| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenhao He, Jinji Lin, Feifei Yu, Yang Leng, Zhenni Pan, Qiwen Liang, Siying Liu, Xinyue Huan. Identification and function analysis of BCL2 in immune response of Pteria Penguin. Fish & shellfish immunology. 2024-05-01. PMID:38692379. |
b-cell lymphoma/leukemia-2 (bcl2), an anti-apoptotic factor in the mitochondrial regulatory pathway of apoptosis, is critically important in immune defenses. |
2024-05-01 |
2024-05-04 |
Not clear |
| Mengxue Zeng, Kun Wang, Qingcui Wu, Jingjin Ding, Dan Xie, Xiangbing Qi, Feng Sha. Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation. Protein & cell. 2024-04-27. PMID:38676703. |
here we conducted an unbiased genome-wide genetic screen and identified that the bcl2 family protein bid is required for piddosome-induced, caspase-2-mediated apoptosis. |
2024-04-27 |
2024-04-30 |
mouse |
| Elena P Khashchenko, Mikhail Yu Vysokikh, Maria V Marey, Ksenia O Sidorova, Ludmila A Manukhova, Natalya N Shkavro, Elena V Uvarova, Vladimir D Chuprynin, Timur Kh Fatkhudinov, Leila V Adamyan, Gennady T Sukhik. Altered Glycolysis, Mitochondrial Biogenesis, Autophagy and Apoptosis in Peritoneal Endometriosis in Adolescents. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673823. |
samples of plasma and peritoneal fluid exosomes, endometrioid foci and non-affected peritoneum were tested for estrogen receptor (erα/β), hexokinase (hex2), pyruvate dehydrogenase kinase (pdk1), glucose transporter (glut1), monocarboxylate transporters (mct1 and mct2), optic atrophy 1 (opa1, mitochondrial fusion protein), dynamin-related protein 1 (drp1, mitochondrial fission protein), bax, bcl2, beclin1, bnip3, p38 mitogen-activated protein kinase (mapk), hypoxia-inducible factor 1 (hif-1α), mitochondrial voltage-dependent anion channel (vdac) and transforming growth factor (tgfβ) proteins as markers of estrogen signaling, glycolysis rates, mitochondrial biogenesis and damage, apoptosis and autophagy (western-blot and pcr). |
2024-04-27 |
2024-04-29 |
Not clear |
| Katja Seipel, Harpreet Mandhair, Ulrike Bacher, Thomas Pabs. FLT3 and IRAK4 Inhibitor Emavusertib in Combination with BH3-Mimetics in the Treatment of Acute Myeloid Leukemia. Current issues in molecular biology. vol 46. issue 4. 2024-04-26. PMID:38666914. |
the flt3 and irak4 inhibitor emavusertib (ca4948), the mcl1 inhibitor s63845, the bcl2 inhibitor venetoclax, and the hsp90 inhibitor pu-h71 were assessed as single agents and in combination for their ability to induce apoptosis and cell death in leukemic cells in vitro. |
2024-04-26 |
2024-04-28 |
Not clear |
| Qiulu Li, Kaixin Ping, Yannan Xiang, YingSun, Zunhan Hu, Shujuan Liu, Xinying Guan, Mian F. Ferulic acid alleviates avermectin induced renal injury in carp by inhibiting inflammation, oxidative stress and apoptosis. Fish & shellfish immunology. 2024-04-25. PMID:38663463. |
at the same time, fa inhibited the apoptosis of renal cells induced by avm by decreasing the transcription level and protein expression level of bax, and increasing the transcription level and protein expression level of bcl2, pi3k and akt. |
2024-04-25 |
2024-04-28 |
cat |
| Firas Khathayer, Mohammed Mikae. Mocetinostat as a novel selective histone deacetylase (HDAC) inhibitor in the promotion of apoptosis in glioblastoma cell line C6 and T98G. Research square. 2024-04-22. PMID:38645087. |
the high doses of mocetinostat drug significantly induce apoptosis and suppress cancer cell proliferation through increased pro-apoptotic proteins (bax) and a down level of anti-apoptotic proteins(bid, bcl2). |
2024-04-22 |
2024-04-24 |
Not clear |
| Lu Zhang, Ying Liu, Qiongyi Zhang, Weiyu Yao, Zenghui Zhao, Xiao Wang, Yongzhan Bao, Wanyu Sh. Salvia miltiorrhiza polysaccharide mitigates AFB1-induced liver injury in rabbits. Ecotoxicology and environmental safety. vol 276. 2024-04-18. PMID:38636259. |
moreover, smp upregulated the expression of nuclear factor e2 related factor 2 (nrf2), heme oxygenase 1 (ho-1), nadph quinone oxidoreductase 1 (nqo1) and b-cell lymphoma 2 (bcl2) while downregulating kelch like ech associated protein 1 (keap1), cytochrome c (cyt.c), caspase9, caspase3, and bcl-2-associated x protein (bax) expression, thereby inhibiting afb1-induced hepatocyte apoptosis. |
2024-04-18 |
2024-04-21 |
cat |
| Wenjie Xie, Juntao Chen, Xiaoqian Cao, Jiannan Zhang, Juanjuan Luo, Yajun Wan. Roxithromycin exposure induces motoneuron malformation and behavioral deficits of zebrafish by interfering with the differentiation of motor neuron progenitor cells. Ecotoxicology and environmental safety. vol 276. 2024-04-16. PMID:38626605. |
concurrently, abnormal apoptosis in rox-exposed zebrafish embryos intensified alongside the upregulation of apoptosis-related genes (bax, bcl2, caspase-3a). |
2024-04-16 |
2024-04-19 |
human |
| Nahide Yildirim, Lakshmi Sarojam, Victoria M Smith, Nadja M Pieper, Marius Anders, Ross A Jackson, Dominik C Fuhrmann, Vinzenz Särchen, Daniela Brücher, Andreas Weigert, Martin J S Dyer, Meike Vogle. Identification of a novel form of caspase-independent cell death triggered by BH3-mimetics in diffuse large B-cell lymphoma cell lines. Cell death & disease. vol 15. issue 4. 2024-04-15. PMID:38622118. |
bh3-mimetics represent promising anti-cancer agents in tumors that rely on the anti-apoptotic function of b-cell lymphoma 2 (bcl2) proteins, particularly in leukemia and lymphoma cells primed for apoptosis. |
2024-04-15 |
2024-04-18 |
Not clear |
| Mohammad Yasin Zamanian, Maryam Golmohammadi, Bekhzod Abdullaev, María Olalla García, Adeeb Abdulally Abdulhussien Alazbjee, Abhinav Kumar, Sameer S Mohaamed, Beneen M Hussien, Fattaneh Khalaj, Seyede Mahsa Hodaei, Niyousha Shirsalimi, Gervason Morias. A narrative review on therapeutic potential of naringenin in colorectal cancer: Focusing on molecular and biochemical processes. Cell biochemistry and function. vol 42. issue 3. 2024-04-08. PMID:38583080. |
the study's findings indicated that nar: (1) interacts with estrogen receptors, (2) regulates the expression of genes related to the p53 signaling pathway, (3) promotes apoptosis by increasing the expression of proapoptotic genes (bax, caspase9, and p53) and downregulation of the antiapoptotic gene bcl2, (4) inhibits the activity of enzymes involved in cell survival and proliferation, (5) decreases cyclin d1 levels, (6) reduces the expression of cyclin-dependent kinases (cdk4, cdk6, and cdk7) and antiapoptotic genes (bcl2, x-iap, and c-iap-2) in crc cells. |
2024-04-08 |
2024-04-10 |
human |
| Bisan El Dakkak, Jalal Taneera, Waseem El-Huneidi, Eman Abu-Gharbieh, Rifat Hamoudi, Mohammad H Semreen, Nelson C Soares, Eman Y Abu-Rish, Mahmoud Y Alkawareek, Alaaldin M Alkilany, Yasser Bustanj. Unlocking the Therapeutic Potential of BCL-2 Associated Protein Family: Exploring BCL-2 Inhibitors in Cancer Therapy. Biomolecules & therapeutics. 2024-04-08. PMID:38589288. |
in the context of cancer, where evasion of apoptosis is a hallmark, the overexpression of anti-apoptotic proteins like bcl2, bcl-xl, and mcl-1 has been documented. |
2024-04-08 |
2024-04-11 |
Not clear |
| Jing Tian, Di Wang, Hongxia Wang, Pin Huan, Baozhong Li. The combination of high temperature and Vibrio infection worsens summer mortality in the clam Meretrix petechialis by increasing apoptosis and oxidative stress. Fish & shellfish immunology. vol 149. 2024-04-07. PMID:38579976. |
additionally, our investigations into apoptosis and autophagy processes exhibited significant induction of mtor and bcl2 of the 31°c-vibrio group in the early challenge stage, followed by inhibition in the later stage. |
2024-04-07 |
2024-04-10 |
Not clear |
| Josipa Skelin, Maja Matulić, Lidija Milković, Darko Heckel, Jelena Skoko, Kristina Ana Škreb, Biljana Jelić Puškarić, Ika Kardum-Skelin, Lipa Čičin-Šain, Delfa Radić-Krišto, Mariastefania Antic. Analysis of Primary Chronic Lymphocytic Leukemia Cells' Signaling Pathways. Biomedicines. vol 12. issue 3. 2024-03-28. PMID:38540136. |
the activation of the notch pathway in vitro increases the susceptibility of primary cll cells to apoptosis despite high bcl2 expression. |
2024-03-28 |
2024-03-30 |
Not clear |
| Shatha M Alobaid, Rahaf M Alshahrani, Asma S Alonazi, Nawal M Alrasheed, Maha A Alamin, Tahani K Alshammari, Anfal F Bin Dayel, Doaa M Elnagar, Rana R Alotaibi, Lama A Almuthnabi, Dalia H Almasud, Shahad E Al-Ammar, Shahad O Almadhi, Reema A Almalke, Nouf T Aldamri, Hanan K Alghibiwi, Dalal A Alkhelb, Nouf M Alrashee. Liraglutide Attenuates Diabetic Cardiomyopathy via the ILK/PI3K/AKT/PTEN Signaling Pathway in Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus. Pharmaceuticals (Basel, Switzerland). vol 17. issue 3. 2024-03-28. PMID:38543160. |
western blotting and immunohistochemical studies revealed increased levels of ilk, p-pi3k, p-akt, and bcl2, as well as those of caspase 3, bax, and p-pten, indicating mitigation of cardiomyocyte apoptosis. |
2024-03-28 |
2024-03-30 |
rat |
| Gaiqin Dong, Qingfeng Li, Chun Yu, Qing Wang, Danhua Zuo, Xiaozhong L. n-Acetylcysteine protects against diazinon-induced histopathological damage and apoptosis in renal tissue of rats. Toxicological research. vol 40. issue 2. 2024-03-25. PMID:38525131. |
the mrna expressions of apoptosis, oxidative stress and inflammatory mediators, including b-cell lymphoma-2 (bcl2), bcl-2-associated x protein (bax), superoxide dismutase (sod), catalase (cat), interleukin 10 (il-10), tumor necrosis factor-α (tnf-α), caspase-3 and caspase-8 were analyzed in kidney tissues using real time pcr method. |
2024-03-25 |
2024-03-27 |
rat |
| Badrah Alghamdi, Emad H M Hassanein, Saif A Alharthy, Reem M Farsi, Steve Harake. Vinpocetine attenuates methotrexate-induced hippocampal intoxication via Keap-1/Nrf2, NF-κB/AP-1, and apoptotic pathways in rats. Drug and chemical toxicology. 2024-03-20. PMID:38508707. |
additionally, vnp attenuated apoptosis by reducing hippocampal bax levels while increasing bcl2 levels in mtx-intoxicated rats. |
2024-03-20 |
2024-03-23 |
rat |
| Prathapan Abeesh, Chandrasekharan Guruvayoorappa. Withaferin A-Encapsulated PEGylated Nanoliposomes Induce Apoptosis in B16F10 Melanoma Cells by Regulating Bcl2 and Bcl xl Genes and Mitigates Murine Solid Tumor Development. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 43. issue 2. 2024-03-20. PMID:38505911. |
withaferin a-encapsulated pegylated nanoliposomes induce apoptosis in b16f10 melanoma cells by regulating bcl2 and bcl xl genes and mitigates murine solid tumor development. |
2024-03-20 |
2024-03-23 |
Not clear |
| Prathapan Abeesh, Chandrasekharan Guruvayoorappa. Withaferin A-Encapsulated PEGylated Nanoliposomes Induce Apoptosis in B16F10 Melanoma Cells by Regulating Bcl2 and Bcl xl Genes and Mitigates Murine Solid Tumor Development. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 43. issue 2. 2024-03-20. PMID:38505911. |
also, lwa administration remarkably inhibited tumor cell proliferation by downregulating the expression of ki-67 and cyclin d1 and induced apoptosis by regulating the expression of bax, bcl2, and bcl xl levels. |
2024-03-20 |
2024-03-23 |
Not clear |
| Tillmann Bork, Camila Hernando-Erhard, Wei Liang, Zhejia Tian, Kosuke Yamahara, Tobias B Hube. Cisplatin Nephrotoxicity Is Critically Mediated by the Availability of BECLIN1. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473806. |
in our study, we assessed the role of the autophagy-related protein beclin1 (atg6) in cisplatin-induced acute renal injury (aki)-a candidate protein involved in autophagy and with putative impact on apoptosis by harboring a b-cell lymphoma 2 (bcl2) interaction site of unknown significance. |
2024-03-13 |
2024-03-15 |
mouse |
| Shucan Dong, Shengwei Jiang, Biwei Hou, Yaokun Li, Baoli Sun, Yongqing Guo, Ming Deng, Dewu Liu, Guangbin Li. miR-128-3p Regulates Follicular Granulosa Cell Proliferation and Apoptosis by Targeting the Growth Hormone Secretagogue Receptor. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473968. |
the results show that overexpression of mir-128-3p inhibited the proliferation of kgn cells, promoted cell apoptosis, and suppressed the expression of proliferating cell nuclear antigen (pcna) and b-cell lymphoma-2 (bcl2) while promoting that of bcl-2 associated x protein (bax). |
2024-03-13 |
2024-03-15 |
human |