bcl2 can suppress stauro-induced apoptosis. |
2000-03-23 |
2023-08-12 |
Not clear |
| T J Moran, S Gray, C A Mikosz, S D Conze. The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer research. vol 60. issue 4. 2000-03-20. PMID:10706096. |
apoptosis is accelerated by ectopic expression of c-myc and blocked by overexpression of bcl2. |
2000-03-20 |
2023-08-12 |
human |
| M Ghosh, J Crocker, A G Morri. CD40 and Bcl2 expression in squamous cell carcinoma of the lung: correlation with apoptosis, survival, and other clinicopathological factors. The Journal of pathology. vol 189. issue 3. 2000-03-13. PMID:10547598. |
cd40 and bcl2 expression in squamous cell carcinoma of the lung: correlation with apoptosis, survival, and other clinicopathological factors. |
2000-03-13 |
2023-08-12 |
Not clear |
| M Ghosh, J Crocker, A G Morri. CD40 and Bcl2 expression in squamous cell carcinoma of the lung: correlation with apoptosis, survival, and other clinicopathological factors. The Journal of pathology. vol 189. issue 3. 2000-03-13. PMID:10547598. |
cd40 is a cell surface receptor which, when ligated, modulates apoptosis in some cell types, perhaps via activation of the expression of members of the bcl2 gene family. |
2000-03-13 |
2023-08-12 |
Not clear |
| M Ghosh, J Crocker, A G Morri. CD40 and Bcl2 expression in squamous cell carcinoma of the lung: correlation with apoptosis, survival, and other clinicopathological factors. The Journal of pathology. vol 189. issue 3. 2000-03-13. PMID:10547598. |
this study sought to determine whether expression of cd40 in a series of 134 squamous cell carcinomas (sccs) of the lung was related to apoptosis or clinical parameters, either alone or in connection with bcl2 expression. |
2000-03-13 |
2023-08-12 |
Not clear |
| M Ghosh, J Crocker, A G Morri. CD40 and Bcl2 expression in squamous cell carcinoma of the lung: correlation with apoptosis, survival, and other clinicopathological factors. The Journal of pathology. vol 189. issue 3. 2000-03-13. PMID:10547598. |
apoptosis did not correlate with cd40 expression, nor was there evidence of a co-operative or an antagonistic effect with bcl2. |
2000-03-13 |
2023-08-12 |
Not clear |