| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Changkun Hu, Zebin Liao, Liangliang Zhang, Zengchun Ma, Chengrong Xiao, Shuai Shao, Yue Ga. Alleviation of Splenic Injury by CB001 after Low-Dose Irradiation Mediated by NLRP3/Caspase-1-BAX/Caspase-3 Axis. Radiation research. 2023-12-28. PMID:38154483. |
furthermore, the crosstalk between apoptosis signaling and nlrp3 inflammasome signaling in mediating the radio-protective activity of cb001 was clarified, in which the pro-apoptotic protein bax but not the anti-apoptotic protein bcl2 was found to be downstream of nlrp3. |
2023-12-28 |
2023-12-31 |
Not clear |
| Ting Yang, Sijuan Tian, Juan Zhao, Meili Pei, Minyi Zhao, Xiaofeng Yan. LncRNA ABHD11-AS1 activates EGFR signaling to promote cervical cancer progression by preventing FUS-mediated degradation of ABHD11 mRNA. Cell cycle (Georgetown, Tex.). 2023-12-26. PMID:38146687. |
knockdown of abhd11-as1 and egfr significantly inhibited the proliferation, migration, and invasion and promoted apoptosis of siha and hela cells by up-regulating p21 and bax and down-regulating cyclin d1, bcl2, mmp9, and vimentin. |
2023-12-26 |
2023-12-28 |
Not clear |
| Takeshi Moriishi, Yosuke Kawai, Ryo Fukuyama, Yuki Matsuo, You-Wen He, Haruhiko Akiyama, Izumi Asahina, Toshihisa Komor. International journal of molecular sciences. vol 24. issue 24. 2023-12-23. PMID:38139148. |
bcl2l1 (bcl-xl) belongs to the bcl-2 family, bcl2 and bcl2-xl are major anti-apoptotic proteins, and the apoptosis of osteoblasts is a key event for bone homeostasis. |
2023-12-23 |
2023-12-25 |
Not clear |
| Bin Li, Qianshan Tao, Xueying Hu, Tan Li, Yangyi Ba. [miR-181b-5p promotes cell proliferation and induces apoptosis in human acute myeloid leukemia by targeting PAX9]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 12. 2023-12-23. PMID:38140866. |
in kasumi-1 and aml5 cells, compared with vector group, proliferation activity of cells, percentage of cells in s phase, and expressions of cdk2, ccnb1 and bcl2 proteins were decreased, while percentage of cells in g0/g1 phase, apoptosis rate and the expression of bax protein were increased in pax9 group. |
2023-12-23 |
2023-12-25 |
human |
| Bin Li, Qianshan Tao, Xueying Hu, Tan Li, Yangyi Ba. [miR-181b-5p promotes cell proliferation and induces apoptosis in human acute myeloid leukemia by targeting PAX9]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 12. 2023-12-23. PMID:38140866. |
compared with mir-nc group, proliferation activity of cells, percentage of cells in s phase, and expressions of cdk2, ccnb1 and bcl2 proteins were increased, while percentage of cells in g0/g1 phase, apoptosis rate and the expression of bax protein were decreased in mir-181b-5p group. |
2023-12-23 |
2023-12-25 |
human |
| Bin Li, Qianshan Tao, Xueying Hu, Tan Li, Yangyi Ba. [miR-181b-5p promotes cell proliferation and induces apoptosis in human acute myeloid leukemia by targeting PAX9]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 12. 2023-12-23. PMID:38140866. |
compared with mir-181b-5p group, proliferation activity of cells, percentage of cells in s phase, and expressions of cdk2, ccnb1 and bcl2 proteins were decreased, while percentage of cells in g0/g1 phase, apoptosis rate and the expression of bax protein were increased in mir-181b-5p combined with pax9 group. |
2023-12-23 |
2023-12-25 |
human |
| Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Isabel Amador-Martínez, Omar Noel Medina-Campos, Misael Garcia-Garcia, Bismarck Bernabe-Yepes, Juan Carlos León-Contreras, Rogelio Hernández-Pando, Omar Emiliano Aparicio-Trejo, Laura Gabriela Sánchez-Lozada, Edilia Tapia, José Pedraza-Chaverr. Sulforaphane protects from kidney damage during the release of unilateral ureteral obstruction (RUUO) by activating nuclear factor erythroid 2-related factor 2 (Nrf2): Role of antioxidant, anti-inflammatory, and antiapoptotic mechanisms. Free radical biology & medicine. 2023-12-23. PMID:38141891. |
reducing oxidative stress and inflammation prevented apoptosis by avoiding caspase 3 cleavage and increasing b-cell lymphoma 2 (bcl2) levels. |
2023-12-23 |
2023-12-25 |
Not clear |
| Wanzhuo Chen, Haining Zhan. Elucidating the mechanism of IL-1β-Mediated Piezo1 expression regulation of chondrocyte autophagy and apoptosis via the PI3K/AKT/mTOR signaling Pathway. Tissue & cell. vol 86. 2023-12-22. PMID:38134572. |
il-1β activates piezo1 to inhibit chondrocyte autophagy and promote chondrocyte apoptosis partially, represented by up-regulation of related proteins c-caspase 3, bax expression, and down-regulation of bcl2, lc3, p62 expression. |
2023-12-22 |
2023-12-25 |
human |
| Mojdeh Soltani, Mahshid Vosoughi, Mazdak Ganjalikhani-Hakemi, Hoorieh Shapoorian, Pezhman Beshkar, Nahid Eskandari, Behrooz Ghezelbas. PD-1/PD-L1 Interaction Regulates BCL2, KI67, BAX, and CASP3, Altering Proliferation, Survival, and Apoptosis in Acute Myeloid Leukemia. Iranian journal of allergy, asthma, and immunology. vol 22. issue 5. 2023-12-12. PMID:38085150. |
pd-1/pd-l1 interaction regulates bcl2, ki67, bax, and casp3, altering proliferation, survival, and apoptosis in acute myeloid leukemia. |
2023-12-12 |
2023-12-17 |
human |
| Mojdeh Soltani, Mahshid Vosoughi, Mazdak Ganjalikhani-Hakemi, Hoorieh Shapoorian, Pezhman Beshkar, Nahid Eskandari, Behrooz Ghezelbas. PD-1/PD-L1 Interaction Regulates BCL2, KI67, BAX, and CASP3, Altering Proliferation, Survival, and Apoptosis in Acute Myeloid Leukemia. Iranian journal of allergy, asthma, and immunology. vol 22. issue 5. 2023-12-12. PMID:38085150. |
findings reveal that pd-l1 stimulation augments aml cell proliferation and survival by enhancing mki67 and bcl2 expressions while concurrently inhibiting cell apoptosis due to decreased bax and casp3 expression following pd-l1 stimulation. |
2023-12-12 |
2023-12-17 |
human |
| Qingfeng Lv, Yuan Wang, Wei Tian, Yuqiu Liu, Mengqi Gu, Xiaotong Jiang, Yanjun Cai, Ruiheng Huo, Yuchen Li, Lei Li, Xietong Wan. Exosomal miR-146a-5p derived from human umbilical cord mesenchymal stem cells can alleviate antiphospholipid antibody-induced trophoblast injury and placental dysfunction by regulating the TRAF6/NF-κB axis. Journal of nanobiotechnology. vol 21. issue 1. 2023-11-14. PMID:37957714. |
exosomal mir-146a-5p suppressed the expression of tumor necrosis factor receptor-associated factor 6 (traf6) and inhibited the activation of nf-κb signaling, leading to the down-regulation of il-1β and il-18 to rescue inflammation and modulation of cleaved-casp3, bax, and bcl2 to inhibit apoptosis in htr8/svneo cells and mice placenta. |
2023-11-14 |
2023-11-20 |
mouse |
| Dennis Juarez, Roberta Buono, Shannon M Matulis, Vikas A Gupta, Madeleine R Duong, Jacob Yudiono, Madhuri Paul, Sharmila Mallya, Grace Diep, Peter Hsin, Alexander Lu, Sang Mi Suh, Vy M Dong, Andrew W Roberts, Joel D Leverson, Muhammad Jalaluddin, Zhuangzhuang Liu, Orlando F Bueno, Lawrence H Boise, David A Fruma. Statin-induced mitochondrial priming sensitizes multiple myeloma cells to BCL2 and MCL1 inhibitors. Cancer research communications. 2023-11-13. PMID:37956312. |
the bcl2 inhibitor venetoclax promotes apoptosis in blood cancer cells and is approved for treatment of chronic lymphocytic leukemia and acute myeloid leukemia. |
2023-11-13 |
2023-11-20 |
Not clear |
| Cui Wang, Xiaoyi Wang, Yinyin Xie, Tingting Peng, Yongfeng Wang, Nan Li, Xiangbo Huang, Xiaomei Hu, Nanchang Xi. ATF5 attenuates low-magnesium-induced apoptosis by inhibiting endoplasmic reticulum stress via the regulation of mitochondrial reactive oxygen species. Neuroscience. 2023-11-01. PMID:37913858. |
furthermore, atf5 overexpression rescued low-magnesium-induced neuronal apoptosis, as evidenced by the reduced expression levels of cleaved-caspase-3 and bax, and the restored levels of bcl2. |
2023-11-01 |
2023-11-08 |
Not clear |
| Yiwei Liao, Sha Huang, Yuhu Zhang, Honghai Zhang, Haiting Zha. Decrease of Cellular Communication Network Factor 1 (CCN1) Attenuates PTZ-Kindled Epilepsy in Mice. Cellular and molecular neurobiology. 2023-10-21. PMID:37864627. |
silencing of ccn1 also reduces neuronal damage and apoptosis, decreases mrna and protein expression of proapoptotic proteins bax and caspase-3, increases mrna expression of antiapoptotic protein bcl2. |
2023-10-21 |
2023-11-08 |
mouse |
| Yuanlong Li, Hua Fan, Xiong Han, Jun Sun, Ming Ni, Xiaodan Hou, Fengqin Fang, Wei Zhang, Peizhi M. Long Non-Coding RNA MALAT1 Protects Against Spinal Cord Injury via Suppressing microRNA-125b-5p Mediated Microglial M1 Polarization, Neuroinflammation, and Neural Apoptosis. Molecular neurobiology. 2023-10-19. PMID:37858031. |
lncrna malat1 overexpression suppressed the microglial m1 polarization (decreased inos but increased arg1), neuroinflammation (declined ptgs2, tnf-α, il-1β, and il-6), and microglia-induced neural apoptosis (lower tunel positive cells and c-caspase3 but higher bcl2) under lps treatment; its knock-down displayed the opposite trend. |
2023-10-19 |
2023-11-08 |
rat |
| Peng Liu, Liwei Zhao, Laurence Zitvogel, Oliver Kepp, Guido Kroeme. The BCL2 inhibitor venetoclax mediates anticancer effects through dendritic cell activation. Cell death and differentiation. 2023-10-16. PMID:37845384. |
pharmacological bcl2 inhibitors have been developed with the scope of driving bcl2-dependent cancer cells into apoptosis, and one bcl2 antagonist, venetoclax, has been clinically approved for the treatment of specific leukemias and lymphomas. |
2023-10-16 |
2023-11-08 |
Not clear |
| Anna Skwarska, Marina Konoplev. BCL-xL Targeting to Induce Apoptosis and to Eliminate Chemotherapy-Induced Senescent Tumor Cells: From Navitoclax to Platelet-Sparing BCL-xL PROTACs. Cancer research. 2023-10-12. PMID:37824434. |
one of the primary mechanisms by which cancer cells evade death and maintain survival in the face of stress signals is by overexpression of prosurvival b-cell lymphoma 2 (bcl2) family members such as bcl2, bcl-xl, and mcl1, which suppress the intrinsic (mitochondrial) pathway of apoptosis through complex protein and membrane interactions. |
2023-10-12 |
2023-10-15 |
Not clear |
| Samuel Wyatt, Karen Glover, Srinivasulu Dasanna, Monica Lewison, Maribel González-García, Christopher L Colbert, Sangita C Sinh. Epstein-Barr Virus Encoded BCL2, BHRF1, Downregulates Autophagy by Noncanonical Binding of BECN1. Biochemistry. 2023-09-30. PMID:37776275. |
γ-herpesviruses (γhvs) encode bcl2 homologues (vbcl2) that bind the bcl-2 homology 3 domains (bh3ds) of diverse proteins, inhibiting apoptosis and promoting host cell and virus survival. |
2023-09-30 |
2023-10-07 |
Not clear |
| Katja Seipel, Scarlett Kohler, Ulrike Bacher, Thomas Pabs. HSP90 Inhibitor PU-H71 in Combination with BH3-Mimetics in the Treatment of Acute Myeloid Leukemia. Current issues in molecular biology. vol 45. issue 9. 2023-09-27. PMID:37754227. |
the hsp90 inhibitor pu-h71, mcl1 inhibitor s63845, and bcl2 inhibitor venetoclax were assessed as single agents and in combination for their ability to induce apoptosis and cell death in leukemic cells. |
2023-09-27 |
2023-10-07 |
Not clear |
| Yu Xia, Gaoran Ge, Haixiang Xiao, Mingzhou Wu, Tianhao Wang, Chengyong Gu, Huilin Yang, Dechun Gen. REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis. Cell death & disease. vol 14. issue 9. 2023-09-25. PMID:37749079. |
furthermore, the levels of bcl2 and bax, which play a key role in the mitochondrial apoptosis pathway, were affected. |
2023-09-25 |
2023-10-07 |
mouse |