| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sreejata Kamila, Koushik Kumar Dey, Ansuman Chattopadhya. Arsenic and Chromium Induced Toxicity on Zebrafish Kidney: Mixture Effects on Oxidative Stress and Involvement of Nrf2-Keap1-ARE, DNA Repair, and Intrinsic Apoptotic Pathways. Journal of applied toxicology : JAT. 2024-10-15. PMID:39402722. |
expressional alteration in bax, bcl2, caspase9, and caspase 3 indicated apoptosis (intrinsic pathway) induction, which was maximum in combined group. |
2024-10-15 |
2024-10-17 |
zebrafish |
| Xiaofeng Zhao, Yunhong Yang, Qiuyue Xie, Jiahan Qiu, Xiaofeng Su. Identification of Biomarkers and Mechanisms Associated with Apoptosis in Recurrent Pregnancy Loss. Biochemical genetics. 2024-10-14. PMID:39400681. |
we identified six differentially expressed genes related to apoptosis, including ctsz, bcl2, pik3cd, kras, gadd45g, and casp8, with gadd45g as the most gene. |
2024-10-14 |
2024-10-16 |
Not clear |
| Yunze Li, Xin Sun, Zhe Huan. USP7 facilitates deubiquitination of LRRC42 in colorectal cancer to accelerate tumorigenesis and augment Wnt/β-catenin signaling. Biochimica et biophysica acta. Molecular cell research. 2024-10-11. PMID:39393471. |
silencing lrrc42 suppressed cell proliferation, induced g0/g1 phase arrest, and promoted apoptosis by reducing bcl2 expression while elevating the expression of bax, cleaved parp and cleaved caspase 3. |
2024-10-11 |
2024-10-14 |
Not clear |
| Xiumei Bai, Yabin Song, Xiangyan Zhang, Liqiong Liu, Haixia Wu, Jiaqing Feng, Lihong Wu, Huizhen Liu, Diangui Zho. Curcumin ameliorates ischemic stroke injury by downregulating GMFB expression: An Biomolecules & biomedicine. 2024-10-10. PMID:39388704. |
gmfb overexpression promoted ogd/r-induced cell viability diminution, increased ldh and ros levels, lessened cell invasion ability, enhanced cell apoptosis, enhanced bax levels, and decreased bcl2 levels. |
2024-10-10 |
2024-10-13 |
Not clear |
| Hong Chen, Jameel Ahmed Buzdar, Roshan Riaz, Dalia Fouad, Nisar Ahmed, Qurban Ali Shah, Shulin Che. Bovine lactoferrin alleviates aflatoxin B1 induced hepatic and renal injury in broilers by mediating Nrf2 signaling pathway. Poultry science. vol 103. issue 12. 2024-10-09. PMID:39383667. |
whereas, mrna level of mitochondrial apoptosis related gene including bcl-2 (bak and bax), caspase-3 and caspase-9 was upregulated, while bcl2 gene were downregulated in afb1 group. |
2024-10-09 |
2024-10-12 |
chicken |
| Yichi Xu, Xiaoli Qin, Weihong Zeng, Fan Wu, Xiaowei Wei, Qian Li, Yi Li. DOCK1 deficiency drives placental trophoblast cell dysfunction by influencing inflammation and oxidative stress, hallmarks of preeclampsia. Hypertension research : official journal of the Japanese Society of Hypertension. 2024-10-08. PMID:39379467. |
moreover, dock1 knockout amplified apoptosis, as indicated by an altered bcl2: bax ratio and enhanced levels of cleaved parp. |
2024-10-08 |
2024-10-11 |
mouse |
| Rahul V G, Govindaraj Ellur, Amir A Gaber, Prem Kumar Govindappa, John C Elfa. 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury in mice. Cell death discovery. vol 10. issue 1. 2024-10-04. PMID:39366954. |
4-ap attenuated apoptosis, with decreases in apoptotic markers bax, caspase-9, and caspase-3 and increases in anti-apoptotic markers bcl2 and bcl-xl. |
2024-10-04 |
2024-10-07 |
mouse |
| Mohammad Yousefi Zardak, Fatemeh Keshavarz, Ali Mahyaei, Morteza Gholami, Fatemeh Sadat Moosavi, Elham Abbasloo, Farzaneh Abdollahi, Maryam Hossein Rezaei, Elham Madadizadeh, Nasrin Soltani, Fatemeh Bejeshk, Niyan Salehi, Fahimeh Rostamabadi, Fatemeh Bagheri, Mahla Jafaraghae, Mahdiyeh Ranjbar Zeydabadi, Meraj Baghgoli, Gholamreza Sepehri, Mohammad Abbas Bejesh. Quercetin as a therapeutic agent activate the Nrf2/Keap1 pathway to alleviate lung ischemia-reperfusion injury. Scientific reports. vol 14. issue 1. 2024-10-04. PMID:39367100. |
furthermore, we examined markers related to inflammation (interleukin-1β and tumor necrosis factor alpha), oxidative stress (malondialdehyde, total oxidant status, superoxide dismutase, glutathione peroxidase, total antioxidant capacity), lung edema (wet/dry lung weight ratio and total protein concentration), apoptosis (bax and bcl2 protein), and histopathological alterations (intra-alveolar edema, alveolar hemorrhage, and neutrophil infiltration). |
2024-10-04 |
2024-10-07 |
rat |
| Juie Nahushkumar Rana, Sohail Mumtaz, Ihn Han, Eun Ha Cho. Harnessing the synergy of nanosecond high-power microwave pulses and cisplatin to increase the induction of apoptosis in cancer cells through the activation of ATR/ATM and intrinsic pathways. Free radical biology & medicine. 2024-10-03. PMID:39362289. |
additionally, upregulation of atr/atm, chk1/chk2, p53, and caspase 3/8, bax, parp, and bcl2 confirms dna damage and mitochondrial dysfunction, leading to apoptosis. |
2024-10-03 |
2024-10-07 |
Not clear |
| Weihua Chen, Xin Liu, Ziping Zhang, Yadong Yua. Sinomenine Hydrochloride Regulates the Apoptosis of Endothelial Cells through PPAR-γ to Alleviate PAH. International heart journal. vol 65. issue 5. 2024-09-29. PMID:39343596. |
it reversed the expression of bcl2 and bax and prevented the apoptosis of endothelial cells. |
2024-09-29 |
2024-10-02 |
rat |
| Ting Zou, Jun-Yan Liu, Zhao-Qian Liu, Di Xiao, Juan Che. The Role of ADCY1 in Regulating the Sensitivity of Platinum-Based Chemotherapy in NSCLC. Pharmaceuticals (Basel, Switzerland). vol 17. issue 9. 2024-09-28. PMID:39338283. |
it may control cell apoptosis by regulating the classical apoptosis biomarkers bax and bcl2. |
2024-09-28 |
2024-10-01 |
Not clear |
| Meng Lian, Boxuan Han, Jiaming Chen, Xixi Shen, Yanming Zhao, Qian Shi, Ling Feng, Shizhi He, Hongzhi Ma, Lizhen Hou, Qi Zhong, Hongbao Cao, Jugao Fan. Investigating the impact of clinical and genetic factors on the post-surgery prognosis of sinonasal squamous cell carcinoma. Scientific reports. vol 14. issue 1. 2024-09-27. PMID:39333222. |
these genes, including egfr, pik3ca, erbb2, pten, bcl2, braf, kras, and prl, form a complex snscc-prognosis pathway and were significantly enriched in 42 kegg pathways and gene ontology (go) terms (fdr-corrected p-value < 0.001), influencing cell growth, apoptosis, and oncogenic signaling pathways. |
2024-09-27 |
2024-10-01 |
Not clear |
| Fatemeh Rahmati-Dehkordi, Hadi Khanifar, Alireza Zare-Hoseinabadi, Ehsan Dadgostar, Hamed Jafarpour, Michael Aschner, Hamed Mirzaei, Omid Reza Tamtaji, Fatemeh Nabavizade. Potential of Edaravone Dexborneol in the treatment of cerebral ischemia: focus on cell death-related signaling pathways. Molecular biology reports. vol 51. issue 1. 2024-09-23. PMID:39312062. |
for example, it inhibits apoptosis by increasing bcl2, and reducing bax and caspase-3 expression. |
2024-09-23 |
2024-09-26 |
Not clear |
| Daniel Westaby, Juan M Jiménez-Vacas, Ines Figueiredo, Jan Rekowski, Claire Pettinger, Bora Gurel, Arian Lundberg, Denisa Bogdan, Lorenzo Buroni, Antje Neeb, Ana Padilha, Joe Taylor, Wanting Zeng, Souvik Das, Emily Hobern, Ruth Riisnaes, Mateus Crespo, Susana Miranda, Ana Ferreira, Brian P Hanratty, Daniel Nava Rodrigues, Claudia Bertan, George Seed, Maria de Los Dolores Fenor de La Maza, Christina Guo, Juliet Carmichael, Rafael Grochot, Khobe Chandran, Anastasia Stavridi, Andreas Varkaris, Nataly Stylianou, Brett G Hollier, Nina Tunariu, Steven P Balk, Suzanne Carreira, Wei Yuan, Peter S Nelson, Eva Corey, Michael Haffner, Johann de Bono, Adam Shar. BCL2 expression is enriched in advanced prostate cancer with features of lineage plasticity. The Journal of clinical investigation. vol 134. issue 18. 2024-09-17. PMID:39286979. |
finally, bcl2 inhibition had antitumor activity in some, but not all, bcl2-positive pc models, highlighting the need for combination strategies to enhance tumor cell apoptosis and enrich response. |
2024-09-17 |
2024-09-20 |
Not clear |
| Ana Portelinha, Shenqiu Wang, Sara Parsa, Man Jiang, Alexander N Gorelick, Sagarajit Mohanty, Soumya Sharma, Elisa de Stanchina, Marjan Berishaj, Chunying Zhao, James Heward, Neeraj K Aryal, Omid Tavana, Jiayu Wen, Jude Fitzgibbon, Ahmet Dogan, Anas Younes, Ari M Melnick, Hans-Guido Wende. SETD1B mutations confer apoptosis resistance and BCL2 independence in B cell lymphoma. The Journal of experimental medicine. vol 221. issue 10. 2024-09-05. PMID:39235528. |
setd1b mutations confer apoptosis resistance and bcl2 independence in b cell lymphoma. |
2024-09-05 |
2024-09-08 |
human |
| Xue-Hui Shi, Chong-Xi Fan, Quan-Long Yang, Xiao-Ying Wang, Dong-Lin Zhao, Man-Hua Li, Xue-Liang Wu, Jian-Chun Fan, Shou-Bin Nin. [Effect of Pterostilbene Regulating Nuclear Factor E2-Related Factor 2 on Apoptosis of Colon Cancer Cells Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 46. issue 4. 2024-09-02. PMID:39223012. |
methods lovo cells were treated with different concentrations (5,10,20,40,60,80,100 μmol/l) of pterostilbene.cell viability,migration,invasion,and apoptosis were examined by cck-8,scratch,transwell,and tunel assays,respectively.the mitochondrial membrane potential was measured by the mitochondrial membrane potential assay kit with jc-1.the reactive oxygen species level was measured by 2',7'-dichlorofluorescein diacetate.the protein levels of nrf2,phosphorylated nrf2,heme oxygenase 1,and apoptotic proteins (bcl2 and bax) were determined by western blotting.in addition,cell viability,nrf2 expression,and apoptosis rate were determined after co-application of the nrf2-specific agonist sulforaphane. |
2024-09-02 |
2024-09-05 |
human |
| Aiguo Zhang, Xuefei Wang, Mingming Fan, Yibo Guan, Yuchen Jiang, Shuangxing Jin, Lingling Liu, Heping Huangfu, Chao Son. Lycopene alleviates zearalenone-induced oxidative stress, apoptosis, and NLRP3 inflammasome activation in mice kidneys. Toxicon : official journal of the International Society on Toxinology. vol 249. 2024-08-25. PMID:39181415. |
moreover, zen ingestion notably resulted in apoptosis, increased the protein levels of bcl2 associated x protein (bax) and cleaved caspase-3, and decreased the protein levels of apoptosis regulator bcl-2 (bcl-2), which were reversed by lycopene intervention. |
2024-08-25 |
2024-08-28 |
mouse |
| Yuxuan Zhang, Biying Xiao, Shuying Yuan, Lele Ding, Yongfu Pan, Yanyu Jiang, Shenghao Sun, Xisong Ke, Lili Cai, Lijun Ji. Tryptanthrin targets GSTP1 to induce senescence and increases the susceptibility to apoptosis by senolytics in liver cancer cells. Redox biology. vol 76. 2024-08-24. PMID:39180983. |
importantly, tryp exposed the vulnerability of tumor cells and sensitized senescent cells to apoptosis induced by senolytic agent abt263, a bcl2 inhibitor. |
2024-08-24 |
2024-08-28 |
Not clear |
| Rania Alaaeldin, Reham H Mohyeldin, Ehab E Sharata, Mina Ezzat Attya, Moustafa Fath. Vincamine exerts hepato-protective activity during colon ligation puncture-induced sepsis by modulating oxidative stress, apoptosis, and TNFα/Nrf-2/Keap-1 signaling pathways. Scientific reports. vol 14. issue 1. 2024-08-22. PMID:39174578. |
the apoptosis was initiated through the activation of bax and cleaved caspase 3 protein expression and inhibition of bcl2 protein expression. |
2024-08-22 |
2024-08-25 |
Not clear |
| Palin Jiwaganont, Kotchapol Jaturanratsamee, Siriwan Thaisakun, Sittiruk Roytrakul, Soontaree Petchde. Analysis of serum proteomic in cats with polycystic kidney disease-1 gene mutation. Heliyon. vol 10. issue 15. 2024-08-22. PMID:39170222. |
the apoptosis regulator bcl-2 (bcl2) was overexpressed in the chronic kidney disease (ckd) group, while apoptotic peptidase activating factor 1 (apaf1) and bcl2-associated x apoptosis regulator (bax) were only expressed in the pkd group. |
2024-08-22 |
2024-08-24 |
Not clear |