| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zixi Song, Mingxu Jiang, Mengya Wang, Jiahong Zou, Zhenwei Chen, Feifei Zheng, Qingchao Wan. MAPK pathways regulated apoptosis and pyroptosis in respiratory epithelial cells of a primitive vertebrate model during bacterial infection. International journal of biological macromolecules. 2024-12-11. PMID:39662566. |
moreover, p38 mapk inhibition significantly decreased the f. columnare infection-induced apoptosis of rtgill-w1 cell via affecting bcl2 protein expression and mitochondrial membrane potential. |
2024-12-11 |
2024-12-14 |
human |
| Eugen Tausch, Christof Schneider, Stephan Stilgenbaue. Risk-stratification in frontline CLL therapy: standard of care. Hematology. American Society of Hematology. Education Program. vol 2024. issue 1. 2024-12-07. PMID:39644006. |
agents focusing on b-cell receptor (in particular bruton tyrosine kinase [btk]) and apoptosis (bcl2) targets have replaced chemoimmunotherapy (cit) as the treatment standard. |
2024-12-07 |
2024-12-10 |
Not clear |
| Harshvardhan Raval, Sankha Bhattacharya, Darshan Bhirud, Preeti Chidambar Sangave, Girdhari Lal Gupta, Gaurav Paraskar, Megha Jha, Satyam Sharma, Sateesh Belemkar, Devendra Kumar, Rahul Maheshwar. Fabrication of lactoferrin-chitosan-etoposide nanoparticles with melatonin via carbodiimide coupling: In-vitro & in-vivo evaluation for colon cancer. Journal of controlled release : official journal of the Controlled Release Society. 2024-12-05. PMID:39637989. |
the nanoparticles exhibited significant cytotoxicity in hct116 cells (ic50 = 15.32 μg/ml), inducing ros generation, apoptosis, and g2/m cell cycle arrest, with notable downregulation of bcl2 gene expression. |
2024-12-05 |
2024-12-08 |
rat |
| Sai Xiao, Ke Peng, Rui Chen, Xinxin Liu, Benliang Zhou, Rijing He, Yujun Yan, Runtian Wan, Ye-Shi Yin, Shengsheng Lu, Xingwei Lian. Equol promotes the in vitro maturation of porcine oocytes by activating the NRF2/KEAP1 signaling pathway. Theriogenology. vol 233. 2024-11-28. PMID:39608307. |
equol also reduced dna damage and early apoptosis, with an associated upregulation of bcl2 and downregulation of bax expression. |
2024-11-28 |
2024-12-01 |
cat |
| Lu Li, Wan Li, Yufeng Liu, Bing Han, Yanbo Yu, Hongjin Li. MEHP induced mitochondrial damage by promoting ROS production in CIK cells, leading to apoptosis, autophagy, cell cycle arrest. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-11-25. PMID:39586385. |
in addition, mehp treatment not only can increase the level of cyt-c, atg12, atg13, atg14, beclin1, ulk1, lc3-ii, caspase3, caspase9, and bax, but also can decrease the level of bcl2, p62, cyclinb, cyclind, and cycline in a concentration-dependent manner, which resulted in apoptosis, autophagy and cell cycle arrest. |
2024-11-25 |
2024-11-28 |
Not clear |
| Shifa Khaja Saleem, Sarah Decker, Sandra Kissel, Marcus Bauer, Dmitry Chernyakov, Daniela Bräuer-Hartmann, Konrad Aumann, Claudia Wickenhauser, Marco Herling, Oleksandra Skorobohatko, Nimitha Mathew, Cornelius Schmidt, Claudius Klein, Marie Follo, Christine Dierk. JNK1 inhibitors target distal B cell receptor signaling and overcome BTK-inhibitor resistance in CLL. The Journal of experimental medicine. vol 222. issue 1. 2024-11-21. PMID:39570282. |
jnk1 inhibition induced apoptosis in primary cll cells, resulting in the downregulation of bcl2, mcl1, and c-jun. |
2024-11-21 |
2024-11-23 |
mouse |
| Zijia Yin, Hongying Zhang, Kaiwen Zhao, Yulong Liu, Ru Guo, Pengxia Xu, Guannan Zhao, Menglei Hu, Chengyu Hu, Xiaowen X. Zebrafish FKBP5 facilitates apoptosis and SVCV propagation by suppressing NF-κB signaling pathway. Fish & shellfish immunology. 2024-11-13. PMID:39537119. |
finally, drfkbp5 activated the expression of apoptosis-related genes, including bax, bcl2, caspase-3 and induced apoptosis under svcv treatment. |
2024-11-13 |
2024-11-17 |
zebrafish |
| Xin-Xin Hu, Ying-Chuan Yin, Peng Xu, Min Wei, Wang Zhan. Network toxicology and cell experiments reveal the mechanism of DEHP-induced diabetic nephropathy via Wnt signaling pathway. Toxicology and applied pharmacology. vol 493. 2024-11-09. PMID:39515621. |
mouse glomerular podocytes (mpc-5) exposed to graded concentrations of dehp, with or without the wnt pathway inhibitor xav-939, displayed significant dehp-induced disruptions: reduced cell adhesion, proliferation, and differentiation; increased autophagy, apoptosis, and migratory activity; elevated inflammatory mediator release; and pronounced activation of the wnt signaling pathway, evidenced by upregulation of β-catenin, egfr, tnf, ccnd1, bcl2 and downregulation of casp3. |
2024-11-09 |
2024-11-17 |
mouse |
| Julia Ayumi Ikeda Kawasaki, Lais Capelasso Lucas Pinheiro, Isabely Mayara da Silva, Carlos Alberto Miqueloto, Karen Brajão de Oliveira, Diego Luís Ribeiro, Alda Fiorina Maria Losi Guembarovski, Fernando Terziotti, Wilner Martinez-López, Juliana Mara Serpeloni, Roberta Losi Guembarovsk. BCL-2 and γ-H2AX immunostaining profile in urothelial bladder cancer prognosis. Pathology, research and practice. vol 264. 2024-11-03. PMID:39488989. |
it is known that the bcl2 apoptosis regulator (bcl-2) gene encodes a mitochondrial protein that regulates programmed death cells by apoptosis. |
2024-11-03 |
2024-11-06 |
Not clear |
| Chuang-Yu Lin, Wen-Chen Liang, Yi-Chen Yu, Shin-Cheng Chang, Ming-Chi Lai, Yuh-Jyh Jon. ETFDH mutation involves excessive apoptosis and neurite outgrowth defect via Bcl2 pathway. Scientific reports. vol 14. issue 1. 2024-10-25. PMID:39455656. |
etfdh mutation involves excessive apoptosis and neurite outgrowth defect via bcl2 pathway. |
2024-10-25 |
2024-10-29 |
Not clear |
| Sreejata Kamila, Koushik Kumar Dey, Ansuman Chattopadhya. Arsenic and Chromium Induced Toxicity on Zebrafish Kidney: Mixture Effects on Oxidative Stress and Involvement of Nrf2-Keap1-ARE, DNA Repair, and Intrinsic Apoptotic Pathways. Journal of applied toxicology : JAT. 2024-10-15. PMID:39402722. |
expressional alteration in bax, bcl2, caspase9, and caspase 3 indicated apoptosis (intrinsic pathway) induction, which was maximum in combined group. |
2024-10-15 |
2024-10-17 |
zebrafish |
| Xiaofeng Zhao, Yunhong Yang, Qiuyue Xie, Jiahan Qiu, Xiaofeng Su. Identification of Biomarkers and Mechanisms Associated with Apoptosis in Recurrent Pregnancy Loss. Biochemical genetics. 2024-10-14. PMID:39400681. |
we identified six differentially expressed genes related to apoptosis, including ctsz, bcl2, pik3cd, kras, gadd45g, and casp8, with gadd45g as the most gene. |
2024-10-14 |
2024-10-16 |
Not clear |
| Yunze Li, Xin Sun, Zhe Huan. USP7 facilitates deubiquitination of LRRC42 in colorectal cancer to accelerate tumorigenesis and augment Wnt/β-catenin signaling. Biochimica et biophysica acta. Molecular cell research. 2024-10-11. PMID:39393471. |
silencing lrrc42 suppressed cell proliferation, induced g0/g1 phase arrest, and promoted apoptosis by reducing bcl2 expression while elevating the expression of bax, cleaved parp and cleaved caspase 3. |
2024-10-11 |
2024-10-14 |
Not clear |
| Xiumei Bai, Yabin Song, Xiangyan Zhang, Liqiong Liu, Haixia Wu, Jiaqing Feng, Lihong Wu, Huizhen Liu, Diangui Zho. Curcumin ameliorates ischemic stroke injury by downregulating GMFB expression: An Biomolecules & biomedicine. 2024-10-10. PMID:39388704. |
gmfb overexpression promoted ogd/r-induced cell viability diminution, increased ldh and ros levels, lessened cell invasion ability, enhanced cell apoptosis, enhanced bax levels, and decreased bcl2 levels. |
2024-10-10 |
2024-10-13 |
Not clear |
| Hong Chen, Jameel Ahmed Buzdar, Roshan Riaz, Dalia Fouad, Nisar Ahmed, Qurban Ali Shah, Shulin Che. Bovine lactoferrin alleviates aflatoxin B1 induced hepatic and renal injury in broilers by mediating Nrf2 signaling pathway. Poultry science. vol 103. issue 12. 2024-10-09. PMID:39383667. |
whereas, mrna level of mitochondrial apoptosis related gene including bcl-2 (bak and bax), caspase-3 and caspase-9 was upregulated, while bcl2 gene were downregulated in afb1 group. |
2024-10-09 |
2024-10-12 |
chicken |
| Yichi Xu, Xiaoli Qin, Weihong Zeng, Fan Wu, Xiaowei Wei, Qian Li, Yi Li. DOCK1 deficiency drives placental trophoblast cell dysfunction by influencing inflammation and oxidative stress, hallmarks of preeclampsia. Hypertension research : official journal of the Japanese Society of Hypertension. 2024-10-08. PMID:39379467. |
moreover, dock1 knockout amplified apoptosis, as indicated by an altered bcl2: bax ratio and enhanced levels of cleaved parp. |
2024-10-08 |
2024-10-11 |
mouse |
| Rahul V G, Govindaraj Ellur, Amir A Gaber, Prem Kumar Govindappa, John C Elfa. 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury in mice. Cell death discovery. vol 10. issue 1. 2024-10-04. PMID:39366954. |
4-ap attenuated apoptosis, with decreases in apoptotic markers bax, caspase-9, and caspase-3 and increases in anti-apoptotic markers bcl2 and bcl-xl. |
2024-10-04 |
2024-10-07 |
mouse |
| Mohammad Yousefi Zardak, Fatemeh Keshavarz, Ali Mahyaei, Morteza Gholami, Fatemeh Sadat Moosavi, Elham Abbasloo, Farzaneh Abdollahi, Maryam Hossein Rezaei, Elham Madadizadeh, Nasrin Soltani, Fatemeh Bejeshk, Niyan Salehi, Fahimeh Rostamabadi, Fatemeh Bagheri, Mahla Jafaraghae, Mahdiyeh Ranjbar Zeydabadi, Meraj Baghgoli, Gholamreza Sepehri, Mohammad Abbas Bejesh. Quercetin as a therapeutic agent activate the Nrf2/Keap1 pathway to alleviate lung ischemia-reperfusion injury. Scientific reports. vol 14. issue 1. 2024-10-04. PMID:39367100. |
furthermore, we examined markers related to inflammation (interleukin-1β and tumor necrosis factor alpha), oxidative stress (malondialdehyde, total oxidant status, superoxide dismutase, glutathione peroxidase, total antioxidant capacity), lung edema (wet/dry lung weight ratio and total protein concentration), apoptosis (bax and bcl2 protein), and histopathological alterations (intra-alveolar edema, alveolar hemorrhage, and neutrophil infiltration). |
2024-10-04 |
2024-10-07 |
rat |
| Juie Nahushkumar Rana, Sohail Mumtaz, Ihn Han, Eun Ha Cho. Harnessing the synergy of nanosecond high-power microwave pulses and cisplatin to increase the induction of apoptosis in cancer cells through the activation of ATR/ATM and intrinsic pathways. Free radical biology & medicine. 2024-10-03. PMID:39362289. |
additionally, upregulation of atr/atm, chk1/chk2, p53, and caspase 3/8, bax, parp, and bcl2 confirms dna damage and mitochondrial dysfunction, leading to apoptosis. |
2024-10-03 |
2024-10-07 |
Not clear |
| Weihua Chen, Xin Liu, Ziping Zhang, Yadong Yua. Sinomenine Hydrochloride Regulates the Apoptosis of Endothelial Cells through PPAR-γ to Alleviate PAH. International heart journal. vol 65. issue 5. 2024-09-29. PMID:39343596. |
it reversed the expression of bcl2 and bax and prevented the apoptosis of endothelial cells. |
2024-09-29 |
2024-10-02 |
rat |