| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahmed R Hamed, Shaymaa M M Yahya, Heba K Nabi. Anti-drug resistance, anti-inflammation, and anti-proliferation activities mediated by melatonin in doxorubicin-resistant hepatocellular carcinoma: in vitro investigations. Naunyn-Schmiedeberg's archives of pharmacology. 2023-01-18. PMID:36651944. |
additionally, qrt-pcr was used to quantify genes having a role in drug resistance phenotype (abcb1, abcc1, abcc2, abcc3, abcc4, abcc5, and abcg2); apoptosis (caspases-3, and -7, bcl2, bax, and p53); anti-oxidation (nrf2); expression of melatonin receptors (mt1, mt2, and mt3); besides, programmed death receptor pd-1 gene. |
2023-01-18 |
2023-08-14 |
human |
| Xiaoxiao Liu, Muli Xu, Wanting Jia, Yu Duan, Jiaxuan Ma, Wenlin Ta. PU.1 negatively regulates tumorigenesis in non-small-cell lung cancer. Medical oncology (Northwood, London, England). vol 40. issue 2. 2023-01-17. PMID:36648591. |
in addition, pu.1 promoted apoptosis of luad cells by decreasing bcl2 and increasing bax/bak1 expression. |
2023-01-17 |
2023-08-14 |
Not clear |
| Ya-Jen Chiu, Yu-Shan Teng, Chiung-Mei Chen, Ying-Chieh Sun, Hsiu Mei Hsieh-Li, Kuo-Hsuan Chang, Guey-Jen Lee-Che. A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment. Biomolecules & therapeutics. 2023-01-16. PMID:36646447. |
treatments with quercetin and apigenin increased trkb tyr516 and tyr817 and downstream camp-response-element binding protein (creb) ser133 to activate transcription of bdnf and bcl2 apoptosis regulator (bcl2), as well as reduced the expression of pro-apoptotic bcl2 associated x protein (bax). |
2023-01-16 |
2023-08-14 |
Not clear |
| Yee Voan Teo, Samuel J Hinthorn, Ashley E Webb, Nicola Nerett. Single-cell transcriptomics of peripheral blood in the aging mouse. Aging. vol 14. 2023-01-09. PMID:36622281. |
in addition, we detected a cluster of activated t cells exclusively found in old blood, with lower expression of cd28 and higher expression of bcl2 and cdkn2a, suggesting that the cells are senescent and resistant to apoptosis. |
2023-01-09 |
2023-08-14 |
mouse |
| Eslam R El-Sawy, Zeinab A El-Shahid, Ahmed A F Soliman, Amr Nassrallah, Ahmed B Abdelwahab, Gilbert Kirsch, Heba Abdelmegee. Synthetic Analogs of Marine Alkaloid Aplysinopsin Suppress Anti-Apoptotic Protein BCL2 in Prostate Cancer. Molecules (Basel, Switzerland). vol 28. issue 1. 2023-01-08. PMID:36615305. |
the inhibition of bcl2 led to the activation of bax, which in turn activated caspase 3, leading to apoptosis. |
2023-01-08 |
2023-08-14 |
Not clear |
| M A Hamzawy, A M Abo-Youssef, M N Malak, M M Khala. Multiple targets of Nrf 2 inhibitor; trigonelline in combating urethane-induced lung cancer by caspase-executioner apoptosis, cGMP and limitation of cyclin D1 and Bcl2. European review for medical and pharmacological sciences. vol 26. issue 24. 2023-01-02. PMID:36591848. |
multiple targets of nrf 2 inhibitor; trigonelline in combating urethane-induced lung cancer by caspase-executioner apoptosis, cgmp and limitation of cyclin d1 and bcl2. |
2023-01-02 |
2023-08-14 |
mouse |
| Ni Zeng, Zaijin Jian, Wenxin Zhu, Junmei Xu, Yongmei Fan, Feng Xia. KLF13 overexpression protects sepsis-induced myocardial injury and LPS-induced cellular inflammation and apoptosis. International journal of experimental pathology. 2022-12-30. PMID:36583453. |
pro-apoptotic cleaved-caspase3/caspase3 and bax levels and anti-apoptotic bcl2 level, inflammatory cytokines (il-1β, tnf-α, il-8 and mcp-1) production and iκb-α protein level and p65 phosphorylation in septic mice and lps-induced cells were detected to evaluate cardiomyocyte apoptosis, inflammatory response and nf-κb pathway activation. |
2022-12-30 |
2023-08-14 |
mouse |
| Ni Zeng, Zaijin Jian, Wenxin Zhu, Junmei Xu, Yongmei Fan, Feng Xia. KLF13 overexpression protects sepsis-induced myocardial injury and LPS-induced cellular inflammation and apoptosis. International journal of experimental pathology. 2022-12-30. PMID:36583453. |
septic heart and lps-induced cell model showed abnormally increased cardiomyocyte apoptosis (increased cleaved-caspase3/caspase and bax protein levels and decreased bcl2 level), elevated inflammation (increased production of inflammatory cytokines) and the activated nf-κb pathway (increased p65 phosphorylation and decreased iκb-α protein level). |
2022-12-30 |
2023-08-14 |
mouse |
| Eric Wang, Jose Mario Bello Pineda, Won Jun Kim, Sisi Chen, Jessie Bourcier, Maximilian Stahl, Simon J Hogg, Jan Phillipp Bewersdorf, Cuijuan Han, Michael E Singer, Daniel Cui, Caroline E Erickson, Steven M Tittley, Alexander V Penson, Katherine Knorr, Robert F Stanley, Jahan Rahman, Gnana Krishnamoorthy, James A Fagin, Emily Creger, Elizabeth McMillan, Chi-Ching Mak, Matthew Jarvis, Carine Bossard, Darrin M Beaupre, Robert K Bradley, Omar Abdel-Waha. Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia. Cancer cell. 2022-12-23. PMID:36563682. |
combined rbm10 and bcl2 inhibition leads to mis-splicing and inactivation of the inhibitor of apoptosis xiap and downregulation of bcl2a1, an anti-apoptotic protein implicated in venetoclax resistance. |
2022-12-23 |
2023-08-14 |
Not clear |
| Yingying Liu, Yanzhen Tan, Guojie Cao, Lei Shi, Yujie Song, Wenju Shan, Miao Zhang, Panpan Li, Haitao Zhou, Bing Zhang, Yang Sun, Wei Y. Bergenin alleviates myocardial ischemia-reperfusion injury via SIRT1 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2022-12-20. PMID:36538860. |
further studies showed that inhibiting sirt1 blocked bergenin's beneficial impact against apoptosis following si/r injury through excessive oxidative stress and depression of the bcl2 to bax ratio. |
2022-12-20 |
2023-08-14 |
mouse |
| Abbas Haddadian, Farnoush Falahi Robattorki, Hedieh Dibah, Ali Soheili, Erfan Ghanbarzadeh, Nasrin Sartipnia, Shadi Hajrasouliha, Kamal Pasban, Romina Andalibi, Mojtaba Hedayati Ch, Arezou Azari, Arman Chitgarzadeh, Aliasghar Bagheri Kashtali, Fatemeh Mastali, Hassan Noorbazargan, Amir Mirzai. Niosomes-loaded selenium nanoparticles as a new approach for enhanced antibacterial, anti-biofilm, and anticancer activities. Scientific reports. vol 12. issue 1. 2022-12-19. PMID:36536030. |
in addition, niosome-loaded senps can upregulate the expression level of bax, cas3, and cas9 apoptosis genes while the expression of the bcl2 gene is down-regulated in all studied cell lines, significantly. |
2022-12-19 |
2023-08-14 |
human |
| Ye Bai, Ning Guo, Zhanwu Xu, Yuxi Chen, Wenjin Zhang, Qinghe Chen, Zhenggang B. S100A1 expression is increased in spinal cord injury and promotes inflammation, oxidative stress and apoptosis of PC12 cells induced by LPS via ERK signaling. Molecular medicine reports. vol 27. issue 2. 2022-12-16. PMID:36524376. |
the protein levels of bax, bcl2 and cleaved caspase‑3 were used for the evaluation of the effects of s100a1 on apoptosis. |
2022-12-16 |
2023-08-14 |
rat |
| Yu Xia, Qihui Luo, Chao Huang, Liangqin Shi, Asad Jahangir, Ting Pan, Xiaoli Wei, Junbo He, Wentao Liu, Riyi Shi, Yi Geng, Jing Fang, Li Tang, Hongrui Guo, Ping Ouyang, Zhengli Che. Ferric citrate-induced colonic mucosal damage associated with oxidative stress, inflammation responses, apoptosis, and the changes of gut microbial composition. Ecotoxicology and environmental safety. vol 249. 2022-12-12. PMID:36508806. |
exposure to fc was positively associated with the mrna and protein expressions of cysteine-aspartic proteases (caspase)- 9, caspase-3, bcl-2-associated x protein (bax), while negatively associated with b-cell lymphoma 2 (bcl2) in mitochondrial apoptosis signaling pathway. |
2022-12-12 |
2023-08-14 |
mouse |
| Lei Li, Yanping Zhan, Haimei Xia, Yunkun Wu, Xiongzhi Wu, Shibiao Che. Sevoflurane protects against intracerebral hemorrhage via microRNA-133b/FOXO4/BCL2 axis. International immunopharmacology. vol 114. 2022-12-08. PMID:36476488. |
mir-133b targeted foxo4 expression, and inhibition of foxo4 attenuated hippocampal neuronal apoptosis by increasing bcl2 expression. |
2022-12-08 |
2023-08-14 |
mouse |
| E A Blinova, V S Nikiforov, A I Kotikova, M A Yanishevskaya, A V Akleye. [Methylation Status of Apoptosis Genes and Intensity of Apoptotic Death of Peripheral Blood Lymphocytes in Persons Chronically Exposed to Radiation]. Molekuliarnaia biologiia. vol 56. issue 6. 2022-12-07. PMID:36475490. |
here, the methylation level of cpg islands of the promoter regions of apoptosis genes (bcl2, atm, mdm2, cdkn1a, stat3, and nfkb1), and also its influence on apoptosis of peripheral blood lymphocytes in chronically exposed persons were studied. |
2022-12-07 |
2023-08-14 |
human |
| Dalia H El-Kashef, Haitham M Sewila. Empagliflozin mitigates methotrexate-induced hepatotoxicity: Targeting ASK-1/JNK/Caspase-3 pathway. International immunopharmacology. vol 114. 2022-12-03. PMID:36462340. |
additionally, empa (10 and 25 mg/kg) markedly suppressed the elevated levels of tumor necrosis factor-alpha, interleukin-6, apoptosis signal-regulating kinase1, c-jun n-terminal kinase, bcl2 associated x protein, and caspase-3 in hepatic tissues and increased the hepatic interleukin-10 levels. |
2022-12-03 |
2023-08-14 |
mouse |
| Irene Peris, Silvia Romero-Murillo, Elena Martínez-Balsalobre, Caroline C Farrington, Elena Arriazu, Nerea Marcotegui, Marta Jiménez-Muñoz, Cristina Alburquerque-Prieto, Andrea Torres-López, Vicente Jose Fresquet, Jose-Angel Martinez-Climent, Maria C Mateos, Maria Luisa Cayuela, Goutham Narla, Maria D Odero, Carmen Vicent. Activation of the PP2A-B56α heterocomplex synergizes with venetoclax therapies in AML through BCL2 and MCL1 modulation. Blood. 2022-12-01. PMID:36455198. |
mechanistically, pp2a reactivation enhances venetoclax-driven apoptosis through simultaneous inhibition of anti-apoptotic bcl2 and erk signaling, the later decreasing mcl1 protein stability. |
2022-12-01 |
2023-08-14 |
Not clear |
| Selvi Jegatheeson, Claire Cannon, Caroline Mansfield, Joanne Devlin, Andrew Robert. Sensitivity of canine hematological cancers to BH3 mimetics. Journal of veterinary internal medicine. 2022-11-26. PMID:36433867. |
inhibition of antiapoptotic b-cell lymphoma 2 (bcl2) proteins by small molecule bcl-2 homology 3 (bh3) mimetics causes rapid induction of apoptosis of human hematological cancers in vitro and in vivo. |
2022-11-26 |
2023-08-14 |
human |
| Musa Zakariah, Reneilwe A Molele, Mohammed A A Mahdy, Mohammed I A Ibrahim, Lyndy J McGa. Regulation of spermatogenic cell apoptosis by the pro-apoptotic proteins in the testicular tissues of mammalian and avian species. Animal reproduction science. vol 247. 2022-11-26. PMID:36435053. |
the intrinsic pathway, on the other hand, is triggered by nutrient deprivation, stress, or dna damage, which in turn activates bcl2 families of pro-apoptotic proteins that foster apoptosis. |
2022-11-26 |
2023-08-14 |
Not clear |
| Vaikundamoorthy Ramalingam, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Rajendran Rajara. N-(2-hydroxyphenyl)-2-phenazinamine from Nocardiopsis exhalans induces p53-mediated intrinsic apoptosis signaling in lung cancer cell lines. Chemico-biological interactions. 2022-11-25. PMID:36427553. |
moreover, the nhp downregulates the oncogenic genes such as il-8, tnfα, mmps and bcl2 and also upregulates the expression of apoptosis marker genes such as cyto c, p53, p21, caspase 9/3 in a549 and h520 human lung cancer cells. |
2022-11-25 |
2023-08-14 |
human |