| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Britta Majchrzak-Stiller, Marie Buchholz, Ilka Peters, Daniel Waschestjuk, Johanna Strotmann, Philipp Höhn, Stephan Hahn, Chris Braumann, Waldemar Uhl, Thomas Müller, Hanns Möhle. GP-2250, a novel anticancer agent, inhibits the energy metabolism, activates AMP-Kinase and impairs the NF-kB pathway in pancreatic cancer cells. Journal of cellular and molecular medicine. 2023-06-30. PMID:37390227. |
a transcriptional deficit of nf-κb (nuclear factor kappa-light-chain-enhancer of activated b cells) was substantiated by the downregulation of cyclin d1 and of the anti-apoptotic bcl2, in line with reduction in tumour cell proliferation and induction of apoptosis, respectively. |
2023-06-30 |
2023-08-14 |
Not clear |
| Ruibiao Wang, Lihao Lin, Yang Han, Zhixin Li, Jingbo Zhen, Yuheng Zhang, Feng Sun, Yixin L. Exosome-delivered miR-153 from Trichinella spiralis promotes apoptosis of intestinal epithelial cells by downregulating Bcl2. Veterinary research. vol 54. issue 1. 2023-06-28. PMID:37381058. |
exosome-delivered mir-153 from trichinella spiralis promotes apoptosis of intestinal epithelial cells by downregulating bcl2. |
2023-06-28 |
2023-08-14 |
Not clear |
| Ruibiao Wang, Lihao Lin, Yang Han, Zhixin Li, Jingbo Zhen, Yuheng Zhang, Feng Sun, Yixin L. Exosome-delivered miR-153 from Trichinella spiralis promotes apoptosis of intestinal epithelial cells by downregulating Bcl2. Veterinary research. vol 54. issue 1. 2023-06-28. PMID:37381058. |
bcl2, an important antiapoptotic protein, plays an essential role in cell apoptosis as a common intersecting molecule of various signal transduction pathways. |
2023-06-28 |
2023-08-14 |
Not clear |
| Ruibiao Wang, Lihao Lin, Yang Han, Zhixin Li, Jingbo Zhen, Yuheng Zhang, Feng Sun, Yixin L. Exosome-delivered miR-153 from Trichinella spiralis promotes apoptosis of intestinal epithelial cells by downregulating Bcl2. Veterinary research. vol 54. issue 1. 2023-06-28. PMID:37381058. |
therefore, we hypothesized that mir-153 derived from tsexos causes cell apoptosis by targeting bcl2. |
2023-06-28 |
2023-08-14 |
Not clear |
| Ruibiao Wang, Lihao Lin, Yang Han, Zhixin Li, Jingbo Zhen, Yuheng Zhang, Feng Sun, Yixin L. Exosome-delivered miR-153 from Trichinella spiralis promotes apoptosis of intestinal epithelial cells by downregulating Bcl2. Veterinary research. vol 54. issue 1. 2023-06-28. PMID:37381058. |
thus, exosome-mediated mir-153 delivery secreted by t. spiralis could induce apoptosis and affect the mapk and p53 signalling pathways by downregulating bcl2 in ipec-j2 cells. |
2023-06-28 |
2023-08-14 |
Not clear |
| Humayra Afrin, Stephanie Vargas Esquivel, Raj Kumar, Md Ikhtiar Zahid, Ikhtiar Zahid, Beu Oporeza, Md Fashiar Rahman, Thomas Boland, Md Nurunnab. β-Glucan-Mediated Oral Codelivery of 5FU and Bcl2 siRNA Attenuates Stomach Cancer. ACS applied materials & interfaces. 2023-06-23. PMID:37350332. |
to accomplish this, we have developed a ß-glucan (bg)-based oral delivery vehicle that can adhere to the mucus lining of the stomach for an extended period while controlling the release of bcl2 sirna and 5-fluorouracil (5fu) payload for over 6 h. we found that bcl2 sirna selectively knocked down the bcl2 gene in a c57bl/6 stomach cancer mouse model followed by upregulation of apoptosis and remission of cancer. |
2023-06-23 |
2023-08-14 |
mouse |
| Xin Zhang, Xueqin Li, Liangyu Zhu, Guoquan Yin, Yuan Zhang, Kun Ly. [Viral myocarditis serum exosome-derived miR-320 promotes the apoptosis of mouse cardiomyocytes by inhibiting AKT/mTOR pathway and targeting phosphatidylinositol 3-kinase regulatory subunit 1 (Pik3r1)]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 6. 2023-06-21. PMID:37340920. |
flow cytometry was used to detect cardiomyocyte apoptosis rate, and the expression levels of b cell lymphoma 2 (bcl2) and bcl2-related x protein (bax) were tested by western blot analysis. |
2023-06-21 |
2023-08-14 |
mouse |
| Xin Zhang, Xueqin Li, Liangyu Zhu, Guoquan Yin, Yuan Zhang, Kun Ly. [Viral myocarditis serum exosome-derived miR-320 promotes the apoptosis of mouse cardiomyocytes by inhibiting AKT/mTOR pathway and targeting phosphatidylinositol 3-kinase regulatory subunit 1 (Pik3r1)]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 6. 2023-06-21. PMID:37340920. |
results viral myocarditis serum exosomes promoted cardiomyocyte apoptosis, and increased the level of bax while the level of bcl2 was decreased. |
2023-06-21 |
2023-08-14 |
mouse |
| Yaping Gan, Ting Liu, Weifeng Feng, Liang Wang, L I Li, Yingxia Nin. Drug repositioning of disulfiram induces endometrioid epithelial ovarian cancer cell death via the both apoptosis and cuproptosis pathways. Oncology research. vol 31. issue 3. 2023-06-12. PMID:37305383. |
mechanistically, dsf treatment significantly reduced the expression of the anti-apoptosis marker b-cell lymphoma/leukemia-2 (bcl-2) and increase the expression of the apoptotic molecules bcl2 associated x (bax) and cleaved caspase-3 to promote human epithelial ovarian cancer cell apoptosis. |
2023-06-12 |
2023-08-14 |
human |
| Haibo Dong, Wei Guo, Zhanxiang Zho. BAX/MLKL signaling contributes to lipotoxicity-induced lysosomal membrane permeabilization in alcohol-associated liver disease. Autophagy. 2023-06-08. PMID:37289043. |
we identified that the apoptotic protein bax (bcl2 associated x, apoptosis regulator) could recruit mlkl (mixed lineage kinase domain-like pseudokinase), a necroptotic executive protein, to lysosomes and induce lmp in various ald models. |
2023-06-08 |
2023-08-14 |
Not clear |
| Yumin Wei, Liping Zhang, Chao Wang, Zefeng Li, Mingjie Luo, Guomin Xie, Xingjiu Yang, Mengyuan Li, Shuyue Ren, Dongbing Zhao, Ran Gao, Jia-Nan Gon. Anti-apoptotic protein BCL-XL as a therapeutic vulnerability in gastric cancer. Animal models and experimental medicine. 2023-06-05. PMID:37271936. |
evasion of programmed cell death (apoptosis) is a hallmark of cancer cells and direct induction of apoptosis by targeting the pro-survival bcl2 family proteins represents a promising therapeutic strategy for cancer treatment. |
2023-06-05 |
2023-08-14 |
Not clear |
| Md Rafi Uz Zama Khan, Emiko Yanase, Vishal Trived. Extraction, phytochemical characterization and anti-cancer mechanism of Haritaki churna: An ayurvedic formulation. PloS one. vol 18. issue 5. 2023-06-01. PMID:37256897. |
cancer cells exhibiting dna fragmentation, changes in expression of several apoptotic proteins such as bcl2, cytochrome-c and formation of cleaved products of caspase 3 and parp-1 suggests ellagic acid induces cell death via mitochondrial pathway of apoptosis. |
2023-06-01 |
2023-08-14 |
human |
| Jian-Fei Wu, Yu Liu, San-Ni Gong, Xiang-Dong Zi, You-Guo Ta. Effects of vascular endothelial growth factor (VEGF) on the viability, apoptosis and steroidogenesis of yak (Bos grunniens) granulosa cells. Theriogenology. vol 207. 2023-05-28. PMID:37245256. |
this treatment significantly reduced gc apoptosis (p < 0.05) by promoting the expression of bcl2 and gdf9 (p < 0.01) and inhibiting the expression of bax and caspase3 (p < 0.05). |
2023-05-28 |
2023-08-14 |
Not clear |
| Fulong Nan, Wenlong Nan, Zhongjie Yu, Hui Wang, Xiaoni Cui, Shasha Jiang, Xianjuan Zhang, Jun Li, Zhifei Wang, Shuyun Zhang, Bin Wang, Yiquan L. Polygalacin D inhibits the growth of hepatocellular carcinoma cells through BNIP3L-mediated mitophagy and endogenous apoptosis pathways. Chinese journal of natural medicines. vol 21. issue 5. 2023-05-28. PMID:37245873. |
in addition, further analysis of autophagy showed that pgd induced mitophagy by increasing bcl2 interacting protein 3 like (bnip3l) levels.in vivo experiments demonstrated that pgd significantly inhibited tumor growth and increased the levels of apoptosis and autophagy in tumors. |
2023-05-28 |
2023-08-14 |
Not clear |
| Mamdoh S Moawadh, Rashid Mir, Faris J Tayeb, Orooba Asim, Mohammad Fahad Ulla. Molecular Evaluation of the Impact of Polymorphic Variants in Apoptotic ( Current issues in molecular biology. vol 45. issue 5. 2023-05-26. PMID:37232720. |
molecular evaluation of the impact of polymorphic variants in apoptotic ( the regulation of apoptosis (the programmed cell death) is dependent on the crucial involvement of bcl2 and bax. |
2023-05-26 |
2023-08-14 |
Not clear |
| Xueping Ke, Shicheng Yu, Shubiao Situ, Zhenqian Lin, Yiqiang Yua. Morroniside inhibits Beclin1-dependent autophagic death and Bax-dependent apoptosis in cardiomyocytes through repressing BCL2 phosphorylation. In vitro cellular & developmental biology. Animal. 2023-05-08. PMID:37155079. |
morroniside inhibits beclin1-dependent autophagic death and bax-dependent apoptosis in cardiomyocytes through repressing bcl2 phosphorylation. |
2023-05-08 |
2023-08-14 |
rat |
| Xueping Ke, Shicheng Yu, Shubiao Situ, Zhenqian Lin, Yiqiang Yua. Morroniside inhibits Beclin1-dependent autophagic death and Bax-dependent apoptosis in cardiomyocytes through repressing BCL2 phosphorylation. In vitro cellular & developmental biology. Animal. 2023-05-08. PMID:37155079. |
finally, the significance of bcl2 or jnk in morroniside-regulated autophagy, apoptosis, and proliferation in h9c2 cells was assessed by combining morroniside and bcl2 competitive inhibitor (abt-737) or jnk activator (anisomycin). |
2023-05-08 |
2023-08-14 |
rat |
| Xueping Ke, Shicheng Yu, Shubiao Situ, Zhenqian Lin, Yiqiang Yua. Morroniside inhibits Beclin1-dependent autophagic death and Bax-dependent apoptosis in cardiomyocytes through repressing BCL2 phosphorylation. In vitro cellular & developmental biology. Animal. 2023-05-08. PMID:37155079. |
overall, morroniside inhibits beclin1-dependent autophagic death and bax-dependent apoptosis via jnk-mediated bcl2 phosphorylation, thereby improving the survival of cardiomyocytes under hypoxia. |
2023-05-08 |
2023-08-14 |
rat |
| Fatemeh Hosseini, Masoumeh Mirzaei Chegeni, Ali Bidaki, Mohammad Zaer, Hossein Abolhassani, Seyed Arsalan Seyedi, Seyed Ali Nabipoorashrafi, Arezoo Ashrafnia Menarbazari, Alaa Moeinzadeh, Ahmad Reza Farmani, Mohammad Tavakkoli Yarak. 3D-printing-assisted synthesis of paclitaxel-loaded niosomes functionalized by cross-linked gelatin/alginate composite: Large-scale synthesis and in-vitro anti-cancer evaluation. International journal of biological macromolecules. 2023-05-08. PMID:37156313. |
the anticancer effect of the designed nanocarrier could be attributed to gene expression regulation, where a significant increase in the expression and activity of genes promoting apoptosis (casp-3, casp-8, and casp-9) and inhibiting metastasis (bax, and p53) and a remarkable decrease in metastasis-enhancing genes (bcl2, mmp-2, and mmp-9) were observed. |
2023-05-08 |
2023-08-14 |
Not clear |
| Jianqiu Han, Chen Zhao, Huixia Guo, Tengfei Liu, Yongmei Li, Yalei Qi, Jan M Deussing, Yanjia Zhang, Juan Tan, Honghui Han, Xueyun M. Obesity induces male mice infertility via oxidative stress, apoptosis and glycolysis. Reproduction (Cambridge, England). 2023-05-04. PMID:37140983. |
our study also found that the expression of cleaved caspase-3 (cc3) and b-cell lymphoma-2 (bcl2) showed an obesity severity-dependent manner indicating that apoptosis is highly correlated with male infertility caused by obesity. |
2023-05-04 |
2023-08-14 |
mouse |