| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sharmeen Ishteyaque, Karan Singh Yadav, Smriti Verma, Kaveri R Washimkar, Madhav Nilakanth Mugal. CYP2E1 triggered GRP78/ATF6/CHOP signalling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma. Archives of biochemistry and biophysics. 2023-07-27. PMID:37499993. |
meanwhile, cyp2e1 stimulated er-stress reduces bcl2 and downregulates the cleaved caspase 3 thus suppresses apoptosis. |
2023-07-27 |
2023-08-14 |
rat |
| Yuan-Yuan Fang, Cui-Liu Gan, Jian-Chao Peng, Yu-Han Xie, Han-Xiao Song, Ya-Qi Mo, Shi-Yan Ou, Michael Aschner, Yue-Ming Jian. Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells. Biological trace element research. 2023-07-27. PMID:37500820. |
we used immunoblotting to analyze the effect of manganese, iron alone, or their combined exposure on the activation of caspase9, p53, bax, and bcl2 apoptosis signaling pathways. |
2023-07-27 |
2023-08-14 |
Not clear |
| Yuan-Yuan Fang, Cui-Liu Gan, Jian-Chao Peng, Yu-Han Xie, Han-Xiao Song, Ya-Qi Mo, Shi-Yan Ou, Michael Aschner, Yue-Ming Jian. Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells. Biological trace element research. 2023-07-27. PMID:37500820. |
and we also found that the apoptosis rate increased, mitochondrial membrane potential decreased, apoptosis-related proteins caspase9, p53, bax, and bcl2 expression increased, and caspase3 activity increased. |
2023-07-27 |
2023-08-14 |
Not clear |
| Nora M Aborehab, Mai A Abd-Elmawla, Abeer M ElSayed, Omar Sabry, Shahira M Ezza. Acovenoside A as a novel therapeutic approach to boost taxol and carboplatin apoptotic and antiproliferative activities in NSCLC: Interplay of miR-630/miR-181a and apoptosis genes. Bioorganic chemistry. vol 139. 2023-07-25. PMID:37490810. |
the present study has proven that the underlying mechanism of acovenoside a is partially attributed to the upregulation of mir-630 and mir-181a gene expressions which in turn targets the intrinsic apoptosis genes as p53, bax and bcl2 as well as caspase 3. |
2023-07-25 |
2023-08-14 |
Not clear |
| Chao-Feng Shi, Fei Han, Xiao Jiang, Zhonghao Zhang, Yingqing Li, Jiankang Wang, Shengqi Sun, Jin-Yi Liu, Jia Ca. Benzo[b]fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology and experimental approaches. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-20. PMID:37473983. |
besides, bbf led to apoptosis in leydig cells, and decreased expressions of p-akt and bcl2, while improving the expressions of p53, bax and cleaved caspase-3 in vivo and in vitro. |
2023-07-20 |
2023-08-14 |
mouse |
| Chao-Feng Shi, Fei Han, Xiao Jiang, Zhonghao Zhang, Yingqing Li, Jiankang Wang, Shengqi Sun, Jin-Yi Liu, Jia Ca. Benzo[b]fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology and experimental approaches. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-20. PMID:37473983. |
similarly, p53 inhibitor pifithrin-α also significantly enhanced the cell vitality, alleviated the apoptosis of tm3 cells induced by bbf, and decreased the expressions of bax and cleaved caspase-3, with the up-regulation of bcl2. |
2023-07-20 |
2023-08-14 |
mouse |
| Hao Yan, Xiangliang Huang, Jiangxin Xu, Ying Zhang, Jiajia Chen, Zhifei Xu, Hui Li, Zeng Wang, Xiaochun Yang, Bo Yang, Qiaojun He, Peihua Lu. Chloroquine Intervenes Nephrotoxicity of Nilotinib through Deubiquitinase USP13-Mediated Stabilization of Bcl-XL. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-07-14. PMID:37452432. |
mechanistically, nilotinib induces intrinsic apoptosis by specifically reducing the level of bcl2 like 1 (bcl-xl) in both vascular endothelial cells and renal tubular epithelial cells, as well as in vivo. |
2023-07-14 |
2023-08-14 |
Not clear |
| Heba M Mahmoud, Deiaa E Elsayed Abouzed, Amira M Abo-Youssef, Ramadan A M Hemeid. Zafirlukast protects against hepatic ischemia-reperfusion injury in rats via modulating Bcl-2/Bax and NF-κB/SMAD-4 pathways. International immunopharmacology. vol 122. 2023-07-07. PMID:37418987. |
inflammatory cytokines, tumor necrosis factor alpha (tnf-α) and interleukin-33 (il-33), in addition to apoptosis biomarkers, bcl2 associated x protein (bax), b-cell lymphoma 2 (bcl2) and galactine-9 (gal9) proteins were also assessed. |
2023-07-07 |
2023-08-14 |
rat |
| K C Pramod Bahadur, Anju Maharjan, Manju Acharya, DaEun Lee, Sarina Kusma, Ravi Gautam, Jung-Taek Kwon, ChangYul Kim, KilSoo Kim, HyoungAh Kim, Yong He. Polytetrafluorethylene microplastic particles mediated oxidative stress, inflammation, and intracellular signaling pathway alteration in human derived cell lines. The Science of the total environment. 2023-07-07. PMID:37419366. |
furthermore, expression of the apoptosis regulator, bcl2, was markedly increased in the a549 and u937 cell lines. |
2023-07-07 |
2023-08-14 |
human |
| Feiyang Ma, Xinyan Ma, Fan Yang, Jianzhao Liao, Na Qiao, Wenlan Yu, Qingyue Han, Ying Li, Jiaqiang Pan, Lianmei Hu, Jianying Guo, Zhaoxin Tan. Exposure to copper induces endoplasmic reticulum (ER) stress-mediated apoptosis in chicken (Gallus gallus) myocardium. Veterinary research communications. 2023-07-05. PMID:37405676. |
meanwhile, grp78, grp94, eif2α, atf6, xbp1, chop, bax, bak1, bcl2, caspase-12 and caspase-3 genes levels, and grp78, grp94 and caspase-3 proteins levels were increased, which indicated that er stress and apoptosis in cardiomyocytes. |
2023-07-05 |
2023-08-14 |
chicken |
| Britta Majchrzak-Stiller, Marie Buchholz, Ilka Peters, Daniel Waschestjuk, Johanna Strotmann, Philipp Höhn, Stephan Hahn, Chris Braumann, Waldemar Uhl, Thomas Müller, Hanns Möhle. GP-2250, a novel anticancer agent, inhibits the energy metabolism, activates AMP-Kinase and impairs the NF-kB pathway in pancreatic cancer cells. Journal of cellular and molecular medicine. 2023-06-30. PMID:37390227. |
a transcriptional deficit of nf-κb (nuclear factor kappa-light-chain-enhancer of activated b cells) was substantiated by the downregulation of cyclin d1 and of the anti-apoptotic bcl2, in line with reduction in tumour cell proliferation and induction of apoptosis, respectively. |
2023-06-30 |
2023-08-14 |
Not clear |
| Ruibiao Wang, Lihao Lin, Yang Han, Zhixin Li, Jingbo Zhen, Yuheng Zhang, Feng Sun, Yixin L. Exosome-delivered miR-153 from Trichinella spiralis promotes apoptosis of intestinal epithelial cells by downregulating Bcl2. Veterinary research. vol 54. issue 1. 2023-06-28. PMID:37381058. |
exosome-delivered mir-153 from trichinella spiralis promotes apoptosis of intestinal epithelial cells by downregulating bcl2. |
2023-06-28 |
2023-08-14 |
Not clear |
| Ruibiao Wang, Lihao Lin, Yang Han, Zhixin Li, Jingbo Zhen, Yuheng Zhang, Feng Sun, Yixin L. Exosome-delivered miR-153 from Trichinella spiralis promotes apoptosis of intestinal epithelial cells by downregulating Bcl2. Veterinary research. vol 54. issue 1. 2023-06-28. PMID:37381058. |
bcl2, an important antiapoptotic protein, plays an essential role in cell apoptosis as a common intersecting molecule of various signal transduction pathways. |
2023-06-28 |
2023-08-14 |
Not clear |
| Ruibiao Wang, Lihao Lin, Yang Han, Zhixin Li, Jingbo Zhen, Yuheng Zhang, Feng Sun, Yixin L. Exosome-delivered miR-153 from Trichinella spiralis promotes apoptosis of intestinal epithelial cells by downregulating Bcl2. Veterinary research. vol 54. issue 1. 2023-06-28. PMID:37381058. |
therefore, we hypothesized that mir-153 derived from tsexos causes cell apoptosis by targeting bcl2. |
2023-06-28 |
2023-08-14 |
Not clear |
| Ruibiao Wang, Lihao Lin, Yang Han, Zhixin Li, Jingbo Zhen, Yuheng Zhang, Feng Sun, Yixin L. Exosome-delivered miR-153 from Trichinella spiralis promotes apoptosis of intestinal epithelial cells by downregulating Bcl2. Veterinary research. vol 54. issue 1. 2023-06-28. PMID:37381058. |
thus, exosome-mediated mir-153 delivery secreted by t. spiralis could induce apoptosis and affect the mapk and p53 signalling pathways by downregulating bcl2 in ipec-j2 cells. |
2023-06-28 |
2023-08-14 |
Not clear |
| Humayra Afrin, Stephanie Vargas Esquivel, Raj Kumar, Md Ikhtiar Zahid, Ikhtiar Zahid, Beu Oporeza, Md Fashiar Rahman, Thomas Boland, Md Nurunnab. β-Glucan-Mediated Oral Codelivery of 5FU and Bcl2 siRNA Attenuates Stomach Cancer. ACS applied materials & interfaces. 2023-06-23. PMID:37350332. |
to accomplish this, we have developed a ß-glucan (bg)-based oral delivery vehicle that can adhere to the mucus lining of the stomach for an extended period while controlling the release of bcl2 sirna and 5-fluorouracil (5fu) payload for over 6 h. we found that bcl2 sirna selectively knocked down the bcl2 gene in a c57bl/6 stomach cancer mouse model followed by upregulation of apoptosis and remission of cancer. |
2023-06-23 |
2023-08-14 |
mouse |
| Xin Zhang, Xueqin Li, Liangyu Zhu, Guoquan Yin, Yuan Zhang, Kun Ly. [Viral myocarditis serum exosome-derived miR-320 promotes the apoptosis of mouse cardiomyocytes by inhibiting AKT/mTOR pathway and targeting phosphatidylinositol 3-kinase regulatory subunit 1 (Pik3r1)]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 6. 2023-06-21. PMID:37340920. |
flow cytometry was used to detect cardiomyocyte apoptosis rate, and the expression levels of b cell lymphoma 2 (bcl2) and bcl2-related x protein (bax) were tested by western blot analysis. |
2023-06-21 |
2023-08-14 |
mouse |
| Xin Zhang, Xueqin Li, Liangyu Zhu, Guoquan Yin, Yuan Zhang, Kun Ly. [Viral myocarditis serum exosome-derived miR-320 promotes the apoptosis of mouse cardiomyocytes by inhibiting AKT/mTOR pathway and targeting phosphatidylinositol 3-kinase regulatory subunit 1 (Pik3r1)]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 6. 2023-06-21. PMID:37340920. |
results viral myocarditis serum exosomes promoted cardiomyocyte apoptosis, and increased the level of bax while the level of bcl2 was decreased. |
2023-06-21 |
2023-08-14 |
mouse |
| Yaping Gan, Ting Liu, Weifeng Feng, Liang Wang, L I Li, Yingxia Nin. Drug repositioning of disulfiram induces endometrioid epithelial ovarian cancer cell death via the both apoptosis and cuproptosis pathways. Oncology research. vol 31. issue 3. 2023-06-12. PMID:37305383. |
mechanistically, dsf treatment significantly reduced the expression of the anti-apoptosis marker b-cell lymphoma/leukemia-2 (bcl-2) and increase the expression of the apoptotic molecules bcl2 associated x (bax) and cleaved caspase-3 to promote human epithelial ovarian cancer cell apoptosis. |
2023-06-12 |
2023-08-14 |
human |
| Haibo Dong, Wei Guo, Zhanxiang Zho. BAX/MLKL signaling contributes to lipotoxicity-induced lysosomal membrane permeabilization in alcohol-associated liver disease. Autophagy. 2023-06-08. PMID:37289043. |
we identified that the apoptotic protein bax (bcl2 associated x, apoptosis regulator) could recruit mlkl (mixed lineage kinase domain-like pseudokinase), a necroptotic executive protein, to lysosomes and induce lmp in various ald models. |
2023-06-08 |
2023-08-14 |
Not clear |