| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ki-Fong Man, Omeed Darweesh, Jinghui Hong, Alexandra Thompson, Charlotte O'Connor, Chiara Bonaldo, Mark N Melkonyan, Mo Sun, Rajnikant Patel, Leif W Ellisen, Tim Robinson, Dong Song, Siang-Boon Ko. CREB1-BCL2 drives mitochondrial resilience in RAS GAP-dependent breast cancer chemoresistance. Oncogene. 2025-01-31. PMID:39890967. |
both proteins decorate mitochondria, where the high levels of mitochondrial rasal2-induced bcl2 expression render the organelles refractory to apoptosis. |
2025-01-31 |
2025-02-04 |
Not clear |
| Abhishek Kumar, Yogita Thakur, Reshma Sinh. Physiological impact of secondary nanoplastics on aquatic inhabitants in special reference to immunotoxicity. Environmental monitoring and assessment. vol 197. issue 2. 2025-01-30. PMID:39885038. |
neural system exposure to nps induces abnormal expression of genes like neurogenin1, gfap, fbj murine osteosarcoma viral oncogene, gap-43, synapsin iia, apoptosis regulator a, bcl2 and caspase a, and apoptosis-related cysteine peptidase. |
2025-01-30 |
2025-02-02 |
zebrafish |
| Yilin Yuan, Jianxiu Zhang, Hui Li, Fengxia Yuan, Qinglong Cui, Di Wu, Haidan Yuan, Guangchun Pia. Scopoletin alleviates acetaminophen-induced hepatotoxicity through modulation of NLRP3 inflammasome activation and Nrf2/HMGB1/TLR4/NF-κB signaling pathway. International immunopharmacology. vol 148. 2025-01-27. PMID:39870009. |
sp inhibited apap-induced hepatocyte apoptosis by regulating the protein levels of apoptosis-related proteins (cytochrome c, bax, caspase-3, bcl2, and parp). |
2025-01-27 |
2025-01-30 |
mouse |
| Marwa M Khalaf, Emad H M Hassanein, Hamada S Qebesy, Abdullatif A Ahmed, Heba M Mahmou. Granisetron ameliorates doxorubicin-evoked nephrotoxicity via modulation of Nrf2 and TLR4/p38 MAPK/NLRP3 signals in rats. Tissue & cell. vol 93. 2025-01-24. PMID:39855027. |
gran prevented apoptosis by controlling renal expression of bax, caspase-3 and bcl2. |
2025-01-24 |
2025-01-28 |
rat |
| Xinyu Yan, Yiyi Zhang, Jingwen Mo, Lindong Xu, Keyu Shi, Yi Zho. Molecular docking and network pharmacology research on the Danggui Sini Decoction's mechanism of action for treating erectile dysfunction. Medicine. vol 103. issue 47. 2025-01-14. PMID:39809170. |
this study demonstrates that dgsnd's compounds stimulate no synthesis and reduce inflammation and cell apoptosis to improve ed by acting on akti, alb, il6, tnf, tp53, and bcl2. |
2025-01-14 |
2025-01-17 |
Not clear |
| Qian Feng, Jin-Xiu Zhi, Xue-Yu Wang, Yi-Di Chen, Guan-Cheng Liu, Cai-Yan Wang, Xia Yang, Fang-Ju Feng, Rong Zhang, Zhong-Qiu Liu, Rong-Rong Zhan. Cynanchum wallichii Wight and CW1 reversed docetaxel resistance effects by inhibiting P-gp and promoting PI3K/Akt-mediated apoptosis in prostate cancer. Biochemical pharmacology. vol 232. 2025-01-10. PMID:39788386. |
in addition, dtx + cw/cw1 co-treatment significantly increased the apoptosis effects in 22rv1/dtx cells by regulating the relative expressions of bax, bcl2, cytochrome c, and caspase 3/9. |
2025-01-10 |
2025-01-13 |
Not clear |
| Shuqing Lv, Xinlu Zhang, Fangfang Lang, Yanmei Wu, Cancan Zhang, Qi Qi, Jie Jian. Long non-coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR-4673/TPX2 axis and activating Wnt/β-catenin signaling pathway. BioFactors (Oxford, England). vol 51. issue 1. 2025-01-09. PMID:39780463. |
knockdown of linc01224 in ec cell lines (hec-1-b and ishikawa) inhibited proliferation, migration, and promoted apoptosis, alongside increased bax and decreased bcl2 expression. |
2025-01-09 |
2025-01-13 |
Not clear |
| Mahrokh Abouali Gale Dari, Bahar Jaberian Asl, Dian Dayer, Shirin Azizidoost, Maryam Farzaneh, Abdolah Mousavi Saleh. miR-34 as a Critical Regulator in Ovarian Cancer. Current molecular medicine. 2025-01-08. PMID:39773049. |
elevated levels of this mirna are associated with the induction of apoptosis and the inhibition of oc cell proliferation by targeting various signaling pathways, including notch1, p21/p53, stat3, and bcl2 in oc. |
2025-01-08 |
2025-01-13 |
Not clear |
| Kumaresan Priyanka, Jilnasree Naduvile Purayil, Kathirvel Preeth. Valorization of pineapple (ANANAS comosus) peel waste for levan production: Assessment of biological activities. International journal of biological macromolecules. 2025-01-08. PMID:39778827. |
anticancerous activity of levan towards mda-mb-231 cell line was apparent with the down regulation of the anti-apoptotic gene bcl2 and upregulation the apoptosis genes comparable to cisplatin. |
2025-01-08 |
2025-01-13 |
Not clear |
| Dandan Gao, Yang Lv, Fei Hong, Dong Wu, Ting Wang, Gongzhizi Gao, Zujie Lin, Ruoyu Yang, Jinsong Hu, Aili He, Pengyu Zhan. Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma. Scientific reports. vol 15. issue 1. 2025-01-03. PMID:39747460. |
then, the expression of bax and bcl2 was imbalance, and the cascade cleavage of parp and caspase 3 was increased, ultimately triggering cell apoptosis. |
2025-01-03 |
2025-01-05 |
mouse |
| Ru Guo, Youjuan Wu, Tingting Yu, Chen Guo, Zijia Yin, Guannan Zhao, Meifeng Li, Huiling Mao, Chengyu Hu, Xiaowen X. Tetrachlorantraniliprole induces neurodevelopmental toxicity through oxidative stress-mediated apoptosis and dysregulation of Wnt signaling pathway. Aquatic toxicology (Amsterdam, Netherlands). vol 279. 2025-01-01. PMID:39742649. |
furthermore, tctp induced brain cells apoptosis, as evidenced by the upregulation of pro-apoptotic genes (bax, p53, tnfα, caspase3 and caspase9) and the downregulation of anti-apoptotic gene (bcl2). |
2025-01-01 |
2025-01-04 |
human |
| Mi Il Kim, Choongho Le. Identification of virus-rich intermediate cells as crucial players in SARS-CoV-2 infection and differentiation dynamics of human airway epithelium. Frontiers in microbiology. vol 15. 2024-12-30. PMID:39735182. |
these vri cells exhibited high viral loads at all infection time points, strong interferon and inflammatory responses, increased mrna expression of microvilli-related genes (pak1, pak4, vil1), and suppression of apoptosis markers (bax, casp3) alongside increased anti-apoptotic gene expression (bcl2). |
2024-12-30 |
2025-01-01 |
human |
| T R Nasibullin, V V Erdman, Y R Timasheva, I A Tuktarova, A A Petinseva, G F Korytin. Polymorphic variants of the genes for enzymes of the antioxidant system, apoptosis and inflammation as potential predictors of myocardial infarction. Vavilovskii zhurnal genetiki i selektsii. vol 28. issue 7. 2024-12-26. PMID:39722671. |
the purpose of the study was to search for informative predictors of mi risk based on polygenic analysis of polymorphic variants of (1) the antioxidant defense enzyme genes pon1 (rs662), pon2 (rs7493), cat (rs1001179), msra (rs10098474) and gstp1 (rs1695); (2) the apoptosis genes casp8 (rs3834129), tp53 (rs1042522) and bcl2 (rs12454712); and (3) the inflammation genes crp (rs1205), cx3cr1 (rs3732378), il6 (rs1800795) and ccl2 (rs1024611). |
2024-12-26 |
2024-12-29 |
human |
| Manal Mohammad Morsy, Heba A Hassan, Reham M Morsi, Ola Elsayed Nafea, Azza I Farag, Rania Saad Ramada. Alogliptin attenuates testicular damage induced by monosodium glutamate in both juvenile and adult male rats by activating autophagy: ROS Dependent AMPK/mTOR. Reproductive toxicology (Elmsford, N.Y.). 2024-12-26. PMID:39725177. |
additionally, alo impeded apoptosis and activated autophagy by decreasing caspase-3 activity, stimulating the ampk/mtor pathway, downregulating bax and sqstm-1/p62 expression, upregulating bcl2 and beclin 1, promoting testicular proliferation (increased number of proliferating cell nuclear antigen-positive cells in the testis), restoring glycogen content in the testis (mild to moderate periodic acid-schiff reaction), and preserving testicular architecture. |
2024-12-26 |
2024-12-29 |
rat |
| Haiming Li, Bin Chen, Zhelin Chen, Jianming Luo, Binyuan Yan. Overexpression of Growth Differentiation Factor 15 Reduces Neuronal Cell Damage Induced by Oxygen-Glucose Deprivation/Reoxygenation via Inhibiting Endoplasmic Reticulum Stress-Mediated Ferroptosis. Developmental neurobiology. vol 85. issue 1. 2024-12-23. PMID:39711090. |
flow cytometry and western blotting results showed that gdf15 overexpression significantly reduced cell apoptosis, reduced caspase3 activity, and regulated the expression of bcl2 and bax. |
2024-12-23 |
2024-12-25 |
Not clear |
| Benjamin Loos, Adrian Salas-Bastos, Anna Nordin, Julien Debbache, Salome Stierli, Phil F Cheng, Stefanie Rufli, Conrad Wyss, Mitchell P Levesque, Reinhard Dummer, Wendy Wei-Lynn Wong, Steve Pascolo, Claudio Cantù, Lukas Somme. TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis. Cell death & disease. vol 15. issue 12. 2024-12-21. PMID:39709491. |
functional validation of signature members highlighted a central role of the pro-apoptotic bcl2 family member bcl2l11 (bim) in mediating apoptosis in this condition. |
2024-12-21 |
2024-12-24 |
human |
| Wenjing Qin, Changliang Peng, Xianhe Yang, Alan Jiang, Nanshan Zhong, Yunyun Liu, Xiaochun Zhang, Angela C Hirbe, Mei Ma, Xin Yu. SS18-SSX drives TYK2 expression to activate STAT3/Bcl2 axis, facilitating apoptosis evasion and advancing synovial sarcoma progression. Cell biology and toxicology. vol 41. issue 1. 2024-12-20. PMID:39707021. |
inhibition of stat3 activation using specific inhibitors can disrupt the tyk2-enhanced expression of bcl2, indicating that the tyk2/stat3/bcl2 axis is a key regulatory pathway mediating apoptosis evasion in ss. |
2024-12-20 |
2024-12-24 |
Not clear |
| Chunli Ma, Yixiao Li, Baoling Liu, Junjie Deng, Xue Gao, Huixin Zhang, Bingqiang Zhang, Qihui Zhou, Xiaoting Peng, Han Zhan. Exosomes derived from adipose mesenchymal stem cells promote corneal injury repair and inhibit the formation of scars by anti-apoptosis. Colloids and surfaces. B, Biointerfaces. vol 247. 2024-12-15. PMID:39675062. |
this effect was attributed to their ability to inhibit apoptosis of corneal stroma cells by upregulating bax and downregulating bcl2, reducing the bax/bcl2 protein expression ratio from 1 to 0.45. |
2024-12-15 |
2024-12-21 |
Not clear |
| Sutanu Nandi, Yuehua Zhu, Lucas A Gillenwater, Marc Subirana-Granés, Haoyu Zhang, Negar Janani, Casey Greene, Milton Pividori, Maria Chikina, James C Costell. A Pathway-Level Information ExtractoR (PLIER) framework to gain mechanistic insights into obesity in Down syndrome. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. vol 30. 2024-12-13. PMID:39670386. |
notably, lvs involving glutathione peroxidase-1 (gpx1) and mcl1 apoptosis regulator, bcl2 family members emerged as crucial mediators. |
2024-12-13 |
2024-12-22 |
human |
| Xiaoqiang Wang, Chao Song, Daqian Zhou, Yongliang Mei, Weiye Cai, Rui Chen, Jiale Lv, Houyin Shi, Zongchao Li. Exploring the therapeutic potential of puerarin on intervertebral disc degeneration by regulating apoptosis of nucleus pulposus cells. JOR spine. vol 7. issue 4. 2024-12-12. PMID:39664589. |
analysis exposes aberrant expression of pivotal apoptosis-associated proteins (il-1β, tnf-α, casp3, casp8, and bcl2) in ivdd patients, with network pharmacology indicating puerarin's potential efficacy in ivdd treatment by modulating apoptosis and cellular senescence pathways. |
2024-12-12 |
2024-12-14 |
Not clear |