| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guangdong Ren, Ran Liu, Huiqiang Mai, Gang Yin, Fulai Ding, Chunmei Wang, Shuxin Chen, Xianqi La. GAB1 attenuates lipopolysaccharide‑mediated endothelial dysfunction via regulation of SOCS3. Experimental and therapeutic medicine. vol 28. issue 4. 2024-08-22. PMID:39171145. |
however, gab1 overexpression significantly mitigated lps-induced cell viability decrease and apoptosis in huvecs, accompanied by upregulation of bcl2 expression, and downregulation of bax and cleaved caspase-3 expression. |
2024-08-22 |
2024-08-24 |
Not clear |
| Prem Kumar Govindappa, Rahul V G, Govindaraj Ellur, Amir A Gaber, John Elfa. 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury. Research square. 2024-08-16. PMID:39149501. |
4-ap attenuated apoptosis, with decreases in apoptotic markers bax, caspase-9, and caspase-3 and increases in anti-apoptotic markers bcl2 and bcl-xl. |
2024-08-16 |
2024-08-18 |
Not clear |
| Qian Ma, Liwei Cai, Yu Zhou, Changyi Zhan. HuMSC-EVs Protect Endothelial Cells Against Hypoxia/Reoxygenation Injury by Inhibiting the Pannexin 1/p38-MAPK Pathway. Transplantation proceedings. 2024-08-15. PMID:39147615. |
mechanistically, humsc-evs were found to inhibit the p38 mitogen-activated protein kinase (mapk)-dependent apoptosis pathway, as evidenced by increased bcl2 expression and reductions in p38 mapk phosphorylation, bax expression, and cleaved-caspase 3 expression. |
2024-08-15 |
2024-08-18 |
human |
| Jiayu Liu, Qiunan Zhou, Kai Meng, Xiaojuan Yang, Bin Ma, Chunxia Su, Xiangguo Dua. Aspirin Inhibits Colorectal Cancer via the TIGIT-BCL2-BAX pathway in T Cells. International journal of medical sciences. vol 21. issue 10. 2024-08-08. PMID:39113892. |
further, aspirin could inhibit jurkat cell proliferation and induce apoptosis via downregulation of tigit expression and the anti-apoptosis b cell lymphoma 2 (bcl2) protein and upregulation of bcl2-associated x protein (bax) expression. |
2024-08-08 |
2024-08-10 |
mouse |
| Mingyuan Li, Siqian Li, YueDong Guo, Ping Hu, Jianlin Sh. Magnetothermal-activated gene editing strategy for enhanced tumor cell apoptosis. Journal of nanobiotechnology. vol 22. issue 1. 2024-07-31. PMID:39080645. |
this study proposes a magnetothermal-induced crispr-cas9 gene editing system for the targeted knockout of hsp70 and bcl2 genes, thereby enhancing tumor cell apoptosis. |
2024-07-31 |
2024-08-02 |
Not clear |
| Siying Wang, Xuyu Chen, Xiaofei Zhang, Kang Wen, Xin Chen, Jingyao Gu, Juan Li, Zhaoxia Wan. Pro-apoptotic gene BAX is a pan-cancer predictive biomarker for prognosis and immunotherapy efficacy. Aging. vol 16. 2024-07-29. PMID:39074253. |
apoptosis regulator bcl2 associated x (bax) is a pro-apoptotic gene. |
2024-07-29 |
2024-08-02 |
Not clear |
| Kira D Leitl, Laura E Sperl, Franz Hag. Preferred inhibition of pro-apoptotic Bak by BclxL via a two-step mechanism. Cell reports. vol 43. issue 8. 2024-07-24. PMID:39046879. |
bak is a pore-forming bcl2 protein that induces apoptosis at the outer mitochondrial membrane, which can either proceed via bak oligomerization or be inhibited by anti-apoptotic bcl2 proteins, such as bclxl. |
2024-07-24 |
2024-07-28 |
Not clear |
| Hossein Rezaei, Alireza Iranbakhsh, Abbas Akhavan Sepahi, Amir Mirzaie, Kambiz Larijan. Formulation, preparation of niosome loaded zinc oxide nanoparticles and biological activities. Scientific reports. vol 14. issue 1. 2024-07-19. PMID:39030347. |
in addition, the impact of niosomes on the expression of genes involved in the apoptosis (bcl2, casp3, casp9, bax) at the mrna level was measured. |
2024-07-19 |
2024-07-22 |
Not clear |
| Changju Chun, Ja Min Byun, Minkwon Cha, Hongwon Lee, Byungsan Choi, Hyunwoo Kim, Saem Hong, Yunseo Lee, Hayoung Park, Youngil Koh, Tae-Young Yoo. Profiling protein-protein interactions to predict the efficacy of B-cell-lymphoma-2-homology-3 mimetics for acute myeloid leukaemia. Nature biomedical engineering. 2024-07-18. PMID:39025942. |
b-cell-lymphoma-2 (bcl2) homology-3 (bh3) mimetics are inhibitors of protein-protein interactions (ppis) that saturate anti-apoptotic proteins in the bcl2 family to induce apoptosis in cancer cells. |
2024-07-18 |
2024-07-21 |
Not clear |
| Toshimichi Ishii, Kento Mori-Kobayashi, Sho Nakamura, Satoshi Ohkura, Shuichi Matsuyam. Carnosine supplementation in cryopreservation solution improved frozen-thawed bovine embryo viability. The Journal of reproduction and development. 2024-07-15. PMID:39010149. |
in frozen-thawed embryos, cryopreservation solution supplemented with carnosine (50 μg/ml) significantly reduced reactive oxygen species (ros) production(p < 0.05), decreased tunel-positive apoptotic cells (p< 0.05), and increased the mrna expression of bcl2 (p< 0.05), an apoptosis suppressor gene. |
2024-07-15 |
2024-07-18 |
cattle |
| B Haridevamuthu, S P Ramya Ranjan Nayak, Raghul Murugan, Gokul Sudhakaran, Raman Pachaiappan, K Manikandan, Vellapandian Chitra, Mikhlid H Almutairi, Bader O Almutairi, M K Kathiravan, Jesu Arockiara. Co-occurrence of azorubine and bisphenol A in beverages increases the risk of developmental toxicity: A study in zebrafish model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-07-11. PMID:38992409. |
critical genes related to the antioxidant response elements (nrf2, ho1, and nqo1), apoptosis activation (bcl2, bax, and p53), and pro/anti-inflammatory cytokines (nfkb, tnfa, il1b, tgfb, il10, and il12) displayed substantial changes, highlighting the molecular mechanisms. |
2024-07-11 |
2024-07-14 |
zebrafish |
| Yide He, Jun Hu, Rosa Freitas, Jie Gu, Guixiang Ji, Yongjun Zhan. Trace-level Gabapentin can Induce Cardiovascular Developmental Toxicity through Apoptosis in Zebrafish Larvae. Environmental pollution (Barking, Essex : 1987). 2024-07-11. PMID:38992826. |
the vascular cell apoptosis was promoted through genes like p53, bad, and bcl2. |
2024-07-11 |
2024-07-14 |
zebrafish |
| Lin Lin, Jing Ding, Simeng Liu, Chunying Liu, Qing Li, Xiang Gao, Yamei Niu, Wei-Min Ton. Protein Phosphatase 2ACα Regulates ATR-Mediated Endogenous DNA Damage Response Against Microcephaly. Molecular neurobiology. 2024-07-08. PMID:38976130. |
importantly, atr/chk1 signaling dysregulation altered both the expression and activity of several critical downstream factors including p53, p21, bcl2, and bax, which led to decreased proliferation of cortical progenitor cells and increased apoptosis in developing cortical neurons. |
2024-07-08 |
2024-07-11 |
mouse |
| Sen Suo, Cheng Fang, Wenting Liu, Qingan Liu, Zhuobo Zhang, Junlei Chang, Guozhong L. FOXM1 c.1205 C > A mutation is associated with unilateral Moyamoya disease and inhibits angiogenesis in human brain endothelial cells. Human genetics. 2024-07-05. PMID:38969938. |
furthermore, foxm1 c.1205 c > a results in increased apoptosis of human brain endothelial cells, mediated by the downregulation of the transcription of the apoptosis-inhibiting protein bcl2. |
2024-07-05 |
2024-07-08 |
human |
| Masoumeh Sharifi-Azad, Masumeh Kaveh Zenjanab, Mohammad Shahpouri, Mohammad Amin Adili-Aghdam, Marziyeh Fathi, Rana Jahanban Esfahla. Codelivery of methotrexate and silibinin by niosome nanoparticles for enhanced chemotherapy of CT26 colon cancer cells. Biomedical materials (Bristol, England). 2024-07-02. PMID:38953496. |
further, nio@ms significantly reduced cell adhesion density, promoted apoptosis and increased gene expression level of caspase 3 and bax while promoted significant downregulation of bcl2. |
2024-07-02 |
2024-07-06 |
Not clear |
| Qiong Xi, Lin Liu, Qin Zhao, Shan Zh. KLF13 Attenuates Lipopolysaccharide-Induced Alveolar Epithelial Cell Damage by Regulating Mitochondrial Quality Control via Binding PGC-1α. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2024-07-01. PMID:38949897. |
moreover, klf13 gain-of-function inhibited lps-induced apoptosis of a549 cells, accompanied by upregulated bcl2 expression and downregulated bax and cleaved caspase3 expression. |
2024-07-01 |
2024-07-04 |
human |
| Meghana Manjunath, Febina Ravindran, Shivangi Sharma, Humaira Siddiqua, Sathees C Raghavan, Bibha Choudhar. Disarib, a Specific BCL2 Inhibitor, Induces Apoptosis in Triple-Negative Breast Cancer Cells and Impedes Tumour Progression in Xenografts by Altering Mitochondria-Associated Processes. International journal of molecular sciences. vol 25. issue 12. 2024-06-27. PMID:38928195. |
disarib, a specific bcl2 inhibitor, induces apoptosis in triple-negative breast cancer cells and impedes tumour progression in xenografts by altering mitochondria-associated processes. |
2024-06-27 |
2024-06-29 |
Not clear |
| Abdulaziz Arif A Alshammari, Awyed Batah Almutairi, Minhajul Arfeen, Abdullah Saleh Alkhamiss, Maha A Aldubayan, Ahmad H Alhowail, Vasudevan Man. Assessing the Influence of Intermittent Alcohol Access on Acrylamide-Induced Neuronal Toxicity in an Experimental Rat Model. Brain sciences. vol 14. issue 6. 2024-06-27. PMID:38928574. |
additionally, elisa assays were performed to examine underlying mechanisms, including markers associated with inflammation (nf-κb, pge2, and tnf-α), apoptosis (bcl2, bax, and caspase-3), and oxidative stress (mda, catalase, and gsh). |
2024-06-27 |
2024-06-29 |
rat |
| Lin Liu, Wenbin Mo, Miao Chen, Yi Qu, Pingping Wang, Ying Liang, Xiaojing Ya. Targeted inhibition of DHODH is synergistic with BCL2 blockade in HGBCL with concurrent MYC and BCL2 rearrangement. BMC cancer. vol 24. issue 1. 2024-06-26. PMID:38918775. |
in this study, the dhodh inhibitor brequinar exhibited growth inhibition, cell cycle blockade, and apoptosis promotion in hgbcl cell lines with myc and bcl2 rearrangements. |
2024-06-26 |
2024-06-29 |
Not clear |
| Lakshmi Thangavelu, Ehssan Moglad, Gaurav Gupta, Soumya V Menon, Ashish Gaur, Snehlata Sharma, Mandeep Kaur, Mamata Chahar, G V Sivaprasad, Mahamedha Deorar. GAS5 lncRNA: A biomarker and therapeutic target in breast cancer. Pathology, research and practice. vol 260. 2024-06-23. PMID:38909406. |
gas5 enhances apoptosis by regulating apoptotic proteins, such as caspases and bcl2 family proteins, and the sensitivity of bccs to chemotherapeutic agents. |
2024-06-23 |
2024-06-26 |
Not clear |