| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akashi Sharma, Aatifa Zehra, Sam J Mathe. Myosin heavy chain-perinatal regulates skeletal muscle differentiation, oxidative phenotype and regeneration. The FEBS journal. 2024-02-15. PMID:38358038. |
paracrine signals mediate the effect of loss of myhc-perinatal function on myogenic differentiation, possibly mediated by non-apoptotic caspase-3 signaling along with enhanced levels of the pro-survival apoptosis regulator bcl2 and nuclear factor kappa-b (nf-κb). |
2024-02-15 |
2024-02-17 |
Not clear |
| Stefano Pagano, Chiara Valenti, Paolo Negri, Monia Billi, Alessandro Di Michele, Stefano Bruscoli, Marta Febo, Maddalena Coniglio, Lorella Marinucc. Acute and chronic cannabidiol treatment: In vitro toxicological aspects on human oral cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-02-11. PMID:38342230. |
viability, morphology, migration, apoptosis and cell cycle, and expression of related genes (p53, bcl2, p21, and bax) and of endocannabinoid system receptors (cb1, cb2 and gpr55) with real-time pcr and dna damage with phospho-γ-h2ax immunofluorescence detection were analyzed. |
2024-02-11 |
2024-02-14 |
human |
| Ribrio Ivan Tavares Pereira Batista, Jenniffer Hauschildt Dias, Joedson Dantas Gonçalves, Gabriel Brun Vergani, Maria Emilia Franco Oliveira, Joanna Maria Gonçalves Souza-Fabjan, Jeferson Ferreira Fonsec. The presence of estradiol benzoate in the cervical relaxation treatment for non-surgical embryo collection does not impair embryonic morphological quality, cryosurvival, and gene expression profile. Theriogenology. vol 218. 2024-02-09. PMID:38335708. |
additionally, the presence of eb did not affect (p > 0.05) the embryo's morphological quality, the development dynamics, or the abundance of transcripts associated with embryonic quality (oct4 and nanog), cellular stress (hsp90 and prdx1), and apoptosis (bcl2 and bax). |
2024-02-09 |
2024-02-12 |
Not clear |
| Barbora Loncová, Zuzana Fabová, Vladimíra Mondočková, Radoslav Omelka, Abdel Halim Harrath, Alexander V Sirotki. Inhibition of vinculin activity has an adverse effect on porcine ovarian cells. Experimental cell research. 2024-02-03. PMID:38309674. |
the expression of vcl, accumulation of vcl protein, cell viability, proliferation (accumulation of pcna and cyclin b1), proportion of proliferative active cells, apoptosis (accumulation of bax, caspase 3, p53, antiapoptotic marker bcl2, and bax/bcl-2 ratio), dna fragmentation, and release of steroid hormones and igf-i were analyzed by rt‒qpcr, trypan blue exclusion test, quantitative immunocytochemistry, xtt assay, tunel assay, and elisa. |
2024-02-03 |
2024-02-06 |
Not clear |
| Xueying Ma, Xu Han, Wenwen Wang, Qin Zhang, Hui Tan. β-Catenin regulates ovarian granulosa cell cycle and proliferation in laying hens by interacting with TCF4. Poultry science. vol 103. issue 3. 2024-02-01. PMID:38301496. |
ctnnb1 did not however affect apoptosis or the expression of related genes baculoviral iap repeat containing 5 (birc5) and bcl2 apoptosis regulator (bcl-2). |
2024-02-01 |
2024-02-04 |
Not clear |
| Esmaeel Babaeenezhad, Omid Dezfoulian, Mostafa Moradi Sarabi, Hassan Ahmadvan. Monoterpene linalool restrains gentamicin-mediated acute kidney injury in rats by subsiding oxidative stress, apoptosis, and the NF-κB/iNOS/TNF-α/IL-1β pathway and regulating TGF-β. Naunyn-Schmiedeberg's archives of pharmacology. 2024-01-31. PMID:38294506. |
interestingly, lin repressed gm-induced apoptosis, as reflected by a marked downregulation of bax and caspase-3 expression, concurrent with the upregulation of bcl2 expression. |
2024-01-31 |
2024-02-02 |
rat |
| Dwaipayan Bhattacharya, Madhu Rani Bharati, Kalyani Sakhare, Piyush Khandelia, Rajkumar Banerjee, Kumar Pranav Naraya. Steroid hormone receptor based gene delivery systems as potential oral cancer therapeutics. Biomedical materials (Bristol, England). 2024-01-30. PMID:38290150. |
transfection of oscc cells with exogenous, anticancer gene p53 lipoplexed with crude saponin-based liposome induced apoptosis of cancer cells via regulation of bax and bcl2 protein levels at levels comparable with pre-established delivery systems based on synthetic shr ligands. |
2024-01-30 |
2024-02-02 |
human |
| Fares E M Ali, Khalid S A Badran, Mohammad A Baraka, Hanan S Althagafy, Emad H M Hassanei. Mechanism and impact of heavy metal-aluminum (Al) toxicity on male reproduction: Therapeutic approaches with some phytochemicals. Life sciences. 2024-01-29. PMID:38286208. |
additionally, substantial evidence concluded the key role of apoptosis in al-induced testicular toxicity mediated by upregulating caspase-3 and downregulating bcl2 protein. |
2024-01-29 |
2024-02-01 |
human |
| Oluwadunni E Emiloju, Jun Yin, Emily Koubek, Joel M Reid, Mitesh J Borad, Yanyan Lou, Mahesh Seetharam, Martin J Edelman, Edward A Sausville, Yixing Jiang, Ahmed O Kaseb, James A Posey, Sarah L Davis, Gregory J Gores, Lewis R Roberts, Naoko Takebe, Gary K Schwartz, Andrea E Wahner Hendrickson, Scott H Kaufmann, Alex A Adjei, Joleen M Hubbard, Brian A Costell. Phase 1 trial of navitoclax and sorafenib in patients with relapsed or refractory solid tumors with hepatocellular carcinoma expansion cohort. Investigational new drugs. 2024-01-25. PMID:38270822. |
navitoclax (abt-263) is an oral bcl2 homology-3 mimetic that binds with high affinity to pro-survival bcl2 proteins, resulting in apoptosis. |
2024-01-25 |
2024-01-27 |
Not clear |
| Sergey Shityakov, Viacheslav Kravtsov, Ekaterina V Skorb, Michael Nosonovsk. Ergodicity Breaking and Self-Destruction of Cancer Cells by Induced Genome Chaos. Entropy (Basel, Switzerland). vol 26. issue 1. 2024-01-22. PMID:38248163. |
clones with frequency above 10% result in cell apoptosis, possibly due to mutations in the bcl2 gene. |
2024-01-22 |
2024-01-24 |
rat |
| Chao Jiang, Jiupan Zhang, Yaping Song, Xiaoyu Song, Hao Wu, Ruopu Jiao, Lanlan Li, Guijie Zhang, Dawei We. FOXO1 regulates bovine skeletal muscle cells differentiation by targeting MYH3. International journal of biological macromolecules. 2024-01-22. PMID:38253149. |
besides, interfering with foxo1 inhibited the apoptosis of bsmcs by up-regulating the expression of anti-apoptosis gene bcl2, while simultaneously down-regulating the expression of the pro-apoptosis genes bad and bax. |
2024-01-22 |
2024-01-25 |
cattle |
| Fawziya A R Ibrahim, Neveen A Hussein, Aisha Y M Soliman, Thanaa I Shalaby, Mona M Rashad, Noura A Matar, Tarek S El-Sewed. Chitosan-loaded piperlongumine nanoparticles and kaempferol enhance the anti-cancer action of doxorubicin in targeting of Ehrlich solid adenocarcinoma: in vivo and in silico modeling study. Medical oncology (Northwood, London, England). vol 41. issue 2. 2024-01-22. PMID:38253759. |
despite receiving half of the overall dose compared to the free drugs, the combined doxorubicin/ piperlongumine-chitosan nanoparticles treatment was the most efficient in reducing tumor volume; down-regulating cyclin d1, and bcl2; as well as the beclin-1, and cyclophilin a genes modulating growth, apoptosis, autophagy, and metastasis, respectively; up-regulating the glutathione peroxidase expression as a defense mechanism protecting from oxidative damage. |
2024-01-22 |
2024-01-25 |
mouse |
| Borgohain Anima, Guruswami Gurusubramanian, Vikas Kumar Ro. Possible role of apelin on the ovarian steroidogenesis and uterine apoptosis of infantile mice: An in vitro study. The Journal of steroid biochemistry and molecular biology. 2024-01-21. PMID:38246202. |
the decreased bcl2 and increased active caspase3 by ml221 suggest the suppressive role of apelin on ovarian apoptosis. |
2024-01-21 |
2024-01-24 |
mouse |
| Mojtaba Moradi, Mohammad Arshia Hashemian, Azita Faramarzi, Nader Goodarzi, Amir Hossein Hashemian, Hadi Cheraghi, Cyrus Jalil. Therapeutic effect of sodium alginate on bleomycin, etoposide and cisplatin (BEP)-induced reproductive toxicity by inhibiting nitro-oxidative stress, inflammation and apoptosis. Scientific reports. vol 14. issue 1. 2024-01-18. PMID:38238398. |
further, modifications to the expression of bcl2, bax, caspase3, p53, and tnf-α suggested that naal alleviated bep-induced apoptosis and inflammation. |
2024-01-18 |
2024-01-21 |
rat |
| Jiuyang Liu, Shuran Li, Qin Wang, Yingcai Feng, Haimei Xing, Xeufei Yang, Ying Guo, Yunhang Guo, Hanzi Sun, Xiaoxin Liu, Shasha Yang, Zhu Mei, Yutong Zhu, Zhenzhen Cheng, Shuaishuai Chen, Min Xu, Wenjing Zhang, Nanyan Wan, Jia Wang, Yanwen Ma, Shuo Zhang, Xudong Luan, Aiying Xu, Lin Li, Haitao Wang, Xiaolong Yang, Yuan Hong, Hai Xue, Xi Yuan, Nan Hu, Xiaomin Song, Zhiwei Wang, Xuesong Liu, Lai Wang, Ye Li. Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood. 2024-01-11. PMID:38211332. |
venetoclax, the first-generation inhibitor of the apoptosis regulator b-cell lymphoma 2 (bcl2), disrupts the interaction between bcl2 and pro-apoptotic proteins, promoting the apoptosis in malignant cells. |
2024-01-11 |
2024-01-14 |
Not clear |
| Peng Hui, Xianrui Zheng, Jiao Dong, Fan Lu, Chao Xu, Huan Qu, Xiaoyang Zhu, Yoshinobu Uemoto, Xiaoyang Lv, Zongjun Yin, Wei Sun, Wenbin Bao, Haifei Wan. Metabolomics and Transcriptomics Analyses of Curcumin Alleviation of Ochratoxin A-Induced Hepatotoxicity. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203339. |
further mechanistical analyses revealed that pa can downregulate the expression level of proapoptotic protein bax, enhance the expression level of apoptosis inhibitory protein bcl2, and decrease the level of phosphorylated extracellular signal-regulated kinase 1/2 (perk1/2). |
2024-01-11 |
2024-01-13 |
mouse |
| Dhaval Dixit, Victoria M Hallisey, Ethan Ys Zhu, Martyna Okuniewska, Ken Cadwell, Jerry E Chipuk, Jordan E Axelrad, Susan R Schwa. S1PR1 inhibition induces pro-apoptotic signaling in T cells and limits humoral responses within lymph nodes. The Journal of clinical investigation. 2024-01-09. PMID:38194271. |
we found that s1pr1 limited apoptosis by maintaining the appropriate balance of bcl2 family members via restraint of jnk activity. |
2024-01-09 |
2024-01-10 |
mouse |
| Chun Yin Yu, Tsz Kwan Yeung, Wai Kuen Fu, Randy Y C Poo. BCL-XL regulates the timing of mitotic apoptosis independently of BCL2 and MCL1 compensation. Cell death & disease. vol 15. issue 1. 2024-01-03. PMID:38172496. |
bcl-xl regulates the timing of mitotic apoptosis independently of bcl2 and mcl1 compensation. |
2024-01-03 |
2024-01-06 |
Not clear |
| Chun Yin Yu, Tsz Kwan Yeung, Wai Kuen Fu, Randy Y C Poo. BCL-XL regulates the timing of mitotic apoptosis independently of BCL2 and MCL1 compensation. Cell death & disease. vol 15. issue 1. 2024-01-03. PMID:38172496. |
our results show that in epithelial cell lines including hela and rpe1, bcl-xl and bcl2 acted collaboratively to suppress apoptosis during both unperturbed cell cycle and mitotic arrest. |
2024-01-03 |
2024-01-06 |
Not clear |
| Lin Li, Liuyan Xin, Xiang Yang, Zhengrong Zo. Oncogenic lncRNA FAM215A promotes the malignant cell phenotypes of acute myeloid leukemia (AML) cell lines. Journal of molecular histology. 2024-01-02. PMID:38165572. |
fam215a knockdown inhibited aml cell viability, elicited g0/g1-phase arrest of cell cycle, enhanced cell apoptosis, increased proapoptotic bax and cleaved-caspase3 levels, and decreased antiapoptotic bcl2. |
2024-01-02 |
2024-01-10 |
Not clear |