| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Md Sohe. Breaking Barriers; Phytoestrogens in the Fight Against Triple-Negative Breast Cancer: A Comprehensive Review. Medicinal research reviews. 2025-03-12. PMID:40072262. |
chemotherapeutics activities are regulated through varieties of mechanisms, including targeting signaling pathways such as phosphor-akt, pi3k/akt/mtor, nf-κb, tnf-α; apoptosis such as fasl, bcl2, bax, bak, bad, apfa1, ask1, capase, and parp; metastasis such as mmps (1,2,3,9), wnt/-β catenin, angiogenesis (e&n cadherin, vimentin), cell proliferation (cyclins-a, b1, d1, e1, and cdks 1, 6,7), inflammatory molecules (tnf-α, nf-κb, il-1β, il-8), regulating tumor suppressor genes (p21, p27, p51, p53) and some nonspecific pathways like dna damage and repair (γh2ax, rad51, and surviving), autophagy (mtor, ulk1, and cathepsin b), epigenetic (hdac1, dnmt1, telomerase production) and metabolism regulation (glucose regulation-glut1 and glut4), showing antioxidant and many other pathways. |
2025-03-12 |
2025-03-14 |
Not clear |
| Le Ba Anh My, Nguyen Lien Boi Linh, Lam Chi Thien, Nhat-Thinh Nguyen, Nguyen Ngoc Thao Vy, Nguyen Van Thuan, Hong-Thuy Bu. Improving porcine in vitro blastocyst development using fetal bovine serum, amino acids, and insulin-transferrin-selenium. The Journal of reproduction and development. 2025-03-09. PMID:40058797. |
furthermore, fbs-aa-its elevated bcl2 expression and reduced bax expression, potentially inhibiting apoptosis. |
2025-03-09 |
2025-03-12 |
cattle |
| Yifei Dong, Wenwen Gao, Kai Liu, Cai Lin, Muhammad Usman, Juan J Loor, Guojin Li, Liguang Cao, Zifeng Yang, Jianchun Luo, Depeng Li, Qianwen Sun, Lin Lei, Xiliang Du, Yuxiang Song, Guowen Liu, Xinwei L. Cullin3 mitigates NEFA-induced oxidative stress in mammary epithelial cells: involvement of BCL2/BECN1 and autophagy. Journal of dairy science. 2025-03-07. PMID:40054686. |
additionally, cul3 overexpression aggravated the nefa-induced decrease in bcl2 apoptosis regulator (bcl2) expression while alleviating the nefa-induced decrease in beclin1(becn1) expression. |
2025-03-07 |
2025-03-12 |
cattle |
| Chiara Tarantelli, Omar Kayali, Elisa Civanelli, Luciano Cascione, Afua Adjeiwaa Mensah, Chiara Folloni, Alberto J Arribas, Andrea Rinaldi, Vladimir Cmiljanovic, Patrizia Mondello, Francesco Berton. Targeting of PIM Kinases Shows Single Agent Efficacy and Synergizes With BCL2 Inhibitors in Diffuse Large B Cell Lymphoma of the ABC Subtype. Hematological oncology. vol 43. issue 2. 2025-03-05. PMID:40040616. |
the combination of azd1208 with the clinically available bcl2 inhibitor venetoclax was synergistic in most dlbcl cell lines, and this combination induced apoptosis and reduced levels of akt and mcl1 proteins. |
2025-03-05 |
2025-03-07 |
Not clear |
| Natália Sudan Parducci, Anali Del Milagro Bernabe Garnique, Bruna Oliveira de Almeida, João Agostinho Machado-Net. Exploring the dual role of SIVA1 in cancer biology. Gene. 2025-03-02. PMID:40024298. |
investigations into siva1's interactions have uncovered its pro-apoptotic mechanisms, such as binding to anti-apoptotic proteins from the bcl2 family, thus promoting apoptosis under stress conditions. |
2025-03-02 |
2025-03-05 |
Not clear |
| Mahima Verma, Shireen Fatima, Asad Syed, Abdallah M Elgorban, Islem Abid, Ling Shing Wong, Mohd Sajid Khan, Irfan Ahmad Ansar. 3-Acetyl-11-keto-β-boswellic acid (AKBA) induced antiproliferative effect by suppressing Notch signaling pathway and synergistic interaction with cisplatin against prostate cancer cells. Naunyn-Schmiedeberg's archives of pharmacology. 2025-02-22. PMID:39985578. |
moreover, akba-elicited apoptosis was evidenced by an augmentation in the bax to bcl2 ratio. |
2025-02-22 |
2025-02-25 |
human |
| Liping Liu, Haoge Luo, Yingdong Xie, Ying Wang, Shiying Ren, Haiyang Sun, Zhuoyuan Xin, Dong L. Endogenous IL-33 inhibits apoptosis in non-small cell lung cancer cells by regulating BCL2/BAX via the ERK1/2 pathway. Scientific reports. vol 15. issue 1. 2025-02-21. PMID:39984631. |
our findings reveal that endogenous il-33 inhibits apoptosis in lung cancer cells by modulating the expression of bcl2 and bax via the erk1/2 pathway in an autocrine manner. |
2025-02-21 |
2025-02-24 |
Not clear |
| Yuanzhao Wu, Ye'anlun Zhu, An Cheng, Weixuan Yao, Binjie Wang, Ruonan Zheng, Jiye Wan. Effects of tefluthrin exposure on early life stages in zebrafish: Insights into cardiac and skeletal development, oxidative stress and apoptosis. Ecotoxicology and environmental safety. vol 292. 2025-02-20. PMID:39978106. |
furthermore, exposure to tefluthrin caused significant cell apoptosis in larvae, accompanied by dysregulation in the transcriptional expression of apoptotic genes (bcl2, bax, p53, and caspase-3). |
2025-02-20 |
2025-02-23 |
cat |
| Anne-Sophie Becker, Friederike Klauk, Thomas Freitag, Daniel Fabian Strüder, Björn Schneider, Annette Zimpfer, Claudia Maletzk. Inhibition of platin-induced BCL2 increase overcomes chemoresistance in squamous cell carcinoma of the head and neck through resensitization to cell death. Translational oncology. vol 53. 2025-02-19. PMID:39970625. |
the anti-apoptotic bcl2 protein is involved in apoptosis resistance and tumor cell invasion/migration. |
2025-02-19 |
2025-02-23 |
Not clear |
| Guoshang Ji, Xue Feng, Chunli Hu, Junxing Zhang, Hui Sheng, Rina Na, Fen Li, Yachun Wang, Yanfen Ma, Bei Cai, Yun M. HADHA promotes apoptosis and inflammatory response in bovine endometrial epithelial cells by regulating transcription and metabolism. International journal of biological macromolecules. 2025-02-14. PMID:39952496. |
it also increased bax and caspase-3 expression while decreasing bcl2 expression, hence promoting beec apoptosis. |
2025-02-14 |
2025-02-18 |
cattle |
| Manoj Soni, Awadhesh Kumar, Rakesh Kumar, Mehak Dangi, Ajit Kumar, Vijay Kuma. Focusing on Keap1, IKKβ, and Bcl2 proteins: predicted targets of stigmasterol in neurodegeneration. Journal of receptor and signal transduction research. 2025-02-13. PMID:39947740. |
in the bcl2-stigmasterol complex, which exhibited a binding energy of -8.41 kcal/mol, hydrophobic interactions with residues ser50, gln52, and leu185 stabilized the complex, indicating stigmasterol's role in inhibiting apoptosis by strengthening of bcl2 mediated inhibition of pro-apoptotic factors like bax. |
2025-02-13 |
2025-02-16 |
Not clear |
| Min Liu, Yuanyuan Li, Zhilin Deng, Ke Zhang, Shuying Huang, Jiamin Xia, Yi Feng, Yundan Liang, Chengfu Sun, Xindong Liu, Shurong Li, Bingyin Su, Yong Dong, Sizhou Huan. Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell death & disease. vol 16. issue 1. 2025-02-10. PMID:39929806. |
detailed analyses demonstrated that the immature t lymphocytes undergo rapid apoptosis via upregulation of tp53 and downregulation of bcl2 transcription in mcm5 mutants. |
2025-02-10 |
2025-02-13 |
mouse |
| H A D B Amarasiri, Danushka Arachchige, Matthew J K Vince, Justin M Holu. Inhibitory Potential and Binding Thermodynamics of Scyllatoxin-Based BH3 Domain Mimetics Targeting Repressor BCL2 Proteins. Journal of molecular recognition : JMR. vol 38. issue 2. 2025-02-05. PMID:39905677. |
the b-cell lymphoma 2 (bcl2) proteins are a class of apoptosis regulators that control the release of apoptogenic factors from mitochondria. |
2025-02-05 |
2025-02-07 |
Not clear |
| H A D B Amarasiri, Danushka Arachchige, Matthew J K Vince, Justin M Holu. Inhibitory Potential and Binding Thermodynamics of Scyllatoxin-Based BH3 Domain Mimetics Targeting Repressor BCL2 Proteins. Journal of molecular recognition : JMR. vol 38. issue 2. 2025-02-05. PMID:39905677. |
under normal physiological conditions, apoptosis is inhibited through the actions of anti-apoptotic (repressor) bcl2 proteins that bind semi-indiscriminately to the helical bh3 domains of pro-apoptotic (effector) bcl2 proteins. |
2025-02-05 |
2025-02-07 |
Not clear |
| Amisha Bisht, Anita Nayal, Disha Tewari, Sanjay Kumar, Subhash Chandr. Investigating the aging-modulatory mechanism of Rasayana Churna, an Ayurvedic herbal formulation, using a computational approach. Biogerontology. vol 26. issue 2. 2025-02-05. PMID:39907831. |
key targets such as akt1, bcl2, esr1, and gsk3b were linked to aging-related pathways, with go and kegg enrichment analyses highlighting processes like apoptosis, oxidative stress response, and pathways like pi3k-akt signaling. |
2025-02-05 |
2025-02-07 |
Not clear |
| Tao Huang, Bo Shao, Zhong-Cheng Gon. The Impact of miR-141 Overexpression on Apoptosis and Proliferation in Tscca and Tca8113 Cell Lines. Journal of stomatology, oral and maxillofacial surgery. 2025-02-05. PMID:39909369. |
these findings indicate that mir-141 may regulate the expression of pten and bcl2 at both the gene and protein levels, thereby influencing cell proliferation, migration, and apoptosis. |
2025-02-05 |
2025-02-08 |
Not clear |
| Xiaopeng Li, Xiaoyong He, Guibi Li, Zhujun Wang, Fuli Huang, Jiasen Chen, Yang Song, Tanze Liu, Zhaoyan Chen, Xiangfeng Wang, Jiwei Hu, Hua He, Hehe Liu, Liang Li, Jiwen Wang, Shenqiang H. Identification of the crucial circ-mi-mRNA interaction networks regulating testicular development and spermatogenesis in ganders. Poultry science. vol 104. issue 3. 2025-02-04. PMID:39904178. |
by constructing the core cerna regulatory networks, several key decircrnas, including 1:98100313|98104995, 1:171413706|171419341, 6:3414226|3418193, and 2:115876735|115880760, were identified to regulate the expression of tgfb2 and bcl2 through interactions with specific mirnas such as novel-mir-265 and novel-mir-266, and such interactions could play crucial roles in regulating the gander testicular cell apoptosis, proliferation, and spermatogenesis. |
2025-02-04 |
2025-02-07 |
Not clear |
| Rigzin Dolkar, Gourav Paudwal, Davinder Singh, Chittaranjan Behera, Sumera Banoo Malik, Syed Mudassir Ali, Harjot Kaur, Amit Nargotra, Ravi Shankar, Shashank K Singh, Prem N Gupt. Mechanistic Approach into 1,2,3-triazoles-based IIIM(S)-RS98 Mediated Apoptosis in Lung Cancer Cells. The AAPS journal. vol 27. issue 1. 2025-02-03. PMID:39900819. |
additionally, the downregulation of pi3k and p-akt pathway leads to the activation of pro-apoptotic proteins bax, downregulation of bcl2, activation of caspase 9, cleaved caspase 3, and cleaved parp1 expression and finally contribute towards apoptosis. |
2025-02-03 |
2025-02-06 |
Not clear |
| Haobo Li, Shuai Yuan, Zhipeng Yue, Lei Zhang, Shu Chen, Qirong Qian, Qiwei Fu, Yi Che. Suppressive effect of curcumin on apoptosis of articular chondrocytes via regulation on NF-κB pathway and NLRP3 inflammasome. Cytotechnology. vol 77. issue 2. 2025-02-03. PMID:39897107. |
il-1β treatment notably diminished chondrocyte viability and increased apoptosis, evidenced by elevated level of bax and cleaved caspase-3, and reduced level of bcl2, while such expression patterns were reversed by curcumin treatment in a concentration-dependent fashion. |
2025-02-03 |
2025-02-05 |
Not clear |
| Xiaohui Jiang, Liming Xu, Boyue Xu, Haotian Peng, Tonghe Yang, Yinying Zhao, Nanxin Wu, Yun-E Zha. SH2B1 promotes apoptosis in diabetic cataract via p38 MAPK pathway. iScience. vol 28. issue 2. 2025-02-03. PMID:39898036. |
under hg conditions, cell proliferation decreased, while migration and apoptosis, alongside changes in bcl2 and caspase-3 expression, increased. |
2025-02-03 |
2025-02-05 |
mouse |